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Search results 101 to 200 out of 239 for Taf10

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:7328719
Assay Type: RNA in situ
Annotation Date: 2022-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1792221
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7328901
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7328719
Assay Type: RNA in situ
Annotation Date: 2022-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1792222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7328901
Age: embryonic day 14.5
Image: E14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7328719
Assay Type: RNA in situ
Annotation Date: 2022-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1792224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:7328901
Age: embryonic day 16.5
Image: E16.5
Specimen Label: E16.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7328719
Assay Type: RNA in situ
Annotation Date: 2022-08-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1792226
Stage: TS26
Assay Id: MGI:7328901
Age: embryonic day 18.5
Image: E18.5
Specimen Label: E18.5
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3701473
Assay Type: RNA in situ
Annotation Date: 2007-03-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3701479
Age: embryonic day 12.5
Specimen Label: 2F
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3701473
Assay Type: RNA in situ
Annotation Date: 2007-03-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3701479
Age: embryonic day 12.5
Specimen Label: 2F
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3701473
Assay Type: RNA in situ
Annotation Date: 2007-03-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738320
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3701479
Age: embryonic day 12.5
Specimen Label: not shown
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3701473
Assay Type: RNA in situ
Annotation Date: 2007-03-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287320
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3701479
Age: embryonic day 12.5
Specimen Label: 2F
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3701473
Assay Type: RNA in situ
Annotation Date: 2007-03-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3701479
Age: embryonic day 12.5
Specimen Label: not shown
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:7328719
Assay Type: RNA in situ
Annotation Date: 2022-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3674122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7328901
Age: embryonic day 14.5
Image: E14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7328719
Assay Type: RNA in situ
Annotation Date: 2022-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3674324
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:7328901
Age: embryonic day 16.5
Image: E16.5
Specimen Label: E16.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7328719
Assay Type: RNA in situ
Annotation Date: 2022-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3674021
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7328901
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3701467
Assay Type: Immunohistochemistry
Annotation Date: 2020-04-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3705415
Stage: TS15
Assay Id: MGI:6406340
Age: embryonic day 9.5
Image: 4J
Specimen Label: 4J
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3701467
Assay Type: Immunohistochemistry
Annotation Date: 2020-04-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3705415
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6406340
Age: embryonic day 9.5
Image: 4I
Specimen Label: 4I
Detected: true
Specimen Num: 1
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Publication
11438666 | J:78794
First Author: Gangloff YG
Year: 2001
Journal: Mol Cell Biol
Title: The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger.
Volume: 21
Issue: 15
Pages: 5109-21
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Publication
7744009 | J:25214
First Author: Le Douarin B
Year: 1995
Journal: EMBO J
Title: The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.
Volume: 14
Issue: 9
Pages: 2020-33
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Publication
17694077 | J:320276
First Author: Nagy Z
Year: 2007
Journal: Oncogene
Title: Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation.
Volume: 26
Issue: 37
Pages: 5341-57
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Publication
9880483 | J:320278
First Author: Schiltz RL
Year: 1999
Journal: J Biol Chem
Title: Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates.
Volume: 274
Issue: 3
Pages: 1189-92
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Publication
11564863 | J:320036
First Author: Martinez E
Year: 2001
Journal: Mol Cell Biol
Title: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.
Volume: 21
Issue: 20
Pages: 6782-95
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Publication
19114550 | J:320037
First Author: Nagy Z
Year: 2009
Journal: Mol Cell Biol
Title: The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.
Volume: 29
Issue: 6
Pages: 1649-60
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Publication
35450884 | J:324708
First Author: Robbe ZL
Year: 2022
Journal: Genes Dev
Title: CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart.
Volume: 36
Issue: 7-8
Pages: 468-482
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Publication
11406595 | J:320001
First Author: Brand M
Year: 2001
Journal: EMBO J
Title: UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.
Volume: 20
Issue: 12
Pages: 3187-96
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Publication
10373431 | J:320038
First Author: Brand M
Year: 1999
Journal: J Biol Chem
Title: Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.
Volume: 274
Issue: 26
Pages: 18285-9
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Publication
18206972 | J:320111
First Author: Zhao Y
Year: 2008
Journal: Mol Cell
Title: A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
Volume: 29
Issue: 1
Pages: 92-101
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Publication
19829382 | J:154054
First Author: Lange A
Year: 2009
Journal: Nature
Title: Integrin-linked kinase is an adaptor with essential functions during mouse development.
Volume: 461
Issue: 7266
Pages: 1002-6
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Publication
22639370 | J:184831
First Author: Uchibe K
Year: 2012
Journal: Dev Dyn
Title: Identification of novel transcription-regulating genes expressed during murine molar development.
Volume: 241
Issue: 7
Pages: 1217-26
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Publication
25209997 | J:228779
 
First Author: Alpern D
Year: 2014
Journal: Elife
Title: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.
Volume: 3
Pages: e03613
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Publication
35361962 | J:337771
First Author: El-Saafin F
Year: 2022
Journal: Cell Death Differ
Title: Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death.
Volume: 29
Issue: 5
Pages: 1013-1027
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Publication
27026076 | J:236825
 
First Author: Langer D
Year: 2016
Journal: Nat Commun
Title: Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.
Volume: 7
Pages: 11063
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Publication
22323595 | J:181994
First Author: Kamileri I
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.
Volume: 109
Issue: 8
Pages: 2995-3000
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Publication
22560297 | J:184521
First Author: Koss M
Year: 2012
Journal: Dev Cell
Title: Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.
Volume: 22
Issue: 5
Pages: 913-26
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25959397 | J:251996
First Author: Iturbide A
Year: 2015
Journal: Mol Cell
Title: LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation.
Volume: 58
Issue: 5
Pages: 755-66
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HT Experiment
E-GEOD-68083 | TAF10 interacts with the GATA1 transcription factor and controls mouse erythropoiesis
Series Id: GSE68083
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-MEXP-3442 | Transcription profiling by array of liver from Taf10 knock out mice
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
15870280 | -
First Author: Soutoglou E
Year: 2005
Journal: Mol Cell Biol
Title: The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners.
Volume: 25
Issue: 10
Pages: 4092-104
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Publication
12471261 | J:80657
First Author: Kashiwabara S
Year: 2002
Journal: Science
Title: Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP.
Volume: 298
Issue: 5600
Pages: 1999-2002
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Publication
11076765 | J:65596
First Author: Voss AK
Year: 2000
Journal: Development
Title: Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos.
Volume: 127
Issue: 24
Pages: 5449-61
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Protein Domain
IPR019473 | TFIID_su8_C
Type: Domain
Description: The TATA Binding Protein (TBP) Associated Factor 8 (TAF8) is one of several TAFs that bind TBP, and is involved in forming the Transcription Factor IID (TFIID) complex. TAF8 plays a role in the differentiation of preadipocyte fibroblasts to adipocytes; it is also required for the integration of TAF10 into the TAF complex. The mouse ortholog of TAF8 is called taube nuss protein (TBN), and is required for early embryonic development. TBN mutant mice exhibit disturbances in the balance between cell death and cell survival in the early embryo. TAF8 plays a role in the differentiation of preadipocyte fibroblasts to adipocytes; it is also required for the integration of TAF10 into the TAF complex. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. TAF8 is also a component of a small TAF complex (SMAT), which contains TAF8, TAF10 and SUPT7L. Several TAFs interact via histone-fold motifs. The histone fold (HFD) is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamer. TAF8 contains an H4 related histone fold motif, and interacts with several subunits of TFIID, including TBP and the histone-fold protein TAF10. Currently, five HF-containing TAF pairs have been described or suggested to exist in TFIID: TAF6-TAF9, TAF4-TAF12, TAF11-TAF13, TAF8-TAF10 and TAF3-TAF10 [, , , , ].This entry represents the C-terminal region of subunit 8 (also known as TAF8) of the transcription factor TFIID []. The adjacent N-terminal region generally contains a histone fold domain (). This subunit is one of the key subunits of TFIID, being one of several general cofactors which are typically involved in gene activation to bring about the communication between gene-specific transcription factors and components of the general transcription machinery [].
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Publication
12389038 | -
First Author: Jacobs SA
Year: 2002
Journal: Nat Struct Biol
Title: The active site of the SET domain is constructed on a knot.
Volume: 9
Issue: 11
Pages: 833-8
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Publication
12514135 | -
First Author: Kwon T
Year: 2003
Journal: EMBO J
Title: Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet.
Volume: 22
Issue: 2
Pages: 292-303
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Publication
15525938 | J:345036
First Author: Chuikov S
Year: 2004
Journal: Nature
Title: Regulation of p53 activity through lysine methylation.
Volume: 432
Issue: 7015
Pages: 353-60
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Publication
18391193 | -
First Author: Zhang X
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases.
Volume: 105
Issue: 15
Pages: 5728-32
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Publication
18471979 | -
First Author: Subramanian K
Year: 2008
Journal: Mol Cell
Title: Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase.
Volume: 30
Issue: 3
Pages: 336-47
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Publication
27088648 | -
First Author: Takemoto Y
Year: 2016
Journal: J Med Chem
Title: Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.
Volume: 59
Issue: 8
Pages: 3650-60
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Protein Domain
IPR044436 | SETD7_SET
Type: Domain
Description: This entry represents the SET domain found in SETD7, an enzyme that specifically monomethylate Lys-4 of histone H3, thereby creating a specific tag for epigenetic transcriptional activation. Methylation of lysine residues in the N-terminal tails of histones is thought to represent an important component of the mechanism that regulates chromatin structure. SETD7 plays a central role in the transcriptional activation of genes such as collagenase and insulin. It is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. SETD7 also has methyltransferase activity toward non-histone proteins, including TAF10 and p53/TP53. SETD7 monomethylates Lys-189 of TAF10, which increases the affinity of TAF10 for RNA polymerase II. SETD7 monomethylates Lys-372 of p53/TP53, which stabilises p53/TP53 and increases p53/TP53-mediated transcriptional activation [, ]. SETD7 also methylates non-histone proteins, including estrogen receptor alpha (ERa), suggesting it has a role in diverse biological processes. ERa methylation by Set7/9 stabilises ERa and activates its transcriptional activities, which are involved in the carcinogenesis of breast cancer. In a high-throughput screen, treatment of human breast cancer cells (MCF7 cells) with cyproheptadine, a Set7/9 inhibitor, decreased the expression and transcriptional activity of ERa, thereby inhibiting estrogen-dependent cell growth [, ].These enzymes contain a SET domain, which is necessary but not sufficient for histone methyltransferase activity []. Human SETD7 contains an N-terminal β-sheet domain in addition to the conserved SET domain []. Mutagenesis studies identified two residues in the C terminus of the protein that appear essential for catalytic activity toward lysine-4 of histone H3; cofactor AdoMet binds to this domain [].
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Protein Domain
IPR017155 | Hist-Lys_N-MeTrfase_SET
Type: Family
Description: This entry represents histone-lysine N-methyltransferase (SETD7 or SET7/9) (), which contains a SET domain []. This enzyme specifically monomethylate Lys-4 of histone H3, thereby creating a specific tag for epigenetic transcriptional activation. Methylation of lysine residues in the N-terminal tails of histones is thought to represent an important component of the mechanism that regulates chromatin structure. As such SETD7 plays a central role in the transcriptional activation of genes such as collagenase and insulin. It is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. SETD7 also has methyltransferase activity toward non-histone proteins, including TAF10 and p53/TP53. SETD7 monomethylates Lys-189 of TAF10, which increases the affinity of TAF10 for RNA polymerase II. SETD7 monomethylates Lys-372 of p53/TP53, which stabilises p53/TP53 and increases p53/TP53-mediated transcriptional activation []. These enzymes contain a SET domain, which is necessary but not sufficient for histone methyltransferase activity []. Human SETD7 contains an N-terminal β-sheet domain in addition to the conserved SET domain []. Mutagenesis studies []identified two residues in the C terminus of the protein that appear essential for catalytic activity toward lysine-4 of histone H3; cofactor AdoMet binds to this domain.
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Publication
34634302 | J:345548
First Author: Scheer E
Year: 2021
Journal: J Biol Chem
Title: TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival.
Volume: 297
Issue: 5
Pages: 101288
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Protein
Q9EQH4
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: false
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Publication
16858867 | -
First Author: Thomas MC
Year: 2006
Journal: Crit Rev Biochem Mol Biol
Title: The general transcription machinery and general cofactors.
Volume: 41
Issue: 3
Pages: 105-78
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Publication
17375202 | -
First Author: Demény MA
Year: 2007
Journal: PLoS One
Title: Identification of a small TAF complex and its role in the assembly of TAF-containing complexes.
Volume: 2
Issue: 3
Pages: e316
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Publication
14660634 | -
First Author: Daniel JA
Year: 2004
Journal: J Biol Chem
Title: Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription.
Volume: 279
Issue: 3
Pages: 1867-71
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Publication
24307402 | -
First Author: Kamata K
Year: 2014
Journal: J Biochem
Title: The N-terminus and Tudor domains of Sgf29 are important for its heterochromatin boundary formation function.
Volume: 155
Issue: 3
Pages: 159-71
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Protein Domain
IPR037802 | SGF29
Type: Family
Description: SAGA-associated factor 29 (SGF29) is a chromatin reader and a component of the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK [, ]. In the SAGA complex, SGF29 binds histone H3 that has been methylated at Lys-4 (H3K4me), and preferably binds the trimethylated form (H3K4me3) []. SGF29 also acts as a boundary, preventing the spread of heterochromatin into neighbouring genes [].The transcription regulatory histone acetylation complex Spt-Ada-Gcn5 acetyltransferase (SAGA) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. SAGA preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B []. SAGA is known as PCAF in vertebrates and PCAF acetylates nucleosomal histone H3 []. The SAGA complex consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1, and some of these components are present as two copies. The complex is built up from distinct modules, each of which has a separate function and crosslinks with either other proteins or other modules in the complex [].SLIK (SAGA-like) is a multi-subunit histone acetyltransferase complex that preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B. It is an embellishment of the SAGA complex. The yeast SLIK complex consists of at least TRA1, CHD1, SPT7, CC TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8 (a deubiquitinase), GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9 [, ].
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Protein Domain
IPR037798 | UBP8
Type: Family
Description: This entry includes the ubiquitin carboxyl-terminal hydrolases 8 (UBP8; from Saccharomyces cerevisiae; MEROPS identifier C19.087). UBP8 is a component of the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK []. In SAGA and SLIK, UBP8 deubiquitinates histone H2B and this regulates transcription []. UBP8 has a zinc-binding domain with which it associates with the SAGA complex via the Sgf11 protein [].The transcription regulatory histone acetylation complex Spt-Ada-Gcn5 acetyltransferase (SAGA) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. SAGA preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B []. SAGA is known as PCAF in vertebrates and PCAF acetylates nucleosomal histone H3 []. The SAGA complex consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1, and some of these components are present as two copies. The complex is built up from distinct modules, each of which has a separate function and crosslinks with either other proteins or other modules in the complex [].SLIK (SAGA-like) is a multi-subunit histone acetyltransferase complex that preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B. It is an embellishment of the SAGA complex. The yeast SLIK complex consists of at least TRA1, CHD1, SPT7, CC TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8 (a deubiquitinase), GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9 [, ].
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Publication
10026213 | -
First Author: Grant PA
Year: 1999
Journal: J Biol Chem
Title: Expanded lysine acetylation specificity of Gcn5 in native complexes.
Volume: 274
Issue: 9
Pages: 5895-900
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Protein
Q8VHL1
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
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Publication
12372304 | -
First Author: Wilson JR
Year: 2002
Journal: Cell
Title: Crystal structure and functional analysis of the histone methyltransferase SET7/9.
Volume: 111
Issue: 1
Pages: 105-15
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Publication
15657441 | -
First Author: Ingvarsdottir K
Year: 2005
Journal: Mol Cell Biol
Title: H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex.
Volume: 25
Issue: 3
Pages: 1162-72
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Protein Domain
IPR037794 | TAF12
Type: Family
Description: Transcription initiation factor TFIID subunit 12 (TAF12) is a component of the DNA-binding general transcription factor complex TFIID []and the transcription regulatory histone acetylation (HAT) complexes SAGA [], SALSA []and SLIK [].The DNA-binding general transcription factor complex TFIID is central to the initiation of DNA-dependent RNA polymerase II transcription. TFIID is the only general transcription initiation factor that bind to the TATA box. The binding of TFIID to the TATA-box is the first step in the formation of a complex able to initiate transcription []. TFIID consists of the TATA binding protein (TBP) and 14 TBP-associated factors (TAFs). One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14 [].The transcription regulatory histone acetylation complex Spt-Ada-Gcn5 acetyltransferase (SAGA) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. SAGA preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B []. SAGA is known as PCAF in vertebrates and PCAF acetylates nucleosomal histone H3 []. The SAGA complex consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1, and some of these components are present as two copies. The complex is built up from distinct modules, each of which has a separate function and crosslinks with either other proteins or other modules in the complex [].SLIK (SAGA-like) is a multi-subunit histone acetyltransferase complex that preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B. It is an embellishment of the SAGA complex. The yeast SLIK complex consists of at least TRA1, CHD1, SPT7, CC TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8 (a deubiquitinase), GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9 [, ].The yeast SALSA complex is an altered form of the SAGA complex and consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3 [].
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Protein Domain
IPR037796 | TAF6
Type: Family
Description: Transcription initiation factor TFIID subunit 6 (TAF6) is a component of the DNA-binding general transcription factor complex TFIID []and the regulatory transcription regulatory histone acetylation (HAT) complexes SAGA [], SALSA []and SLIK [].The DNA-binding general transcription factor complex TFIID is central to the initiation of DNA-dependent RNA polymerase II transcription. TFIID is the only general transcription initiation factor that bind to the TATA box. The binding of TFIID to the TATA-box is the first step in the formation of a complex able to initiate transcription []. TFIID consists of the TATA binding protein (TBP) and 14 TBP-associated factors (TAFs). One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14 [].The transcription regulatory histone acetylation complex Spt-Ada-Gcn5 acetyltransferase (SAGA) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. SAGA preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B []. SAGA is known as PCAF in vertebrates and PCAF acetylates nucleosomal histone H3 []. The SAGA complex consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1, and some of these components are present as two copies. The complex is built up from distinct modules, each of which has a separate function and crosslinks with either other proteins or other modules in the complex [].SLIK (SAGA-like) is a multi-subunit histone acetyltransferase complex that preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B. It is an embellishment of the SAGA complex. The yeast SLIK complex consists of at least TRA1, CHD1, SPT7, CC TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8 (a deubiquitinase), GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9 [, ].The yeast SALSA complex is an altered form of the SAGA complex and consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3 [].
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Publication
15647753 | -
First Author: Pray-Grant MG
Year: 2005
Journal: Nature
Title: Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.
Volume: 433
Issue: 7024
Pages: 434-8
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Publication
12446794 | -
First Author: Pray-Grant MG
Year: 2002
Journal: Mol Cell Biol
Title: The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.
Volume: 22
Issue: 24
Pages: 8774-86
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Publication
25216679 | -
First Author: Han Y
Year: 2014
Journal: EMBO J
Title: Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex.
Volume: 33
Issue: 21
Pages: 2534-46
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Publication
9674426 | -
First Author: Grant PA
Year: 1998
Journal: Cell
Title: A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation.
Volume: 94
Issue: 1
Pages: 45-53
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Publication
17301242 | J:219098
First Author: Wiper-Bergeron N
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.
Volume: 104
Issue: 8
Pages: 2703-8
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Protein
Q9DA08
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: false
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Protein
E9Q1F7
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Protein
A0A0U1RNS1
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Protein
F6ZCH1
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Protein
F6SIC5
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Publication
21685874 | -
First Author: Bian C
Year: 2011
Journal: EMBO J
Title: Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Volume: 30
Issue: 14
Pages: 2829-42
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