Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2854023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13009 |
|
Specimen Label: |
GUDMAP:13009 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2762123 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13008 |
|
Specimen Label: |
GUDMAP:13008 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2762123 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13009 |
|
Specimen Label: |
GUDMAP:13009 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797223 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13008 |
|
Specimen Label: |
GUDMAP:13008 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1832123 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13008 |
|
Specimen Label: |
GUDMAP:13008 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1832123 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13009 |
|
Specimen Label: |
GUDMAP:13009 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2851823 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13008 |
|
Specimen Label: |
GUDMAP:13008 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2851823 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13009 |
|
Specimen Label: |
GUDMAP:13009 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615411 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617761 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615411 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754027 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617761 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2760523 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13008 |
|
Specimen Label: |
GUDMAP:13008 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2760523 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13009 |
|
Specimen Label: |
GUDMAP:13009 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615411 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280927 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617761 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615411 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267921 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617761 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
|
Specimen Label: |
E13.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2852723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13008 |
|
Specimen Label: |
GUDMAP:13008 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2852723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13009 |
|
Specimen Label: |
GUDMAP:13009 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2874723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13009 |
|
Specimen Label: |
GUDMAP:13009 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615411 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3617761 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
|
Specimen Label: |
E13.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615411 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3617761 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2850023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13008 |
|
Specimen Label: |
GUDMAP:13008 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2850023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13009 |
|
Specimen Label: |
GUDMAP:13009 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5001554 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796223 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5542108 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13009 |
|
Specimen Label: |
GUDMAP:13009 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Melot T |
Year: |
2001 |
Journal: |
Eur J Biochem |
Title: |
Characterization of a new brain-specific isoform of the EWS oncoprotein. |
Volume: |
268 |
Issue: |
12 |
Pages: |
3483-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gasperini L |
Year: |
2018 |
Journal: |
Mol Biol Cell |
Title: |
The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization. |
|
|
Pages: |
mbcE18020108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scekic-Zahirovic J |
Year: |
2016 |
Journal: |
EMBO J |
Title: |
Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. |
Volume: |
35 |
Issue: |
10 |
Pages: |
1077-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamileri I |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. |
Volume: |
109 |
Issue: |
8 |
Pages: |
2995-3000 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
McKee AE |
Year: |
2005 |
Journal: |
BMC Dev Biol |
Title: |
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. |
Volume: |
5 |
|
Pages: |
14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mutant Mouse Regional Resource Centers |
Year: |
2004 |
Journal: |
Unpublished |
Title: |
Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mammalian Functional Genomics Centre |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hoffman BG |
Year: |
2008 |
Journal: |
Genome Biol |
Title: |
Identification of transcripts with enriched expression in the developing and adult pancreas. |
Volume: |
9 |
Issue: |
6 |
Pages: |
R99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
RIKEN Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
•
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Allele |
Name: |
TATA-box binding protein associated factor 15; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
113
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents the multi-functional TET (TAF15/EWS/TLS) or FET (FUS/EWS/TLS) protein family.TAF15/EWS/TLS family members include human FUS (Fused in liposarcoma), EWS (Ewing Sarcoma) and TAF15 (TATA binding associated factor 15), and the Drosophila orthologue Cabeza. They are RNA binding proteins that contain a transcriptional-activation domain (EAD), 3 glycine-arginine (RGG) rich regions, an RNA-binding domain (RBD), and a zinc finger domain [, ]. They are involved in transcription and alternative splicing. They are subjected to different environmental signals that induce post-translational modifications in their RBD and in the RGG domains, thus modulating their activity []. TAF15/EWS/TLS play important roles in oncogenesis and neuronal disease []. |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
325
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
354
 |
Fragment?: |
false |
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•
•
•
•
•
|
Publication |
First Author: |
Giannattasio T |
Year: |
2023 |
Journal: |
Cell Mol Life Sci |
Title: |
The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots. |
Volume: |
80 |
Issue: |
4 |
Pages: |
107 |
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•
•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
RNA-binding protein EWS (also known as EWSR1) participates in transcriptional regulation and RNA processing. It is structurally and functionally related to FUS (TLS) protein []. EWSR1 gene rearrangements are often observed in myoepithelial tumours [, ].TAF15/EWS/TLS family members include human FUS (Fused in liposarcoma), EWS (Ewing Sarcoma) and TAF15 (TATA binding associated factor 15), and the Drosophila orthologue Cabeza. They are RNA binding proteins that contain a transcriptional-activation domain (EAD), 3 glycine-arginine (RGG) rich regions, an RNA-binding domain (RBD), and a zinc finger domain [, ]. They are involved in transcription and alternative splicing. They are subjected to different environmental signals that induce post-translational modifications in their RBD and in the RGG domains, thus modulating their activity []. TAF15/EWS/TLS play important roles in oncogenesis and neuronal disease []. |
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•
•
•
•
•
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Publication |
First Author: |
Luo Y |
Year: |
2015 |
Journal: |
BMC Genomics |
Title: |
EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions. |
Volume: |
16 |
|
Pages: |
929 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang SC |
Year: |
2015 |
Journal: |
Genes Chromosomes Cancer |
Title: |
Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors. |
Volume: |
54 |
Issue: |
5 |
Pages: |
267-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Agaram NP |
Year: |
2015 |
Journal: |
Genes Chromosomes Cancer |
Title: |
EWSR1-PBX3: a novel gene fusion in myoepithelial tumors. |
Volume: |
54 |
Issue: |
2 |
Pages: |
63-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamelgarn M |
Year: |
2016 |
Journal: |
Biochim Biophys Acta |
Title: |
Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS. |
Volume: |
1862 |
Issue: |
10 |
Pages: |
2004-14 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
FUS (FUsed in Sarcoma, also known as TLS, Translocated in LipoSarcoma) is a RNA binding protein participating in nucleo-cytoplasmic RNA shuttling. It has functions in multiple cellular pathways. Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS), a progressive and ultimately fatal neurodegenerative disease of the upper and lower motor neurons of the brain and spinal cord []. TLS contains the unstructured N-terminal half followed by the RRM and zinc finger-like domains, which are connected to each other by a flexible linker. Interestingly, whether its RRM domain functions in the binding with RNAs is controversial. Moreover, its C-terminal RGG2-zinc finger-RGG3 domains have been found to function in the interaction with RNA [].TAF15/EWS/TLS family members include human FUS (Fused in liposarcoma), EWS (Ewing Sarcoma) and TAF15 (TATA binding associated factor 15), and the Drosophila orthologue Cabeza. They are RNA binding proteins that contain a transcriptional-activation domain (EAD), 3 glycine-arginine(RGG) rich regions, an RNA-binding domain (RBD), and a zinc finger domain [, ]. They are involved in transcription and alternative splicing. They are subjected to different environmental signals that induce post-translational modifications in their RBD and in the RGG domains, thus modulating their activity []. TAF15/EWS/TLS play important roles in oncogenesis and neuronal disease []. |
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•
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
104
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
280
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
655
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
518
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
518
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
333
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
655
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
518
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
618
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
130
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
661
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
656
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
518
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
517
 |
Fragment?: |
false |
|
•
•
•
•
•
|