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Search results 101 to 122 out of 122 for Tbca

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0.019s

Type

Details

Score

Publication

35027651 | J:322600

First Author:	Yu H
Year:	2022
Journal:	Commun Biol
Title:	Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase.
Volume:	5
Issue:	1
Pages:	51

•

Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Otp-cre)1Hzo/?
Background:	involves: 129S4/SvJae * C57BL/6 * FVB/N
Zygosity:	cn
Has Mutant Allele:	true

•

Genotype

Symbol:	Cic/Cic Tg(Otp-cre)1Hzo/?
Background:	involves: C57BL/6 * C57BL/6N * FVB/N
Zygosity:	cn
Has Mutant Allele:	true

•

Protein

B1ATU0

Organism:	Mus musculus/domesticus
Length:	84
Fragment?:	true

•

Protein

F6UI15

Organism:	Mus musculus/domesticus
Length:	72
Fragment?:	true

•

Publication

12225668 | -

First Author:	Kirik V
Year:	2002
Journal:	Curr Biol
Title:	Functional analysis of the tubulin-folding cofactor C in Arabidopsis thaliana.
Volume:	12
Issue:	17
Pages:	1519-23

•

Publication

11847227 | -

First Author:	Bartolini F
Year:	2002
Journal:	J Biol Chem
Title:	Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.
Volume:	277
Issue:	17
Pages:	14629-34

•

Publication

11959844 | -

First Author:	Steinborn K
Year:	2002
Journal:	Genes Dev
Title:	The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth.
Volume:	16
Issue:	8
Pages:	959-71

•

Publication

10099932 | -

First Author:	Mayer U
Year:	1999
Journal:	Eur J Cell Biol
Title:	Mutations in the pilz group genes disrupt the microtubule cytoskeleton and uncouple cell cycle progression from cell division in Arabidopsis embryo and endosperm.
Volume:	78
Issue:	2
Pages:	100-8

•

Publication

26208336 | -

First Author:	Nithianantham S
Year:	2015
Journal:	Elife
Title:	Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics.
Volume:	4

•

Protein Domain

IPR027684 | TBCC

Type:

Family

Description:

The tubulin heterodimer consists of one alpha- and one beta-tubulin polypeptide. In humans, five tubulin-specific chaperones termed TBCA/B/C/D/E are essential for bring the alpha- and beta-tubulin subunits together into a tightly associated heterodimer. Following the generation of quasi-native beta- and alpha-tubulin polypeptides (via multiple rounds of ATP-dependent interaction with the cytosolic chaperonin), TBCA and TBCB bind to and stabilise newly synthesised beta- and alpha-tubulin, respectively. The exchange of beta-tubulin between TBCA and TBCD, and of alpha-tubulin between TBCB and TBCE, resulting in the formation of TBCD/beta and TBCE/alpha. These two complexes then interact with each other and form a supercomplex (TBCE/alpha/TBCD/beta). Interaction of the supercomplex with TBCC causes the disassembly of the supercomplex and the release of E-site GDP-bound alpha/beta tubulin heterodimer, which becomes polymerization competent following spontaneous exchange with GTP [].This entry represents tubulin-specific chaperone C (TBCC, also known as tubulin-folding cofactor C), which is involved in the final step of the tubulin folding pathway [, ]. In Arabidopsis thaliana, it is required for continuous microtubule cytoskeleton organisation, mitotic division, cytokinesis, and to couple cell cycle progression to cell division in embryos and endosperms [, ].

•

Protein Domain

IPR033162 | TBCD

Type:

Family

Description:

The tubulin heterodimer consists of one alpha- and one beta-tubulin polypeptide. In humans, five tubulin-specific chaperones termed TBCA/B/C/D/E are essential for bring the alpha- and beta-tubulin subunits together into a tightly associated heterodimer. Following the generation of quasi-native beta- and alpha-tubulin polypeptides (via multiple rounds of ATP-dependent interaction with the cytosolic chaperonin), TBCA and TBCB bind to and stabilise newly synthesised beta- and alpha-tubulin, respectively. The exchange of beta-tubulin between TBCA and TBCD, and of alpha-tubulin between TBCB and TBCE, resulting in the formation of TBCD/beta and TBCE/alpha. These two complexes then interact with each other and form a supercomplex (TBCE/alpha/TBCD/beta). Interaction of the supercomplex with TBCC causes the disassembly of the supercomplex and the release of E-site GDP-bound alpha/beta tubulin heterodimer, which becomes polymerization competent following spontaneous exchange with GTP [].This entry represents tubulin-folding cofactor D (TBCD) and its homologues. Its ability to interact with beta tubulin is regulated via its interaction with ARL2 (ADP ribosylation factor-like protein 2), a small monomeric G protein. ARL2 inhibits the beta-tubulin GTPase activating protein (GAP) activity of TBCD, and its interaction with native tubulin dimers [, ].

•

Publication

23756185 | J:207060

First Author:	Song W
Year:	2013
Journal:	Neuroscience
Title:	Globular adiponectin elicits neuroprotection by inhibiting NADPH oxidase-mediated oxidative damage in ischemic stroke.
Volume:	248

Pages:	136-44

•

Genotype

Symbol:	Cic/Cic Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Otp-cre)1Hzo/?
Background:	involves: 129S4/SvJae * C57BL/6N * FVB/N
Zygosity:	cn
Has Mutant Allele:	true

•

Publication

26176793 | J:260641

First Author:	Iniaghe LO
Year:	2015
Journal:	Neurobiol Dis
Title:	Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage.
Volume:	82

Pages:	349-358

•

Protein

Q8CHC0

Organism:	Mus musculus/domesticus
Length:	352
Fragment?:	true

•

Protein

Q8R199

Organism:	Mus musculus/domesticus
Length:	151
Fragment?:	true

•

Publication

10831612 | -

First Author:	Bhamidipati A
Year:	2000
Journal:	J Cell Biol
Title:	ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.
Volume:	149
Issue:	5
Pages:	1087-96

•

Protein

Q8BYA0

Organism:	Mus musculus/domesticus
Length:	1196
Fragment?:	false

•

Publication

28288114 | J:240674

First Author:	Lu HC
Year:	2017
Journal:	Nat Genet
Title:	Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.
Volume:	49
Issue:	4
Pages:	527-536

•

Protein

Q8VCN9

Organism:	Mus musculus/domesticus
Length:	341
Fragment?:	false

•

Protein

A0A0R4J0M1

Organism:	Mus musculus/domesticus
Length:	341
Fragment?:	false

•

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