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Search results 101 to 144 out of 144 for Tfg

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0.025s

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Type Details Score
Protein Domain
IPR025768 | TFG_box
Type: Domain
Description: Sm and Sm-like proteins of the RNA-binding Lsm (like Sm) domain family arefound in all domains of life and are generally involved in important RNA-processing tasks. Lsm13-16 homologues share a domain organisation consisting ofa divergent N-terminal Lsm domain and a central or C-terminal consensus motifDFDF-x(7)-F. In few other sequences, the DFDF box is replaced by a DYDF or EFDF box [].The FFD box and TFG box are two other strongly conserved sequence motifs(Y-x-K-x(3)-FFD-x-[IL]-S and [RKH]-x(2,5)-E-x(0-2)-[RK]-x(3,4)-[DE]-TFG respectively) contained in Lsm13-15, but not Lsm16, homologues. They succeed the DFDF-x(7)-F motif and are also predicted to be of helical nature [].This entry represents the TGF box.
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Protein
A0A0U1RP30
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
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Protein
Q3TS70
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Protein
Q8BM41
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Protein
Q4KL69
Organism: Mus musculus/domesticus
Length: 240  
Fragment?: false
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Publication
9488046 | -
First Author: Greco A
Year: 1998
Journal: Oncogene
Title: Role of the TFG N-terminus and coiled-coil domain in the transforming activity of the thyroid TRK-T3 oncogene.
Volume: 16
Issue: 6
Pages: 809-16
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DO Term
DOID:0110809 | hereditary spastic paraplegia 57
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Protein
Q8K2F8
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Protein
Q8CGC4
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Publication
15225602 | -
First Author: Albrecht M
Year: 2004
Journal: FEBS Lett
Title: Novel Sm-like proteins with long C-terminal tails and associated methyltransferases.
Volume: 569
Issue: 1-3
Pages: 18-26
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Allele
Tg(Tfg-EGFP)IH44Gsat | MGI:4847485
Name: transgene insertion IH44, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003962 | STOCK Tg(Tfg-EGFP)IH44Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Tg(Itgax-TGFBR2)1Flv | MGI:3795208
Name: transgene insertion 1, Richard A Flavell
Allele Type: Transgenic
Attribute String: Dominant negative, Humanized sequence, Inserted expressed sequence
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Publication
22489105 | -
First Author: Takeuchi S
Year: 2012
Journal: Acta Histochem Cytochem
Title: Immunohistochemical Mapping of TRK-Fused Gene Products in the Rat Brainstem.
Volume: 45
Issue: 1
Pages: 57-64
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Publication
22581839 | -
First Author: Lim B
Year: 2012
Journal: Carcinogenesis
Title: The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC.
Volume: 33
Issue: 8
Pages: 1450-8
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Protein Domain
IPR034857 | PB1_TFG
Type: Domain
Description: This is the PB1 domain found in TFG protein (TRK-fused gene), an oncogenic gene product first identified as a fusion partner to nerve growth factor tyrosine kinase receptor TrkA/NTRK1 []and subsequently found as an oncogenic fusion gene in various cancers [, ]. TFG is localised at endoplasmic reticulum (ER) exit sites and modulates ER export []. It may function at the ER/ERGIC interface to locally concentrate COPII-coated transport carriers and link exit sites on the ER to ERGIC membranes []. It is also a an inhibitory regulator of the ubiquitin-proteasome system [].The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster []. The PB1 domain of TFG represent a type I/II domain.
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Strain
MGI:3795449 | C.Cg-Tg(Itgax-TGFBR2)1Flv
Attribute String: congenic, transgenic
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Strain
MGI:3795476 | B6.Cg-Tg(Itgax-TGFBR2)1Flv/J
Attribute String: congenic, transgenic
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Publication
15852008 | J:98953
First Author: Laouar Y
Year: 2005
Journal: Nat Immunol
Title: Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma.
Volume: 6
Issue: 6
Pages: 600-7
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Publication
22863752 | J:187587
First Author: Marcoe JP
Year: 2012
Journal: Nat Immunol
Title: TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy.
Volume: 13
Issue: 9
Pages: 843-50
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Publication
25361568 | J:227805
First Author: Domingo-Gonzalez R
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation.
Volume: 308
Issue: 1
Pages: L86-95
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Publication
23008450 | J:190616
First Author: Domingo-Gonzalez R
Year: 2012
Journal: J Immunol
Title: COX-2 expression is upregulated by DNA hypomethylation after hematopoietic stem cell transplantation.
Volume: 189
Issue: 9
Pages: 4528-36
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Genotype
Genotype
Symbol: Tg(Itgax-TGFBR2)1Flv/?
Background: C.Cg-Tg(Itgax-TGFBR2)1Flv
Zygosity: ot
Has Mutant Allele: true
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Protein Domain
IPR025761 | FFD_box
Type: Domain
Description: Sm and Sm-like proteins of the RNA-binding Lsm (like Sm) domain family arefound in all domains of life and are generally involved in important RNA-processing tasks. Lsm13-16 homologues share a domain organisation consisting ofa divergent N-terminal Lsm domain and a central or C-terminal consensus motifDFDF-x(7)-F. In few other sequences, the DFDF box is replaced by a DYDF or EFDF box [].The FFD box and TFG box are two other strongly conserved sequence motifs(Y-x-K-x(3)-FFD-x-[IL]-S and [RKH]-x(2,5)-E-x(0-2)-[RK]-x(3,4)-[DE]-TFG respectively) contained in Lsm13-15, but not Lsm16, homologues. They succeed the DFDF-x(7)-F motif and are also predicted to be of helical nature [].This entry represents the FFD box.
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Genotype
Genotype
Symbol: Eomes/? Tg(Itgax-TGFBR2)1Flv/?
Background: involves: C3H * C57BL/6 * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
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Publication
24632608 | J:218620
First Author: Hsu TI
Year: 2015
Journal: Oncogene
Title: MMP7-mediated cleavage of nucleolin at Asp255 induces MMP9 expression to promote tumor malignancy.
Volume: 34
Issue: 7
Pages: 826-37
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Publication
7485998 | J:28117
First Author: Mahmood R
Year: 1995
Journal: Anat Embryol (Berl)
Title: The effects of retinoid status on TGF beta expression during mouse embryogenesis.
Volume: 192
Issue: 1
Pages: 21-33
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Publication
23925295 | J:201617
First Author: Hanks BA
Year: 2013
Journal: J Clin Invest
Title: Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
Volume: 123
Issue: 9
Pages: 3925-40
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Publication
18669656 | J:140054
First Author: Laouar Y
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis.
Volume: 105
Issue: 31
Pages: 10865-70
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Publication
28214225 | J:258622
First Author: Mondanelli G
Year: 2017
Journal: Immunity
Title: A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.
Volume: 46
Issue: 2
Pages: 233-244
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Publication
21880769 | J:177047
First Author: Allen SJ
Year: 2011
Journal: J Virol
Title: Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation.
Volume: 85
Issue: 21
Pages: 11448-56
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Publication
21924228 | J:180020
First Author: Coomes SM
Year: 2011
Journal: Am J Pathol
Title: Severe gammaherpesvirus-induced pneumonitis and fibrosis in syngeneic bone marrow transplant mice is related to effects of transforming growth factor-β.
Volume: 179
Issue: 5
Pages: 2382-96
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Publication
19285948 | -
First Author: Tritschler F
Year: 2009
Journal: Mol Cell
Title: Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B.
Volume: 33
Issue: 5
Pages: 661-8
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Protein Domain
IPR025762 | DFDF
Type: Domain
Description: Sm and Sm-like proteins of the RNA-binding Lsm (like Sm) domain family arefound in all domains of life and are generally involved in important RNA-processing tasks. Lsm13-16 homologs share a domain organisation consisting ofa divergent N-terminal Lsm domain and a central or C-terminal consensus motifDFDF-x(7)-F closely preceded and followed by further phenylalanines andcharged aspartates/glutamates and arginines/lysines/histidines. The variableseven-residue tract of this consensus motif usually contains an asparagine atthe third or fourth position except of one sequence where the asparagine isreplaced by a glycine. In few other sequences, the DFDF box is replaced by aDYDF or EFDF box []. The DFDF domain is a heterodimerization domain, whichadopts a helical conformation upon binding. It folds into twoconsecutive alpha helices that are preceded and connected by the FDF and arelated FDK sequence [].Two other strongly conserved FFD box and TFG box sequence motifs Y-x-K-x(3)-FFD-x-[IL]-S and [RKH]-x(2,5)-E-x(0-2)-[RK]-x(3,4)-[DE]-TFG contained inLsm13-15, but not Lsm16, homologs succeed the DFDF-x(7)-F motif and are alsopredicted to be of helical nature [].This entry represents the DFDF domain.
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Publication
36817487 | J:335154
 
First Author: Hirose S
Year: 2023
Journal: Front Immunol
Title: IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination.
Volume: 14
Pages: 1102486
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Publication
24516120 | J:210160
First Author: Daussy C
Year: 2014
Journal: J Exp Med
Title: T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow.
Volume: 211
Issue: 3
Pages: 563-77
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Publication
19604492 | J:151577
First Author: Sanjabi S
Year: 2009
Journal: Immunity
Title: Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells.
Volume: 31
Issue: 1
Pages: 131-44
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Publication
24497535 | J:210177
First Author: Wong WW
Year: 2014
Journal: Blood
Title: cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.
Volume: 123
Issue: 16
Pages: 2562-72
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Publication
18516051 | J:137043
First Author: Town T
Year: 2008
Journal: Nat Med
Title: Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
Volume: 14
Issue: 6
Pages: 681-7
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Publication
17726178 | -
First Author: Sumimoto H
Year: 2007
Journal: Sci STKE
Title: Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants.
Volume: 2007
Issue: 401
Pages: re6
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Protein
F6X2V9
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: true
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Protein
Q8K2D3
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Protein
A0ELI5
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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