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Search results 101 to 163 out of 163 for Tnfrsf10b

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Type Details Score
Publication
33323382 | J:303990
First Author: Kon N
Year: 2021
Journal: Cancer Res
Title: Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function.
Volume: 81
Issue: 4
Pages: 935-944
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Publication
21040902 | J:167536
First Author: Abbas HA
Year: 2010
Journal: Cell Stem Cell
Title: Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.
Volume: 7
Issue: 5
Pages: 606-17
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Publication
30635284 | J:272566
 
First Author: Yang R
Year: 2019
Journal: Development
Title: CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
Volume: 146
Issue: 2
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Publication
30858352 | J:276962
First Author: Kon N
Year: 2019
Journal: Cell Death Dis
Title: Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo.
Volume: 10
Issue: 3
Pages: 237
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Publication
26383973 | J:239805
First Author: Grigaravicius P
Year: 2016
Journal: Cell Death Differ
Title: Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain.
Volume: 23
Issue: 3
Pages: 454-68
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Publication
38131461 | J:352165
First Author: Lin Y
Year: 2024
Journal: Dev Dyn
Title: Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development.
Volume: 253
Issue: 7
Pages: 635-647
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Publication
11239407 | J:74923
First Author: Locksley RM
Year: 2001
Journal: Cell
Title: The TNF and TNF receptor superfamilies: integrating mammalian biology.
Volume: 104
Issue: 4
Pages: 487-501
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Publication
18776938 | J:141141
First Author: Song B
Year: 2008
Journal: J Clin Invest
Title: Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
Volume: 118
Issue: 10
Pages: 3378-89
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Publication
37813816 | J:358134
First Author: Soma S
Year: 2024
Journal: Stem Cells
Title: O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation.
Volume: 42
Issue: 1
Pages: 55-63
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Publication
12819136 | J:84168
First Author: Reed JC
Year: 2003
Journal: Genome Res
Title: Comparative analysis of apoptosis and inflammation genes of mice and humans.
Volume: 13
Issue: 6B
Pages: 1376-88
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Publication
- | J:342609
       
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Tnfrsf10b<em1(TNFRSF10B)Smoc> | MGI:7292870
Name: tumor necrosis factor receptor superfamily, member 10b; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tnfrsf10b<em2Smoc> | MGI:7292871
Name: tumor necrosis factor receptor superfamily, member 10b; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6771225 | C57BL/6JSmoc-Tnfrsf10b<em1(TNFRSF10B)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6429696 | C57BL/6JSmoc-Tnfrsf10B<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
17381838 | J:355763
 
First Author: Edwards MG
Year: 2007
Journal: BMC Genomics
Title: Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program.
Volume: 8
Pages: 80
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HT Experiment
E-GEOD-6323 | Transcription profiling of skeletal muscles from young, old, and old calorie restricted C57BL/6NHsd mice to investigate age-related changes in the transcriptional profile
Series Id: GSE6323
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
15538968 | -
First Author: Kimberley FC
Year: 2004
Journal: Cell Res
Title: Following a TRAIL: update on a ligand and its five receptors.
Volume: 14
Issue: 5
Pages: 359-72
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Publication
23584885 | -
First Author: Gottwald L
Year: 2013
Journal: Arch Gynecol Obstet
Title: Membrane expression of TRAIL receptors DR4, DR5, DcR1 and DcR2 in the normal endometrium, atypical endometrial hyperplasia and endometrioid adenocarcinoma: a tissue microarray study.
Volume: 288
Issue: 4
Pages: 889-99
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Publication
24649804 | -
First Author: Gottwald L
Year: 2014
Journal: J Obstet Gynaecol
Title: Membrane expression of trail receptors DcR1 and DcR2 in the normal endometrium, endometrial atypical hyperplasia and endometrioid endometrial cancer.
Volume: 34
Issue: 4
Pages: 346-9
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Publication
24211571 | -
First Author: Venza M
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma.
Volume: 441
Issue: 4
Pages: 743-50
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Publication
18310272 | -
First Author: Murphy TM
Year: 2008
Journal: Endocr Relat Cancer
Title: The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer.
Volume: 15
Issue: 1
Pages: 11-25
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Publication
20571073 | -
First Author: Spitzer D
Year: 2010
Journal: Mol Cancer Ther
Title: A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing.
Volume: 9
Issue: 7
Pages: 2142-51
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Publication
12655296 | -
First Author: LeBlanc HN
Year: 2003
Journal: Cell Death Differ
Title: Apo2L/TRAIL and its death and decoy receptors.
Volume: 10
Issue: 1
Pages: 66-75
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Publication
9430228 | -
First Author: Schneider P
Year: 1997
Journal: Immunity
Title: TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
Volume: 7
Issue: 6
Pages: 831-6
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Publication
16980609 | -
First Author: Mérino D
Year: 2006
Journal: Mol Cell Biol
Title: Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.
Volume: 26
Issue: 19
Pages: 7046-55
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Protein Domain
IPR034024 | TNFRSF10_N
Type: Domain
Description: Tumor necrosis factor receptor superfamily member 10 (TNFRSF10) family contains TNFRSF10A (also known as DR4, Apo2, TRAIL-R1, CD261), TNFRSF10B (also known as DR5, KILLER, TRICK2A, TRAIL-R2, TRICKB, CD262), TNFRSF10C (also known as DcR1, TRAIL-R3, LIT, TRID, CD263), and TNFRSF10D (also known as DcR2, TRUNDD, TRAIL-R4, CD264). Tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL) binds to all 4 receptors.DR4 (TRAIL-R1) and DR5 (TRAIL-R2) are membrane-bound and contain a death domain in their intracellular portion, which is able to transmit an apoptotic signal, thus often called death receptors. In contrast, DcR1 (TRAIL-R3), which lacks the complete intracellular portion and DcR2 (TRAIL-R4), which has a truncated cytoplasmic death domain, do not transmit an apoptotic signal, thus known as decoy receptors [, ]. Apoptosis mediated by DR4 and DR5 requires Fas (TNFRSF6)-associated via death domain (FADD), a death domain containing adaptor protein []. DcR1 appears to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis; DcR2 has been shown to play an inhibitory role in TRAIL-induced cell apoptosis []. The membrane expression of all of these receptors (DR4, DR5, DcR1, and DcR2) is greater in normal endometrium (NE) than in endometrioid adenocarcinoma (EAC) [, ]. In EAC patients, membrane expression of these receptors are not independent predictors of survival. DcR1 and DcR2 expression is critical in cell growth and apoptosis in cutaneous or uveal melanoma []; DcR1 and DcR2 are frequently methylated in both, leading to loss of gene expression and melanomagenesis. On the other hand, DR4 and DR5 methylation is rare in cutaneous melanoma and frequent in uveal melanoma; their expression is wholly independent of the promoter methylation status. DcR1 and DcR2 genes are also reported to be hyper-methylated in prostate cancer []. The TRAIL ligand, a potent and specific inducer of apoptosis in cancer cells, has been explored as a therapeutic drug; experimental data has shown that DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer [].This entry represents the N-terminal domain of TNFRSF10. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].
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Protein
Q9QZM4
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
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Publication
9538693 | -
First Author: Naismith JH
Year: 1998
Journal: Trends Biochem Sci
Title: Modularity in the TNF-receptor family.
Volume: 23
Issue: 2
Pages: 74-9
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Publication
11796220 | -
First Author: Bodmer JL
Year: 2002
Journal: Trends Biochem Sci
Title: The molecular architecture of the TNF superfamily.
Volume: 27
Issue: 1
Pages: 19-26
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Publication
8387891 | -
First Author: Banner DW
Year: 1993
Journal: Cell
Title: Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
Volume: 73
Issue: 3
Pages: 431-45
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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