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Search results 101 to 114 out of 114 for Tnfrsf25

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0.019s

Type

Details

Score

Publication

24453414 | -

First Author:	Aiba Y
Year:	2013
Journal:	Mediators Inflamm
Title:	The role of TL1A and DR3 in autoimmune and inflammatory diseases.
Volume:	2013

Pages:	258164

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Publication

22017439 | -

First Author:	Meylan F
Year:	2011
Journal:	Immunol Rev
Title:	TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation.
Volume:	244
Issue:	1
Pages:	188-96

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Publication

26099067 | -

First Author:	Siakavellas SI
Year:	2015
Journal:	Inflamm Bowel Dis
Title:	Tumor Necrosis Factor-like Cytokine TL1A and Its Receptors DR3 and DcR3: Important New Factors in Mucosal Homeostasis and Inflammation.
Volume:	21
Issue:	10
Pages:	2441-52

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Publication

8875942 | -

First Author:	Chinnaiyan AM
Year:	1996
Journal:	Science
Title:	Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.
Volume:	274
Issue:	5289
Pages:	990-2

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Protein Domain

IPR034050 | TNFRSF25_N

Type:

Domain

Description:

TNFRSF25 (also known as death receptor 3 (DR3), death domain receptor 3 (DDR3), apoptosis-mediating receptor, lymphocyte associated receptor of death (LARD), apoptosis inducing receptor (AIR), APO-3, translocating chain-association membrane protein (TRAMP), WSL-1, WSL-LR or TNFRSF12) is preferentially expressed in thymocytes and lymphocytes, and may play a role in regulating lymphocyte homeostasis [, ]. Various death domain containing adaptor proteins mediate the signal transduction of this receptor; it activates nuclear factor kappa-B (NFkB) and induces cell apoptosis by associating with TNFRSF1A-associated via death domain (TRADD), which is known to mediate signal transduction of tumor necrosis factor receptors []. DR3 associates with tumor necrosis factor (TNF)-like cytokine 1A (TL1A also known as TNFSF15) on activated lymphocytes and induces pro-inflammatory signals; TL1A also binds decoy receptor DcR3 (also known as TNFRSF6B) []. DR3/DcR3/TL1A expression is increased in both serum and inflamed tissues in autoimmune diseases such as in several autoimmune diseases, including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), allergic asthma, experimental autoimmune encephalomyelitis, type 1 diabetes, ankylosing spondylitis (AS), and primary biliary cirrhosis (PBC), making modulation of TL1A-DR3 interaction a potential therapeutic target [].This entry represents the N-terminal domain of TNFRSF25. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].

•

Protein

Q5UBV8

Organism:	Mus musculus/domesticus
Length:	252
Fragment?:	false

•

Protein

B2RR33

Organism:	Mus musculus/domesticus
Length:	252
Fragment?:	false

•

Protein

A0A0U5J7F3

Organism:	Mus musculus/domesticus
Length:	270
Fragment?:	false

•

Protein

Q8VD70

Organism:	Mus musculus/domesticus
Length:	387
Fragment?:	false

•

Protein

Q99MM1

Organism:	Mus musculus/domesticus
Length:	413
Fragment?:	false

•

Protein

B1AWN9

Organism:	Mus musculus/domesticus
Length:	411
Fragment?:	false

•

Publication

9538693 | -

First Author:	Naismith JH
Year:	1998
Journal:	Trends Biochem Sci
Title:	Modularity in the TNF-receptor family.
Volume:	23
Issue:	2
Pages:	74-9

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Publication

11796220 | -

First Author:	Bodmer JL
Year:	2002
Journal:	Trends Biochem Sci
Title:	The molecular architecture of the TNF superfamily.
Volume:	27
Issue:	1
Pages:	19-26

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Publication

8387891 | -

First Author:	Banner DW
Year:	1993
Journal:	Cell
Title:	Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
Volume:	73
Issue:	3
Pages:	431-45

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