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Search results 101 to 116 out of 116 for Tnfsf15

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0.016s

Type

Details

Score

Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

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Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

•

Allele

Tnfsf15<em1Smoc> | MGI:7292906

Name:	tumor necrosis factor (ligand) superfamily, member 15; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

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Allele

Tnfsf15<tm1(TNFSF15)Smoc> | MGI:7786969

Name:	tumor necrosis factor (ligand) superfamily, member 15; targeted mutation 1, Shanghai Model Organisms Center
Allele Type:	Targeted
Attribute String:	Humanized sequence, Inserted expressed sequence

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Strain

MGI:6429707 | C57BL/6JSmoc-Tnfsf15<em1Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

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Publication

27492902 | J:241269

First Author:	Zhao Y
Year:	2016
Journal:	Nat Commun
Title:	Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.
Volume:	7

Pages:	12368

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Publication

18411341 | J:136276

First Author:	Fang L
Year:	2008
Journal:	J Exp Med
Title:	Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation.
Volume:	205
Issue:	5
Pages:	1037-48

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Publication

22138299 | J:180526

First Author:	Barrett R
Year:	2012
Journal:	Am J Pathol
Title:	Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.
Volume:	180
Issue:	2
Pages:	636-49

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Publication

22325083 | -

First Author:	Chen MH
Year:	2012
Journal:	Clin Exp Rheumatol
Title:	Overexpression of decoy receptor 3 in synovial tissues of inflammatory arthritis.
Volume:	30
Issue:	2
Pages:	171-7

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Publication

22626963 | -

First Author:	Hung SC
Year:	2012
Journal:	Clin J Am Soc Nephrol
Title:	Decoy receptor 3, a novel inflammatory marker, and mortality in hemodialysis patients.
Volume:	7
Issue:	8
Pages:	1257-65

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Publication

21295012 | -

First Author:	Lin WW
Year:	2011
Journal:	Biochem Pharmacol
Title:	Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer.
Volume:	81
Issue:	7
Pages:	838-47

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Publication

18201904 | -

First Author:	Inoue Y
Year:	2008
Journal:	Fish Shellfish Immunol
Title:	Molecular cloning and preliminary expression analysis of banded dogfish (Triakis scyllia) TNF decoy receptor 3 (TNFRSF6B).
Volume:	24
Issue:	3
Pages:	360-5

•

Protein Domain

IPR034023 | TNFRSF6B_N

Type:

Domain

Description:

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as decoy receptor 3 (DcR3), M68, or TR6. This protein is a soluble receptor secreted by cells, that does not contain a death domain and cytoplasmic domain. It acts as a decoy receptor that competes with death receptors for ligand binding. It is a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases, and cancer []. Over-expression of this gene has been noted in several cancers, including pancreatic carcinoma, and gastrointestinal tract tumors. It can neutralize the biological effects of three tumor necrosis factor superfamily (TNFSF) members: TNFSF6 (Fas ligand/FasL/CD95L) and TNFSF14 (LIGHT) which are both involved in apoptosis and inflammation, and TNFSF15 (TNF-like molecule 1A/TL1A), which is a T cell co-stimulator and involved in gut inflammation []. DcR3 is a novel inflammatory marker; higher DcR3 levels strongly correlate with inflammation and independently predict cardiovascular and all-cause mortality in chronic kidney disease (CKD) patients on hemodialysis []. Increased synovial inflammatory cells infiltration in rheumatoid arthritis and ankylosing spondylitis is also associated with the elevated DcR3 expression []. In cartilaginous fish, mRNA expression of DcR3 in the thymus and leydig, which are the representative lymphoid tissues of elasmobranchs, suggests that DcR3 may act as a modulator in the immune system. Interestingly, in banded dogfish (Triakis scyllia), DcR3 mRNA is strongly expressed in the gill, compared with human expression in the normal lung; both are respiratory organs, suggesting potential relevance of DcR3 to respiratory function [].This entry represents the N-terminal domain of TNFRSF6B. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].

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Publication

9538693 | -

First Author:	Naismith JH
Year:	1998
Journal:	Trends Biochem Sci
Title:	Modularity in the TNF-receptor family.
Volume:	23
Issue:	2
Pages:	74-9

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Publication

11796220 | -

First Author:	Bodmer JL
Year:	2002
Journal:	Trends Biochem Sci
Title:	The molecular architecture of the TNF superfamily.
Volume:	27
Issue:	1
Pages:	19-26

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Publication

8387891 | -

First Author:	Banner DW
Year:	1993
Journal:	Cell
Title:	Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
Volume:	73
Issue:	3
Pages:	431-45

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