Type |
Details |
Score |
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
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•
•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Kawamura-Tsuzuku J |
Year: |
2004 |
Journal: |
Oncogene |
Title: |
Nuclear localization of Tob is important for regulation of its antiproliferative activity. |
Volume: |
23 |
Issue: |
39 |
Pages: |
6630-8 |
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HT Experiment |
Series Id: |
GSE21836 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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Allele |
Name: |
transducer of ErbB-2.1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Interaction Experiment |
Description: |
Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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GXD Expression |
Probe: |
MGI:7662583 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716319 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:7662603 |
Age: |
embryonic day 11.5 |
|
Note: |
Expression was often observed in association with Tob1 throughout the vesicle, and in larger cytoplasmic complexes in posterior vesicle cells. |
Specimen Label: |
2b |
Detected: |
true |
Specimen Num: |
1 |
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•
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Publication |
First Author: |
Xiong B |
Year: |
2006 |
Journal: |
Dev Cell |
Title: |
Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. |
Volume: |
11 |
Issue: |
2 |
Pages: |
225-38 |
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Protein Domain |
Type: |
Family |
Description: |
Tob (transducer of ErbB2) is a member of the BTG/Tob family. Tob2 consists of 344 amino acids with high similarity to the Tob1 protein. Like the Tob1 protein, Tob2 can inhibit cell cycle progression from the G0/G1 to S phases. This cell cycle regulatory function may occur in part, through their interaction with CAF1 [].The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subunit of the CCR4-NOT complex. They display antiproliferative properties as their ectopic expression in a variety of cell lines reduced cell proliferation []. |
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Protein Domain |
Type: |
Family |
Description: |
Tob1 and Tob2 are members of the BTG/Tob family.The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subunit of the CCR4-NOT complex. They display antiproliferative properties as their ectopic expression in a variety of cell lines reduced cell proliferation []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
 |
Fragment?: |
true |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
345
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
348
 |
Fragment?: |
true |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
44
 |
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
345
 |
Fragment?: |
false |
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•
•
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•
|
Publication |
First Author: |
Ng R |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice. |
Volume: |
19 |
Issue: |
6 |
Pages: |
1229-1246 |
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•
•
•
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Publication |
First Author: |
Ezzeddine N |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities. |
Volume: |
32 |
Issue: |
6 |
Pages: |
1089-98 |
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•
•
•
•
•
|
Publication |
First Author: |
Quan Y |
Year: |
2022 |
Journal: |
Nucleic Acids Res |
Title: |
Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition. |
Volume: |
50 |
Issue: |
8 |
Pages: |
4414-4435 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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•
•
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•
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