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Search results 101 to 188 out of 188 for Tom1l1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_04
Specimen Label: euxassay_011406_04
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_05
Specimen Label: euxassay_011406_05
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_06
Specimen Label: euxassay_011406_06
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_07
Specimen Label: euxassay_011406_07
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_08
Specimen Label: euxassay_011406_08
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_17
Specimen Label: euxassay_011406_17
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_18
Specimen Label: euxassay_011406_18
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_19
Specimen Label: euxassay_011406_19
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_20
Specimen Label: euxassay_011406_20
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_21
Specimen Label: euxassay_011406_21
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_22
Specimen Label: euxassay_011406_22
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_23
Specimen Label: euxassay_011406_23
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1761223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_11
Specimen Label: euxassay_011406_11
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1761223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_14
Specimen Label: euxassay_011406_14
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_08
Specimen Label: euxassay_011406_08
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_09
Specimen Label: euxassay_011406_09
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_10
Specimen Label: euxassay_011406_10
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_11
Specimen Label: euxassay_011406_11
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_15
Specimen Label: euxassay_011406_15
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_16
Specimen Label: euxassay_011406_16
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_17
Specimen Label: euxassay_011406_17
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_18
Specimen Label: euxassay_011406_18
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5827639
Assay Type: RNA in situ
Annotation Date: 2017-03-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5827685
Age: embryonic day 16.5
Image: 3K
Note: Coexpression with Slc1a3 was noted.
Specimen Label: 3K
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1784723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_11
Specimen Label: euxassay_011406_11
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1784723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_12
Specimen Label: euxassay_011406_12
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1784723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_14
Specimen Label: euxassay_011406_14
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4415965
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1784723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828867
Age: embryonic day 14.5
Image: euxassay_011406_15
Specimen Label: euxassay_011406_15
Detected: true
Specimen Num: 13
•
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•
•
Publication
17046829 | J:118155
First Author: Li W
Year: 2007
Journal: J Biol Chem
Title: Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation.
Volume: 282
Issue: 2
Pages: 1161-9
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Publication
27881777 | J:237193
First Author: Chaboub LS
Year: 2016
Journal: J Neurosci
Title: Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury.
Volume: 36
Issue: 47
Pages: 11904-11917
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Publication
17273973 | J:125240
First Author: Yan J
Year: 2007
Journal: Am J Hum Genet
Title: Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike.
Volume: 80
Issue: 3
Pages: 518-25
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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•
•
Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GXD Expression
GXD Expression
Probe: MGI:5827672
Assay Type: Immunohistochemistry
Annotation Date: 2017-03-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3579528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5827688
Age: postnatal day 7
Image: 3L
Note: Coexpression with Tom1l1 was noted.
Specimen Label: 3L
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5827669
Assay Type: RNA in situ
Annotation Date: 2017-03-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5827682
Age: embryonic day 16.5
Image: 3K
Note: Coexpression with Tom1l1 was noted.
Specimen Label: 3K
Detected: true
Specimen Num: 2
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Publication
15611048 | -
First Author: Puertollano R
Year: 2005
Journal: J Biol Chem
Title: Interactions of TOM1L1 with the multivesicular body sorting machinery.
Volume: 280
Issue: 10
Pages: 9258-64
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Allele
Tom1l1<em1Smoc> | MGI:7292945
Name: target of myb1-like 1 (chicken); endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6476515 | C57BL/6JSmoc-Tom1l1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
14563850 | J:148073
First Author: Yamakami M
Year: 2003
Journal: J Biol Chem
Title: Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.
Volume: 278
Issue: 52
Pages: 52865-72
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Publication
15056867 | -
First Author: Yamakami M
Year: 2004
Journal: Biol Pharm Bull
Title: Tom1 (target of Myb 1) is a novel negative regulator of interleukin-1- and tumor necrosis factor-induced signaling pathways.
Volume: 27
Issue: 4
Pages: 564-6
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Protein Domain
IPR014645 | TOM1
Type: Family
Description: Tom1 (target of Myb 1) and its related proteins (Tom1L1 and Tom1L2) constitute a protein family and share an N-terminal VHS (Vps27p/Hrs/Stam) domain followed by a GAT (GGA and Tom1) domain.VHS domains are found at the N termini of select proteins involved in intracellular membrane trafficking and are often localized to membranes. The three dimensional structure of human TOM1 VHS domain reveals eight helices arranged in a superhelix. The surface of the domain has two main features: (1) a basic patch on one side due to several conserved positively charged residues on helix 3 and (2) a negatively charged ridge on the opposite side, formed by residues on helix 2 []. The basic patch is thought to mediate membrane binding.It was demonstrated that the GAT domain of both Tom1 and Tom1L1 binds ubiquitin, suggesting that these proteins might participate in the sorting of ubiquitinated proteins into multivesicular bodies (MVB) []. Moreover, Tom1L1 interacts with members of the MVB sorting machinery. Specifically, the VHS domain of Tom1L1 interacts with Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate), whereas a PTAP motif, located between the VHS and GAT domains of Tom1L1, is responsible for binding to TSG101 (tumour susceptibility gene 101). Myc epitope-tagged Tom1L1 is recruited to endosomes following Hrs expression. In addition, Tom1L1 possesses several tyrosine motifs at the C-terminal region that mediate interactions with members of the Src family kinases and other signalling proteins such as Grb2 and p85. Expression of a constitutively active form of Fyn kinase promotes the recruitment of Tom1L1 to enlarged endosomes. It is proposed that Tom1L1 could act as an intermediary between the signalling and degradative pathways [].Over expression of Tom1 suppresses activation of the transcription factors NF-kappaB and AP-1, induced by either IL-1beta or tumour necrosis factor (TNF)-alpha, and the VHS domain of Tom1 is indispensable for this suppressive activity. This suggests that Tom1 is a common negative regulator of signalling pathways induced by IL-1beta and TNF-alpha [].
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Publication
10854325 | J:64697
First Author: Burns K
Year: 2000
Journal: Nat Cell Biol
Title: Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
Volume: 2
Issue: 6
Pages: 346-51
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Protein Domain
IPR041799 | TOLIP_CUE
Type: Domain
Description: Tollip (Toll-interacting protein) is a component of the IL-1RI pathway which contains an N-terminal C2 domain and a C-terminal CUE domain. Tollip binds to the cytoplasmic TIR domain of IL-1Rs after IL-1 stimulation. It is sufficient for recruitment of IRAK to IL-1Rs and negatively regulates IL-1-induced signaling by inhibiting IRAK phosphorylation. In addition, Tollip directly interacts with toll-like receptors TLR2 and TLR4, and plays an inhibitory role in TLR-mediated cell activation through suppressing phosphorylation and kinase activity of IRAK. Moreover, Tollip can associate with GAT domains of Tom1 and its related proteins Tom1L1 and Tom1L2, and facilitate the recruitment of clathrin onto endosomes [, ].
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Publication
10985773 | -
First Author: Misra S
Year: 2000
Journal: Biochemistry
Title: Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes.
Volume: 39
Issue: 37
Pages: 11282-90
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Protein
O88746
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
Q5SRX1
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q3UDC3
Organism: Mus musculus/domesticus
Length: 516  
Fragment?: false
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Protein
Q5SXA4
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Protein
Q5SXA5
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
Q561M4
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Publication
11751856 | -
First Author: Zhang G
Year: 2002
Journal: J Biol Chem
Title: Negative regulation of toll-like receptor-mediated signaling by Tollip.
Volume: 277
Issue: 9
Pages: 7059-65
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Protein
Q9QZ06
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: false
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Protein
F7AT44
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
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Protein
A9JEI5
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
Q8BQL7
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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