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Search results 101 to 155 out of 155 for Topbp1

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0.032s

Type

Details

Score

Gene

453642 | TICRR

Type:	gene
Organism:	chimpanzee

•

Gene

529868 | TICRR

Type:	gene
Organism:	cattle

•

Gene

415489 | TICRR

Type:	gene
Organism:	chicken

•

Gene

700248 | TICRR

Type:	gene
Organism:	macaque, rhesus

•

Publication

16530042 | -

First Author:	Kumagai A
Year:	2006
Journal:	Cell
Title:	TopBP1 activates the ATR-ATRIP complex.
Volume:	124
Issue:	5
Pages:	943-55

•

Publication

28439015 | J:242221

First Author:	Liu K
Year:	2017
Journal:	Proc Natl Acad Sci U S A
Title:	Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
Volume:	114
Issue:	19
Pages:	E3766-E3775

•

Interaction Experiment

Liu K (2006)

Description:

Regulation of TopBP1 oligomerization by Akt/PKB for cell survival.

•

Publication

20116089 | -

First Author:	Kumagai A
Year:	2010
Journal:	Cell
Title:	Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.
Volume:	140
Issue:	3
Pages:	349-59

•

Publication

20871591 | -

First Author:	Cescutti R
Year:	2010
Journal:	EMBO J
Title:	TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.
Volume:	29
Issue:	21
Pages:	3723-32

•

Protein

Q6ZQF0

Organism:	Mus musculus/domesticus
Length:	1515
Fragment?:	false

•

Publication

21659603 | -

First Author:	Cotta-Ramusino C
Year:	2011
Journal:	Science
Title:	A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
Volume:	332
Issue:	6035
Pages:	1313-7

•

Publication

15138768 | -

First Author:	Reini K
Year:	2004
Journal:	Chromosoma
Title:	TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis.
Volume:	112
Issue:	7
Pages:	323-30

•

Publication

17913746 | -

First Author:	Sjøttem E
Year:	2007
Journal:	Nucleic Acids Res
Title:	The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription.
Volume:	35
Issue:	19
Pages:	6648-62

•

Publication

22925454 | -

First Author:	Ueda S
Year:	2012
Journal:	Genes Cells
Title:	Two serine phosphorylation sites in the C-terminus of Rad9 are critical for 9-1-1 binding to TopBP1 and activation of the DNA damage checkpoint response in HeLa cells.
Volume:	17
Issue:	10
Pages:	807-16

•

Protein

Q8BRB3

Organism:	Mus musculus/domesticus
Length:	131
Fragment?:	false

•

Publication

21646402 | -

First Author:	Kumagai A
Year:	2011
Journal:	J Cell Biol
Title:	Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication.
Volume:	193
Issue:	6
Pages:	995-1007

•

Publication

19937654 | -

First Author:	Leung CC
Year:	2010
Journal:	Protein Sci
Title:	Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIbeta binding protein 1.
Volume:	19
Issue:	1
Pages:	162-7

•

Protein Domain

IPR026153 | Treslin

Type:

Family

Description:

Treslin, a TopBP1-interacting protein, is necessary for DNA replication in vertebrates []. Prior to the initiation of DNA replication, treslin associates with TopBP1 in a Cdk2-dependent manner []. The proteins then collaborate in the Cdk2-mediated loading of Cdc45 onto replication origins [].Treslin is also an important checkpoint regulator, and is required to prevent mitotic entry after treatment with ionizing radiation [].

•

Protein Domain

IPR044737 | TopBP1_BRCT_1

Type:	Domain
Description:	TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA []. It has been shown to activate the ATR-ATRIP complex []. TopBP1 contains six copies of BRCT domain. The entry corresponds to the first BRCT domain, which is a protein-protein binding module [].

•

Protein

Q8K3A4

Organism:	Mus musculus/domesticus
Length:	235
Fragment?:	false

•

Protein

E9Q1D4

Organism:	Mus musculus/domesticus
Length:	235
Fragment?:	false

•

Protein

D3YUX9

Organism:	Mus musculus/domesticus
Length:	129
Fragment?:	true

•

Publication

20811708 | -

First Author:	Kim JW
Year:	2010
Journal:	Int J Oncol
Title:	Involvement of C12orf32 overexpression in breast carcinogenesis.
Volume:	37
Issue:	4
Pages:	861-7

•

Protein Domain

IPR029293 | RHNO1

Type:

Family

Description:

This entry represents Rad9, Rad1, Hus1-interacting nuclear orphan protein 1 (RHINO or RHNO1), which plays a role in DNA damage response (DDR) signalling upon genotoxic stresses such as ionizing radiation (IR) during the S phase []. RHNO1 is recruited to sites of DNA damage through interaction with the Rad9-Rad1-Hus1 (9-1-1) complex and ATR activator TopBP1. It plays a role in ATR-mediated activation of Chk1 driven by TopBP1 and 9-1-1 []. It is involved in mammary carcinogenesis [].

•

Protein

Q8BQ33

Organism:	Mus musculus/domesticus
Length:	1889
Fragment?:	false

•

Protein

Q3UV49

Organism:	Mus musculus/domesticus
Length:	718
Fragment?:	false

•

Protein

A0A0U1RNX1

Organism:	Mus musculus/domesticus
Length:	968
Fragment?:	false

•

Protein

Q8C6J3

Organism:	Mus musculus/domesticus
Length:	968
Fragment?:	false

•

Protein

A0A0U1RQ28

Organism:	Mus musculus/domesticus
Length:	409
Fragment?:	false

•

Publication

20080954 | -

First Author:	Sansam CL
Year:	2010
Journal:	Genes Dev
Title:	A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.
Volume:	24
Issue:	2
Pages:	183-94

•

Publication

12408820 | J:79336

First Author:	Herold S
Year:	2002
Journal:	Mol Cell
Title:	Negative regulation of the mammalian UV response by Myc through association with Miz-1.
Volume:	10
Issue:	3
Pages:	509-21

•

Protein Domain

IPR026584 | Rad9

Type:

Family

Description:

This entry includes DNA damage checkpoint proteins Rad9. Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage []. It is worth noting that this entry including the mamalian Rad9, which is homologous to the fission yeast Rad9 and the budding yeast Ddc1. Members of this family do not share the sequence homology with the budding yeast Rad9.Rad9 forms a complex with Hus1 and Rad1, called 9-1-1 complex. In human, 9-1-1 binds to TopBP1 and activates the ATR-Chk1 checkpoint pathway []. Rad9 also shows 3'-5' exonuclease activity []. Besides its function in the 9-1-1 complex, Rad9 can act as a transcriptional factor, participate in immunoglobulin classswitch recombination []. Aberrant Rad9 expression has been associated with prostate, breast, lung, skin, thyroid, and gastric cancers [].

•

Publication

37831098 | J:343314

First Author:	Zhang B
Year:	2023
Journal:	Nucleic Acids Res
Title:	ADAR1 links R-loop homeostasis to ATR activation in replication stress response.
Volume:	51
Issue:	21
Pages:	11668-11687

•

Publication

27940962 | J:237487

First Author:	Vélez-Cruz R
Year:	2016
Journal:	Genes Dev
Title:	RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1.
Volume:	30
Issue:	22
Pages:	2500-2512

•

Publication

35051531 | J:319625

First Author:	Ma S
Year:	2022
Journal:	Cancer Lett
Title:	Disrupting PHF8-TOPBP1 connection elicits a breast tumor-specific vulnerability to chemotherapeutics.
Volume:	530

Pages:	29-44

•

Protein

Q9Z0F6

Organism:	Mus musculus/domesticus
Length:	389
Fragment?:	false

•

Protein

Q6WBX7

Organism:	Mus musculus/domesticus
Length:	403
Fragment?:	false

•

Protein

Q8VC54

Organism:	Mus musculus/domesticus
Length:	403
Fragment?:	false

•

Protein

D3Z3W7

Organism:	Mus musculus/domesticus
Length:	366
Fragment?:	false

•

Publication

22034047 | -

First Author:	Broustas CG
Year:	2012
Journal:	J Cell Biochem
Title:	Contributions of Rad9 to tumorigenesis.
Volume:	113
Issue:	3
Pages:	742-51

•

Publication

10713044 | -

First Author:	Bessho T
Year:	2000
Journal:	J Biol Chem
Title:	Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease.
Volume:	275
Issue:	11
Pages:	7451-4

•

Publication

20729201 | J:166880

First Author:	An L
Year:	2010
Journal:	J Biol Chem
Title:	Rad9 is required for B cell proliferation and immunoglobulin class switch recombination.
Volume:	285
Issue:	46
Pages:	35267-73

•

Protein

F6VRS2

Organism:	Mus musculus/domesticus
Length:	92
Fragment?:	true

•

Protein

A0A494BAY5

Organism:	Mus musculus/domesticus
Length:	144
Fragment?:	true

•

Protein

A0A494BAL0

Organism:	Mus musculus/domesticus
Length:	73
Fragment?:	false

•

Protein

D3Z515

Organism:	Mus musculus/domesticus
Length:	64
Fragment?:	true

•

Protein

A0A494B9R8

Organism:	Mus musculus/domesticus
Length:	80
Fragment?:	true

•

Protein

Q8QZZ4

Organism:	Mus musculus/domesticus
Length:	122
Fragment?:	true

•

Publication

9755168 | -

First Author:	Vialard JE
Year:	1998
Journal:	EMBO J
Title:	The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.
Volume:	17
Issue:	19
Pages:	5679-88

•

Protein Domain

IPR007268 | Rad9/Ddc1

Type:

Family

Description:

This entry represents the DNA damage checkpoint protein Rad9 and its homologue in budding yeast, Ddc1. Rad9 forms a complex with Hus1 and Rad1 (called 9-1-1 complex). Ddc1 forms a similar complex with Mec1 and Rad17. Structurally, the 9-1-1 / Ddc1-Mec3-Rad17 complex is similar to the PCNA complex, which forms trimeric ring-shaped clamps. The 9-1-1 / Ddc1-Mec3-Rad17 complex plays a role in checkpoint activation that permits DNA-repair pathways to prevent cell cycle progression in response to DNA damage and replication stress [, ].In humans, 9-1-1 binds to TopBP1 and activates the ATR-Chk1 checkpoint pathway []. Besides its function in the 9-1-1 complex, Rad9 can also act as a transcriptional factor and participate in immunoglobulin class switch recombination []. It also shows 3'-5' exonuclease activity []. Aberrant Rad9 expression has been associated with prostate, breast, lung, skin, thyroid, and gastric cancers [].In budding yeast, Ddc1 can activate Mec1 (the principal checkpoint protein kinase, human ATR homologue) in G1 phase. In G2 phase, Ddc1 can either activate Mec1 directly or recruit Dpb11 (the orthologue of human TopBP1) and subsequently activate Mec1 []. Ddc1 does not have DNA exonuclease function [].It is worth noting that the Rad9 proteins referred to in this entry are the mammalian and fission yeast homologues of budding yeast Ddc1. Members of this family do not share the sequence homology another DNA damage-dependent checkpoint protein from budding yeast, confusingly also called Rad9.

•

Publication

23468651 | J:195191

First Author:	Lyndaker AM
Year:	2013
Journal:	PLoS Genet
Title:	Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.
Volume:	9
Issue:	2
Pages:	e1003320

•

Publication

20005839 | -

First Author:	Navadgi-Patil VM
Year:	2009
Journal:	Mol Cell
Title:	The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.
Volume:	36
Issue:	5
Pages:	743-53

•

Publication

9311982 | -

First Author:	Longhese MP
Year:	1997
Journal:	EMBO J
Title:	The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.
Volume:	16
Issue:	17
Pages:	5216-26

•

Publication

21978893 | -

First Author:	Eichinger CS
Year:	2011
Journal:	Trends Biochem Sci
Title:	9-1-1: PCNA's specialized cousin.
Volume:	36
Issue:	11
Pages:	563-8

•

Publication

12604797 | -

First Author:	Majka J
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.
Volume:	100
Issue:	5
Pages:	2249-54

•

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Search results 101 to 155 out of 155 for Topbp1

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