|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 171 out of 171 for Tpcn2

<< First    < Previous  |  Next >    Last >>
0.013s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1685328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311088
Specimen Label: MRC Harwell_1311088
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1685328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_2132625
Specimen Label: MRC Harwell_2132625
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311095
Specimen Label: MRC Harwell_1311095
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3590528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311094
Specimen Label: MRC Harwell_1311094
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1752528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311090
Specimen Label: MRC Harwell_1311090
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311093
Specimen Label: MRC Harwell_1311093
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311088
Specimen Label: MRC Harwell_1311088
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311094
Specimen Label: MRC Harwell_1311094
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311092
Specimen Label: MRC Harwell_1311092
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3281228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311088
Specimen Label: MRC Harwell_1311088
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3281228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_2132625
Specimen Label: MRC Harwell_2132625
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311096
Specimen Label: MRC Harwell_1311096
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_2132624
Specimen Label: MRC Harwell_2132624
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_2132628
Specimen Label: MRC Harwell_2132628
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_2132629
Specimen Label: MRC Harwell_2132629
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692557
Age: postnatal adult
Image: MRC Harwell_1311096
Specimen Label: MRC Harwell_1311096
Detected: true
Specimen Num: 10
•
•
•
•
•
Publication
24776928 | J:306709
First Author: Cang C
Year: 2014
Journal: Nat Chem Biol
Title: The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
Volume: 10
Issue: 6
Pages: 463-9
•
•
•
•
•
Publication
25722412 | J:306587
First Author: Sakurai Y
Year: 2015
Journal: Science
Title: Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.
Volume: 347
Issue: 6225
Pages: 995-8
•
•
•
•
•
Publication
29563152 | J:262211
First Author: Hamilton A
Year: 2018
Journal: Diabetes
Title: Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.
Volume: 67
Issue: 6
Pages: 1128-1139
•
•
•
•
•
Publication
26152717 | J:336382
First Author: Arredouani A
Year: 2015
Journal: J Biol Chem
Title: Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.
Volume: 290
Issue: 35
Pages: 21376-92
•
•
•
•
•
Publication
35885013 | J:338463
 
First Author: Royer J
Year: 2022
Journal: Biomedicines
Title: Unexpected Motherhood-Triggered Hearing Loss in the Two-Pore Channel (TPC) Mutant Mouse.
Volume: 10
Issue: 7
•
•
•
•
•
Publication
25545384 | J:221929
First Author: Lear PV
Year: 2015
Journal: Endocrinology
Title: Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.
Volume: 156
Issue: 3
Pages: 975-86
•
•
•
•
•
Publication
38134531 | J:358631
 
First Author: de Zélicourt A
Year: 2024
Journal: Cell Calcium
Title: Two-pore channels (TPCs) acts as a hub for excitation-contraction coupling, metabolism and cardiac hypertrophy signalling.
Volume: 117
Pages: 102839
•
•
•
•
•
Publication
26438825 | J:227419
First Author: Capel RA
Year: 2015
Journal: J Biol Chem
Title: Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.
Volume: 290
Issue: 50
Pages: 30087-98
•
•
•
•
•
Publication
30482851 | J:284400
 
First Author: Foster WJ
Year: 2018
Journal: Sci Signal
Title: Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling.
Volume: 11
Issue: 558
•
•
•
•
•
Publication
25144390 | J:225206
 
First Author: Grimm C
Year: 2014
Journal: Nat Commun
Title: High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.
Volume: 5
Pages: 4699
•
•
•
•
•
Publication
23063126 | J:189070
First Author: Wang X
Year: 2012
Journal: Cell
Title: TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
Volume: 151
Issue: 2
Pages: 372-83
•
•
•
•
•
Publication
23394946 | J:193600
First Author: Cang C
Year: 2013
Journal: Cell
Title: mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.
Volume: 152
Issue: 4
Pages: 778-790
•
•
•
•
•
Publication
31806695 | J:285199
First Author: Freeman SA
Year: 2020
Journal: Science
Title: Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance.
Volume: 367
Issue: 6475
Pages: 301-305
•
•
•
•
•
Publication
36744839 | J:334504
 
First Author: Kounoupa Z
Year: 2023
Journal: J Cell Sci
Title: Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons.
Volume: 136
Issue: 6
•
•
•
•
•
Publication
26571400 | J:229827
First Author: Shigeto M
Year: 2015
Journal: J Clin Invest
Title: GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
Volume: 125
Issue: 12
Pages: 4714-28
•
•
•
•
•
Publication
32510172 | J:336348
First Author: Davis LC
Year: 2020
Journal: EMBO J
Title: NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca(2+) nanodomains, calcineurin and dynamin.
Volume: 39
Issue: 14
Pages: e104058
•
•
•
•
•
Publication
23103503 | J:206556
 
First Author: Neely Kayala KM
Year: 2012
Journal: Brain Res
Title: Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.
Volume: 1489
Pages: 8-16
•
•
•
•
•
Publication
30563862 | J:284476
 
First Author: Diercks BP
Year: 2018
Journal: Sci Signal
Title: ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.
Volume: 11
Issue: 561
•
•
•
•
•
Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
•
•
•
•
•
Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
•
•
•
•
•
Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
•
•
•
•
•
Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
•
•
•
•
•
Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
•
•
•
•
•
Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Allele
Tpcn2<em1Lwbch> | MGI:7450918
Name: two pore segment channel 2; endonuclease-mediated mutation 1, Wei Li
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
•
•
•
•
•
Allele
Tpcn2<tm1.1(cre)Lrcb> | MGI:7486452
Name: two pore segment channel 2; targeted mutation 1.1, Christian Grimm
Allele Type: Targeted
Attribute String: Recombinase
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tpcn2/Tpcn2<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom