Type |
Details |
Score |
Publication |
First Author: |
Fujita H |
Year: |
2014 |
Journal: |
Mol Cell Biol |
Title: |
Mechanism underlying IκB kinase activation mediated by the linear ubiquitin chain assembly complex. |
Volume: |
34 |
Issue: |
7 |
Pages: |
1322-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kondylis V |
Year: |
2015 |
Journal: |
Cancer Cell |
Title: |
NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. |
Volume: |
28 |
Issue: |
5 |
Pages: |
582-598 |
|
•
•
•
•
•
|
Publication |
First Author: |
Holbrook J |
Year: |
2019 |
Journal: |
F1000Res |
Title: |
Tumour necrosis factor signalling in health and disease. |
Volume: |
8 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hofmann K |
Year: |
1999 |
Journal: |
Cell Mol Life Sci |
Title: |
The modular nature of apoptotic signaling proteins. |
Volume: |
55 |
Issue: |
8-9 |
Pages: |
1113-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang P |
Year: |
2013 |
Journal: |
Sci Signal |
Title: |
Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects. |
Volume: |
6 |
Issue: |
290 |
Pages: |
ra74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Melnick M |
Year: |
2001 |
Journal: |
Anat Rec |
Title: |
Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. |
Volume: |
262 |
Issue: |
3 |
Pages: |
318-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuriakose T |
Year: |
2016 |
Journal: |
Sci Immunol |
Title: |
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. |
Volume: |
1 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Keegan CE |
Year: |
2005 |
Journal: |
Hum Mol Genet |
Title: |
Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. |
Volume: |
14 |
Issue: |
1 |
Pages: |
113-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gurung P |
Year: |
2017 |
Journal: |
Immunity |
Title: |
Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease. |
Volume: |
46 |
Issue: |
4 |
Pages: |
635-648 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nechiporuk T |
Year: |
2016 |
Journal: |
Elife |
Title: |
The REST remodeling complex protects genomic integrity during embryonic neurogenesis. |
Volume: |
5 |
|
Pages: |
e09584 |
|
•
•
•
•
•
|
Publication |
First Author: |
Soma S |
Year: |
2024 |
Journal: |
Stem Cells |
Title: |
O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. |
Volume: |
42 |
Issue: |
1 |
Pages: |
55-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reed JC |
Year: |
2003 |
Journal: |
Genome Res |
Title: |
Comparative analysis of apoptosis and inflammation genes of mice and humans. |
Volume: |
13 |
Issue: |
6B |
Pages: |
1376-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Copeland NG |
Year: |
1999 |
Journal: |
Database Release |
Title: |
Copeland-Jenkins (Frederick) Interspecific Backcross Mapping Data |
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|
•
•
•
•
•
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Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
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•
•
•
•
•
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Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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|
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
•
•
•
•
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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|
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•
•
•
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•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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|
|
•
•
•
•
•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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|
|
•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
|
Allele |
Name: |
TNFRSF1A-associated via death domain; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
Interaction Experiment |
Description: |
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. |
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•
•
•
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
•
•
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Publication |
First Author: |
Micheau O |
Year: |
2003 |
Journal: |
Cell |
Title: |
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. |
Volume: |
114 |
Issue: |
2 |
Pages: |
181-90 |
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•
•
•
•
•
|
Publication |
First Author: |
Tsao DH |
Year: |
2000 |
Journal: |
Mol Cell |
Title: |
Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway. |
Volume: |
5 |
Issue: |
6 |
Pages: |
1051-7 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
TRADD is a signalling adaptor protein involved in tumour necrosis factor-receptor I (TNFR1)-associated apoptosis and cell survival. The decision between apoptosis and cell survival involves the interplay between two sequential signalling complexes. The plasma membrane-bound complex I is comprised of TNFR1, TRADD, the kinase RIP1, and TRAF2, which together mediate the activation of NF-kappaB. Subsequently, complex II is formed in the cytoplasm, where TRADD and RIP1 associate with FADD and caspase-8. If NF-kappaB is activated by complex I, then complex II will associate with the caspase-8 inhibitor FLIP(L) and the cell survives, while the failure to activate NF-kappaB leads to apoptosis [].TRADD contains two functionally separate domains, which allow the protein to couple to two distinct signaling pathways. The TRADD C-terminal death domain is responsible for its association with TNFR1, and with the death-domain proteins FADD and RIP1, which promote apoptosis. The TRADD N-terminal domain binds TRAF2 and promotes TRAF2 recruitment to TNFR1, thereby mediating the activation of NK-kappaB and JNK/AP1, which promote cell survival []. The N-terminal TRADD domain is composed of an α/β sandwich, where the β-strands form an antiparallel β-sheet. |
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•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
TRADD is a signalling adaptor protein involved in tumour necrosis factor-receptor I (TNFR1)-associated apoptosis and cell survival. The decision between apoptosis and cell survival involves the interplay between two sequential signalling complexes. The plasma membrane-bound complex I is comprised of TNFR1, TRADD, the kinase RIP1, and TRAF2, which together mediate the activation of NF-kappaB. Subsequently, complex II is formed in the cytoplasm, where TRADD and RIP1 associate with FADD and caspase-8. If NF-kappaB is activated by complex I, then complex II will associate with the caspase-8 inhibitor FLIP(L) and the cell survives, while the failure to activate NF-kappaB leads to apoptosis [].TRADD contains two functionally separate domains, which allow the protein to couple to two distinct signaling pathways. The TRADD C-terminal death domain is responsible for its association with TNFR1, and with the death-domain proteins FADD and RIP1, which promote apoptosis. The TRADD N-terminal domain binds TRAF2 and promotes TRAF2 recruitment to TNFR1, thereby mediating the activation of NK-kappaB and JNK/AP1, which promote cell survival []. The N-terminal TRADD domain is composed of an α/β sandwich, where the β-strands form an antiparallel β-sheet. |
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•
•
•
•
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Publication |
First Author: |
Newton K |
Year: |
1998 |
Journal: |
EMBO J |
Title: |
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. |
Volume: |
17 |
Issue: |
3 |
Pages: |
706-18 |
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•
•
•
•
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Publication |
First Author: |
Tewari M |
Year: |
1996 |
Journal: |
Curr Opin Genet Dev |
Title: |
Recent advances in tumor necrosis factor and CD40 signaling. |
Volume: |
6 |
Issue: |
1 |
Pages: |
39-44 |
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•
•
•
•
•
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Publication |
First Author: |
Kumar A |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. |
Volume: |
276 |
Issue: |
4 |
Pages: |
2668-77 |
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•
•
•
•
•
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Publication |
First Author: |
Majumder M |
Year: |
2002 |
Journal: |
Virology |
Title: |
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice. |
Volume: |
294 |
Issue: |
1 |
Pages: |
94-105 |
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•
•
•
•
•
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Publication |
First Author: |
Tran AHV |
Year: |
2017 |
Journal: |
J Cell Biochem |
Title: |
MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis. |
Volume: |
118 |
Issue: |
7 |
Pages: |
1827-1838 |
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•
•
•
•
•
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Publication |
First Author: |
Koseki T |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. |
Volume: |
95 |
Issue: |
9 |
Pages: |
5156-60 |
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•
•
•
•
•
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Publication |
First Author: |
Pantano C |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Hydrogen peroxide signaling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase. |
Volume: |
278 |
Issue: |
45 |
Pages: |
44091-6 |
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•
•
•
•
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Publication |
First Author: |
Zörnig M |
Year: |
1998 |
Journal: |
Curr Biol |
Title: |
p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice. |
Volume: |
8 |
Issue: |
8 |
Pages: |
467-70 |
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•
•
•
•
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Publication |
First Author: |
Festjens N |
Year: |
2007 |
Journal: |
Cell Death Differ |
Title: |
RIP1, a kinase on the crossroads of a cell's decision to live or die. |
Volume: |
14 |
Issue: |
3 |
Pages: |
400-10 |
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•
•
•
•
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Publication |
First Author: |
Rittore C |
Year: |
2014 |
Journal: |
Ann Rheum Dis |
Title: |
Identification of a new exon 2-skipped TNFR1 transcript: regulation by three functional polymorphisms of the TNFR-associated periodic syndrome (TRAPS) gene. |
Volume: |
73 |
Issue: |
1 |
Pages: |
290-7 |
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•
•
•
•
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Publication |
First Author: |
Diniz BS |
Year: |
2010 |
Journal: |
J Alzheimers Dis |
Title: |
Higher serum sTNFR1 level predicts conversion from mild cognitive impairment to Alzheimer's disease. |
Volume: |
22 |
Issue: |
4 |
Pages: |
1305-11 |
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•
•
•
•
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Publication |
First Author: |
Hope S |
Year: |
2013 |
Journal: |
Schizophr Res |
Title: |
Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder. |
Volume: |
145 |
Issue: |
1-3 |
Pages: |
36-42 |
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•
•
•
•
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Publication |
First Author: |
Comabella M |
Year: |
2013 |
Journal: |
Neurology |
Title: |
TNFRSF1A polymorphisms rs1800693 and rs4149584 in patients with multiple sclerosis. |
Volume: |
80 |
Issue: |
22 |
Pages: |
2010-6 |
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•
•
•
•
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Publication |
First Author: |
Cantarini L |
Year: |
2013 |
Journal: |
Intern Med J |
Title: |
Expanding spectrum of TNFRSF1A gene mutations among patients with idiopathic recurrent acute pericarditis. |
Volume: |
43 |
Issue: |
6 |
Pages: |
725-7 |
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•
•
•
•
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Publication |
First Author: |
Espín R |
Year: |
2013 |
Journal: |
Dis Model Mech |
Title: |
TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. |
Volume: |
6 |
Issue: |
2 |
Pages: |
383-96 |
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•
•
•
•
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Publication |
First Author: |
Ofengeim D |
Year: |
2013 |
Journal: |
Nat Rev Mol Cell Biol |
Title: |
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. |
Volume: |
14 |
Issue: |
11 |
Pages: |
727-36 |
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•
•
•
•
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Publication |
First Author: |
Declercq W |
Year: |
2009 |
Journal: |
Cell |
Title: |
RIP kinases at the crossroads of cell death and survival. |
Volume: |
138 |
Issue: |
2 |
Pages: |
229-32 |
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•
•
•
•
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Publication |
First Author: |
Zhang D |
Year: |
2010 |
Journal: |
Cell Mol Immunol |
Title: |
Receptor-interacting protein (RIP) kinase family. |
Volume: |
7 |
Issue: |
4 |
Pages: |
243-9 |
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•
•
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•
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Protein Domain |
Type: |
Domain |
Description: |
This subfamily of tumor necrosis factor receptor 1A (TNFRSF1, also known as type I TNFR, TNFR1, DR1, TNFRSF1A, CD120a, p55) is found in teleosts. It binds TNF-alpha, through the death domain (DD), and activates NF-kappaB, mediates apoptosis and activates signaling pathways controlling inflammatory, immune, and stress responses. It mediates signal transduction by interacting with antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRAF2 and TRADD that play regulatory roles [, ].Knockout studies in zebrafish embryos have shown that a signaling balance between TNFRSF1A and TNFRSF1B is required for endothelial cell integrity. TNFRSF1A signals apoptosis through caspase-8, whereas TNFRSF1B signals survival via NF-kappaB in endothelial cells. Thus, this apoptotic pathway seems to be evolutionarily conserved, as TNFalpha promotes apoptosis of human endothelial cells and triggers caspase-2 and P53 activation in these cells via TNFRSF1A [].This entry represents the N-terminal domain of TNFR1A from teleosts. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ]. |
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Protein Domain |
Type: |
Domain |
Description: |
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A, also known as type I TNFR, TNFR1, DR1, CD120a, p55) binds TNF-alpha, through the death domain (DD), and activates NF-kappaB, mediates apoptosis and activates signaling pathways controlling inflammatory, immune, and stress responses. It mediates signal transduction by interacting with antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRAF2 and TRADD that play regulatory roles [, ].The human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS), or periodic fever syndrome, is associated with germline mutations of the extracellular domains of this receptor, possibly due to impaired receptor clearance []. TNFRSF1A polymorphisms rs1800693 and rs4149584 are associated with elevated risk of multiple sclerosis []. Serum levels of TNFRSF1A are elevated in schizophrenia and bipolar disorder, and high levels are also associated with cognitive impairment and dementia [, ]. Patients with idiopathic recurrent acute pericarditis (IRAP), presumed to be an autoimmune process, have also been shown to carry rare mutations (R104Q and D12E) in the TNFRSF1A gene [].This entry represents the N-terminal domain of TNFR1A. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ]. |
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Protein Domain |
Type: |
Domain |
Description: |
RIP kinases serve as essential sensors of cellular stress. Vertebrates contain several types containing a homologous N-terminal kinase domain and varying C-terminal domains [, ]. RIP1 harbours a C-terminal Death domain (DD), which binds death receptors (DRs) including TNF receptor 1, Fas, TNF-related apoptosis-inducing ligand receptor 1 (TRAILR1), and TRAILR2. It also interacts with other DD-containing adaptor proteins such as TRADD and FADD. RIP1 plays a crucial role in determining a cell's fate, between survival or death, following exposure to stress signals. It is important in the signaling of NF-kappaB and MAPKs, and it links DR-associated signaling to reactive oxygen species (ROS) production. Abnormal RIP1 function may result in ROS accumulation affecting inflammatory responses, innate immunity, stress responses, and cell survival [, ]. DDs (Death domains) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [, ]. |
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Publication |
First Author: |
Chang NS |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. |
Volume: |
276 |
Issue: |
5 |
Pages: |
3361-70 |
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Publication |
First Author: |
Weng SC |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
Decoy Receptor 3 Suppresses T-Cell Priming and Promotes Apoptosis of Effector T-Cells in Acute Cell-Mediated Rejection: The Role of Reverse Signaling. |
Volume: |
13 |
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Pages: |
879648 |
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Publication |
First Author: |
Chen G |
Year: |
2002 |
Journal: |
Science |
Title: |
TNF-R1 signaling: a beautiful pathway. |
Volume: |
296 |
Issue: |
5573 |
Pages: |
1634-5 |
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Publication |
First Author: |
Cabal-Hierro L |
Year: |
2012 |
Journal: |
Cell Signal |
Title: |
Signal transduction by tumor necrosis factor receptors. |
Volume: |
24 |
Issue: |
6 |
Pages: |
1297-305 |
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Publication |
First Author: |
Zhou J |
Year: |
2019 |
Journal: |
World J Gastroenterol |
Title: |
Herbs-partitioned moxibustion alleviates aberrant intestinal epithelial cell apoptosis by upregulating A20 expression in a mouse model of Crohn's disease. |
Volume: |
25 |
Issue: |
17 |
Pages: |
2071-2085 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
656
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
454
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
440
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
454
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
454
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
440
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
597
 |
Fragment?: |
true |
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Publication |
First Author: |
Naismith JH |
Year: |
1998 |
Journal: |
Trends Biochem Sci |
Title: |
Modularity in the TNF-receptor family. |
Volume: |
23 |
Issue: |
2 |
Pages: |
74-9 |
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Publication |
First Author: |
Bodmer JL |
Year: |
2002 |
Journal: |
Trends Biochem Sci |
Title: |
The molecular architecture of the TNF superfamily. |
Volume: |
27 |
Issue: |
1 |
Pages: |
19-26 |
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Publication |
First Author: |
Feinstein E |
Year: |
1995 |
Journal: |
Trends Biochem Sci |
Title: |
The death domain: a module shared by proteins with diverse cellular functions. |
Volume: |
20 |
Issue: |
9 |
Pages: |
342-4 |
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Publication |
First Author: |
Park HH |
Year: |
2007 |
Journal: |
Annu Rev Immunol |
Title: |
The death domain superfamily in intracellular signaling of apoptosis and inflammation. |
Volume: |
25 |
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Pages: |
561-86 |
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Publication |
First Author: |
Banner DW |
Year: |
1993 |
Journal: |
Cell |
Title: |
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. |
Volume: |
73 |
Issue: |
3 |
Pages: |
431-45 |
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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