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Search results 101 to 171 out of 171 for Traf5

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Type Details Score
Publication
18079694 | J:130530
First Author: Hasegawa M
Year: 2008
Journal: EMBO J
Title: A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.
Volume: 27
Issue: 2
Pages: 373-83
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Publication
16147974 | J:100699
First Author: Kim N
Year: 2005
Journal: J Exp Med
Title: Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis.
Volume: 202
Issue: 5
Pages: 589-95
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Publication
16026622 | J:100364
 
First Author: Wesselkamper SC
Year: 2005
Journal: Respir Res
Title: Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice.
Volume: 6
Pages: 73
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Publication
23951545 | J:207797
 
First Author: Liu S
Year: 2013
Journal: Elife
Title: MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades.
Volume: 2
Pages: e00785
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Publication
11092979 | J:66211
First Author: Dragani TA
Year: 2000
Journal: Jpn J Cancer Res
Title: Mapping of melanoma modifier loci in RET transgenic mice.
Volume: 91
Issue: 11
Pages: 1142-7
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Publication
16002709 | J:100702
First Author: Chen Y
Year: 2005
Journal: J Immunol
Title: Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.
Volume: 175
Issue: 2
Pages: 1080-9
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Publication
21903422 | J:176666
First Author: Li S
Year: 2011
Journal: Immunity
Title: Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Volume: 35
Issue: 3
Pages: 426-40
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Publication
20614026 | J:161997
First Author: Hostager BS
Year: 2010
Journal: PLoS One
Title: HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex.
Volume: 5
Issue: 6
Pages: e11380
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Interaction Experiment
Sun D (2011)
Description: Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF).
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Publication
19409903 | -
First Author: Zhang L
Year: 2009
Journal: J Mol Biol
Title: TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells.
Volume: 389
Issue: 3
Pages: 495-510
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Ontology Term
- | Inhibition of host TRAFs by virus
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Protein Domain
IPR037308 | TRAF5_MATH
Type: Domain
Description: TNF receptor-associated factor 5 (TRAF5) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. TRAF5 mediates activation of NF-kappa-B and probably JNK [, , , ]. TRAF5 contains a RING finger domain, five zinc finger domains, and a TRAF domain.The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded β-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [, ].
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Publication
9153189 | J:40487
First Author: Hsu H
Year: 1997
Journal: J Biol Chem
Title: ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.
Volume: 272
Issue: 21
Pages: 13471-4
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Publication
9511754 | J:46104
First Author: Mizushima S
Year: 1998
Journal: Gene
Title: Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).
Volume: 207
Issue: 2
Pages: 135-40
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Publication
19198591 | J:146475
First Author: Rub A
Year: 2009
Journal: Nat Immunol
Title: Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function.
Volume: 10
Issue: 3
Pages: 273-80
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Publication
24659185 | -
First Author: Hansen HP
Year: 2014
Journal: J Pathol
Title: Protrusion-guided extracellular vesicles mediate CD30 trans-signalling in the microenvironment of Hodgkin's lymphoma.
Volume: 232
Issue: 4
Pages: 405-14
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Publication
8999898 | -
First Author: Aizawa S
Year: 1997
Journal: J Biol Chem
Title: Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.
Volume: 272
Issue: 4
Pages: 2042-5
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Publication
2849300 | -
First Author: Pallesen G
Year: 1988
Journal: Am J Pathol
Title: Ki-1 (CD30) antigen is regularly expressed by tumor cells of embryonal carcinoma.
Volume: 133
Issue: 3
Pages: 446-50
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Publication
11799147 | -
First Author: Leroy X
Year: 2002
Journal: J Histochem Cytochem
Title: CD30 and CD117 (c-kit) used in combination are useful for distinguishing embryonal carcinoma from seminoma.
Volume: 50
Issue: 2
Pages: 283-5
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Publication
10192335 | J:54099
First Author: Kurts C
Year: 1999
Journal: Nature
Title: Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells.
Volume: 398
Issue: 6725
Pages: 341-4
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Publication
10727988 | -
First Author: Dürkop H
Year: 2000
Journal: J Pathol
Title: Expression of the CD30 antigen in non-lymphoid tissues and cells.
Volume: 190
Issue: 5
Pages: 613-8
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Publication
12714494 | -
First Author: Francisco JA
Year: 2003
Journal: Blood
Title: cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity.
Volume: 102
Issue: 4
Pages: 1458-65
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Publication
19760068 | -
 
First Author: Gough MJ
Year: 2009
Journal: Adv Exp Med Biol
Title: OX40 (CD134) and OX40L.
Volume: 647
Pages: 94-107
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Publication
15173831 | -
First Author: Sugamura K
Year: 2004
Journal: Nat Rev Immunol
Title: Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40.
Volume: 4
Issue: 6
Pages: 420-31
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Publication
11567634 | J:71803
First Author: Rogers PR
Year: 2001
Journal: Immunity
Title: OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells.
Volume: 15
Issue: 3
Pages: 445-55
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Publication
27519474 | -
First Author: Chua KH
Year: 2016
Journal: Int J Immunogenet
Title: TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population.
Volume: 43
Issue: 5
Pages: 303-9
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Protein Domain
IPR034002 | TNFRSF8_N
Type: Domain
Description: Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30, Ki-1 or D1S166E, is expressed by activated T and B cells. It transduces signals that lead to the activation of NF-kappaB, mediated by the adaptor proteins TRAF2 and TRAF5 []. This receptor has been shown to limit the proliferative potential of auto-reactive CD8 effector T cells and protect the body against autoimmunity []. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. CD30 is expressed in malignant Hodgkin and Reed-Sternberg cells on the surface of extracellular vesicles, facilitating CD30-CD30L interaction between cell types []. This receptor is also associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma, but not in seminoma, making it a useful marker in distinguishing between these germ cell tumors [, ]. Since CD30 has restricted expression in normal tissues, it is an optimal target for selectively eliminating CD30-expressing neoplastic cells by specific toxin-conjugated monoclonal antibodies (mAbs) [, ].This entry represents the N-terminal domain of TNFRSF8. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].
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Protein Domain
IPR034022 | TNFRSF4_N
Type: Domain
Description: Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as OX40, ACT35, CD134, IMD16 or TXGP1L, activates NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5 []. It also promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis []. It is primarily expressed on activated CD4+ and CD8+ T cells, where it is transiently expressed and upregulated on the most recently antigen-activated T cells within inflammatory lesions. This makes it an attractive target to modulate immune responses, i.e. TNFRSF4 (OX40) blocking agents to inhibit adverse inflammation or agonists to enhance immune responses [, ]. An artificially created biologic fusion protein, OX40-immunoglobulin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Some single nucleotide polymorphisms (SNPs) of its natural ligand OX40 ligand (OX40L, CD252), which is also found on activated T cells, have been associated with systemic lupus erythematosus [].This entry represents the N-terminal domain of TNFRSF4. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number of modules can vary in number and type in different members of the family [, , ].
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Publication
12019265 | J:78258
First Author: Sasazuki T
Year: 2002
Journal: J Biol Chem
Title: Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death.
Volume: 277
Issue: 32
Pages: 28853-60
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Publication
17158868 | J:164781
First Author: He JQ
Year: 2007
Journal: J Biol Chem
Title: Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway.
Volume: 282
Issue: 6
Pages: 3688-94
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Publication
8910514 | J:36721
First Author: Ishida T
Year: 1996
Journal: J Biol Chem
Title: Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region.
Volume: 271
Issue: 46
Pages: 28745-8
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Publication
29619270 | J:274120
 
First Author: Wang T
Year: 2018
Journal: Bone Res
Title: CHIP regulates bone mass by targeting multiple TRAF family members in bone marrow stromal cells.
Volume: 6
Pages: 10
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Publication
16858409 | J:200433
First Author: Saha SK
Year: 2006
Journal: EMBO J
Title: Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.
Volume: 25
Issue: 14
Pages: 3257-63
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Publication
11275257 | J:68102
First Author: Grech A
Year: 2000
Journal: Mol Immunol
Title: Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.
Volume: 37
Issue: 12-13
Pages: 721-34
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Publication
20345905 | J:198907
First Author: Ando K
Year: 2010
Journal: FEBS J
Title: Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling.
Volume: 277
Issue: 9
Pages: 2051-66
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Publication
9366415 | J:43977
First Author: Hsing Y
Year: 1997
Journal: J Immunol
Title: Characterization of CD40 signaling determinants regulating nuclear factor-kappa B activation in B lymphocytes.
Volume: 159
Issue: 10
Pages: 4898-906
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Protein
P47741
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Protein
B1ASL3
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Publication
10518213 | J:57751
First Author: Ye H
Year: 1999
Journal: Mol Cell
Title: The structural basis for the recognition of diverse receptor sequences by TRAF2.
Volume: 4
Issue: 3
Pages: 321-30
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Protein
Q60846
Organism: Mus musculus/domesticus
Length: 498  
Fragment?: false
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Protein
D6RHK4
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Publication
10206649 | -
First Author: Park YC
Year: 1999
Journal: Nature
Title: Structural basis for self-association and receptor recognition of human TRAF2.
Volume: 398
Issue: 6727
Pages: 533-8
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Publication
9538693 | -
First Author: Naismith JH
Year: 1998
Journal: Trends Biochem Sci
Title: Modularity in the TNF-receptor family.
Volume: 23
Issue: 2
Pages: 74-9
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Publication
11796220 | -
First Author: Bodmer JL
Year: 2002
Journal: Trends Biochem Sci
Title: The molecular architecture of the TNF superfamily.
Volume: 27
Issue: 1
Pages: 19-26
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Publication
8387891 | -
First Author: Banner DW
Year: 1993
Journal: Cell
Title: Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
Volume: 73
Issue: 3
Pages: 431-45
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