Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797223 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5109 |
|
Specimen Label: |
GUDMAP:5109 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1832123 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5108 |
|
Specimen Label: |
GUDMAP:5108 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1832123 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5109 |
|
Specimen Label: |
GUDMAP:5109 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2256111 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-01-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:7575817 |
Age: |
embryonic day 14.5 |
|
Note: |
Caudal expression was greater than rostral. |
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2851823 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5108 |
|
Specimen Label: |
GUDMAP:5108 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2851823 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5109 |
|
Specimen Label: |
GUDMAP:5109 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2760523 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5108 |
|
Specimen Label: |
GUDMAP:5108 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2760523 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5109 |
|
Specimen Label: |
GUDMAP:5109 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2852723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5108 |
|
Specimen Label: |
GUDMAP:5108 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2852723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5109 |
|
Specimen Label: |
GUDMAP:5109 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2874723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5108 |
|
Specimen Label: |
GUDMAP:5108 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2850023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5108 |
|
Specimen Label: |
GUDMAP:5108 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2850023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5109 |
|
Specimen Label: |
GUDMAP:5109 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000599 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796223 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541159 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5108 |
|
Specimen Label: |
GUDMAP:5108 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki N |
Year: |
2003 |
Journal: |
DNA Res |
Title: |
Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
Volume: |
10 |
Issue: |
1 |
Pages: |
35-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration |
Year: |
2001 |
|
Title: |
LocusLink Collaboration |
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|
•
•
•
•
•
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Publication |
First Author: |
Blackshaw S |
Year: |
2004 |
Journal: |
PLoS Biol |
Title: |
Genomic analysis of mouse retinal development. |
Volume: |
2 |
Issue: |
9 |
Pages: |
E247 |
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•
•
•
•
•
|
Publication |
First Author: |
University of California, Davis |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the University of California, Davis |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
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|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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•
•
•
•
•
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Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
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|
•
•
•
•
•
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
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Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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•
•
•
•
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
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•
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Publication |
First Author: |
Bertaux F |
Year: |
1998 |
Journal: |
FEBS Lett |
Title: |
HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice. |
Volume: |
426 |
Issue: |
2 |
Pages: |
229-32 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
628
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
326
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
241
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
304
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
24
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
256
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Li XJ |
Year: |
1995 |
Journal: |
Nature |
Title: |
A huntingtin-associated protein enriched in brain with implications for pathology. |
Volume: |
378 |
Issue: |
6555 |
Pages: |
398-402 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang GZ |
Year: |
2012 |
Journal: |
J Neurochem |
Title: |
Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. |
Volume: |
122 |
Issue: |
5 |
Pages: |
1010-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu LL |
Year: |
2009 |
Journal: |
Cell Adh Migr |
Title: |
Huntingtin associated protein 1 and its functions. |
Volume: |
3 |
Issue: |
1 |
Pages: |
71-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lumsden AL |
Year: |
2016 |
Journal: |
BMC Evol Biol |
Title: |
Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine. |
Volume: |
16 |
Issue: |
1 |
Pages: |
214 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a N-terminal conserved region found in huntingtin-associated protein 1 (HAP1), trafficking Kinesin proteins TRAK1 and TRAK2 (vertebrate), Milton (Drosophila) and T27A3.1 (C. elegans) []. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner [, , ]. It is involved in intracellular trafficking []. HAP1 is also linked to Alzheimer's disease. It regulates amyloid precursor protein subcellular trafficking to the non-amyloidogenic pathway and may negatively regulate Abeta production in neurons [].TRAK1 binds to both kinesin-1 and dynein/dynactin, is prominently localized in axons, and is needed for normal axon outgrowth, whereas TRAK2 predominantly interacts with dynein/dynactin, is more abundantly present in dendrites, and is required for dendritic development []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
234
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
524
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
241
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain can be found at the C terminus of the eukaryotic trafficking kinesin-binding proteins, including TRAK1 and TRAK2. TRAK1 binds to both kinesin-1 and dynein/dynactin, is prominently localized in axons, and is needed for normal axon outgrowth, whereas TRAK2 predominantly interacts with dynein/dynactin, is more abundantly present in dendrites, and is required for dendritic development []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
939
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
606
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
664
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
968
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
947
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
560
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
524
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
731
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
672
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
913
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
913
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee IW |
Year: |
2024 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
An aggregated mitochondrial distribution in preimplantation embryos disrupts nuclear morphology, function, and developmental potential. |
Volume: |
121 |
Issue: |
27 |
Pages: |
e2317316121 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Doménech G |
Year: |
2018 |
Journal: |
EMBO J |
Title: |
Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution. |
Volume: |
37 |
Issue: |
3 |
Pages: |
321-336 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ugbode CI |
Year: |
2014 |
Journal: |
J Neurochem |
Title: |
Neuronal influences are necessary to produce mitochondrial co-localization with glutamate transporters in astrocytes. |
Volume: |
130 |
Issue: |
5 |
Pages: |
668-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Colomer V |
Year: |
1997 |
Journal: |
Hum Mol Genet |
Title: |
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. |
Volume: |
6 |
Issue: |
9 |
Pages: |
1519-25 |
|
•
•
•
•
•
|