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Search results 101 to 163 out of 163 for Trex1

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Type Details Score
Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GXD Expression
GXD Expression
       
Probe: MGI:6454686
Assay Type: RT-PCR
Annotation Date: 2020-09-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:6454688
Age: embryonic day 14.0
Specimen Label: E14 Trex1 WT
Specimen Num: 2
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GXD Expression
GXD Expression
       
Probe: MGI:6454686
Assay Type: RT-PCR
Annotation Date: 2020-09-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:6454688
Age: embryonic day 17.0
Specimen Label: E17 Trex1 WT
Specimen Num: 4
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Strain
MGI:7570794 | 129S6(129S4)-Trex1<tm1.1Fwpe>/Fwpe
Attribute String: mutant strain, targeted mutation
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Allele
Trex1<tm2.1Fwpe> | MGI:6751624
Name: three prime repair exonuclease 1; targeted mutation 2.1, Fred W Perrino
Allele Type: Targeted
Attribute String: Not Specified
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Allele
Trex1<em1Lutzy> | MGI:6864520
Name: three prime repair exonuclease 1; endonuclease-mediated mutation 1, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Publication
27886180 | J:243061
 
First Author: Wilson R
Year: 2016
Journal: Nat Commun
Title: MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment.
Volume: 7
Pages: 13597
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Publication
21239708 | J:169164
First Author: Serra M
Year: 2011
Journal: J Immunol
Title: Characterization of Trex1 induction by IFN-γ in murine macrophages.
Volume: 186
Issue: 4
Pages: 2299-308
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HT Experiment
GSE77693 | Loss of Trex1 in dendritic cells is sufficient to trigger systemic autoimmunity
Series Id: E-GEOD-77693
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q91XB0
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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HT Experiment
E-GEOD-11698 | Transcription profiling of mouse Trex1 WT and Trex1 KO hearts on RAG2KO background
Series Id: GSE11698
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Interaction Experiment
de Silva U (2007)
Description: The crystal structure of TREX1 explains the 3 nucleotide specificity and reveals a polyproline II helix for protein partnering.
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Allele
Trex1<tm1.1Beh> | MGI:6393252
Name: three prime repair exonuclease 1; targeted mutation 1.1, Rayk Behrendt
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
22071149 | -
First Author: Bailey SL
Year: 2012
Journal: DNA Repair (Amst)
Title: Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.
Volume: 11
Issue: 1
Pages: 65-73
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Allele
Trex1<tm1.1Kpk> | MGI:6393254
Name: three prime repair exonuclease 1; targeted mutation 1.1, Klaus-Peter Knobeloch
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Trex1/Trex1
Background: involves: 129P2/OlaHsd * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Publication
18780819 | -
First Author: Brucet M
Year: 2008
Journal: Protein Sci
Title: Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases.
Volume: 17
Issue: 12
Pages: 2059-69
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DO Term
DOID:0111567 | retinal vasculopathy with cerebral leukodystrophy
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DO Term
DOID:0060386 | Chilblain lupus
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Publication
27365293 | J:238143
First Author: Manils J
Year: 2016
Journal: J Invest Dermatol
Title: The Exonuclease Trex2 Shapes Psoriatic Phenotype.
Volume: 136
Issue: 12
Pages: 2345-2355
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Publication
27884288 | -
First Author: Mathers AR
Year: 2016
Journal: J Invest Dermatol
Title: TREX through Cutaneous Health and Disease.
Volume: 136
Issue: 12
Pages: 2337-2339
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Publication
17426129 | -
First Author: Chen MJ
Year: 2007
Journal: Nucleic Acids Res
Title: Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2.
Volume: 35
Issue: 8
Pages: 2682-94
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Protein Domain
IPR034926 | TREX2
Type: Family
Description: TREX1 and TREX2 are DNAQ-like 3'-5' exonucleases that process the 3' termini during DNA replication, repair, and degradation [, ]. TREX1 is expressed in all cells, whereas TREX2 is expressed primarily in keratinocytes []. TREX2 plays an important function during DNA metabolism and cellular proliferation []. Its overexpression plays a role in developing the psoriasis phenotype [].
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Publication
19321497 | -
First Author: de Silva U
Year: 2009
Journal: Nucleic Acids Res
Title: DNA binding induces active site conformational change in the human TREX2 3'-exonuclease.
Volume: 37
Issue: 7
Pages: 2411-7
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Protein Domain
IPR040393 | TREX1/2
Type: Family
Description: Three prime repair exonuclease (TREX)1 and TREX2 are closely related DEDDh-type DnaQ-like 3'-5' exonucleases. They contain three conserved sequence motifs known as ExoI, II, and III, with a specific Hx(4)D conserved pattern at ExoIII. These motifs contain four conserved acidic residues that participate in coordination of divalent metal ions required for catalysis. Both proteins play a role in the metabolism and clearance of DNA []. TREX1 is the major 3'-5' exonuclease activity detected in mammalian cells. Mutations in the human TREX1 gene can cause Aicardi-Goutieres syndrome (AGS), which is characterized by perturbed innate immunity and presents itself as a severe neurological disease []. TREX1 degrades ssDNA generated by aberrant replication intermediates to prevent checkpoint activation and autoimmune disease []. There are distinct structural differences between TREX1 and TREX2 that point to different biological roles for these proteins. The main difference is the presence of about 70 amino acids at the C terminus of TREX1. In addition, TREX1 has a nonrepetitive proline-rich region that is not present in the TREX2 protein. Furthermore, TREX2 contains a conserved DNA binding loop positioned adjacent to the active site that has a sequence distinct from the corresponding loop in TREX1. Truncations in the C terminus of human TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy (RVCL), a neurovascular syndrome featuring a progressive loss of visual acuity combined with a variable neurological picture [, ].
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Genotype
Genotype
Symbol: Cd19/Cd19<+> Trex1/Trex1
Background: involves: 129P2/OlaHsd * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Protein
Q9R1A9
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
Q3SXB3
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Gene
25939 | SAMHD1
Type: gene
Organism: human
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Publication
29593264 | J:260479
First Author: Takahashi A
Year: 2018
Journal: Nat Commun
Title: Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.
Volume: 9
Issue: 1
Pages: 1249
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Publication
21478870 | J:171353
First Author: Schoggins JW
Year: 2011
Journal: Nature
Title: A diverse range of gene products are effectors of the type I interferon antiviral response.
Volume: 472
Issue: 7344
Pages: 481-5
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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