| Type |
Details |
Score |
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
2025
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seo BA |
| Year: |
2021 |
| Journal: |
Neuron |
| Title: |
TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease. |
| Volume: |
109 |
| Issue: |
23 |
| Pages: |
3758-3774.e11 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
2 |
| Description: |
E3 ubiquitin-protein ligase TRIP12 |
| Type: |
chain |
| End: |
2025 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
830
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
146
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
65
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
98
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
423
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
33
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
346
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gudjonsson T |
| Year: |
2012 |
| Journal: |
Cell |
| Title: |
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. |
| Volume: |
150 |
| Issue: |
4 |
| Pages: |
697-709 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park Y |
| Year: |
2009 |
| Journal: |
J Biol Chem |
| Title: |
The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway. |
| Volume: |
284 |
| Issue: |
3 |
| Pages: |
1540-9 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sarkar AA |
| Year: |
2012 |
| Journal: |
J Cell Biol |
| Title: |
Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme. |
| Volume: |
196 |
| Issue: |
6 |
| Pages: |
789-800 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zohn IE |
| Year: |
2007 |
| Journal: |
Dev Biol |
| Title: |
The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. |
| Volume: |
306 |
| Issue: |
1 |
| Pages: |
208-21 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
70
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
243
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes a group of E3 ubiquitin-protein ligases, including HECTD1/TRIP12 from humans, Ufd4 from budding yeasts and UPL3/4 from Arabidopsis. TRIP12 is involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair [, ]. HECTD1 regulates intracellular localization and secretion of Hsp90 and is essential for the correct development of the cranial neural folds and neural tube closure [, ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hsu H |
| Year: |
1995 |
| Journal: |
Cell |
| Title: |
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. |
| Volume: |
81 |
| Issue: |
4 |
| Pages: |
495-504 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents TRADD (or tumour necrosis factor receptor type 1-associated DEATH domain protein). TRADD interacts with the cytoplasmic domain of activated TNFRSF1A/TNFR1, which in turn enables it to interact with FADD. Overexpression of TRADD results in apoptosis and activation of NF-kappa-B []. TRADD shuttles from the cytoplasm into the nucleus. The nuclear form of TRADD is a tumour suppressor, which by interacting with TRIP12 disrupts its complex with isoform p19ARF/ARF of CDKN2A, preventing ubiquitination and degradation []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Amici DR |
| Year: |
2024 |
| Journal: |
Life Sci Alliance |
| Title: |
Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life. |
| Volume: |
7 |
| Issue: |
5 |
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
639
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
58
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
308
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
119
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
64
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
149
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
213
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
982
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
310
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
310
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
499
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
642
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
763
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
494
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
2618
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
2610
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trost M |
| Year: |
2009 |
| Journal: |
Immunity |
| Title: |
The phagosomal proteome in interferon-gamma-activated macrophages. |
| Volume: |
30 |
| Issue: |
1 |
| Pages: |
143-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park J |
| Year: |
2013 |
| Journal: |
Mol Cell |
| Title: |
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. |
| Volume: |
50 |
| Issue: |
6 |
| Pages: |
919-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2000 |
| Journal: |
Genome Res |
| Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
| Volume: |
10 |
| Issue: |
10 |
| Pages: |
1617-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
1999 |
| Journal: |
Methods Enzymol |
| Title: |
High-efficiency full-length cDNA cloning. |
| Volume: |
303 |
|
| Pages: |
19-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shibata K |
| Year: |
2000 |
| Journal: |
Genome Res |
| Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
| Volume: |
10 |
| Issue: |
11 |
| Pages: |
1757-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Katayama S |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
Antisense transcription in the mammalian transcriptome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1564-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huttlin EL |
| Year: |
2010 |
| Journal: |
Cell |
| Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
| Volume: |
143 |
| Issue: |
7 |
| Pages: |
1174-89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Church DM |
| Year: |
2009 |
| Journal: |
PLoS Biol |
| Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
e1000112 |
|
•
•
•
•
•
|