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Search results 101 to 200 out of 721 for Tsc1

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Type Details Score
Publication  
First Author: Prabhakar S
Year: 2015
Journal: Neurobiol Dis
Title: Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.
Volume: 82
Pages: 22-31
Publication
First Author: Di Nardo A
Year: 2014
Journal: Hum Mol Genet
Title: Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.
Volume: 23
Issue: 14
Pages: 3865-74
Publication
First Author: Anderl S
Year: 2011
Journal: Hum Mol Genet
Title: Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.
Volume: 20
Issue: 23
Pages: 4597-604
Publication
First Author: Meikle L
Year: 2008
Journal: J Neurosci
Title: Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function.
Volume: 28
Issue: 21
Pages: 5422-32
Publication
First Author: Di Nardo A
Year: 2009
Journal: J Neurosci
Title: Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner.
Volume: 29
Issue: 18
Pages: 5926-37
Publication  
First Author: McMahon JJ
Year: 2015
Journal: Neurobiol Dis
Title: Seizure-dependent mTOR activation in 5-HT neurons promotes autism-like behaviors in mice.
Volume: 73
Pages: 296-306
Publication
First Author: El-Hashemite N
Year: 2005
Journal: Cancer Res
Title: Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis.
Volume: 65
Issue: 6
Pages: 2474-81
Publication
First Author: Kladney RD
Year: 2010
Journal: Cancer Res
Title: Tuberous sclerosis complex 1: an epithelial tumor suppressor essential to prevent spontaneous prostate cancer in aged mice.
Volume: 70
Issue: 21
Pages: 8937-47
Publication
First Author: O'Brien TF
Year: 2011
Journal: Eur J Immunol
Title: Regulation of T-cell survival and mitochondrial homeostasis by TSC1.
Volume: 41
Issue: 11
Pages: 3361-70
Publication
First Author: Wilson C
Year: 2005
Journal: Hum Mol Genet
Title: A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma.
Volume: 14
Issue: 13
Pages: 1839-50
Publication
First Author: Li C
Year: 2019
Journal: Cell Death Differ
Title: mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis.
Volume: 26
Issue: 10
Pages: 2015-2028
Publication
First Author: Erbayat-Altay E
Year: 2007
Journal: Epilepsia
Title: The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.
Volume: 48
Issue: 8
Pages: 1470-6
Publication  
First Author: Yu R
Year: 2018
Journal: EBioMedicine
Title: Activation of mTORC1 signaling in gastric X/A-like cells induces spontaneous pancreatic fibrosis and derangement of glucose metabolism by reducing ghrelin production.
Volume: 36
Pages: 304-315
Publication
First Author: Parker WE
Year: 2011
Journal: Am J Pathol
Title: Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex.
Volume: 178
Issue: 1
Pages: 296-305
Publication
First Author: Chao X
Year: 2023
Journal: Hepatology
Title: Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis.
Volume: 78
Issue: 2
Pages: 503-517
Publication
First Author: Guo Y
Year: 2016
Journal: PLoS One
Title: Analysis of a Mouse Skin Model of Tuberous Sclerosis Complex.
Volume: 11
Issue: 12
Pages: e0167384
Publication
First Author: Maldonado M
Year: 2003
Journal: Neurobiol Dis
Title: Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex.
Volume: 14
Issue: 2
Pages: 279-90
Publication  
First Author: Li T
Year: 2020
Journal: Front Cell Dev Biol
Title: Defects in mTORC1 Network and mTORC1-STAT3 Pathway Crosstalk Contributes to Non-inflammatory Hepatocellular Carcinoma.
Volume: 8
Pages: 225
Publication  
First Author: Nechama M
Year: 2020
Journal: JCI Insight
Title: Rapamycin and dexamethasone during pregnancy prevent tuberous sclerosis complex-associated cystic kidney disease.
Volume: 5
Issue: 13
Publication
First Author: Liang Z
Year: 2021
Journal: J Immunol
Title: The Development and Survival of Thymic Epithelial Cells Require TSC1-Dependent Negative Regulation of mTORC1 Activity.
Volume: 207
Issue: 8
Pages: 2039-2050
Publication
First Author: Ess KC
Year: 2004
Journal: Glia
Title: Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology.
Volume: 46
Issue: 1
Pages: 28-40
Publication
First Author: Magdalon J
Year: 2016
Journal: Biochim Biophys Acta
Title: Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice.
Volume: 1861
Issue: 5
Pages: 430-8
Publication
First Author: Zeng LH
Year: 2008
Journal: Ann Neurol
Title: Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.
Volume: 63
Issue: 4
Pages: 444-53
Publication  
First Author: Koene LM
Year: 2021
Journal: JCI Insight
Title: Identifying the temporal electrophysiological and molecular changes that contribute to TSC-associated epileptogenesis.
Volume: 6
Issue: 23
Publication
First Author: Magini A
Year: 2017
Journal: Hum Mol Genet
Title: TFEB activation restores migration ability to Tsc1-deficient adult neural stem/progenitor cells.
Volume: 26
Issue: 17
Pages: 3303-3312
Publication
First Author: Zhang HM
Year: 2017
Journal: Sci Rep
Title: Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice.
Volume: 7
Issue: 1
Pages: 834
Publication
First Author: Gui YS
Year: 2015
Journal: PLoS One
Title: mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.
Volume: 10
Issue: 9
Pages: e0138625
Publication
First Author: Chen C
Year: 2009
Journal: Sci Signal
Title: mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.
Volume: 2
Issue: 98
Pages: ra75
Publication
First Author: Chen C
Year: 2008
Journal: J Exp Med
Title: TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species.
Volume: 205
Issue: 10
Pages: 2397-408
Publication
First Author: Mori H
Year: 2009
Journal: Cell Metab
Title: Critical role for hypothalamic mTOR activity in energy balance.
Volume: 9
Issue: 4
Pages: 362-74
Publication
First Author: Ebrahimi-Fakhari D
Year: 2016
Journal: Cell Rep
Title: Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex.
Volume: 17
Issue: 4
Pages: 1053-1070
Publication
First Author: Cho JH
Year: 2017
Journal: Nat Commun
Title: Notch transactivates Rheb to maintain the multipotency of TSC-null cells.
Volume: 8
Issue: 1
Pages: 1848
Publication
First Author: Wang C
Year: 2019
Journal: Nat Metab
Title: Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells.
Volume: 1
Issue: 11
Pages: 1127-1140
Publication
First Author: Wu J
Year: 2014
Journal: J Immunol
Title: Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity.
Volume: 192
Issue: 6
Pages: 2643-50
Publication
First Author: Kucejova B
Year: 2016
Journal: Cell Rep
Title: Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity.
Volume: 16
Issue: 2
Pages: 508-19
Publication
First Author: Zeng LH
Year: 2010
Journal: Neurobiol Dis
Title: Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex.
Volume: 37
Issue: 3
Pages: 764-71
Publication
First Author: Zhang L
Year: 2012
Journal: PLoS One
Title: TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice.
Volume: 7
Issue: 2
Pages: e30592
Publication
First Author: Uhlmann EJ
Year: 2004
Journal: Glia
Title: Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation.
Volume: 47
Issue: 2
Pages: 180-8
Publication
First Author: Khatri S
Year: 2010
Journal: J Biol Chem
Title: FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.
Volume: 285
Issue: 21
Pages: 15960-5
Publication
First Author: McLane LE
Year: 2017
Journal: J Neurosci
Title: Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination.
Volume: 37
Issue: 31
Pages: 7534-7546
Publication  
First Author: Cox RL
Year: 2018
Journal: Front Mol Neurosci
Title: Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain.
Volume: 11
Pages: 409
Publication
First Author: Zou J
Year: 2017
Journal: Epilepsia
Title: Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner.
Volume: 58
Issue: 12
Pages: 2053-2063
Publication
First Author: Dibble CC
Year: 2012
Journal: Mol Cell
Title: TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Volume: 47
Issue: 4
Pages: 535-46
Publication
First Author: Benhamron S
Year: 2011
Journal: Eur J Immunol
Title: Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells.
Volume: 41
Issue: 8
Pages: 2390-6
Publication
First Author: Liko D
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs.
Volume: 117
Issue: 3
Pages: 1524-1532
Publication  
First Author: Lozovaya N
Year: 2014
Journal: Nat Commun
Title: Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.
Volume: 5
Pages: 4563
Publication
First Author: Hernandez O
Year: 2007
Journal: Genesis
Title: Generation of a conditional disruption of the Tsc2 gene.
Volume: 45
Issue: 2
Pages: 101-6
Publication
First Author: Gonçalves AF
Year: 2017
Journal: Nat Commun
Title: Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.
Volume: 8
Issue: 1
Pages: 1466
Publication
First Author: Yang SB
Year: 2012
Journal: Neuron
Title: Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.
Volume: 75
Issue: 3
Pages: 425-36
Publication
First Author: Schrötter S
Year: 2022
Journal: Cell Rep
Title: The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth.
Volume: 39
Issue: 7
Pages: 110824
Publication  
First Author: Zhang J
Year: 2022
Journal: Cell Signal
Title: LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions.
Volume: 100
Pages: 110468
Publication
First Author: Carson RP
Year: 2012
Journal: Neurobiol Dis
Title: Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin.
Volume: 45
Issue: 1
Pages: 369-80
Publication
First Author: Gong QQ
Year: 2021
Journal: PLoS One
Title: A novel mouse line with epididymal initial segment-specific expression of Cre recombinase driven by the endogenous Lcn9 promoter.
Volume: 16
Issue: 7
Pages: e0254802
Publication
First Author: Goorden SM
Year: 2011
Journal: Mol Cell Biol
Title: Rheb is essential for murine development.
Volume: 31
Issue: 8
Pages: 1672-8
Publication
First Author: Lipton JO
Year: 2017
Journal: Cell Rep
Title: Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy.
Volume: 20
Issue: 4
Pages: 868-880
Publication  
First Author: Byles V
Year: 2013
Journal: Nat Commun
Title: The TSC-mTOR pathway regulates macrophage polarization.
Volume: 4
Pages: 2834
Publication
First Author: Chen R
Year: 2017
Journal: Oncogene
Title: mTOR promotes pituitary tumor development through activation of PTTG1.
Volume: 36
Issue: 7
Pages: 979-988
Publication
First Author: Harputlugil E
Year: 2014
Journal: Cell Rep
Title: The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo.
Volume: 8
Issue: 4
Pages: 1160-70
Publication
First Author: Yecies JL
Year: 2011
Journal: Cell Metab
Title: Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.
Volume: 14
Issue: 1
Pages: 21-32
Publication
First Author: Gan B
Year: 2010
Journal: Cancer Cell
Title: FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis.
Volume: 18
Issue: 5
Pages: 472-84
Publication
First Author: Volovelsky O
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Hamartin regulates cessation of mouse nephrogenesis independently of Mtor.
Volume: 115
Issue: 23
Pages: 5998-6003
Publication
First Author: Herrema H
Year: 2014
Journal: Biochem Biophys Res Commun
Title: IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance.
Volume: 443
Issue: 2
Pages: 689-93
Publication
First Author: Sun S
Year: 2015
Journal: Cancer Cell
Title: Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling.
Volume: 28
Issue: 6
Pages: 758-772
Publication  
First Author: Pema M
Year: 2016
Journal: Nat Commun
Title: mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
Volume: 7
Pages: 10786
Publication
First Author: Wang F
Year: 2014
Journal: Oncogene
Title: Pivotal role of augmented αB-crystallin in tumor development induced by deficient TSC1/2 complex.
Volume: 33
Issue: 34
Pages: 4352-8
Publication
First Author: Bartley CM
Year: 2014
Journal: PLoS One
Title: FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity.
Volume: 9
Issue: 5
Pages: e96956
Publication
First Author: Karalis V
Year: 2022
Journal: Nat Commun
Title: Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex.
Volume: 13
Issue: 1
Pages: 4665
Publication
First Author: Ozcan U
Year: 2008
Journal: Mol Cell
Title: Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.
Volume: 29
Issue: 5
Pages: 541-51
Publication
First Author: Choi YJ
Year: 2008
Journal: Genes Dev
Title: Tuberous sclerosis complex proteins control axon formation.
Volume: 22
Issue: 18
Pages: 2485-95
Publication
First Author: Gilbert ER
Year: 2013
Journal: Am J Pathol
Title: Positioning ganglioside D3 as an immunotherapeutic target in lymphangioleiomyomatosis.
Volume: 183
Issue: 1
Pages: 226-34
Publication
First Author: Nagai K
Year: 2017
Journal: J Am Soc Nephrol
Title: Mesangial Cell Mammalian Target of Rapamycin Complex 1 Activation Results in Mesangial Expansion.
Volume: 28
Issue: 10
Pages: 2879-2885
Publication
First Author: Mori H
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Critical roles for the TSC-mTOR pathway in β-cell function.
Volume: 297
Issue: 5
Pages: E1013-22
Publication
First Author: Pan H
Year: 2012
Journal: J Immunol
Title: The role of tuberous sclerosis complex 1 in regulating innate immunity.
Volume: 188
Issue: 8
Pages: 3658-66
Publication  
First Author: Sato A
Year: 2012
Journal: Nat Commun
Title: Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex.
Volume: 3
Pages: 1292
Publication
First Author: Menon S
Year: 2012
Journal: Sci Signal
Title: Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
Volume: 5
Issue: 217
Pages: ra24
Publication  
First Author: Cho CS
Year: 2019
Journal: Cell Discov
Title: Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury.
Volume: 5
Pages: 60
Publication
First Author: Ercan E
Year: 2017
Journal: J Exp Med
Title: Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex.
Volume: 214
Issue: 3
Pages: 681-697
Publication
First Author: Xiang X
Year: 2015
Journal: Diabetes
Title: Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch.
Volume: 64
Issue: 2
Pages: 519-28
Publication
First Author: Xiang X
Year: 2013
Journal: Exp Physiol
Title: Deficiency in pulmonary surfactant proteins in mice with fatty acid binding protein 4-Cre-mediated knockout of the tuberous sclerosis complex 1 gene.
Volume: 98
Issue: 3
Pages: 830-41
Publication
First Author: Wang L
Year: 2021
Journal: J Cell Physiol
Title: αB-crystallin/HSPB2 is critical for hyperactive mTOR-induced cardiomyopathy.
Volume: 236
Issue: 12
Pages: 8110-8121
Publication
First Author: Mao J
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Mammalian target of rapamycin complex 1 activation in podocytes promotes cellular crescent formation.
Volume: 307
Issue: 9
Pages: F1023-32
Publication
First Author: Chen Z
Year: 2014
Journal: J Am Soc Nephrol
Title: Activation of mTORC1 in collecting ducts causes hyperkalemia.
Volume: 25
Issue: 3
Pages: 534-45
Publication
First Author: Koene LMC
Year: 2019
Journal: Ann Clin Transl Neurol
Title: Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model.
Volume: 6
Issue: 7
Pages: 1273-1291
Publication
First Author: Lu J
Year: 2018
Journal: J Bone Miner Res
Title: Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice.
Volume: 33
Issue: 5
Pages: 909-920
Publication
First Author: Nellist M
Year: 2001
Journal: Hum Mol Genet
Title: TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex.
Volume: 10
Issue: 25
Pages: 2889-98
Publication
First Author: Medvetz D
Year: 2015
Journal: Mol Cancer Res
Title: Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift.
Volume: 13
Issue: 1
Pages: 3-8
Publication
First Author: Selen ES
Year: 2021
Journal: J Biol Chem
Title: mTORC1 activation is not sufficient to suppress hepatic PPARα signaling or ketogenesis.
Volume: 297
Issue: 1
Pages: 100884
Publication
First Author: Wang Z
Year: 2023
Journal: Int Immunopharmacol
Title: Tuberous sclerosis complex 1 targeted depletion in macrophages promotes osteogenesis by modulating secretion of Oncostatin M in the inflammatory stage of bone healing.
Volume: 124
Issue: Pt A
Pages: 110895
Publication  
First Author: Huynh H
Year: 2018
Journal: Commun Biol
Title: mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1.
Volume: 1
Pages: 29
Publication
First Author: He D
Year: 2020
Journal: Nat Commun
Title: Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway.
Volume: 11
Issue: 1
Pages: 37
Publication  
First Author: Yang M
Year: 2016
Journal: Nat Commun
Title: NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.
Volume: 7
Pages: 12730
Publication
First Author: Shinoda G
Year: 2013
Journal: Stem Cells
Title: Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.
Volume: 31
Issue: 8
Pages: 1563-73
Publication
First Author: Li K
Year: 2021
Journal: Cell Rep
Title: mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways.
Volume: 35
Issue: 5
Pages: 109069
Publication
First Author: Guo Y
Year: 2014
Journal: Oncogene
Title: Tsc1-Tp53 loss induces mesothelioma in mice, and evidence for this mechanism in human mesothelioma.
Volume: 33
Issue: 24
Pages: 3151-60
Publication
First Author: Cho JH
Year: 2019
Journal: Mol Cancer Res
Title: The Codon 72 TP53 Polymorphism Contributes to TSC Tumorigenesis through the Notch-Nodal Axis.
Volume: 17
Issue: 8
Pages: 1639-1651
Publication
First Author: Guo D
Year: 2022
Journal: Bone Res
Title: FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis.
Volume: 10
Issue: 1
Pages: 45
Publication  
First Author: Barone S
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.
Volume: 118
Issue: 6
Publication
First Author: Kenerson HL
Year: 2011
Journal: PLoS One
Title: Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.
Volume: 6
Issue: 3
Pages: e18075
Publication
First Author: Zordan P
Year: 2018
Journal: J Clin Invest
Title: Tuberous sclerosis complex-associated CNS abnormalities depend on hyperactivation of mTORC1 and Akt.
Volume: 128
Issue: 4
Pages: 1688-1706
Publication
First Author: Zhao JP
Year: 2019
Journal: Mol Brain
Title: Hyperexcitability of the local cortical circuit in mouse models of tuberous sclerosis complex.
Volume: 12
Issue: 1
Pages: 6