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Search results 101 to 200 out of 219 for Tyk2

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Type Details Score
Publication
11114383 | J:65966
First Author: Oppmann B
Year: 2000
Journal: Immunity
Title: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Volume: 13
Issue: 5
Pages: 715-25
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Publication
19088061 | J:319975
First Author: van de Wetering D
Year: 2009
Journal: Int Immunol
Title: IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12.
Volume: 21
Issue: 2
Pages: 145-53
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Publication
24069548 | J:202463
First Author: Li J
Year: 2013
Journal: JAKSTAT
Title: JAK-STAT and bone metabolism.
Volume: 2
Issue: 3
Pages: e23930
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Publication
22995073 | -
 
First Author: Argiriadi MA
Year: 2012
Journal: BMC Struct Biol
Title: Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.
Volume: 12
Pages: 22
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Publication
11437454 | J:70363
First Author: Brunskill EW
Year: 2001
Journal: Dev Biol
Title: Novel cell lines promote the discovery of genes involved in early heart development.
Volume: 235
Issue: 2
Pages: 507-20
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Publication
7893599 | J:22208
First Author: Ruiz JC
Year: 1994
Journal: Mech Dev
Title: Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.
Volume: 48
Issue: 3
Pages: 153-64
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Publication
32428860 | J:336999
First Author: Riedelberger M
Year: 2020
Journal: iScience
Title: Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.
Volume: 23
Issue: 5
Pages: 101121
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Publication
32075740 | J:349194
First Author: Riedelberger M
Year: 2020
Journal: Cell Host Microbe
Title: Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.
Volume: 27
Issue: 3
Pages: 454-466.e8
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Publication
15254900 | J:91730
First Author: Verma-Kurvari S
Year: 2004
Journal: Dev Dyn
Title: Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.
Volume: 230
Issue: 4
Pages: 660-5
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Ontology Term
- | Inhibition of host TYK2 by virus
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GO Term
GO:0039574 | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
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UniProt Feature
UniProt Feature
Begin: 1
Description: Non-receptor tyrosine-protein kinase TYK2
Type: chain
End: 1184
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Protein
Q9R117
Organism: Mus musculus/domesticus
Length: 1184  
Fragment?: false
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Publication
22859374 | J:193351
First Author: Zhang X
Year: 2012
Journal: FASEB J
Title: Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway.
Volume: 26
Issue: 11
Pages: 4603-13
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Protein
A0A1L1SVI6
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Publication
7579387 | J:29195
First Author: Novak U
Year: 1995
Journal: Blood
Title: Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts.
Volume: 86
Issue: 8
Pages: 2948-56
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UniProt Feature
UniProt Feature
Begin: 701
Description: Phosphotyrosine; by JAK1, JAK2 or TYK2
Type: modified residue
End: 701
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Publication
10502458 | J:156077
First Author: Hellgren G
Year: 1999
Journal: Growth Horm IGF Res
Title: The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.
Volume: 9
Issue: 3
Pages: 212-8
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Publication
9733772 | J:50019
First Author: Richter MF
Year: 1998
Journal: J Biol Chem
Title: Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1.
Volume: 273
Issue: 38
Pages: 24723-9
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DO Term
DOID:0111989 | immunodeficiency 35
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Allele
Tyk2<em1Smoc> | MGI:7293051
Name: tyrosine kinase 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6476571 | C57BL/6JSmoc-Tyk2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
16239216 | -
First Author: Staerk J
Year: 2005
Journal: J Biol Chem
Title: JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
Volume: 280
Issue: 51
Pages: 41893-9
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Publication
23658297 | J:200541
First Author: Fontan L
Year: 2013
Journal: Cancer Discov
Title: Discovering what makes STAT signaling TYK in T-ALL.
Volume: 3
Issue: 5
Pages: 494-6
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Protein Domain
IPR031994 | JAKMIP_C
Type: Domain
Description: This domain is found at the C terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1 [, , ].
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Protein
Q5DTN8
Organism: Mus musculus/domesticus
Length: 844  
Fragment?: false
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Publication
14718537 | J:89173
First Author: Couve A
Year: 2004
Journal: J Biol Chem
Title: Marlin-1, a novel RNA-binding protein associates with GABA receptors.
Volume: 279
Issue: 14
Pages: 13934-43
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Publication
17532644 | J:123202
First Author: Vidal RL
Year: 2007
Journal: Mol Cell Neurosci
Title: Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport.
Volume: 35
Issue: 3
Pages: 501-12
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Protein
Q8BVL9
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
G3UYZ9
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: false
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Protein
A0A1D5RLA4
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
A0A803ZCJ0
Organism: Mus musculus/domesticus
Length: 772  
Fragment?: false
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Protein
E9Q7K7
Organism: Mus musculus/domesticus
Length: 667  
Fragment?: true
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Protein
D3YXK0
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
D3Z4U5
Organism: Mus musculus/domesticus
Length: 831  
Fragment?: false
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Publication
15277531 | -
First Author: Steindler C
Year: 2004
Journal: J Biol Chem
Title: Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules.
Volume: 279
Issue: 41
Pages: 43168-77
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Publication
2156206 | J:10367
First Author: Krolewski JJ
Year: 1990
Journal: Oncogene
Title: Identification and chromosomal mapping of new human tyrosine kinase genes.
Volume: 5
Issue: 3
Pages: 277-82
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Protein
G3UXP1
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Protein
G3UY22
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: true
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Protein
G3UXP3
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
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Protein
D3Z555
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: true
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Protein
Q3UPL4
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: true
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Protein
Q8CEM9
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Protein
A0A140LIJ5
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Protein Domain
IPR024836 | JAKMIP
Type: Family
Description: Janus kinase and microtubule interacting proteins (JAKMIPs) are predominantly expressed in neural tissues and lymphoid organs. Three family members have been identified, termed JAKMIP1-3. They contain an N-terminal region that targets the protein to microtubule polymers and a C-terminal region that is able to associate with Janus kinase (Jak) family members, such as Tyk2 or Jak1 []. The proteins may have a role in Jak signalling and regulation of microtubule cytoskeleton rearrangements.JAKMIP1 has also been shown to interact with GABA(B) receptor R1 subunits [], and may be involved in microtubule-dependent transport of the GABA-B receptor [].
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HT Experiment
GSE227168 | JAK-STAT signaling maintains homeostasis in T cells and macrophages (spatial transcriptomics)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
10320373 | J:54604
First Author: Diefenbach A
Year: 1999
Journal: Science
Title: Requirement for type 2 NO synthase for IL-12 signaling in innate immunity.
Volume: 284
Issue: 5416
Pages: 951-5
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Publication
7481769 | J:29723
First Author: Nosaka T
Year: 1995
Journal: Science
Title: Defective lymphoid development in mice lacking Jak3.
Volume: 270
Issue: 5237
Pages: 800-2
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Publication
14978102 | J:88228
First Author: Muromoto R
Year: 2004
Journal: J Immunol
Title: Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1.
Volume: 172
Issue: 5
Pages: 2985-93
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Publication
27472900 | J:235436
   
First Author: Sullivan KD
Year: 2016
Journal: Elife
Title: Trisomy 21 consistently activates the interferon response.
Volume: 5
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Publication
35394840 | J:339141
First Author: Zuo Y
Year: 2022
Journal: Sci Adv
Title: LATS1 is a central signal transmitter for achieving full type-I interferon activity.
Volume: 8
Issue: 14
Pages: eabj3887
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Publication
22791342 | J:188528
First Author: Kang MK
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration.
Volume: 303
Issue: 7
Pages: F1060-9
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Publication
12805384 | J:85186
First Author: Chang HC
Year: 2003
Journal: J Biol Chem
Title: STAT4 requires the N-terminal domain for efficient phosphorylation.
Volume: 278
Issue: 34
Pages: 32471-7
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Publication
32161097 | J:287105
First Author: McCormack R
Year: 2020
Journal: J Immunol
Title: An Essential Role for Perforin-2 in Type I IFN Signaling.
Volume: 204
Issue: 8
Pages: 2242-2256
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Publication
10719664 | J:60437
 
First Author: Bogdan C
Year: 2000
Journal: Immunol Rev
Title: The role of nitric oxide in innate immunity.
Volume: 173
Pages: 17-26
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Publication
16737695 | J:111382
First Author: Rajasingh J
Year: 2006
Journal: Exp Cell Res
Title: 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells.
Volume: 312
Issue: 13
Pages: 2538-46
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Publication
16818774 | J:134993
First Author: Muromoto R
Year: 2006
Journal: J Immunol
Title: Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.
Volume: 177
Issue: 2
Pages: 1160-70
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Publication
18571728 | J:137670
First Author: Xu H
Year: 2008
Journal: Mol Immunol
Title: Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages.
Volume: 45
Issue: 13
Pages: 3545-52
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Publication
25825724 | J:220454
First Author: Hammarén HM
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.
Volume: 112
Issue: 15
Pages: 4642-7
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Publication
7518579 | J:19408
First Author: Rane SG
Year: 1994
Journal: Oncogene
Title: JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells.
Volume: 9
Issue: 8
Pages: 2415-23
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Publication
25849644 | J:233410
First Author: Conti HR
Year: 2015
Journal: PLoS One
Title: Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis.
Volume: 10
Issue: 4
Pages: e0122807
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Publication
8943354 | J:36542
First Author: Jiao H
Year: 1996
Journal: Mol Cell Biol
Title: Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1.
Volume: 16
Issue: 12
Pages: 6985-92
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Publication
23285207 | J:195747
First Author: Li H
Year: 2012
Journal: PLoS One
Title: Yohimbine enhances protection of berberine against LPS-induced mouse lethality through multiple mechanisms.
Volume: 7
Issue: 12
Pages: e52863
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Protein Domain
IPR016045 | Tyr_kinase_non-rcpt_TYK2_N
Type: Domain
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].TYK2 was first identified by low-stringency hybridisation screening of ahuman lymphoid cDNA library with the catalytic domain of proto-oncogene c-fms []. Mouse and puffer fish orthlogues have also been identified. In common with JAK1 and JAK2, and by contrast with JAK3, TYK2 appears to be ubiquitously expressed. This entry represents the N-terminal region of TYK2.
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