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Search results 101 to 161 out of 161 for Ubash3a

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Type Details Score
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692214
Age: postnatal adult
Image: HMGU_693285
Specimen Label: HMGU_693285
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692214
Age: postnatal adult
Image: HMGU_1366799
Specimen Label: HMGU_1366799
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692214
Age: postnatal adult
Image: HMGU_693287
Specimen Label: HMGU_693287
Detected: true
Specimen Num: 4
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Publication
32371395 | J:296042
First Author: Yin Y
Year: 2020
Journal: J Biol Chem
Title: An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling.
Volume: 295
Issue: 25
Pages: 8514-8523
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Publication
23149425 | J:219059
First Author: Back SH
Year: 2013
Journal: Cell Mol Life Sci
Title: TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function.
Volume: 70
Issue: 7
Pages: 1269-84
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Publication
26365512 | J:239223
First Author: Zhang J
Year: 2015
Journal: Stem Cell Reports
Title: The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
Volume: 5
Issue: 4
Pages: 633-46
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Publication
19733910 | J:155244
First Author: Carpino N
Year: 2009
Journal: Mol Immunol
Title: The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.
Volume: 46
Issue: 16
Pages: 3224-31
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Publication
17679096 | J:134815
First Author: Mikhailik A
Year: 2007
Journal: Mol Cell
Title: A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling.
Volume: 27
Issue: 3
Pages: 486-97
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Publication
24587276 | J:214469
First Author: Cieniewicz B
Year: 2014
Journal: PLoS One
Title: Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2.
Volume: 9
Issue: 2
Pages: e90196
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Publication
30018105 | J:289212
 
First Author: Frank D
Year: 2018
Journal: mBio
Title: Phagocytes from Mice Lacking the Sts Phosphatases Have an Enhanced Antifungal Response to Candida albicans.
Volume: 9
Issue: 4
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Publication
30723173 | J:284383
 
First Author: Kong MS
Year: 2019
Journal: Sci Signal
Title: Inhibition of T cell activation and function by the adaptor protein CIN85.
Volume: 12
Issue: 567
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Publication
14738763 | J:89761
First Author: Carpino N
Year: 2004
Journal: Immunity
Title: Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2.
Volume: 20
Issue: 1
Pages: 37-46
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Publication
20585042 | J:165882
First Author: Thomas DH
Year: 2010
Journal: Blood
Title: A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.
Volume: 116
Issue: 14
Pages: 2570-8
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Publication
38091950 | J:353503
First Author: Tsai YL
Year: 2023
Journal: Immunity
Title: TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments.
Volume: 56
Issue: 12
Pages: 2682-2698.e9
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Publication
27609517 | J:237276
First Author: Reppschläger K
Year: 2016
Journal: J Biol Chem
Title: TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.
Volume: 291
Issue: 43
Pages: 22427-22441
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Publication
26390156 | J:233782
First Author: Yang M
Year: 2015
Journal: Nat Immunol
Title: K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation.
Volume: 16
Issue: 12
Pages: 1253-62
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Publication
12466855 | J:80501
First Author: Gitton Y
Year: 2002
Journal: Nature
Title: A gene expression map of human chromosome 21 orthologues in the mouse.
Volume: 420
Issue: 6915
Pages: 586-90
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Publication
12466854 | J:80502
First Author: Reymond A
Year: 2002
Journal: Nature
Title: Human chromosome 21 gene expression atlas in the mouse.
Volume: 420
Issue: 6915
Pages: 582-6
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
11281453 | -
First Author: Wattenhofer M
Year: 2001
Journal: Hum Genet
Title: Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains.
Volume: 108
Issue: 2
Pages: 140-7
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Interaction Experiment
Ge Y (2017)
Description: UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor-Induced NF-B Signaling.
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Publication
28607106 | -
First Author: Ge Y
Year: 2017
Journal: Diabetes
Title: UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor-Induced NF-κB Signaling.
Volume: 66
Issue: 7
Pages: 2033-2043
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Publication
17709377 | -
First Author: Collingwood TS
Year: 2007
Journal: J Biol Chem
Title: T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.
Volume: 282
Issue: 42
Pages: 30920-8
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Publication
19585081 | -
First Author: Tsygankov AY
Year: 2009
Journal: Cell Mol Life Sci
Title: TULA-family proteins: an odd couple.
Volume: 66
Issue: 17
Pages: 2949-52
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Protein Domain
IPR035634 | UBASH3A_SH3
Type: Domain
Description: UBASH3A (ubiquitin-associated and SH3 domain-containing protein A, also known as STS-2 or TULA) belongs to the TULA family. It is only found in lymphoid cells and exhibits weak phosphatase activity [, ]. UBASH3A facilitates T cell-induced apoptosis through interaction with the apoptosis-inducing factor AIF []. It is involved in regulating the level of phosphorylation of the zeta-associated protein (ZAP)-70 tyrosine kinase [].This entry represents the SH3 domain of UBASH3A. The TULA family includes two members termed p70/STS-1/TULA-2 and UBASH3A/STS-2/TULA/Cbl-InteractingProtein 4 (CLIP4). TULA proteins contain an N-terminal UBA domain, a central SH3 domain, and a C-terminal histidine phosphatase domain. They bind c-Cbl (a multidomain adaptor and an E3 ubiquitinligase) through the SH3 domain []and to ubiquitin via UBA [].
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Publication
15159412 | -
First Author: Kowanetz K
Year: 2004
Journal: J Biol Chem
Title: Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
Volume: 279
Issue: 31
Pages: 32786-95
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Publication
18344182 | -
First Author: Tsygankov AY
Year: 2008
Journal: IUBMB Life
Title: Multidomain STS/TULA proteins are novel cellular regulators.
Volume: 60
Issue: 4
Pages: 224-31
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Publication
33125054 | J:302818
 
First Author: Mori D
Year: 2021
Journal: J Exp Med
Title: The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation.
Volume: 218
Issue: 2
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Protein
Q8BX41
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
Q3V3E1
Organism: Mus musculus/domesticus
Length: 624  
Fragment?: false
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Protein
A0A498WGR9
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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