Type |
Details |
Score |
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
153
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Webb GC |
Year: |
1990 |
Journal: |
Am J Hum Genet |
Title: |
Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12. |
Volume: |
46 |
Issue: |
2 |
Pages: |
308-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mei-Ling Liu J |
Year: |
2018 |
Journal: |
Dev Neurobiol |
Title: |
Development of a Novel FIJI-Based Method to Investigate Neuronal Circuitry in Neonatal Mice. |
Volume: |
78 |
Issue: |
11 |
Pages: |
1146-1167 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suh J |
Year: |
2019 |
Journal: |
J Cell Physiol |
Title: |
Growth differentiation factor 11 locally controls anterior-posterior patterning of the axial skeleton. |
Volume: |
234 |
Issue: |
12 |
Pages: |
23360-23368 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gokozan HN |
Year: |
2016 |
Journal: |
J Comp Neurol |
Title: |
Area postrema undergoes dynamic postnatal changes in mice and humans. |
Volume: |
524 |
Issue: |
6 |
Pages: |
1259-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou Y |
Year: |
2014 |
Journal: |
Dev Cell |
Title: |
Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling. |
Volume: |
31 |
Issue: |
2 |
Pages: |
248-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hayashi Y |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Norrie disease protein is essential for cochlear hair cell maturation. |
Volume: |
118 |
Issue: |
39 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2012 |
Journal: |
Cell |
Title: |
Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity. |
Volume: |
151 |
Issue: |
6 |
Pages: |
1332-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rattner A |
Year: |
2014 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling. |
Volume: |
55 |
Issue: |
12 |
Pages: |
8614-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reichman DE |
Year: |
2018 |
Journal: |
Development |
Title: |
Wnt inhibition promotes vascular specification of embryonic cardiac progenitors. |
Volume: |
145 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Simonson L |
Year: |
2022 |
Journal: |
Development |
Title: |
Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development. |
Volume: |
149 |
Issue: |
22 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ghimire SR |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons. |
Volume: |
39 |
Issue: |
41 |
Pages: |
8013-8023 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu X |
Year: |
2021 |
Journal: |
J Clin Invest |
Title: |
Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling. |
Volume: |
131 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Arcourt A |
Year: |
2017 |
Journal: |
Neuron |
Title: |
Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination. |
Volume: |
93 |
Issue: |
1 |
Pages: |
179-193 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rattner A |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. |
Volume: |
110 |
Issue: |
40 |
Pages: |
E3830-9 |
|
•
•
•
•
•
|
Other Genome Feature |
Type: |
sequence_feature |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 11, Scott Wilson |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Ron R Kopito |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaden JH |
Year: |
2015 |
Journal: |
Front Mol Neurosci |
Title: |
Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14. |
Volume: |
8 |
|
Pages: |
11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaden JH |
Year: |
2019 |
Journal: |
J Neurochem |
Title: |
Chronic over-expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in mice. |
Volume: |
148 |
Issue: |
3 |
Pages: |
386-399 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from The Jackson Laboratory, Bar Harbor, ME |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 8630, FW van Leeuwen |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 1; targeted mutation 1, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 1; targeted mutation 2, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 1; targeted mutation 3, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 1; targeted mutation 6, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 1; targeted mutation 7, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 1; targeted mutation 8, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 1; targeted mutation 9, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 1; targeted mutation 10, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 1; targeted mutation 11, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Ryu KY |
Year: |
2007 |
Journal: |
EMBO J |
Title: |
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. |
Volume: |
26 |
Issue: |
11 |
Pages: |
2693-706 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 3413-1, FW van Leeuwen |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, coisogenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Schipanski A |
Year: |
2014 |
Journal: |
Neurobiol Aging |
Title: |
Lectin OS-9 delivers mutant neuroserpin to endoplasmic reticulum associated degradation in familial encephalopathy with neuroserpin inclusion bodies. |
Volume: |
35 |
Issue: |
10 |
Pages: |
2394-403 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gentier RJ |
Year: |
2015 |
Journal: |
Front Neuroanat |
Title: |
Localization of mutant ubiquitin in the brain of a transgenic mouse line with proteasomal inhibition and its validation at specific sites in Alzheimer's disease. |
Volume: |
9 |
|
Pages: |
26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Irmler M |
Year: |
2012 |
Journal: |
Acta Neuropathol |
Title: |
Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients. |
Volume: |
124 |
Issue: |
2 |
Pages: |
187-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Braun RJ |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin. |
|
|
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Yi-Ping Hsueh |
Allele Type: |
Transgenic |
Attribute String: |
Knockdown, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 1; targeted mutation 5, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change, Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hprt1/? Ubc/Ubc |
Background: |
involves: 129 * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hprt1/Hprt1 Ubc/Ubc |
Background: |
involves: 129 * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Camk2a-UBB*)3413-1Fwvl/? |
Background: |
C57BL/6-Tg(Camk2a-UBB*)3413-1Fwvl |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Thy1-UBB*)8630Fwvl/Tg(Thy1-UBB*)8630Fwvl |
Background: |
involves: FVB/N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> |
Background: |
involves: 129 * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> |
Background: |
involves: 129 * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> |
Background: |
involves: 129 * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> |
Background: |
involves: 129 * C57BL/6J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Greer PL |
Year: |
2010 |
Journal: |
Cell |
Title: |
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. |
Volume: |
140 |
Issue: |
5 |
Pages: |
704-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen CY |
Year: |
2011 |
Journal: |
J Cell Biol |
Title: |
Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology. |
Volume: |
193 |
Issue: |
4 |
Pages: |
769-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen PC |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Ubiquitin homeostasis is critical for synaptic development and function. |
Volume: |
31 |
Issue: |
48 |
Pages: |
17505-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin CW |
Year: |
2014 |
Journal: |
Brain Behav Immun |
Title: |
Sarm1, a neuronal inflammatory regulator, controls social interaction, associative memory and cognitive flexibility in mice. |
Volume: |
37 |
|
Pages: |
142-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin CW |
Year: |
2014 |
Journal: |
Front Cell Neurosci |
Title: |
Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator. |
Volume: |
8 |
|
Pages: |
87 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(UBB-EmGFP/RNAi:Sarm1)#Yph/? |
Background: |
involves: C57BL/6J |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> |
Background: |
involves: 129 * C57BL/6J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Webb GC |
Year: |
1994 |
Journal: |
Genomics |
Title: |
Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12. |
Volume: |
19 |
Issue: |
3 |
Pages: |
567-9 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> Tg(Six3-cre)69Frty/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> Tg(Pdgfra-cre)1Clc/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> Foxg1/Foxg1<+> |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> Tg(KRT5-cre)5132Jlj/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kusakabe T |
Year: |
2006 |
Journal: |
Dev Dyn |
Title: |
Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid. |
Volume: |
235 |
Issue: |
5 |
Pages: |
1300-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ozaki T |
Year: |
2011 |
Journal: |
Lab Invest |
Title: |
Development of thyroid gland and ultimobranchial body cyst is independent of p63. |
Volume: |
91 |
Issue: |
1 |
Pages: |
138-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fischer DF |
Year: |
2009 |
Journal: |
Neurobiol Aging |
Title: |
Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin. |
Volume: |
30 |
Issue: |
6 |
Pages: |
847-63 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> Tg(Pax6-cre,GFP)2Pgr/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaughan VC |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Eicosapentaenoic acid and oxypurinol in the treatment of muscle wasting in a mouse model of cancer cachexia. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e45900 |
|
•
•
•
•
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Genotype |
Symbol: |
Igs1/Igs1 Edil3/? |
Background: |
involves: 129 * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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•
•
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•
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Genotype |
Symbol: |
Fzd4/Fzd4<+> Igs1/Igs1 Edil3/? |
Background: |
involves: 129 * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Genotype |
Symbol: |
Fzd4/Fzd4 Igs1/Igs1 Edil3/? |
Background: |
involves: 129 * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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•
•
•
•
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Genotype |
Symbol: |
Ednrb/Ednrb Igs1/Igs1<+> Tg(Pax6-cre,GFP)2Pgr/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Igs1/Igs1<+> Edil3/Edil3<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
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Publication |
First Author: |
McGehee AM |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production. |
Volume: |
6 |
Issue: |
4 |
Pages: |
e18817 |
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Publication |
First Author: |
Verheijen BM |
Year: |
2018 |
Journal: |
Neurobiol Aging |
Title: |
Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model. |
Volume: |
72 |
|
Pages: |
62-71 |
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Genotype |
Symbol: |
Lrp5/Lrp5 Igs1/Igs1 Edil3/? |
Background: |
involves: 129 * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
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