Type |
Details |
Score |
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3273028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6690951 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1312040 |
|
Specimen Label: |
MRC Harwell_1312040 |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3273028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6690951 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1312048 |
|
Specimen Label: |
MRC Harwell_1312048 |
Detected: |
true |
Specimen Num: |
28 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1757728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6690951 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1312046 |
|
Specimen Label: |
MRC Harwell_1312046 |
Detected: |
true |
Specimen Num: |
26 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3281228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6690951 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1312048 |
|
Specimen Label: |
MRC Harwell_1312048 |
Detected: |
true |
Specimen Num: |
28 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2991528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6690951 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1312051 |
|
Specimen Label: |
MRC Harwell_1312051 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6690951 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1312050 |
|
Specimen Label: |
MRC Harwell_1312050 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6690951 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1312053 |
|
Specimen Label: |
MRC Harwell_1312053 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6690951 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1312057 |
|
Specimen Label: |
MRC Harwell_1312057 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6690951 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1312051 |
|
Specimen Label: |
MRC Harwell_1312051 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
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Cooke HJ |
Year: |
2002 |
Journal: |
Nat Rev Genet |
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Mouse models of male infertility. |
Volume: |
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10 |
Pages: |
790-801 |
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•
•
•
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|
Publication |
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Year: |
2006 |
Journal: |
Exp Cell Res |
Title: |
Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. |
Volume: |
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19 |
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•
•
•
•
•
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Publication |
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Journal: |
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Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin-conjugating enzyme. |
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•
•
•
•
•
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Publication |
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Loss of RAD6B induces degeneration of the cochlea in mice. |
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•
•
•
•
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Publication |
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The Role of RAD6B and PEDF in Retinal Degeneration. |
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•
•
•
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Science |
Title: |
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. |
Volume: |
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•
•
•
•
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Publication |
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Koken MH |
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3 |
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447-53 |
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•
•
•
•
•
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Publication |
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Nucleic Acids Res |
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•
•
•
•
•
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Publication |
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Journal: |
J Biol Chem |
Title: |
A mouse amidase specific for N-terminal asparagine. The gene, the enzyme, and their function in the N-end rule pathway. |
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45 |
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28521-32 |
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•
•
•
•
•
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Publication |
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Mol Cell Biol |
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Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells. |
Volume: |
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•
•
•
•
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Publication |
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Kwon YT |
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2003 |
Journal: |
Mol Cell Biol |
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Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. |
Volume: |
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22 |
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•
•
•
•
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Publication |
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Tasaki T |
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J Biol Chem |
Title: |
Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems. |
Volume: |
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25 |
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18510-20 |
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•
•
•
•
•
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Publication |
First Author: |
Rout UK |
Year: |
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Journal: |
Cell Calcium |
Title: |
Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst. |
Volume: |
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6 |
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•
•
•
•
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Publication |
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Grootegoed JA |
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Journal: |
Mol Cell Endocrinol |
Title: |
Knockout mouse model and gametogenic failure. |
Volume: |
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1-2 |
Pages: |
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•
•
•
•
•
|
Publication |
First Author: |
Kwon YT |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway. |
Volume: |
20 |
Issue: |
11 |
Pages: |
4135-48 |
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•
•
•
•
•
|
Publication |
First Author: |
Baarends WM |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. |
Volume: |
25 |
Issue: |
3 |
Pages: |
1041-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
van der Laan R |
Year: |
2004 |
Journal: |
J Cell Sci |
Title: |
Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase. |
Volume: |
117 |
Issue: |
Pt 21 |
Pages: |
5023-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roller ML |
Year: |
1995 |
Journal: |
Mamm Genome |
Title: |
Localization of sequences related to the human RAD6 DNA repair gene on mouse chromosomes 11 and 13. |
Volume: |
6 |
Issue: |
4 |
Pages: |
305-6 |
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•
•
•
•
•
|
Publication |
First Author: |
Zhou J |
Year: |
2017 |
Journal: |
Biochim Biophys Acta |
Title: |
Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. |
Volume: |
1860 |
Issue: |
12 |
Pages: |
1159-1168 |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from Europhenome |
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•
•
•
•
•
|
Publication |
First Author: |
Dickinson ME |
Year: |
2016 |
Journal: |
Nature |
Title: |
High-throughput discovery of novel developmental phenotypes. |
Volume: |
537 |
Issue: |
7621 |
Pages: |
508-514 |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Mouse Synonym Curation |
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•
•
•
•
•
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Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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•
•
•
•
•
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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•
•
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•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
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Title: |
MGI Sequence Curation Reference |
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•
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•
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
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Issue: |
6821 |
Pages: |
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Publication |
First Author: |
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Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
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Publication |
First Author: |
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Year: |
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Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
UniProt-GOA |
Year: |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
GOA curators |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Publication |
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Year: |
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Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
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Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
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First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
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Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
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Year: |
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Journal: |
Database Release |
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Publication |
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Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
241
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Unk I |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. |
Volume: |
103 |
Issue: |
48 |
Pages: |
18107-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiao W |
Year: |
2000 |
Journal: |
Genetics |
Title: |
The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways. |
Volume: |
155 |
Issue: |
4 |
Pages: |
1633-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parker JL |
Year: |
2012 |
Journal: |
Nucleic Acids Res |
Title: |
A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA. |
Volume: |
40 |
Issue: |
22 |
Pages: |
11380-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes Rad18 from eukaryotes. Rad18 is a E3 ubiquitin ligase required for postreplication repair []. In budding yeast, Rad18 forms a heterodimer with Rad6 to monoubiquitinate PCNA at a highly conserved lysine, 'Lys-164' []. In humans, Rad18 associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164' []. |
|
•
•
•
•
•
|
Allele |
Name: |
ubiquitin-conjugating enzyme E2B; targeted mutation 1, Jan H J Hoeijmakers |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ube2b/Ube2b |
Background: |
involves: 129P2/OlaHsd * FVB/NJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ube2b/Ube2b |
Background: |
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N) |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ube2b/Ube2b |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ube2b/Ube2b |
Background: |
involves: 129 * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ube2b/Ube2b |
Background: |
FVB.129P2-Ube2b |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ube2a/? Ube2b/Ube2b |
Background: |
involves: 129P2/OlaHsd * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ube2a/? Ube2b/Ube2b<+> |
Background: |
involves: 129P2/OlaHsd * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ube2a/Ube2a Ube2b/Ube2b |
Background: |
involves: 129P2/OlaHsd * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ube2a/Ube2a<+> Ube2b/Ube2b |
Background: |
involves: 129P2/OlaHsd * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ube2a/Ube2a Ube2b/Ube2b<+> |
Background: |
involves: 129P2/OlaHsd * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Robson A |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility. |
Volume: |
116 |
Issue: |
28 |
Pages: |
14049-14054 |
|
•
•
•
•
•
|
Publication |
First Author: |
Howard M |
Year: |
2016 |
Journal: |
In Vitro Cell Dev Biol Anim |
Title: |
The function and interrelationship between GDF5 and ERG-010 during chondrogenesis in vitro. |
Volume: |
52 |
Issue: |
2 |
Pages: |
182-92 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
509
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
496
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
556
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
309
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
428
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
449
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
309
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
556
 |
Fragment?: |
false |
|
•
•
•
•
•
|