| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1775122 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3274122 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287422 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3266022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1624622 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
| Note: |
Expression was detected in the digestive system. |
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1721422 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1646922 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1736222 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1683322 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1082094 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3574228 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3585274 |
| Age: |
postnatal day 8-10 |
| Image: |
P8/10 |
| Note: |
Expression was detected in amacrine cells. |
| Specimen Label: |
P8/10 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1082094 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3574228 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3585274 |
| Age: |
postnatal adult |
| Image: |
Adult |
| Note: |
Expression was detected in amacrine cells. |
| Specimen Label: |
Adult |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1700022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1832122 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
| Note: |
Expression was weak in the immune system. |
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1741222 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1082094 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3573928 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:3585274 |
| Age: |
postnatal day 8-10 |
| Image: |
P8/10 |
|
| Specimen Label: |
P8/10 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3599822 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3280922 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1833322 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1821522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3557722 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1702122 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756322 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1668822 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757722 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757522 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1738322 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1802422 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
| Note: |
Expression was weak in the skull (base and vault). |
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3724606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2672022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5421266 |
| Age: |
embryonic day 14.5 |
| Image: |
MH802; Specimen C1242 |
| Note: |
Expression was weak in whisker follicle. |
| Specimen Label: |
MH802; Specimen C1242 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wanaka A |
| Year: |
1999 |
| Journal: |
GenBank Submission |
| Title: |
Mus musculus mRNA for huntingtin interacting protein-2, complete cds |
|
|
| Pages: |
AB011081 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wassler MJ |
| Year: |
2008 |
| Journal: |
Stem Cells |
| Title: |
Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells. |
| Volume: |
26 |
| Issue: |
8 |
| Pages: |
2006-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2000 |
| Journal: |
Genomics |
| Title: |
YAC/BAC-based physical and transcript mapping around the gracile axonal dystrophy (gad) locus identifies Uchl1, Pmx2b, Atp3a2, and Hip2 genes. |
| Volume: |
66 |
| Issue: |
3 |
| Pages: |
333-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Su J |
| Year: |
2018 |
| Journal: |
Cell Death Dis |
| Title: |
Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models. |
| Volume: |
9 |
| Issue: |
10 |
| Pages: |
1020 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rock JR |
| Year: |
2008 |
| Journal: |
Dev Dyn |
| Title: |
Expression of TMEM16 paralogs during murine embryogenesis. |
| Volume: |
237 |
| Issue: |
9 |
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Mouse Gene Trap Data Load from dbGSS |
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Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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2012 |
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Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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2005 |
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•
|
| Allele |
| Name: |
ubiquitin-conjugating enzyme E2K; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Rajsbaum R |
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2014 |
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Immunity |
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Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. |
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40 |
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6 |
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880-95 |
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Wilson RC |
| Year: |
2009 |
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Acta Crystallogr Sect F Struct Biol Cryst Commun |
| Title: |
Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2). |
| Volume: |
65 |
| Issue: |
Pt 5 |
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440-4 |
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•
•
•
•
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| First Author: |
de Pril R |
| Year: |
2007 |
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Mol Cell Neurosci |
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Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. |
| Volume: |
34 |
| Issue: |
1 |
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10-9 |
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•
•
•
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| Publication |
| First Author: |
Wilson RC |
| Year: |
2011 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity. |
| Volume: |
405 |
| Issue: |
4 |
| Pages: |
662-6 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Song S |
| Year: |
2003 |
| Journal: |
Mol Cell |
| Title: |
Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity. |
| Volume: |
12 |
| Issue: |
3 |
| Pages: |
553-63 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Ubiquitin-conjugating enzyme E2 K (UBE2K) is a multi-ubiquitinating enzyme with the ability to synthesize Lys48-linked polyubiquitin chains which is involved in the ubiquitin (Ub)-dependent proteolytic pathway []. It interacts with the frameshift mutant of ubiquitin B and functions as a crucial factor regulating amyloid-beta neurotoxicity []. It has also been characterised as Huntingtin-interacting protein that modulates the neurotoxicity of Amyloid-beta (Abeta), the principal protein involved in Alzheimer's disease pathogenesis []. Moreover, E2-25K increases aggregate the formation of expanded polyglutamine proteins and polyglutamine-induced cell death in the pathology of polyglutamine diseases []. UBE2K and its yeast homologue UBC1 are unique class II E2 conjugating enzymes, both of which contain a C-terminal ubiquitin-associated (UBA) domain in addition to an N-terminal catalytic ubiquitin-conjugating enzyme E2 (UBCc) domain []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
200
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
139
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
200
 |
| Fragment?: |
false |
|
•
•
•
•
•
|