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Search results 101 to 200 out of 229 for Upf2

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Type Details Score
HT Experiment
E-MTAB-7062 | Microarray profiling of mouse pachytene cells deficient for UPF2 or both TUT4 and TUT7
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-55180 | UPF2 establishes testis-specific transcriptome enriched in transcripts with shorter 3'UTRs
Series Id: GSE55180
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
16186820 | J:319990
First Author: Hosoda N
Year: 2005
Journal: Nat Struct Mol Biol
Title: CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.
Volume: 12
Issue: 10
Pages: 893-901
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HT Experiment
E-MTAB-7064 | Microarray profiling of UPF2-deficient mouse GV oocytes
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Sample
UPF2 cKO 1
Organism Name: mouse, laboratory
Sex: Male
Age: postnatal adult
Stage: 28
Structure . Name: primary spermatocyte
Notes: pachytene/diplotene stage
Curation Status: Curated
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HT Sample
UPF2 cKO 2
Organism Name: mouse, laboratory
Sex: Male
Age: postnatal adult
Stage: 28
Structure . Name: primary spermatocyte
Notes: pachytene/diplotene stage
Curation Status: Curated
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HT Sample
UPF2 cKO 3
Organism Name: mouse, laboratory
Sex: Male
Age: postnatal adult
Stage: 28
Structure . Name: primary spermatocyte
Notes: pachytene/diplotene stage
Curation Status: Curated
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HT Sample
UPF2 cKO 1
Organism Name: mouse, laboratory
Sex: Female
Age: postnatal week 3-5
Stage: 28
Structure . Name: primary oocyte
Notes: germinal vesicle stage
Curation Status: Curated
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HT Sample
UPF2 cKO 2
Organism Name: mouse, laboratory
Sex: Female
Age: postnatal week 3-5
Stage: 28
Structure . Name: primary oocyte
Notes: germinal vesicle stage
Curation Status: Curated
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HT Sample
UPF2 cKO 3
Organism Name: mouse, laboratory
Sex: Female
Age: postnatal week 3-5
Stage: 28
Structure . Name: primary oocyte
Notes: germinal vesicle stage
Curation Status: Curated
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HT Experiment
E-MEXP-2248 | Transcription profiling of fetal livers of UPF2 null mice
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
A2AT37
Organism: Mus musculus/domesticus
Length: 1269  
Fragment?: false
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HT Experiment
GSE191039 | RNA sequencing of blastocyst-stage mouse embryos in the presence or absence of RNA decay activator UPF2
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
15004547 | -
First Author: Kadlec J
Year: 2004
Journal: Nat Struct Mol Biol
Title: The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3.
Volume: 11
Issue: 4
Pages: 330-7
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Publication
18066079 | -
First Author: Chamieh H
Year: 2008
Journal: Nat Struct Mol Biol
Title: NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.
Volume: 15
Issue: 1
Pages: 85-93
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Allele
Upf2<+> | MGI:2449308
   
Name: UPF2 regulator of nonsense transcripts homolog (yeast); wild type
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Publication
11113196 | -
First Author: Serin G
Year: 2001
Journal: Mol Cell Biol
Title: Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).
Volume: 21
Issue: 1
Pages: 209-23
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Allele
Upf2<tm1Btp> | MGI:3790198
Name: UPF2 regulator of nonsense transcripts homolog (yeast); targeted mutation 1, Bo Torben Porse
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Upf2<tm1.1Btp> | MGI:3790199
Name: UPF2 regulator of nonsense transcripts homolog (yeast); targeted mutation 1.1, Bo Torben Porse
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Upf2<Gt(M123A12)Wrst> | MGI:3859675
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap M123A12, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Upf2<Gt(P062E01)Wrst> | MGI:3865703
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap P062E01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Upf2<Gt(P068C10)Wrst> | MGI:3866066
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap P068C10, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Upf2<Gt(CSE040)Byg> | MGI:3875852
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap CSE040, BayGenomics
Allele Type: Gene trapped
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Allele
Upf2<Gt(CSE032)Byg> | MGI:3875857
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap CSE032, BayGenomics
Allele Type: Gene trapped
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Allele
Upf2<Gt(D129D01)Wrst> | MGI:3891524
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap D129D01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Upf2<Gt(E077D10)Wrst> | MGI:3895257
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap E077D10, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Upf2<Gt(E085B04)Wrst> | MGI:3895507
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap E085B04, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Upf2<Gt(E129D01)Wrst> | MGI:3896505
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap E129D01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Upf2<Gt(E144B02)Wrst> | MGI:3915695
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap E144B02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Upf2<Gt(XF042)Byg> | MGI:4127997
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap XF042, BayGenomics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST1729)Lex> | MGI:4132107
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST1729, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST23276)Lex> | MGI:4145807
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST23276, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST55804)Lex> | MGI:4164385
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST55804, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST56720)Lex> | MGI:4165004
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST56720, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST67267)Lex> | MGI:4171750
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST67267, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST67670)Lex> | MGI:4172037
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST67670, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST100587)Lex> | MGI:4183449
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST100587, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST111408)Lex> | MGI:4188028
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST111408, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST112106)Lex> | MGI:4188358
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST112106, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST116634)Lex> | MGI:4190511
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST116634, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST117307)Lex> | MGI:4190766
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST117307, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST123052)Lex> | MGI:4193712
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST123052, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST169414)Lex> | MGI:4212976
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST169414, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST199282)Lex> | MGI:4228225
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST199282, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST201236)Lex> | MGI:4229299
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST201236, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST206279)Lex> | MGI:4231762
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST206279, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST208792)Lex> | MGI:4233013
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST208792, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST216958)Lex> | MGI:4236804
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST216958, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST219025)Lex> | MGI:4237788
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST219025, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST220857)Lex> | MGI:4238755
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST220857, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST230828)Lex> | MGI:4242357
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST230828, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST275663)Lex> | MGI:4260054
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST275663, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST276960)Lex> | MGI:4260675
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST276960, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST279012)Lex> | MGI:4261576
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST279012, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST279983)Lex> | MGI:4262072
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST279983, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST291658)Lex> | MGI:4267505
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST291658, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST303558)Lex> | MGI:4272552
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST303558, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST308453)Lex> | MGI:4274053
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST308453, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST374191)Lex> | MGI:4298359
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST374191, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST396993)Lex> | MGI:4305111
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST396993, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(OST458991)Lex> | MGI:4324564
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap OST458991, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Upf2<Gt(A20000)Wrst> | MGI:4335443
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap A20000, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Upf2<Gt(EUCE0089d11)Hmgu> | MGI:4385247
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap EUCE0089d11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Upf2<tm1a(EUCOMM)Hmgu> | MGI:4457521
Name: UPF2 regulator of nonsense transcripts homolog (yeast); targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Upf2<tm1e(EUCOMM)Hmgu> | MGI:4458668
Name: UPF2 regulator of nonsense transcripts homolog (yeast); targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Upf2<Gt(EUCJ0022h09)Hmgu> | MGI:4869633
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap EUCJ0022h09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Upf2<Gt(EUCJ0144c09)Hmgu> | MGI:4875126
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap EUCJ0144c09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Upf2<em2Cya> | MGI:7587429
Name: UPF2 regulator of nonsense transcripts homolog (yeast); endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Upf2<Gt(271A6)Cmhd> | MGI:4960348
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap 271A6, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Upf2<Gt(IST13373A7)Tigm> | MGI:5163999
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap IST13373A7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Upf2<Gt(IST13930C8)Tigm> | MGI:5193995
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap IST13930C8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Upf2<Gt(IST14592H5)Tigm> | MGI:5244562
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap IST14592H5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Upf2<Gt(IST14664F12)Tigm> | MGI:5249613
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap IST14664F12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Upf2<Gt(IST14707B5)Tigm> | MGI:5256770
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap IST14707B5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Upf2<Gt(IST14740B11)Tigm> | MGI:5258094
 
Name: UPF2 regulator of nonsense transcripts homolog (yeast); gene trap IST14740B11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:7589620 | C57BL/6J-Upf2<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Upf2/Upf2
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2 Lyz2/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-cre)548Jxm/? Upf2/Upf2
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2 Tg(Mx1-cre)1Cgn/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2 Tg(Atoh1-cre)1Bfri/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2 Tg(Alb1-cre)7Gsc/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2 Tg(Stra8-icre)1Reb/?
Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2 Tg(Zp3-cre)93Knw/?
Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR039762 | Nmd2/UPF2
Type: Family
Description: This entry includes Nmd2 from yeasts and UPF2 from animals. They are involved in the nonsense-mediated mRNA decay (NMD) pathway [, ]. In the human UPF complex (composed of UPF1/2/3), UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1 [].
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Publication
21419344 | -
First Author: Chakrabarti S
Year: 2011
Journal: Mol Cell
Title: Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.
Volume: 41
Issue: 6
Pages: 693-703
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Publication
19556969 | -
First Author: Clerici M
Year: 2009
Journal: EMBO J
Title: Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.
Volume: 28
Issue: 15
Pages: 2293-306
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Protein Domain
IPR040812 | UPF1_1B_dom
Type: Domain
Description: UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. Together with UPF2 and UPF3, forms a surveillance complex, in which UPF2 acts as a bridge between UPF1 and UPF3. UPF2 and UPF3 are nonenzymatic components of the complex that stimulate the activity of UPF1 []. UPF1 has a N-terminal cysteine/histidine-rich zinc-binding domain (CH/ZBD), a regulatory 1B domain, followed by a helicase core that belongs to superfamily 1 (SF1).This is 1B domain of UPF1 which has a regulatory role. It suffers conformational changes from an inhibitory state to a transition-state complex that modulate RNA binding [, ].
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Genotype
Genotype
Symbol: Upf2/Upf2 En1/En1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Publication
16931876 | -
First Author: Kadlec J
Year: 2006
Journal: RNA
Title: Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1.
Volume: 12
Issue: 10
Pages: 1817-24
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Protein Domain
IPR018999 | UPF1_CH/ZBD
Type: Domain
Description: UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. Together with UPF2 and UPF3, forms a surveillance complex, in which UPF2 acts as a bridge between UPF1 and UPF3. UPF2 and UPF3 are nonenzymatic components of the complex that stimulate the activity of UPF1 []. UPF1 has a N-terminal cysteine/histidine-rich zinc-binding domain (CH/ZBD), a regulatory 1B domain, followed by a helicase core that belongs to superfamily 1 (SF1).This is the N-terminal CH/ZBD which contains 3 zinc binding motifs that interacts with UPF2 and it also has a cis-inhibitory effect on the ATPase activity. After binding to UPF2, the CH/ZBD suffers a large conformational change that causes the catalytic helicase domain to bind RNA less extensively and triggering its helicase activity [, ].
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Protein
F6Q8N5
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: true
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Publication
11368911 | -
First Author: Aronoff R
Year: 2001
Journal: Gene
Title: Molecular identification of smg-4, required for mRNA surveillance in C. elegans.
Volume: 268
Issue: 1-2
Pages: 153-64
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Publication
12718880 | -
First Author: Gehring NH
Year: 2003
Journal: Mol Cell
Title: Y14 and hUpf3b form an NMD-activating complex.
Volume: 11
Issue: 4
Pages: 939-49
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Publication
15048104 | -
First Author: Lykke-Andersen J
Year: 2004
Journal: Nat Struct Mol Biol
Title: Making structural sense of nonsense-mediated decay.
Volume: 11
Issue: 4
Pages: 305-6
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