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Search results 101 to 175 out of 175 for Upf3b

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:5615753
Assay Type: RNA in situ
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5615948
Age: postnatal day 8
Specimen Label: S4 P8
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:5615753
Assay Type: RNA in situ
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5615948
Age: postnatal adult
Note: Expression was in neurons.
Specimen Label: S4 Adult
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:5615753
Assay Type: RNA in situ
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5615948
Age: postnatal adult
Note: Expression was in neurons.
Specimen Label: S2 Adult
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:5615753
Assay Type: RNA in situ
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5615948
Age: embryonic day 14.5
Specimen Label: 1Ai
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5615934
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5615970
Age: embryonic day 14.5
Specimen Label: 1B E14.5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:5615934
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5615970
Age: embryonic day 14.5
Note: Expression was in neuronal progenitor cells.
Specimen Label: S7
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
   
Probe: MGI:5615934
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5615970
Age: embryonic day 14.5
Specimen Label: S9A
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
   
Probe: MGI:5615753
Assay Type: RNA in situ
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5615948
Age: embryonic day 14.5
Specimen Label: S2 E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5615753
Assay Type: RNA in situ
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5615948
Age: embryonic day 18.5
Specimen Label: S2 E18.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5615934
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5615970
Age: embryonic day 18.5
Specimen Label: 1B E18.5
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:5615934
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5615970
Age: embryonic day 18.5
Specimen Label: S6
Detected: true
Specimen Num: 16
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Publication
16789828 | J:116443
First Author: Ciaudo C
Year: 2006
Journal: PLoS Genet
Title: Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation.
Volume: 2
Issue: 6
Pages: e94
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Publication
- | J:200814
     
First Author: Toronto Centre for Phenogenomics
Year: 2013
Journal: MGI Direct Data Submission
Title: Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051).
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE146043 | The role of the NMD factor UPF3B in olfactory sensory neurons
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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DO Term
DOID:0060821 | syndromic X-linked intellectual disability 14
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Publication
11113196 | -
First Author: Serin G
Year: 2001
Journal: Mol Cell Biol
Title: Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).
Volume: 21
Issue: 1
Pages: 209-23
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Publication
11546873 | -
First Author: Kim VN
Year: 2001
Journal: Science
Title: Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.
Volume: 293
Issue: 5536
Pages: 1832-6
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Protein Domain
IPR034979 | UPF3B_RRM-like
Type: Domain
Description: This entry represents the RNA recognition motif (RRM)-like domain in Upf3B, a human orthologue of yeast Upf3p and Caenorhabditis elegans SMG-4 []. It derives from X-linked gene UPF3B and is required for nonsense-mediated mRNA decay (NMD) in human []. Upf3B is a nucleocytoplasmic shuttling protein that associates selectively with spliced beta-globin mRNA in vivo []. Like other Upf3 proteins, Upf3B contains nuclear import and export signals, and a conserved domain with some similarity to an RNA recognition motif (RRM), indicating that it may be an RNA binding protein.
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Publication
9032286 | -
First Author: He F
Year: 1997
Journal: Mol Cell Biol
Title: Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway.
Volume: 17
Issue: 3
Pages: 1580-94
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Protein
F6Q8N5
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: true
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Publication
11163187 | -
First Author: Lykke-Andersen J
Year: 2000
Journal: Cell
Title: Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.
Volume: 103
Issue: 7
Pages: 1121-31
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Protein Domain
IPR039722 | Upf3
Type: Family
Description: This entry includes nonsense-mediated mRNA decay protein 3 (Upf3) and its homologues. In budding yeasts, Upf3 is involved in the nonsense-mediated mRNA decay (NMD) pathway []. Human Upf3a and Upf3b are components of the exon-junction complex (EJC), which promotes nonsense-mediated mRNA decay (NMD) and regulate translation efficiency [].
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Protein Domain
IPR039762 | Nmd2/UPF2
Type: Family
Description: This entry includes Nmd2 from yeasts and UPF2 from animals. They are involved in the nonsense-mediated mRNA decay (NMD) pathway [, ]. In the human UPF complex (composed of UPF1/2/3), UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1 [].
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Publication
11368911 | -
First Author: Aronoff R
Year: 2001
Journal: Gene
Title: Molecular identification of smg-4, required for mRNA surveillance in C. elegans.
Volume: 268
Issue: 1-2
Pages: 153-64
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Publication
12718880 | -
First Author: Gehring NH
Year: 2003
Journal: Mol Cell
Title: Y14 and hUpf3b form an NMD-activating complex.
Volume: 11
Issue: 4
Pages: 939-49
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Publication
15048104 | -
First Author: Lykke-Andersen J
Year: 2004
Journal: Nat Struct Mol Biol
Title: Making structural sense of nonsense-mediated decay.
Volume: 11
Issue: 4
Pages: 305-6
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Publication
15004547 | -
First Author: Kadlec J
Year: 2004
Journal: Nat Struct Mol Biol
Title: The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3.
Volume: 11
Issue: 4
Pages: 330-7
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Protein Domain
IPR005120 | UPF3_dom
Type: Domain
Description: Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism by which eukaryotic cells detect and degrade transcripts containing premature termination codons. Three 'up-frameshift' proteins, UPF1, UPF2 and UPF3, are essential for this process in organisms ranging from yeast, human to plants []. Exon junction complexes (EJCs) are deposited ~24 nucleotides upstream of exon-exon junctions after splicing. Translation causes displacement of the EJCs, however, premature translation termination upstream of one or more EJCs triggers the recruitment of UPF1, UPF2 and UPF3 and activates the NMD pathway [, ]. This entry contains UPF3. The crystal structure of the complex between human UPF2 and UPF3b, which are, respectively, a MIF4G (middle portion of eIF4G) domain and an RNP domain (ribonucleoprotein-type RNA-binding domain) has been determined to 1.95A. The protein-protein interface is mediated by highly conserved charged residues in UPF2 and UPF3b and involves the β-sheet surface of the UPF3b ribonucleoprotein (RNP) domain, which is generally used by these domains to bind nucleic acids. In UPF3b the RNP domain does not bind RNA, whereas the UPF2 construct and the complex do. It is clear that some RNP domains have evolved for specific protein-protein interactions rather than as nucleic acid binding modules [].
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Protein
Q9CS15
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Protein
Q3ULL6
Organism: Mus musculus/domesticus
Length: 472  
Fragment?: false
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Publication
36997282 | J:353269
 
First Author: Chen C
Year: 2023
Journal: Life Sci Alliance
Title: UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells.
Volume: 6
Issue: 6
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Protein
Q9CUH6
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: true
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Protein
Q8CCF7
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
Q9CTQ4
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
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Protein
Q3ULJ3
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Publication
16601204 | -
First Author: Kunz JB
Year: 2006
Journal: RNA
Title: Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.
Volume: 12
Issue: 6
Pages: 1015-22
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Publication
28444146 | J:247924
First Author: MacDonald CC
Year: 2017
Journal: Biol Reprod
Title: Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.
Volume: 96
Issue: 5
Pages: 939-947
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Publication
18066079 | -
First Author: Chamieh H
Year: 2008
Journal: Nat Struct Mol Biol
Title: NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.
Volume: 15
Issue: 1
Pages: 85-93
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Protein
A2AT37
Organism: Mus musculus/domesticus
Length: 1269  
Fragment?: false
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Protein
F6Q3G7
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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