Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
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•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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•
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Publication |
First Author: |
Khan A |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase. |
Volume: |
112 |
Issue: |
27 |
Pages: |
8338-43 |
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Interaction Experiment |
Description: |
The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. |
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•
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Interaction Experiment |
Description: |
USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency. |
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•
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Publication |
First Author: |
Liu X |
Year: |
2016 |
Journal: |
Signal Transduct Target Ther |
Title: |
USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency. |
Volume: |
1 |
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Pages: |
16024 |
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Publication |
First Author: |
Okuda H |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
The USP21 short variant (USP21SV) lacking NES, located mostly in the nucleus in vivo, activates transcription by deubiquitylating ubH2A in vitro. |
Volume: |
8 |
Issue: |
11 |
Pages: |
e79813 |
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Publication |
First Author: |
Saksouk N |
Year: |
2014 |
Journal: |
Mol Cell |
Title: |
Redundant mechanisms to form silent chromatin at pericentromeric regions rely on BEND3 and DNA methylation. |
Volume: |
56 |
Issue: |
4 |
Pages: |
580-94 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
159
 |
Fragment?: |
true |
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Publication |
First Author: |
Sathyan KM |
Year: |
2011 |
Journal: |
J Cell Sci |
Title: |
A BEN-domain-containing protein associates with heterochromatin and represses transcription. |
Volume: |
124 |
Issue: |
Pt 18 |
Pages: |
3149-63 |
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Publication |
First Author: |
Khan A |
Year: |
2015 |
Journal: |
Transcription |
Title: |
BEND3 mediates transcriptional repression and heterochromatin organization. |
Volume: |
6 |
Issue: |
5 |
Pages: |
102-5 |
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•
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•
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Publication |
First Author: |
Pitchai GP |
Year: |
2017 |
Journal: |
Nucleic Acids Res |
Title: |
A novel TPR-BEN domain interaction mediates PICH-BEND3 association. |
Volume: |
45 |
Issue: |
19 |
Pages: |
11413-11424 |
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Protein Domain |
Type: |
Family |
Description: |
BEND3 is a transcriptional repressor that associates with the nucleolar-remodeling complex (NoRC) and is involved in ribosomal DNA (rDNA) silencing []. SUMOylated BEND3 stabilizes the NoRC component Tip5 via USP21 deubiquitinase []. NorC serves as a molecular platform that recruits chromatin modifiers, such as histone deacetylases and histone methyltransferases, leading to deacetylation of histone H4 and trimethylation of H3K9 and H4K20 []. NoRC also targets histone deacetylases and histone methyltransferases to rDNA to establish a heterochromatic state that inhibits transcription activation. Hence, BEND3 and NoRC seem to play a concerted role in the maintenance of heterochromatin architecture [, ].BEND3 has also been shown to mediate Polycomb recruitment in the absence of H3K9Me3 or DNA methylation at the pericentromeric regions []. BEND3 interacts with PICH (ERCC6L), a DNA translocase required for the maintenance of chromosome stability, and stimulates its translocase and ATPase activities. This interaction occurs via an interface between a TPR domain in PICH and a BEN domain in BEND3 []. |
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Publication |
First Author: |
Jullien J |
Year: |
2017 |
Journal: |
Mol Cell |
Title: |
Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways. |
Volume: |
65 |
Issue: |
5 |
Pages: |
873-884.e8 |
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Publication |
First Author: |
Ungaro P |
Year: |
2010 |
Journal: |
Diabetologia |
Title: |
Hepatocyte nuclear factor (HNF)-4alpha-driven epigenetic silencing of the human PED gene. |
Volume: |
53 |
Issue: |
7 |
Pages: |
1482-92 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
825
 |
Fragment?: |
false |
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