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Search results 101 to 177 out of 177 for Uvrag

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Type Details Score
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
26234763 | J:233989
 
First Author: He S
Year: 2015
Journal: Nat Commun
Title: Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.
Volume: 6
Pages: 7839
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Publication
30061422 | J:266274
First Author: Yang Y
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Central role of autophagic UVRAG in melanogenesis and the suntan response.
Volume: 115
Issue: 33
Pages: E7728-E7737
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein associated with UVRAG as autophagy enhancer
Type: chain
End: 648
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Publication
30704899 | J:272052
First Author: Cheng X
Year: 2019
Journal: Mol Cell
Title: Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism.
Volume: 73
Issue: 4
Pages: 788-802.e7
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Protein
Q3TD16
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
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Protein
F8WGX2
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Publication
24056303 | J:201816
First Author: He S
Year: 2013
Journal: Nat Cell Biol
Title: PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.
Volume: 15
Issue: 10
Pages: 1206-1219
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Interaction Experiment
Feng X (2019)
Description: Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
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Publication
20643123 | -
First Author: Thoresen SB
Year: 2010
Journal: Exp Cell Res
Title: A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
Volume: 316
Issue: 20
Pages: 3368-78
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Publication
30686098 | -
First Author: Feng X
Year: 2019
Journal: Autophagy
Title: Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
Volume: 15
Issue: 7
Pages: 1130-1149
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Protein
Q78YZ6
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Protein
A0A1D5RML7
Organism: Mus musculus/domesticus
Length: 47  
Fragment?: false
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Protein
A0A1D5RMF2
Organism: Mus musculus/domesticus
Length: 35  
Fragment?: true
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Publication
22354037 | -
First Author: McKnight NC
Year: 2012
Journal: EMBO J
Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
Volume: 31
Issue: 8
Pages: 1931-46
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Protein Domain
IPR019357 | SCOC
Type: Family
Description: This entry represents short coiled-coil protein (SCOC). In human, SCOC is required for autophagosome formation during amino acid starvation. It forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1 and may regulate ULK1 and Beclin 1 complex activities [].
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Publication
18843052 | -
First Author: Itakura E
Year: 2008
Journal: Mol Biol Cell
Title: Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.
Volume: 19
Issue: 12
Pages: 5360-72
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Protein
Q8CDJ3
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Publication
19050071 | -
First Author: Sun Q
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
Volume: 105
Issue: 49
Pages: 19211-6
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Publication
16799551 | -
First Author: Liang C
Year: 2006
Journal: Nat Cell Biol
Title: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.
Volume: 8
Issue: 7
Pages: 688-99
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Protein Domain
IPR018791 | UV_resistance/autophagy_Atg14
Type: Family
Description: This entry includes Atg14 (autophagy-related protein 14) from budding yeasts, Vps38 from fission yeasts and their homologues, Atg14L/Bakor (beclin-1-associated autophagy-related key regulator) and UVRAG (UV irradiation resistance-associated gene), from animals. Atg14 is a hydrophilic protein with a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole [].Barkor positively regulates autophagy through its interaction with Beclin-1, with decreased levels of autophagosome formation observed when Barkor expression is eliminated []. UVRAG is also a Beclin1 binding protein that positively stimulate starvation-induced autophagy []. Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer. Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase complexes are known: complex I (Vps34, Vps15, Vps30/Atg6, and Atg14) is involved in autophagy, andcomplex II (Vps34, Vps15, Vps30/Atg6, and Vps38) functions in the vacuolar protein sorting pathway []. In mammals, complex II is also involved in autophagy []. The mammalian counterparts of Vps34, Vps15, and Vps30/Atg6 are Vps34, p150, and Beclin 1, respectively, and UV irradiation resistance-associated gene (UVRAG) has been identified as identical to yeast Vps38 [].
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Publication
19270696 | J:158180
First Author: Matsunaga K
Year: 2009
Journal: Nat Cell Biol
Title: Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
Volume: 11
Issue: 4
Pages: 385-96
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Publication
24849286 | J:220500
 
First Author: Lu J
Year: 2014
Journal: Nat Commun
Title: NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity.
Volume: 5
Pages: 3920
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Publication
26098576 | J:261225
First Author: Martinez J
Year: 2015
Journal: Nat Cell Biol
Title: Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins.
Volume: 17
Issue: 7
Pages: 893-906
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Publication
21499257 | J:345915
First Author: Wong AS
Year: 2011
Journal: Nat Cell Biol
Title: Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease.
Volume: 13
Issue: 5
Pages: 568-79
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Publication
36947051 | J:335555
First Author: Zhang H
Year: 2023
Journal: EMBO Mol Med
Title: Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression.
Volume: 15
Issue: 5
Pages: e15924
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Publication
11157979 | -
First Author: Kihara A
Year: 2001
Journal: J Cell Biol
Title: Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.
Volume: 152
Issue: 3
Pages: 519-30
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Publication
32051584 | J:291761
First Author: Liu Y
Year: 2020
Journal: Nature
Title: TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise.
Volume: 578
Issue: 7796
Pages: 605-609
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Publication
18806760 | J:158108
First Author: Maiuri MC
Year: 2009
Journal: Cell Death Differ
Title: Control of autophagy by oncogenes and tumor suppressor genes.
Volume: 16
Issue: 1
Pages: 87-93
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Publication
34646380 | J:313643
First Author: Xu C
Year: 2021
Journal: Theranostics
Title: TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG.
Volume: 11
Issue: 19
Pages: 9452-9469
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Publication
26834238 | J:230431
First Author: Xu DQ
Year: 2016
Journal: EMBO J
Title: PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity.
Volume: 35
Issue: 5
Pages: 496-514
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Publication
9712845 | -
First Author: Kametaka S
Year: 1998
Journal: J Biol Chem
Title: Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae.
Volume: 273
Issue: 35
Pages: 22284-91
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Publication
25498145 | J:219629
First Author: McEwan DG
Year: 2015
Journal: Mol Cell
Title: PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
Volume: 57
Issue: 1
Pages: 39-54
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Protein
A0A0B6VSG3
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Protein
Q3U2M6
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
A0A0B6VQN9
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
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Protein
Q7TPZ3
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
D5MR38
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Publication
20943950 | -
First Author: Tabata K
Year: 2010
Journal: Mol Biol Cell
Title: Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain.
Volume: 21
Issue: 23
Pages: 4162-72
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Publication
32632011 | -
First Author: Bhargava HK
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.
Volume: 117
Issue: 29
Pages: 17003-17010
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Publication
33854187 | -
First Author: Nah J
Year: 2021
Journal: Exp Mol Med
Title: The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death.
Volume: 53
Issue: 4
Pages: 528-536
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Publication
30581147 | -
First Author: Chang C
Year: 2019
Journal: Mol Cell
Title: Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics.
Volume: 73
Issue: 2
Pages: 339-353.e6
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Publication
28325809 | -
First Author: Marwaha R
Year: 2017
Journal: J Cell Biol
Title: The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.
Volume: 216
Issue: 4
Pages: 1051-1070
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Publication
27291868 | -
First Author: Bo T
Year: 2016
Journal: J Bone Miner Res
Title: Characterization of a Relatively Malignant Form of Osteopetrosis Caused by a Novel Mutation in the PLEKHM1 Gene.
Volume: 31
Issue: 11
Pages: 1979-1987
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Publication
28306502 | -
First Author: Cheng X
Year: 2017
Journal: Mol Cell
Title: Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17.
Volume: 65
Issue: 6
Pages: 1029-1043.e5
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Publication
30917850 | J:357800
First Author: Beltran S
Year: 2019
Journal: Mol Neurodegener
Title: Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis.
Volume: 14
Issue: 1
Pages: 14
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Protein Domain
IPR025258 | RH_dom
Type: Domain
Description: This is the Rubicon homology domain (RH) characterised at the C-terminal of Rubicon, PLEKHM1 and Pacer, proteins that modulate late steps in autophagy [, ]. Rubicon (RUBCN) negatively regulates autophagy and endolysosomal trafficking by inhibiting PI3K complex II (PI3KC3-C2), which impairs autophagosome maturation process. Decrease in autophagy is associated to aging, then suppression of this process by Rubicon has been linked to decreased clearance of alpha-synuclein aggregates in neural tissues, impairment of liver cell homeostasis, and interstitial fibrosis in the kidney. PLEKHM1 is an adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways [, ], being involved in the suppression of endocytic transport rather than autophagosome maturation. Mutations in PLEKHM1 causes osteopetrosis []. On the other hand, Pacer (Protein associated with UVRAG as autophagy enhancer or Rubicon-like) positively regulates autophagy, promoting autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns3P) in late steps of autophagy [, ]. It antagonizes RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex []. Pacer is involved in neuronal autophagy, whose deficiency leads to impaired autophagy and accumulation of protein aggregates in ALS which correlates with cell death and vulnerability of motoneurons during ALS pathogenesis [].This domain contains nine conserved cysteines and one conserved histidine, which have been predicted to bind divalent zinc cations, being required for Rubicon and PLEKHM1 to interact with Rab7 [, ].
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Protein
Q8K245
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
Q8BJ94
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
Q8BXW8
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
Q99J78
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Protein
Q80U62
Organism: Mus musculus/domesticus
Length: 956  
Fragment?: false
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Protein
A0A0R4IZW6
Organism: Mus musculus/domesticus
Length: 460  
Fragment?: false
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Protein
D3Z7B1
Organism: Mus musculus/domesticus
Length: 880  
Fragment?: false
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Protein
G3X9U5
Organism: Mus musculus/domesticus
Length: 472  
Fragment?: false
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Protein
Q8BM47
Organism: Mus musculus/domesticus
Length: 761  
Fragment?: false
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Protein
Q7TSI1
Organism: Mus musculus/domesticus
Length: 1074  
Fragment?: false
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Publication
19144319 | J:143718
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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