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Search results 101 to 184 out of 184 for Vps13c

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Type Details Score
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
A1ILH4
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
A1ILH1
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
A1ILG9
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: true
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Protein
A1ILH0
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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UniProt Feature
UniProt Feature
Begin: 1
Description: Intermembrane lipid transfer protein VPS13C
Type: chain
End: 3748
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Protein
A1ILH3
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
A1ILH2
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
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Protein
Q8BX70
Organism: Mus musculus/domesticus
Length: 3748  
Fragment?: false
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Protein
Q8BX70-3
Organism: Mus musculus/domesticus
Length: 3708  
Fragment?: false
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Protein
Q8BX70-2
Organism: Mus musculus/domesticus
Length: 3623  
Fragment?: false
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Publication
30093493 | -
First Author: Kumar N
Year: 2018
Journal: J Cell Biol
Title: VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.
Volume: 217
Issue: 10
Pages: 3625-3639
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Allele
Vps13c<em2Smoc> | MGI:7293140
Name: vacuolar protein sorting 13C; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6429783 | C57BL/6JSmoc-Vps13c<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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DO Term
DOID:0060896 | Parkinson's disease 23
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Allele
Vps13c<em1Smoc> | MGI:7293139
Name: vacuolar protein sorting 13C; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
17196930 | -
First Author: Mizuno E
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Brain-specific transcript variants of 5' and 3' ends of mouse VPS13A and VPS13C.
Volume: 353
Issue: 4
Pages: 902-7
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Strain
MGI:6476604 | C57BL/6JSmoc-Vps13c<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
21764909 | -
First Author: Samaranayake HS
Year: 2011
Journal: Eukaryot Cell
Title: Vacuolar protein sorting protein 13A, TtVPS13A, localizes to the tetrahymena thermophila phagosome membrane and is required for efficient phagocytosis.
Volume: 10
Issue: 9
Pages: 1207-18
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Protein
A2RSJ4
Organism: Mus musculus/domesticus
Length: 1457  
Fragment?: false
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Protein
Q570Z6
Organism: Mus musculus/domesticus
Length: 1510  
Fragment?: true
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Protein
B2KF50
Organism: Mus musculus/domesticus
Length: 1429  
Fragment?: false
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Protein
A0A3B2WCQ2
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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Publication
30952800 | -
First Author: Valverde DP
Year: 2019
Journal: J Cell Biol
Title: ATG2 transports lipids to promote autophagosome biogenesis.
Volume: 218
Issue: 6
Pages: 1787-1798
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Protein Domain
IPR031646 | VPS13_N2
Type: Domain
Description: This domain lies towards the N terminus, just downstream from . This domain is involved in lipid binding and transport [, , ]. This domain specifically interacts with phosphatidic acid and phosphorylated forms of phosphatidyl inositol [].VPS13 proteins have been implicated in processes including vesicle fusion, autophagy, and actin regulation. They bind phospholipids and act as channels that mediate the transfer of lipids between membranes at organelle contact sites [, , ]. It has been proposed that members of this entry have the capacity to bind and likely transfer tens of glycerolipids at once. Yeast VPS13 acts at multiple cellular sites, namely the interface between mitochondria and the vacuole, on endosomes, on the nuclear-vacuole junction and the vacuole, depending on the carbon source and metabolic state. Most evidence showed that mammalian VPS13A, VPS13C and VPS13D localize at contacts between the ER and other organelles, i.e. VPS13A and VPS13D bridge the ER to mitochondria, VPS13C bridges the ER to late endosomes and lysosomes and VPS13B may localize to endosome-endosome contacts [, , ]. Mutations in human VPS13 proteins (VPS13A-D) cause different diseases such as Chorea-acanthocytosis, Cohen syndrome, Parkinson's disease, and spastic ataxia, respectively which suggests they have different functions [, ].
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Protein Domain
IPR031645 | VPS13_DH-like
Type: Domain
Description: This entry represents a domain reminiscent of a DH domain (DH-Like domain) found adjacent the C-terminal PH-like domain of VPS13 proteins [, , , ]. DHL-PH domains has been identified as the mitochondria-binding region of VPS13A and the lipid droplet-binding region of both proteins. These two domains contain a region of high similarity to ATG2, which also binds lipid droplets [, ].VPS13 proteins have been implicated in processes including vesicle fusion, autophagy, and actin regulation. They bind phospholipids and act as channels that mediate the transfer of lipids between membranes at organelle contact sites [, , ]. It has been proposed that members of this entry have the capacity to bind and likely transfer tens of glycerolipids at once. Yeast VPS13 acts at multiple cellular sites, namely the interface between mitochondria and the vacuole, on endosomes, on the nuclear-vacuole junction and the vacuole, depending on the carbon source and metabolic state. Most evidence showed that mammalian VPS13A, VPS13C and VPS13D localize at contacts between the ER and other organelles, i.e. VPS13A and VPS13D bridge the ER to mitochondria, VPS13C bridges the ER to late endosomes and lysosomes and VPS13B may localize to endosome-endosome contacts [, , ]. Mutations in human VPS13 proteins (VPS13A-D) cause different diseases such as Chorea-acanthocytosis, Cohen syndrome, Parkinson's disease, and spastic ataxia, respectively which suggests they have different functions [, ].
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Protein Domain
IPR031642 | VPS13_mid_rpt
Type: Domain
Description: This entry represents the repeating region of VPS13. This repeating region shares a common core element that includes a well-conserved P-X4-P-X13-17-G sequence [, ]. This region contains a FFAT motif which mediates VAMP binding and tethering of the ER.VPS13 proteins have been implicated in processes including vesicle fusion, autophagy, and actin regulation. They bind phospholipids and act as channels that mediate the transfer of lipids between membranes at organelle contact sites [, , ]. It has been proposed that members of this entry have the capacity to bind and likely transfer tens of glycerolipids at once. Yeast VPS13 acts at multiple cellular sites, namely the interface between mitochondria and the vacuole, on endosomes, on the nuclear-vacuole junction and the vacuole, depending on the carbon source and metabolic state. Most evidence showed that mammalian VPS13A, VPS13C and VPS13D localize at contacts between the ER and other organelles, i.e. VPS13A and VPS13D bridge the ER to mitochondria, VPS13C bridges the ER to late endosomes and lysosomes and VPS13B may localize to endosome-endosome contacts [, , ]. Mutations in human VPS13 proteins (VPS13A-D) cause different diseases such as Chorea-acanthocytosis, Cohen syndrome, Parkinson's disease, and spastic ataxia, respectively which suggests they have different functions [, ].
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Protein Domain
IPR026854 | VPS13-like_N
Type: Domain
Description: This is the N-terminal chorein domain of VPS13 and ATG2 proteins, which is highly conserved. ATG2 proteins are involved in autophagosome assembly, playing a key role in nonvesicular lipid transfer [, , , ]. This domain has a scoop shape whose concave surface is lined by hydrophobic residues which bind glycerophospholipids.VPS13 proteins have been implicated in processes including vesicle fusion, autophagy, and actin regulation. They bind phospholipids and act as channels that mediate the transfer of lipids between membranes at organelle contact sites [, , ]. It has been proposed that members of this entry have the capacity to bind and likely transfer tens of glycerolipids at once. Yeast VPS13 acts at multiple cellular sites, namely the interface between mitochondria and the vacuole, on endosomes, on the nuclear-vacuole junction and the vacuole, depending on the carbon source and metabolic state. Most evidence showed that mammalian VPS13A, VPS13C and VPS13D localize at contacts between the ER and other organelles, i.e. VPS13A and VPS13D bridge the ER to mitochondria, VPS13C bridges the ER to late endosomes and lysosomes and VPS13B may localize to endosome-endosome contacts [, , ]. Mutations in human VPS13 proteins (VPS13A-D) cause different diseases such as Chorea-acanthocytosis, Cohen syndrome, Parkinson's disease, and spastic ataxia, respectively which suggests they have different functions [, ].
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Publication
30018089 | -
First Author: Bean BDM
Year: 2018
Journal: J Cell Biol
Title: Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites.
Volume: 217
Issue: 10
Pages: 3593-3607
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Publication
30741634 | -
   
First Author: Yeshaw WM
Year: 2019
Journal: Elife
Title: Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility.
Volume: 8
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Publication
30709847 | -
 
First Author: Muñoz-Braceras S
Year: 2019
Journal: Dis Model Mech
Title: VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation.
Volume: 12
Issue: 2
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Publication
34216812 | -
First Author: Leonzino M
Year: 2021
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
Title: Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport.
Volume: 1866
Issue: 10
Pages: 159003
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Protein
Q3TN78
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
F6XI52
Organism: Mus musculus/domesticus
Length: 1078  
Fragment?: true
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Protein
A1ILH6
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
A0A286YCT3
Organism: Mus musculus/domesticus
Length: 2339  
Fragment?: false
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Protein
Q8C9M0
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Protein
A0A2I3BPN3
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
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Publication
23444357 | -
First Author: Koizumi K
Year: 2013
Journal: Development
Title: Identification of SHRUBBY, a SHORT-ROOT and SCARECROW interacting protein that controls root growth and radial patterning.
Volume: 140
Issue: 6
Pages: 1292-300
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Publication
28122955 | -
First Author: De M
Year: 2017
Journal: J Cell Biol
Title: The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion.
Volume: 216
Issue: 2
Pages: 425-439
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Protein Domain
IPR009543 | VPS13_VAB
Type: Domain
Description: This entry represents the VPS13 adaptor binding (VAB) domain, previously known as SHR-BD, found in VPS13 []. These proteins interact with membrane-specific adaptor proteins such as Ypt35, Spo71 and the mitochondrial membrane protein Mcp1, to be recruited to different membranes. This domain interacts with Ypt35 which recruits VPS13 to endosomal and vacuolar membranes, and with Mcp1 to target VPS13 at mitochondria []. In plants, this domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY () [].This domain likely adopts an elongated structure consisting of β-sheets. It has been described as a β-propeller/WD40-like structure [, ], however, based on structural models, it does not seem to have that 3D arrangement.VPS13 proteins have been implicated in processes including vesicle fusion, autophagy, and actin regulation. They bind phospholipids and act as channels that mediate the transfer of lipids between membranes at organelle contact sites [, , ]. It has been proposed that members of this entry have the capacity to bind and likely transfer tens of glycerolipids at once. Yeast VPS13 acts at multiple cellular sites, namely the interface between mitochondria and the vacuole, on endosomes, on the nuclear-vacuole junction and the vacuole, depending on the carbon source and metabolic state. Most evidence showed that mammalian VPS13A, VPS13C and VPS13D localize at contacts between the ER and other organelles, i.e. VPS13A and VPS13D bridge the ER to mitochondria, VPS13C bridges the ER to late endosomes and lysosomes and VPS13B may localize to endosome-endosome contacts [, , ]. Mutations in human VPS13 proteins (VPS13A-D) cause different diseases such as Chorea-acanthocytosis, Cohen syndrome, Parkinson's disease, and spastic ataxia, respectively which suggests they have different functions [, ].
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Protein
Q80TY5
Organism: Mus musculus/domesticus
Length: 3993  
Fragment?: false
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Protein
A0A1L1SUY8
Organism: Mus musculus/domesticus
Length: 771  
Fragment?: false
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Publication
15498460 | -
First Author: Velayos-Baeza A
Year: 2004
Journal: Genomics
Title: Analysis of the human VPS13 gene family.
Volume: 84
Issue: 3
Pages: 536-49
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Protein
Q5H8C4
Organism: Mus musculus/domesticus
Length: 3166  
Fragment?: false
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Protein
A1ILG8
Organism: Mus musculus/domesticus
Length: 3748  
Fragment?: false
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Protein
B1ART1
Organism: Mus musculus/domesticus
Length: 4359  
Fragment?: false
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Protein
B1ART2
Organism: Mus musculus/domesticus
Length: 4390  
Fragment?: false
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Publication
34830155 | -
 
First Author: Kolakowski D
Year: 2021
Journal: Int J Mol Sci
Title: The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus.
Volume: 22
Issue: 22
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Protein
Q6P4T0
Organism: Mus musculus/domesticus
Length: 1914  
Fragment?: false
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Protein
Q80XK6
Organism: Mus musculus/domesticus
Length: 2075  
Fragment?: false
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Publication
33492421 | J:302207
First Author: Mousavy Gharavy SN
Year: 2021
Journal: Diabetologia
Title: Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.
Volume: 64
Issue: 4
Pages: 850-864
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Protein
Q8CDS8
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: false
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Protein
A0A286YCC3
Organism: Mus musculus/domesticus
Length: 857  
Fragment?: true
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Protein
Q6P6M9
Organism: Mus musculus/domesticus
Length: 1186  
Fragment?: true
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Protein
A0A1L1SS63
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: true
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Protein
V9GX23
Organism: Mus musculus/domesticus
Length: 3211  
Fragment?: true
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Protein
Q6A066
Organism: Mus musculus/domesticus
Length: 1918  
Fragment?: true
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
19131326 | -
First Author: Sweet SM
Year: 2009
Journal: Mol Cell Proteomics
Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Volume: 8
Issue: 5
Pages: 904-12
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Publication
24129315 | J:306378
First Author: Guo A
Year: 2014
Journal: Mol Cell Proteomics
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
Volume: 13
Issue: 1
Pages: 372-87
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Publication
19144319 | J:143718
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
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Publication
17242355 | -
First Author: Villén J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Large-scale phosphorylation analysis of mouse liver.
Volume: 104
Issue: 5
Pages: 1488-93
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom