Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
•
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Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
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•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; wild type |
|
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST17630, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST18210, Lexicon Genetics |
Allele Type: |
Gene trapped |
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|
•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST24044, Lexicon Genetics |
Allele Type: |
Gene trapped |
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|
•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST28280, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST93118, Lexicon Genetics |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST98823, Lexicon Genetics |
Allele Type: |
Gene trapped |
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•
•
•
•
•
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Allele |
Name: |
VPS29 retromer complex component; gene trap OST113533, Lexicon Genetics |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST127837, Lexicon Genetics |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST135740, Lexicon Genetics |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST309649, Lexicon Genetics |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST405406, Lexicon Genetics |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST456377, Lexicon Genetics |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; gene trap OST471276, Lexicon Genetics |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; endonuclease-mediated mutation 1, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
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Allele |
Name: |
VPS29 retromer complex component; endonuclease-mediated mutation 3, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
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Allele |
Name: |
VPS29 retromer complex component; endonuclease-mediated mutation 2, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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•
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•
•
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Strain |
Attribute String: |
mutant stock, gene trap |
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•
•
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Allele |
Name: |
VPS29 retromer complex component; gene trap IST13632H9, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
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•
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Allele |
Name: |
VPS29 retromer complex component; gene trap IST14664C1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
VPS29 retromer complex component; endonuclease-mediated mutation 1, Baylor College of Medicine |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
•
•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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Publication |
First Author: |
Swarbrick JD |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins. |
Volume: |
6 |
Issue: |
5 |
Pages: |
e20420 |
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•
•
•
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Strain |
Attribute String: |
coisogenic |
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•
•
•
•
•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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Genotype |
Symbol: |
Vps29/Vps29 |
Background: |
C57BL/6N-Vps29/BayMmucd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
•
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•
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Genotype |
Symbol: |
Vps29/Vps29<+> |
Background: |
C57BL/6N-Vps29/BayMmucd |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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GO Term |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
204
 |
Fragment?: |
true |
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•
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•
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Protein Domain |
Type: |
Family |
Description: |
This entry represents vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes.Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [, ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo []. Mutations in the Vps35 gene have been linked to Parkinson's disease []. Structurally, VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid []. |
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•
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•
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Publication |
First Author: |
Seaman MN |
Year: |
1997 |
Journal: |
J Cell Biol |
Title: |
Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. |
Volume: |
137 |
Issue: |
1 |
Pages: |
79-92 |
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•
•
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•
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Protein Domain |
Type: |
Family |
Description: |
Members of this largely uncharacterised family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11, and a family of uncharacterised archaeal putative phosphoesterases. In this family, the His residue in GNHD portion of the motif is not conserved. The member MJ0936, one of two from Methanocaldococcus jannaschii (Methanococcus jannaschii), was shown []to act on model phosphodiesterase substrates; a divalent cation was required. This entry also represents Vps29 which is part of the retromer complex in yeast [].This entry also includes vacuolar protein sorting-associated protein 29 (vps29), which is an essential component of the retromer complex, a conserved complex required in endosome-to-Golgi retrograde transport []. |
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•
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•
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Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This superfamily represents the α-helical C-terminal domain found in vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes.Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [, ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo []. Mutations in the Vps35 gene have been linked to Parkinson's disease []. Structurally, VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid []. |
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•
•
•
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•
|
Publication |
First Author: |
Parra Bravo C |
Year: |
2024 |
Journal: |
Cell |
Title: |
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. |
Volume: |
187 |
Issue: |
10 |
Pages: |
2446-2464.e22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reddy JV |
Year: |
2001 |
Journal: |
Mol Biol Cell |
Title: |
Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval. |
Volume: |
12 |
Issue: |
10 |
Pages: |
3242-56 |
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•
•
•
•
•
|
Publication |
First Author: |
Hierro A |
Year: |
2007 |
Journal: |
Nature |
Title: |
Functional architecture of the retromer cargo-recognition complex. |
Volume: |
449 |
Issue: |
7165 |
Pages: |
1063-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Munsie LN |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N. |
Volume: |
24 |
Issue: |
6 |
Pages: |
1691-703 |
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•
•
•
•
•
|
Publication |
First Author: |
Fuse A |
Year: |
2015 |
Journal: |
FEBS Lett |
Title: |
VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process. |
Volume: |
589 |
Issue: |
13 |
Pages: |
1430-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seaman MN |
Year: |
2012 |
Journal: |
J Cell Sci |
Title: |
The retromer complex - endosomal protein recycling and beyond. |
Volume: |
125 |
Issue: |
Pt 20 |
Pages: |
4693-702 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
796
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
796
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
730
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
796
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
796
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen XQ |
Year: |
2023 |
Journal: |
Ann Neurol |
Title: |
Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator. |
Volume: |
94 |
Issue: |
2 |
Pages: |
245-258 |
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•
•
•
•
•
|
Publication |
First Author: |
Zhao Y |
Year: |
2021 |
Journal: |
Int J Mol Sci |
Title: |
Expression of Low Level of VPS35-mCherry Fusion Protein Diminishes Vps35 Depletion Induced Neuron Terminal Differentiation Deficits and Neurodegenerative Pathology, and Prevents Neonatal Death. |
Volume: |
22 |
Issue: |
16 |
|
|
•
•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen S |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii. |
Volume: |
279 |
Issue: |
30 |
Pages: |
31854-62 |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
|