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Search results 101 to 127 out of 127 for Vps36

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Type Details Score
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR031558 | Vps36-NZF-N
Type: Domain
Description: This NZF-N zinc-finger domain of Vps36 protein interacts with the C terminus of vacuolar protein sorting 28 [].
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Protein Domain
IPR040608 | Snf8/Vps36
Type: Family
Description: This family includes Snf8 and Vps36. Vps36 is involved in Golgi to endosome trafficking. Snf8 is a component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs [].
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Publication
17057714 | -
First Author: Hirano S
Year: 2006
Journal: Nat Struct Mol Biol
Title: Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain.
Volume: 13
Issue: 11
Pages: 1031-2
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Publication
16615903 | -
First Author: Eathiraj S
Year: 2006
Journal: Structure
Title: ESCRT complexes assembled and GLUEd.
Volume: 14
Issue: 4
Pages: 631-2
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Publication
17034365 | -
First Author: Hurley JH
Year: 2006
Journal: Biochem J
Title: Ubiquitin-binding domains.
Volume: 399
Issue: 3
Pages: 361-72
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Protein Domain
IPR021648 | GLUE_dom
Type: Domain
Description: Vps36 is a subunit of ESCRT-II, a protein complex involved in driving protein sorting from endosomes to lysosomes. The GLUE domain of Vps36 allows for a tight interaction to occur between the protein and Vps28, a subunit of ESCRT-I. This interaction is critical for ubiquitinated cargo progression from early to late endosomes []. The multivesicular body (MVB) protein-sorting pathway targets transmembraneproteins either for degradation or for function in the vacuole/lysosomes. Thesignal for entry into this pathway is monoubiquitination of protein cargo,which results in incorporation of cargo into luminal vesicles at lateendosomes. Another crucial player is phosphatidylinositol 3-phosphate(PtdINS(3)P), which is enriched on early endosomes and on the luminal vesiclesof MVBs. The ESCRT complexes are critical for MVB budding and sorting ofmonoubiquitinated cargo into the luminal vesicles. Various Ub-binding domains(UBDs), such as UIM, UEV and NZF are found in suchmachineries. The Vps 36 subunit of the ESCRT-II trafficking complex binds bothphosphoinositides and ubiquitin. All members of the Vps36 family contain adivergent GRAM/PH-like domain and yeast and some other fungi have one or twoNZF domains inserted in the GRAM/PH-like domain.The N-terminal region of Vps36 (EAP45) has been named the GLUE (GRAM-like ubiquitin-binding in EAP45)domain. The GLUE domain acts as a central cog driving the endosomal ESCRTmachinery, through simultaneous interactions with PtdIns3P-containingmembranes, ubiquitin, and ESCRT-I. Like other known ubiquitin-binding domains,the GLUE domain interacts with the hydrophobic surface patch of ubiquitin. TheGLUE domain is the first ubiquitin-binding domain shown to bindphosphoinositides, and the ability of the same domain to bind both ubiquitinand a phosphoinositide opens interesting possibilities for coordination ofmembrane interactions and cargo recognition [, , , , ].The GLUE domain has a split PH-domain fold with two curved beta sheets andone long alpha helix. The two sheets (beta1-beta4 and beta5-beta7) form a beta barrel-like structure, the C-terminal alpha helix is wedgedbetween the two beta sheets, covering a hydrophobic core. The Vps36 GLUEdomain binds PtdIns3P via a positively charged lipid binding pocket,delineated by the variable loops beta1/beta2, beta5/beta6 and beta7/alpha1, incontrast to the vast majority of characterised PH domains, which use adifferent lipid binding pocket [, ].
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Publication
34882480 | J:333945
First Author: Gulluni F
Year: 2021
Journal: Science
Title: PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Volume: 374
Issue: 6573
Pages: eabk0410
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Publication
38030597 | J:343170
First Author: Lin SJ
Year: 2023
Journal: Nat Commun
Title: Endosomal Arl4A attenuates EGFR degradation by binding to the ESCRT-II component VPS36.
Volume: 14
Issue: 1
Pages: 7859
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Publication
17428789 | J:320141
First Author: Nebauer R
Year: 2007
Journal: J Biol Chem
Title: Phosphatidylethanolamine, a limiting factor of autophagy in yeast strains bearing a defect in the carboxypeptidase Y pathway of vacuolar targeting.
Volume: 282
Issue: 23
Pages: 16736-43
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Publication
22021616 | J:179594
First Author: McLeod IX
Year: 2011
Journal: J Immunol
Title: The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
Volume: 187
Issue: 10
Pages: 5051-61
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Protein
Q9CZ28
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
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Protein
A2A6M1
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Publication
12194858 | -
First Author: Babst M
Year: 2002
Journal: Dev Cell
Title: Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body.
Volume: 3
Issue: 2
Pages: 283-9
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