Type |
Details |
Score |
Allele |
Name: |
VPS41 HOPS complex subunit; targeted mutation 1.1, Yoh Wada |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
VPS41 HOPS complex subunit; gene trap XS0589, Wellcome Trust Sanger Institute |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
gene trap, mutant stock |
|
•
•
•
•
•
|
Allele |
Name: |
VPS41 HOPS complex subunit; gene trap EUCE00123e06, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Gene trapped |
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|
•
•
•
•
•
|
Allele |
Name: |
VPS41 HOPS complex subunit; gene trap EUCJ00133g04, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS41 HOPS complex subunit; gene trap IST15072F11, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, congenic, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
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•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, congenic, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Vps41/Vps41 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Vps41/Vps41 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Chassefeyre R |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
Endosomal sorting drives the formation of axonal prion protein endoggresomes. |
Volume: |
7 |
Issue: |
52 |
Pages: |
eabg3693 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes Vps41 and Vps8.Vps41 is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport [, , ].Vps8 is one of the Golgi complex components necessary for vacuolar sorting []. Eukaryotic cells contain a highly dynamic endomembrane system, in which individual organelles keep their identity despite continuous vesicle generation and fusion. Vesicles that bud from a donor membrane are targeted and delivered to each individual organelle, where they release their cargo after fusion with the acceptor membrane. Vps8 is the core component of the endosomal tethering complex CORVET (class C core vacuole/endosome tethering). Vps8 co-operates with Vps21-GTP to mediate endosomal clustering in a reaction that is dependent on Vps3. Vps8 is the only CORVET subunit that is enriched on late endosomes, suggesting that it is a marker for the maturation of late endosomes. Late endosomes form intraluminal vesicles, and the resulting multivesicular bodies fuse with the vacuole to release their cargoes []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen YJ |
Year: |
1996 |
Journal: |
Eur J Cell Biol |
Title: |
The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae. |
Volume: |
70 |
Issue: |
4 |
Pages: |
289-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Markgraf DF |
Year: |
2009 |
Journal: |
Mol Biol Cell |
Title: |
The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments. |
Volume: |
20 |
Issue: |
24 |
Pages: |
5276-89 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
604
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
•
|