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Search results 101 to 182 out of 182 for Vps72

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754021
Pattern: Single cells
Stage: TS21
Assay Id: MGI:3507890
Age: embryonic day 13.5
Image: 1
Note: Expression was detected in some cells.
Specimen Label: 1
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3507890
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886415
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945351
Age: postnatal day 7
Image: g00850 P7
Specimen Label: g00850 P7
Detected: true
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539381
Age: embryonic day 15.5
Image: GUDMAP:5686
Specimen Label: GUDMAP:5686
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3507890
Age: postnatal newborn
Image: 2
Note: The tissue was olfactory epithelium and/or bulb.
Specimen Label: 2
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:4886415
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945351
Age: embryonic day 15.5
Image: g00850 E15.5
Specimen Label: g00850 E15.5
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4886415
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945351
Age: postnatal day 7
Image: g00850 P7
Note: Expression was region specific and scattered.
Specimen Label: g00850 P7
Detected: true
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886415
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945351
Age: embryonic day 15.5
Image: g00850 E15.5
Specimen Label: g00850 E15.5
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
   
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267921
Stage: TS21
Assay Id: MGI:3507890
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3507890
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539381
Age: embryonic day 15.5
Image: GUDMAP:5686
Specimen Label: GUDMAP:5686
Detected: true
Specimen Num: 1
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539381
Age: embryonic day 15.5
Image: GUDMAP:5686
Specimen Label: GUDMAP:5686
Detected: true
Specimen Num: 1
•
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•
•
GXD Expression
GXD Expression
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Single cells
Stage: TS21
Assay Id: MGI:3507890
Age: embryonic day 13.5
Image: 1
Note: Expression was detected in some cells.
Specimen Label: 1
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3507890
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4886415
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945351
Age: embryonic day 15.5
Image: g00850 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00850 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4886415
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945351
Age: postnatal day 7
Image: g00850 P7
Specimen Label: g00850 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539381
Age: embryonic day 15.5
Image: GUDMAP:5686
Specimen Label: GUDMAP:5686
Detected: true
Specimen Num: 1
•
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506366
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5539381
Age: embryonic day 15.5
Image: GUDMAP:5686
Specimen Label: GUDMAP:5686
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:4844618
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1638815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848520
Age: embryonic day 9.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4844618
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848520
Age: embryonic day 10.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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Publication
13679025 | J:85319
First Author: Buchner DA
Year: 2003
Journal: Genomics
Title: High-resolution mapping of the sodium channel modifier Scnm1 on mouse chromosome 3 and identification of a 1.3-kb recombination hot spot.
Volume: 82
Issue: 4
Pages: 452-9
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Publication
30842416 | J:276456
First Author: Zhao B
Year: 2019
Journal: Nat Commun
Title: Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation.
Volume: 10
Issue: 1
Pages: 1071
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Publication
16634648 | J:320032
First Author: Ruhl DD
Year: 2006
Journal: Biochemistry
Title: Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes.
Volume: 45
Issue: 17
Pages: 5671-7
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Publication
14966270 | J:320265
First Author: Doyon Y
Year: 2004
Journal: Mol Cell Biol
Title: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.
Volume: 24
Issue: 5
Pages: 1884-96
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Publication
19379700 | J:150463
First Author: Deneault E
Year: 2009
Journal: Cell
Title: A functional screen to identify novel effectors of hematopoietic stem cell activity.
Volume: 137
Issue: 2
Pages: 369-79
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Publication
27153538 | J:319957
First Author: Jacquet K
Year: 2016
Journal: Mol Cell
Title: The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Volume: 62
Issue: 3
Pages: 409-421
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Publication
33913477 | J:305946
 
First Author: Xu M
Year: 2021
Journal: Development
Title: The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development.
Volume: 148
Issue: 8
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Publication
22174793 | J:182258
First Author: Taher L
Year: 2011
Journal: PLoS One
Title: Global gene expression analysis of murine limb development.
Volume: 6
Issue: 12
Pages: e28358
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Publication
- | J:165963
     
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR008895 | Vps72/YL1
Type: Family
Description: This entry include a group of proteins involved in chromatin remodelling, including Vps72 (vacuolar protein sorting-associated protein 72) from budding yeasts. Vps72 is a Htz1-binding component of the SWR1 complex, which is required for the incorporation of the histone variant H2AZ into chromatin []. It is also required for vacuolar protein sorting in budding yeasts [].The Vps72 homologue from animals, YL-1, is a deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. It is component of the SRCAP and Tip60 complexes, and mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling [, ].
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Publication
26974124 | -
First Author: Liang X
Year: 2016
Journal: Nat Struct Mol Biol
Title: Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1.
Volume: 23
Issue: 4
Pages: 317-23
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Protein Domain
IPR046757 | YL1_N
Type: Domain
Description: This entry include a group of proteins involved in chromatin remodelling, including Vps72 (vacuolar protein sorting-associated protein 72) from budding yeasts. Vps72 is a Htz1-binding component of the SWR1 complex, which is required for the incorporation of the histone variant H2AZ into chromatin []. It is also required for vacuolar protein sorting in budding yeasts [].The Vps72 homologue from animals, YL-1, is a deposition-and-exchangehistone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. It is component of the SRCAP and Tip60 complexes, and mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling [, ].This is the N-terminal region from Vps72/YL1, which covers the aspartate- and glutamate-rich N-terminal domain and the central DNA-binding domain [, ].
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Protein
Q62481
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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Publication
23580526 | -
First Author: Watanabe S
Year: 2013
Journal: Science
Title: A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme.
Volume: 340
Issue: 6129
Pages: 195-9
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Publication
15528408 | -
First Author: Kusch T
Year: 2004
Journal: Science
Title: Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions.
Volume: 306
Issue: 5704
Pages: 2084-7
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Publication
26974126 | -
First Author: Latrick CM
Year: 2016
Journal: Nat Struct Mol Biol
Title: Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.
Volume: 23
Issue: 4
Pages: 309-16
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Publication
39761726 | J:361288
   
First Author: Vázquez Salgado AM
Year: 2025
Journal: Cell Mol Gastroenterol Hepatol
Title: In Vivo CRISPR Activation Screening Reveals Chromosome 1q Genes VPS72, GBA1, and MRPL9 Drive Hepatocellular Carcinoma.
Pages: 101460
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Publication
19088068 | -
First Author: Wu WH
Year: 2009
Journal: J Biol Chem
Title: N terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex.
Volume: 284
Issue: 10
Pages: 6200-7
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Publication
16299513 | -
First Author: Wu WH
Year: 2005
Journal: Nat Struct Mol Biol
Title: Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange.
Volume: 12
Issue: 12
Pages: 1064-71
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Protein Domain
IPR020195 | SWR1_Swc7
Type: Family
Description: Th SWR1 complex is involved in chromatin-remodelling by promoting the the ATP-dependent exchange of histone H2A for the H2A variant HZT1 in Saccharomyces cerevisiae (Baker's yeast) or H2AZ in mammals. The SWR1 chromatin-remodelling complex is composed of at least 14 subunits and has a molecular mass of about 1.2 to 1.5 MDa. In S. cerevisiae the core conserved subunits are: ATPase; Swr1.RuvB-like; Rvb1 and Rvb2.Actin; Act1.Actin-related: Arp4 and Arp6.YEATS protein []; Yaf9.The non-conserved subunits are: Vps71 (Swc6), Vps72 (Swc2), Swc3, Swc4, Swc5, Swc7, Bdf1 [].Seven of the SWR1 subunits are involved in maintaining complex integrity and H2AZ histone replacement activity: Swr1, Swc2, Swc3, Arp6, Swc5, Yaf9 and Swc6. Arp4 is required for the association of Bdf1, Yaf9, and Swc4 and Arp4 is also required for SWR1 H2AZ histone replacement activity in vitro. Furthermore the N-terminal region of the ATPase Swr1 provides the platform upon which Bdf1, Swc7, Arp4, Act1, Yaf9 and Swc4 associate []; it also contains an additional H2AZ-H2B specific binding site, distinct from the binding site of the Swc2 subunit []. In eukaryotes the deposition of variant histones into nucleosomes by the chromatin-remodelling complexes such as the SWR1 and INO80 complexes have many crucial functions including the control of gene regulation and expression, checkpoint regulation, DNA replication and repair, telomer maintenance and chromosomal segregation and as such represent critical components of pathways that maintain genomic integrity. This entry represents the subunit Swc7; the smallestsubunit of the SWR1 complex. Swc7 is not required for H2AZ binding. Swc7 associates with the N terminus of Swr1, and the association of Bdf1 requires Swc7, Yaf9, and Arp4 [].
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Publication
19234524 | -
First Author: Schulze JM
Year: 2009
Journal: Biochem Cell Biol
Title: YEATS domain proteins: a diverse family with many links to chromatin modification and transcription.
Volume: 87
Issue: 1
Pages: 65-75
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Publication
19424290 | -
First Author: Morrison AJ
Year: 2009
Journal: Nat Rev Mol Cell Biol
Title: Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes.
Volume: 10
Issue: 6
Pages: 373-84
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