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Search results 101 to 200 out of 207 for Wdr5

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Type Details Score
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Gene
694668 | GCAWKR
Type: gene
Organism: macaque, rhesus
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Gene
107968451 | GCAWKR
Type: gene
Organism: chimpanzee
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UniProt Feature
UniProt Feature
Begin: 3759
Description: WDR5 interaction motif (WIN)
Type: short sequence motif
End: 3764
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UniProt Feature
UniProt Feature
Begin: 5388
Description: WDR5 interaction motif (WIN)
Type: short sequence motif
End: 5393
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UniProt Feature
UniProt Feature
Begin: 4699
Description: WDR5 interaction motif (WIN)
Type: short sequence motif
End: 4704
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UniProt Feature
UniProt Feature
Begin: 1501
Description: WDR5 interaction motif (WIN)
Type: short sequence motif
End: 1506
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UniProt Feature
UniProt Feature
Begin: 1764
Description: WDR5 interaction motif (WIN)
Type: short sequence motif
End: 1769
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UniProt Feature
UniProt Feature
Begin: 2506
Description: WDR5 interaction motif (WIN)
Type: short sequence motif
End: 2511
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Publication
29718303 | J:263804
First Author: Hung KH
Year: 2018
Journal: Nucleic Acids Res
Title: The KDM4A/KDM4C/NF-κB and WDR5 epigenetic cascade regulates the activation of B cells.
Volume: 46
Issue: 11
Pages: 5547-5560
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Publication
26471359 | J:226765
First Author: Sun Y
Year: 2015
Journal: Cancer Res
Title: WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.
Volume: 75
Issue: 23
Pages: 5143-54
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GO Term
GO:0071339 | MLL1 complex
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GO Term
GO:0044545 | NSL complex
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Protein Domain
IPR037915 | PHF20
Type: Family
Description: PHD finger protein 20 (PHF20) binds dimethyl lysine residues via its Tudor domain []. It is a component of the MLL1, MOF histone acetyltransferase []and NSL protein complexes [].The NSL complex is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. The complex is composed of at least MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 [].
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Publication
15960975 | J:156231
First Author: Dou Y
Year: 2005
Journal: Cell
Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Volume: 121
Issue: 6
Pages: 873-85
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Publication
28600172 | J:251235
First Author: Liu Z
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Conditional knockout of microRNA-31 promotes the development of colitis associated cancer.
Volume: 490
Issue: 1
Pages: 62-68
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Protein Coding Gene
MGI:1923969 | Kansl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2444148 | Phf20
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22862943 | J:338458
First Author: Li X
Year: 2012
Journal: Cell Stem Cell
Title: The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network.
Volume: 11
Issue: 2
Pages: 163-78
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Publication
32960481 | J:306156
First Author: Schutt C
Year: 2020
Journal: EMBO J
Title: Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy.
Volume: 39
Issue: 22
Pages: e105098
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Publication
37149865 | J:348574
First Author: Dang B
Year: 2023
Journal: Cell Rep
Title: The glycolysis/HIF-1α axis defines the inflammatory role of IL-4-primed macrophages.
Volume: 42
Issue: 5
Pages: 112471
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Publication
31844669 | J:285275
First Author: Han X
Year: 2019
Journal: Sci Adv
Title: LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE.
Volume: 5
Issue: 12
Pages: eaax9230
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Publication
22072714 | J:228714
First Author: Badeaux AI
Year: 2012
Journal: J Biol Chem
Title: Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.
Volume: 287
Issue: 1
Pages: 429-37
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Publication
17998332 | -
First Author: Lee JH
Year: 2008
Journal: Mol Cell Biol
Title: Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.
Volume: 28
Issue: 2
Pages: 609-18
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Publication
25561738 | -
First Author: Shinsky SA
Year: 2015
Journal: J Biol Chem
Title: Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.
Volume: 290
Issue: 10
Pages: 6361-75
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Protein Domain
IPR034467 | Set1A_RRM
Type: Domain
Description: This entry represents the RNA recognition motif (RRM) of Setd1A (also known as Set1A), a ubiquitously expressed vertebrates histone methyltransferase that exhibits high homology to yeast Set1. Set1A is localized to euchromatic nuclear speckles and associates with a complex containing six human homologs of the yeast Set1/COMPASS complex, including CXXC finger protein 1 (CFP1; homologous to yeast Spp1), Rbbp5 (homologous to yeast Swd1), Ash2 (homologous to yeast Bre2), Wdr5 (homologous to yeast Swd3), and Wdr82 (homologous to yeast Swd2) []. Set1A contains an N-terminal RNA recognition motif (RRM), an N-SET domain, and a C-terminal catalytic SET domain followed by a post-SET domain. In contrast to Set1B, Set1A additionally contains an HCF-1 binding motif that interacts with HCF-1 in vivo.
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Protein Domain
IPR034468 | Set1B_RRM
Type: Domain
Description: This entry represents the RNA recognition motif (RRM) of Setd1B (also known as Set1B), a ubiquitously expressed vertebrates histone methyltransferase that exhibits high homology to yeast Set1. Set1B is localised to euchromatic nuclear speckles and associates with a complex containing six human homologues of the yeast Set1/COMPASS complex, including CXXC finger protein 1 (CFP1; homologous to yeast Spp1), Rbbp5 (homologous to yeast Swd1), Ash2 (homologous to yeast Bre2), Wdr5 (homologous to yeast Swd3), and Wdr82 (homologous to yeast Swd2). Set1B complex is a histone methyltransferase that produces trimethylated histone H3 at Lys4 [, ]. Set1B contains an N-terminal RNA recognition motif (RRM), an N-SET domain, and a C-terminal catalytic SET domain followed by a post-SET domain.
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Publication
28484075 | J:242579
First Author: Malek R
Year: 2017
Journal: Cancer Res
Title: TWIST1-WDR5-Hottip Regulates Hoxa9 Chromatin to Facilitate Prostate Cancer Metastasis.
Volume: 77
Issue: 12
Pages: 3181-3193
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Publication
25349198 | J:327005
First Author: Xu H
Year: 2015
Journal: J Am Soc Nephrol
Title: Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy.
Volume: 26
Issue: 7
Pages: 1648-60
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Publication
31690669 | J:283708
First Author: Bhattacharya U
Year: 2020
Journal: Cancer Res
Title: Heparanase and Chemotherapy Synergize to Drive Macrophage Activation and Enhance Tumor Growth.
Volume: 80
Issue: 1
Pages: 57-68
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Publication
30139920 | J:265896
First Author: Ahmed ASI
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells.
Volume: 115
Issue: 37
Pages: E8660-E8667
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Publication
26383167 | J:225948
First Author: Thomas LR
Year: 2015
Journal: Cancer Res
Title: The MYC-WDR5 Nexus and Cancer.
Volume: 75
Issue: 19
Pages: 4012-5
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Publication
29383478 | J:261596
First Author: Schilders K
Year: 2018
Journal: Transgenic Res
Title: Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo.
Volume: 27
Issue: 1
Pages: 75-85
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Publication
31072927 | J:276232
First Author: Kikani CK
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program.
Volume: 116
Issue: 21
Pages: 10382-10391
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Publication
23395176 | J:198047
First Author: Li MD
Year: 2013
Journal: Cell Metab
Title: O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination.
Volume: 17
Issue: 2
Pages: 303-10
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Publication
15361863 | -
First Author: Jínek M
Year: 2004
Journal: Nat Struct Mol Biol
Title: The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.
Volume: 11
Issue: 10
Pages: 1001-7
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Publication
20018868 | -
First Author: Whelan SA
Year: 2010
Journal: J Biol Chem
Title: Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes.
Volume: 285
Issue: 8
Pages: 5204-11
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Publication
22923583 | -
First Author: Yi W
Year: 2012
Journal: Science
Title: Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.
Volume: 337
Issue: 6097
Pages: 975-80
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Publication
22121020 | -
First Author: Fujiki R
Year: 2011
Journal: Nature
Title: GlcNAcylation of histone H2B facilitates its monoubiquitination.
Volume: 480
Issue: 7378
Pages: 557-60
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Protein Domain
IPR037919 | OGT
Type: Family
Description: The UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (OGT; ) is a heterotrimer of one 78kDa subunit and two 110kDa subunits. OGT catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in a protein. Substrate proteins include histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. The consequences of this form of glycosylation are diverse, including insulin resistance in muscle and adipocyte cells (brought about by inhibiting the 'Thr-308' phosphorylation of AKT1) []; regulation of glycolysis by inhibiting PFKL activity []; in the cell cycle O-glycosylation stabilizes ARNTL/BMAL1 and CLOCK, preventing their ubiquitination and subsequent degradation []; glycosylation of HCFC1 and interaction with TET proteins promotes binding of the SET1/COMPASS methyltransferase SETD1A to chromatin []; and H2B GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination []. It is a component of several complexes, including MLL5-L, NSL []and THAP1/THAP3-HCFC1-OGT [].This entry represents the 110kDa subunit which has thirteen tetratricopeptide (TPR) repeats that are required for substrate binding and oligomerization [].The NSL complex is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. The complex is composed of at least MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 [].
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Protein Coding Gene
MGI:1918055 | Kansl3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915941 | Kansl1l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915609 | Bacc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2444412 | Phf20l1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916862 | Kansl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1344413 | Tex10
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
32358019 | J:292161
First Author: Zhang Z
Year: 2020
Journal: J Immunol
Title: Suppression of Mll1-Complex by Stat3/Cebpβ-Induced miR-21a/21b/181b Maintains the Accumulation, Homeostasis, and Immunosuppressive Function of Polymorphonuclear Myeloid-Derived Suppressor Cells.
Volume: 204
Issue: 12
Pages: 3400-3415
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Publication
23353889 | J:194478
First Author: Deplus R
Year: 2013
Journal: EMBO J
Title: TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.
Volume: 32
Issue: 5
Pages: 645-55
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Protein
A2AV92
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
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Protein Coding Gene
MGI:1923380 | Las1l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2158736 | Senp3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922523 | Pelp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1354159 | E2f6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913560 | Dpy30
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1352483 | Mga
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1344416 | Ash2l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1858420 | Mcrs1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105942 | Hcfc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
20018852 | -
First Author: Cai Y
Year: 2010
Journal: J Biol Chem
Title: Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.
Volume: 285
Issue: 7
Pages: 4268-72
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Protein Coding Gene
MGI:1918367 | Rbbp5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915183 | Hcfc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2443014 | Ino80c
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916238 | Prpf31
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915023 | Kat8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
20200153 | -
First Author: Mazars R
Year: 2010
Journal: J Biol Chem
Title: The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.
Volume: 285
Issue: 18
Pages: 13364-71
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Publication
17355966 | -
First Author: Lee JH
Year: 2007
Journal: J Biol Chem
Title: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.
Volume: 282
Issue: 18
Pages: 13419-28
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Protein
Q3TQV0
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: false
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Protein
Q3URP1
Organism: Mus musculus/domesticus
Length: 737  
Fragment?: true
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Protein
D3YUD4
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
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Protein
D3YX07
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Protein
Q80XU6
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
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Protein
Q8C676
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein Coding Gene
MGI:1101759 | Rnf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96921 | Max
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915022 | Chd8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2152346 | Taf4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8CGY8
Organism: Mus musculus/domesticus
Length: 1046  
Fragment?: false
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Protein Coding Gene
MGI:1346348 | Taf7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109129 | Taf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96995 | Kmt2a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1888697 | Taf9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1928760 | Ruvbl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1342299 | Ruvbl2
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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