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Search results 101 to 200 out of 200 for Whrn

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0.039s
Type Details Score
GXD Expression
Probe: MGI:7852333
Assay Type: Immunohistochemistry
Annotation Date: 2025-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1906128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7852334
Age: postnatal day 6
Image: 3C'
Note: In this mutant xpression is only seen at the apical end of stereocilia.
Specimen Label: 3C'
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3653113
Assay Type: RNA in situ
Annotation Date: 2006-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1758220
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3653115
Age: embryonic day 12.5
Specimen Label: 3B
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3653113
Assay Type: RNA in situ
Annotation Date: 2006-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3573928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3653115
Age: postnatal day 7
Note: Expression is present in a subset of the ganglion cells.
Specimen Label: 3H
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:3653113
Assay Type: RNA in situ
Annotation Date: 2006-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3573928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3653115
Age: postnatal day 90
Note: Expression is present in a subset of the ganglion cells.
Specimen Label: 3I
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:3653113
Assay Type: RNA in situ
Annotation Date: 2006-08-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1821522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3653115
Age: embryonic day 14.5
Note: Expression is present in the ventral tegmental area.
Specimen Label: 3C
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3653113
Assay Type: RNA in situ
Annotation Date: 2006-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3653115
Age: embryonic day 10.5
Note: Expression is present in the neural epithelium, with the strongest staining in the ventral neural epithelium.
Specimen Label: 3A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3653113
Assay Type: RNA in situ
Annotation Date: 2006-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:3653115
Age: embryonic day 12.5
Note: Expression is present in the complete neuroepithelium, except in the neocortex.
Specimen Label: 3B
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3653113
Assay Type: RNA in situ
Annotation Date: 2006-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717120
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:3653115
Age: embryonic day 12.5
Note: Expression is present in the inner neuroblastic layer of the retina.
Specimen Label: 3D
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3653113
Assay Type: RNA in situ
Annotation Date: 2006-08-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1717122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3653115
Age: embryonic day 14.5
Note: Expression is present in the inner neuroblastic layer of the retina.
Specimen Label: 3E
Detected: true
Specimen Num: 5
Publication
First Author: Kikkawa Y
Year: 2005
Journal: Hum Mol Genet
Title: Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium.
Volume: 14
Issue: 3
Pages: 391-400
Publication
First Author: Sackler AM
Year: 1967
Journal: J Exp Zool
Title: Metabolic and endocrine differences between the mutation whirler and normal female mice.
Volume: 164
Issue: 2
Pages: 133-40
Publication
First Author: Belyantseva IA
Year: 2005
Journal: Nat Cell Biol
Title: Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia.
Volume: 7
Issue: 2
Pages: 148-56
Publication
First Author: Gosens I
Year: 2007
Journal: Hum Mol Genet
Title: MPP1 links the Usher protein network and the Crumbs protein complex in the retina.
Volume: 16
Issue: 16
Pages: 1993-2003
Publication
First Author: de Nooij JC
Year: 2015
Journal: J Neurosci
Title: The PDZ-domain protein Whirlin facilitates mechanosensory signaling in mammalian proprioceptors.
Volume: 35
Issue: 7
Pages: 3073-84
Publication
First Author: Rinchik EM
Year: 1994
Journal: Genetics
Title: Molecular genetics of the brown (b)-locus region of mouse chromosome 4. II. Complementation analyses of lethal brown deletions.
Volume: 137
Issue: 3
Pages: 855-65
Publication
First Author: Cryns K
Year: 2002
Journal: Genome Res
Title: Vestibular dysfunction in the epistatic circler mouse is caused by phenotypic interaction of one recessive gene and three modifier genes.
Volume: 12
Issue: 4
Pages: 613-7
Publication  
First Author: LANE PW
Year: 1963
Journal: J Hered
Title: WHIRLER MICE: A RECESSIVE BEHAVIOR MUTATION IN LINKAGE GROUP VIII.
Volume: 54
Pages: 263-6
Publication
First Author: Ciardo MG
Year: 2016
Journal: Biochim Biophys Acta
Title: Whirlin increases TRPV1 channel expression and cellular stability.
Volume: 1863
Issue: 1
Pages: 115-27
Publication  
First Author: Tian M
Year: 2014
Journal: Exp Eye Res
Title: Photoreceptors in whirler mice show defective transducin translocation and are susceptible to short-term light/dark changes-induced degeneration.
Volume: 118
Pages: 145-53
Publication
First Author: Rinchik EM
Year: 1994
Journal: Genetics
Title: Molecular genetics of the brown (b)-locus region of mouse chromosome 4. I. Origin and molecular mapping of radiation- and chemical-induced lethal brown deletions.
Volume: 137
Issue: 3
Pages: 845-54
Publication
First Author: Adato A
Year: 2005
Journal: Hum Mol Genet
Title: Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells.
Volume: 14
Issue: 24
Pages: 3921-32
Publication
First Author: Manor U
Year: 2011
Journal: Curr Biol
Title: Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.
Volume: 21
Issue: 2
Pages: 167-72
Publication
First Author: Delprat B
Year: 2005
Journal: Hum Mol Genet
Title: Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly.
Volume: 14
Issue: 3
Pages: 401-10
Publication
First Author: Mburu P
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Whirlin complexes with p55 at the stereocilia tip during hair cell development.
Volume: 103
Issue: 29
Pages: 10973-8
Publication
First Author: Wright RN
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: RpgrORF15 connects to the usher protein network through direct interactions with multiple whirlin isoforms.
Volume: 53
Issue: 3
Pages: 1519-29
Publication
First Author: Mburu P
Year: 2003
Journal: Nat Genet
Title: Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.
Volume: 34
Issue: 4
Pages: 421-8
Publication
First Author: van Wijk E
Year: 2006
Journal: Hum Mol Genet
Title: The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1.
Volume: 15
Issue: 5
Pages: 751-65
Publication  
First Author: Lane PW
Year: 1968
Journal: Mouse News Lett
Title: New allele of diabetes.
Volume: 38
Pages: 24
Publication
First Author: Prosser HM
Year: 2008
Journal: Mol Cell Biol
Title: Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.
Volume: 28
Issue: 5
Pages: 1702-12
Publication        
First Author: IMGC
Year: 2014
Title: Abstracts for the IMGC2014 meeting (October, 2014)
Publication  
First Author: Mauriac SA
Year: 2017
Journal: Nat Commun
Title: Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.
Volume: 8
Pages: 14907
Publication  
First Author: Paige AJW
Year: 1997
Journal: Genet Res
Title: Genetic and physical mapping in the vicinity of the wi locus on mouse Chromosome 4
Volume: 70
Pages: 85 (Abstr.)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication
First Author: Yang J
Year: 2010
Journal: PLoS Genet
Title: Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss.
Volume: 6
Issue: 5
Pages: e1000955
Publication
First Author: Grati M
Year: 2012
Journal: J Neurosci
Title: Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the Usher syndrome protein network.
Volume: 32
Issue: 41
Pages: 14288-93
Publication
First Author: Michel V
Year: 2020
Journal: Sci Rep
Title: Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.
Volume: 10
Issue: 1
Pages: 16430
Publication
First Author: Lewis MA
Year: 2009
Journal: Nat Genet
Title: An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.
Volume: 41
Issue: 5
Pages: 614-8
Publication
First Author: Etournay R
Year: 2010
Journal: Development
Title: Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.
Volume: 137
Issue: 8
Pages: 1373-83
Publication
First Author: British Society of Audiology short papers meeting on experimental studies of hearing and deafness. Cambridge, United Kingdom, 22-23 September 1996. Kiernan BW
Year: 1997
Journal: Br J Audiol
Title: Analysis of the deaf mouse mutant, whirler.
Volume: 31
Issue: 2
Pages: 73-132 (84-5 Abstr.)
Publication
First Author: Maerker T
Year: 2008
Journal: Hum Mol Genet
Title: A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells.
Volume: 17
Issue: 1
Pages: 71-86
Publication
First Author: Fleming J
Year: 1994
Journal: Genomics
Title: Linkage analysis of the whirler deafness gene on mouse chromosome 4.
Volume: 21
Issue: 1
Pages: 42-8
Publication
First Author: Rogers MJ
Year: 1999
Journal: Mamm Genome
Title: Genetic mapping of the whirler mutation.
Volume: 10
Issue: 5
Pages: 513-9
Publication
First Author: Zou J
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors.
Volume: 52
Issue: 5
Pages: 2343-51
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Dunbar LA
Year: 2019
Journal: EMBO Mol Med
Title: Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.
Volume: 11
Issue: 9
Pages: e10288
Publication  
First Author: Cosgrove D
Year: 2014
Journal: Int J Biochem Cell Biol
Title: Usher protein functions in hair cells and photoreceptors.
Volume: 46
Pages: 80-9
Publication
First Author: Giese APJ
Year: 2017
Journal: Nat Commun
Title: CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
Volume: 8
Issue: 1
Pages: 43
Publication
First Author: Michalski N
Year: 2007
Journal: J Neurosci
Title: Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.
Volume: 27
Issue: 24
Pages: 6478-88
Publication
First Author: Akturk A
Year: 2022
Journal: Sci Adv
Title: RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.
Volume: 8
Issue: 42
Pages: eabq2826
Publication
First Author: Grimsley-Myers CM
Year: 2009
Journal: J Neurosci
Title: The small GTPase Rac1 regulates auditory hair cell morphogenesis.
Volume: 29
Issue: 50
Pages: 15859-69
Publication  
First Author: Potter PK
Year: 2016
Journal: Nat Commun
Title: Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.
Volume: 7
Pages: 12444
Publication      
First Author: The Mammalian Genetics Unit at Harwell
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK
Publication
First Author: Schilling K
Year: 2009
Journal: Cerebellum
Title: The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.
Volume: 8
Issue: 4
Pages: 477-89
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
Publication
First Author: Lewandowski JP
Year: 2015
Journal: Dev Biol
Title: Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Volume: 406
Issue: 1
Pages: 92-103
Publication  
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Allele
Name: PDZ domain containing 7; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: whirlin; targeted mutation 1, Tiansen Li
Allele Type: Targeted
Attribute String: Modified isoform(s), Null/knockout
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Genotype
Symbol: Pdzd7/Pdzd7
Background: involves: C57BL/6J * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
Allele  
Name: whirlin; whirler
Allele Type: Spontaneous
Genotype
Symbol: Whrn/Whrn
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rpe65<450L>/Rpe65<450L> Whrn/Whrn
Background: 129.Cg(B6)-Whrn
Zygosity: cx
Has Mutant Allele: true
DO Term
Genotype
Symbol: Whrn/Whrn
Background: involves: C57BL/6J * STOCK a Tyrp1 Myo5a Oca2

Ednrb

Zygosity: hm
Has Mutant Allele: true
DO Term
Allele
Name: transgene insertion ES699, Nathaniel Heintz
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: mutant stock, transgenic
Publication
First Author: Kersten FF
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Association of whirlin with Cav1.3 (alpha1D) channels in photoreceptors, defining a novel member of the usher protein network.
Volume: 51
Issue: 5
Pages: 2338-46
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME