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Search results 101 to 197 out of 197 for Wrn

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Type Details Score
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
10628995 | J:95127
First Author: Wang L
Year: 2000
Journal: Genetics
Title: Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.
Volume: 154
Issue: 1
Pages: 357-62
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Gene
282835 | Wrnip1
Type: gene
Organism: rat
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Gene
462392 | WRNIP1
Type: gene
Organism: chimpanzee
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Gene
478698 | WRNIP1
Type: gene
Organism: dog, domestic
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Gene
788824 | WRNIP1
Type: gene
Organism: cattle
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Gene
405856 | wrnip1
Type: gene
Organism: zebrafish
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Gene
707250 | WRNIP1
Type: gene
Organism: macaque, rhesus
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HT Experiment
E-GEOD-14549 | Transcription profiling of mouse liver from wild type and Wrn mutant animals with or without vitamin C treatment
Series Id: GSE14549
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
O09053
Organism: Mus musculus/domesticus
Length: 1401  
Fragment?: false
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Publication
29483835 | J:319607
First Author: Si X
Year: 2018
Journal: Int J Biol Sci
Title: Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency.
Volume: 14
Issue: 2
Pages: 165-177
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Allele
Wrn<em1Smoc> | MGI:7293192
Name: Werner syndrome RecQ like helicase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Tg(CAG-WRN*K577M)5025Wcl | MGI:3525073
Name: transgene insertion 5025, Warren C Ladiges
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6429799 | C57BL/6JSmoc-Wrn<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Tg(CAG-WRN*K577M)5025Wcl/?
Background: involves: C3H * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Publication
12034829 | -
First Author: Liu H
Year: 2002
Journal: Nucleic Acids Res
Title: Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.
Volume: 30
Issue: 11
Pages: 2417-26
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Allele
Wrn<tm1Led> | MGI:2156622
Name: Werner syndrome RecQ like helicase; targeted mutation 1, Philip Leder
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Wrn<tm1Lgu> | MGI:2386438
Name: Werner syndrome RecQ like helicase; targeted mutation 1, Leonard Guarente
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:3525264 | B6.Cg-Tg(CAG-WRN*K577M)5025Wcl/Mmmh
Attribute String: congenic, mutant strain, transgenic
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Publication
18639560 | J:139038
First Author: Yamamoto ML
Year: 2008
Journal: Mutat Res
Title: Effects of human Werner helicase on intrachromosomal homologous recombination mediated DNA deletions in mice.
Volume: 644
Issue: 1-2
Pages: 11-6
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Transgene
MGI:3525072 | Tg(CAG-WRN*K577M)5025Wcl
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Wrn/Wrn
Background: B6.129S6(BKSW)-Wrn
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:5688 | Werner syndrome
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Genotype
Genotype
Symbol: Terc/Terc Wrn/Wrn
Background: involves: 129/Sv * BALB/c * C57BL/6 * SLJ
Zygosity: cx
Has Mutant Allele: true
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Allele
Terc<tm1Rdp> | MGI:1857930
Name: telomerase RNA component; targeted mutation 1, Ronald DePinho
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
9288107 | -
First Author: Gray MD
Year: 1997
Journal: Nat Genet
Title: The Werner syndrome protein is a DNA helicase.
Volume: 17
Issue: 1
Pages: 100-3
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Publication
9697700 | -
First Author: Yan H
Year: 1998
Journal: Nat Genet
Title: Replication focus-forming activity 1 and the Werner syndrome gene product.
Volume: 19
Issue: 4
Pages: 375-8
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Publication
9224595 | -
First Author: Suzuki N
Year: 1997
Journal: Nucleic Acids Res
Title: DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.
Volume: 25
Issue: 15
Pages: 2973-8
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Publication
33926956 | -
First Author: Pezo V
Year: 2021
Journal: Science
Title: Noncanonical DNA polymerization by aminoadenine-based siphoviruses.
Volume: 372
Issue: 6541
Pages: 520-524
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Publication
15377656 | -
First Author: Andraos N
Year: 2004
Journal: J Biol Chem
Title: The highly processive DNA polymerase of bacteriophage T5. Role of the unique N and C termini.
Volume: 279
Issue: 48
Pages: 50609-18
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Protein Domain
IPR002562 | 3'-5'_exonuclease_dom
Type: Domain
Description: This entry represents the domain that is responsible for the 3'-5' exonuclease proofreading activity of Escherichia coli DNA polymerase I (polI) and other enzymes which catalyse the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI and is also found in the Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (also known as Werner syndrome helicase), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D) [].Werner syndrome is a human genetic disorder causing premature ageing; the WRN protein has helicase activity in the 3'-5' direction [, ]. The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein []. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.This domain is also found in some DNA polymerases from phages, including the DNA polymerase from Escherichia phage T5, exonucleolytic activity [], and the DNA polymerase DpoZ from Acinetobacter phage SH-Ab 15497, which preferentially incorporates the non-canonical base aminoadenine/dZTP instead of adenine into the synthesized DNA [].
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Publication
11979727 | J:85891
First Author: Ichikawa K
Year: 2002
Journal: Nihon Yakurigaku Zasshi
Title: [Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases].
Volume: 119
Issue: 4
Pages: 219-26
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Protein
Q8CDF7
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q8VEG4
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
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Protein
Q3TZ13
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
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Protein
B2RWQ8
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q3UIJ1
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
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Protein
A0A1W2P7Q1
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
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Protein Domain
IPR010997 | HRDC-like_sf
Type: Homologous_superfamily
Description: This superfamily represents the HRDC (helicase and RNaseD C-terminal) domain, which comprises two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein. The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM (previously known as Werner and Bloom syndrome proteins) []. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed α-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin [, ].
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Publication
17587522 | J:126579
First Author: Cheng WH
Year: 2007
Journal: Exp Gerontol
Title: Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.
Volume: 42
Issue: 9
Pages: 871-8
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Publication
31754102 | J:283828
First Author: Fang EF
Year: 2019
Journal: Nat Commun
Title: NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.
Volume: 10
Issue: 1
Pages: 5284
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Protein
Q99KY7
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: true
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Gene
4000 | LMNA
Type: gene
Organism: human
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Publication
10647186 | -
First Author: Liu Z
Year: 1999
Journal: Structure
Title: The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Volume: 7
Issue: 12
Pages: 1557-66
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Publication
15591044 | -
First Author: Armache KJ
Year: 2005
Journal: J Biol Chem
Title: Structures of complete RNA polymerase II and its subcomplex, Rpb4/7.
Volume: 280
Issue: 8
Pages: 7131-4
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Protein
P56960
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
Q9CYJ3
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: false
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Protein
Q8R2R0
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
F6VYQ6
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Protein
Q3UNK6
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
Q8K366
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Publication
9397680 | -
First Author: Morozov V
Year: 1997
Journal: Trends Biochem Sci
Title: A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases.
Volume: 22
Issue: 11
Pages: 417-8
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Protein
A0A0J9YVE5
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: false
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Protein
A0A0U1RPP0
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
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Protein
A0A0U1RPS3
Organism: Mus musculus/domesticus
Length: 42  
Fragment?: true
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Protein Domain
IPR002121 | HRDC_dom
Type: Domain
Description: The HRDC (helicase and RNaseD C-terminal) domain is comprised of two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein. It has been suggested that this domain plays a role dissolving double Holliday junctions efficiently [].HRDC domains are found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM [, ]. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed alpha-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin [, ].The HRDC domain has a putative role in nucleic acid binding. Mutations in the HRDC domain associated with the human BLM gene result in Bloom Syndrome (BS), an autosomal recessive disorder characterised by proportionate pre- and postnatal growth deficiency; sun-sensitive, telangiectatic, hypo- and hyperpigmented skin; predisposition to malignancy; and chromosomal instability [].
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Protein Domain
IPR044876 | HRDC_dom_sf
Type: Homologous_superfamily
Description: The HRDC (helicase and RNaseD C-terminal) domain is comprised of two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein. It has been suggested that this domain plays a role dissolving double Holliday junctions efficiently [].HRDC domains are found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM [, ]. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed alpha-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin [, ].The HRDC domain has a putative role in nucleic acid binding. Mutations in the HRDC domain associated with the human BLM gene result in Bloom Syndrome (BS), an autosomal recessive disorder characterised by proportionate pre- and postnatal growth deficiency; sun-sensitive, telangiectatic, hypo- and hyperpigmented skin; predisposition to malignancy; and chromosomal instability [].
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Publication
11167012 | J:67348
First Author: Ohhata T
Year: 2000
Journal: Gene
Title: Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RecQ helicase protein-like 4.
Volume: 261
Issue: 2
Pages: 251-8
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Publication
17961633 | J:141467
First Author: Pereira M
Year: 2007
Journal: Mech Ageing Dev
Title: Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.
Volume: 128
Issue: 11-12
Pages: 609-17
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Publication
19145458 | J:144991
First Author: Paul E
Year: 2009
Journal: Mamm Genome
Title: Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.
Volume: 20
Issue: 2
Pages: 92-108
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Publication
23519127 | J:274834
 
First Author: Bopp A
Year: 2013
Journal: Cell Death Dis
Title: Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging.
Volume: 4
Pages: e558
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Publication
31757807 | J:284953
First Author: Morales C
Year: 2020
Journal: J Biol Chem
Title: PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.
Volume: 295
Issue: 1
Pages: 146-157
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Publication
31523200 | J:282261
First Author: Zhao J
Year: 2019
Journal: Int J Biol Sci
Title: p53 Mutant p53N236S Induces Neural Tube Defects in Female Embryos.
Volume: 15
Issue: 9
Pages: 2006-2015
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Publication
22296597 | J:214934
First Author: Croteau DL
Year: 2012
Journal: Aging Cell
Title: RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity.
Volume: 11
Issue: 3
Pages: 456-66
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Publication
19741171 | J:356528
First Author: Massip L
Year: 2010
Journal: FASEB J
Title: Vitamin C restores healthy aging in a mouse model for Werner syndrome.
Volume: 24
Issue: 1
Pages: 158-72
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Publication
25901030 | -
First Author: Newman JA
Year: 2015
Journal: Nucleic Acids Res
Title: Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.
Volume: 43
Issue: 10
Pages: 5221-35
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Protein
Q3TRD0
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: true
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Protein
Q8BWH5
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: true
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Publication
11741548 | -
First Author: Todone F
Year: 2001
Journal: Mol Cell
Title: Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex.
Volume: 8
Issue: 5
Pages: 1137-43
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Protein
Q3TMV6
Organism: Mus musculus/domesticus
Length: 789  
Fragment?: false
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Protein
Q3TB25
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: true
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Protein
O88700
Organism: Mus musculus/domesticus
Length: 1416  
Fragment?: false
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Protein
E9PZ97
Organism: Mus musculus/domesticus
Length: 1419  
Fragment?: false
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Protein
A0A1B0GR54
Organism: Mus musculus/domesticus
Length: 1158  
Fragment?: false
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Protein
O35427
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
Q9D7M8
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
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Protein
A0A0J9YU23
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
A0A3Q4L2S8
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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