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Search results 101 to 170 out of 170 for Ythdc2

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-21
Strength: Present
Sex: Female
Emaps: EMAPS:1796523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6724542
Age: embryonic day 15.5
Image: 5-S1I
Specimen Label: 5-S1I
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-21
Strength: Absent
Sex: Male
Emaps: EMAPS:3148228
Stage: TS28
Assay Id: MGI:6724542
Age: postnatal adult
Image: 1E
Note: No expression in spermatogonia next to tubule wall.
Specimen Label: 1E
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6694252
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6716019
Age: postnatal day 8
Image: 9d Meioc+/+ 8-dpp
Specimen Label: 9d Meioc+/+ 8-dpp
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6694252
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6716019
Age: postnatal day 16
Image: 9d Meioc+/+ 16-dpp
Specimen Label: 9d Meioc+/+ 16-dpp
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6694252
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-18
Strength: Weak
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6716019
Age: postnatal day 8
Image: 9d Meioc-/- 8-dpp
Specimen Label: 9d Meioc-/- 8-dpp
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6694252
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-18
Strength: Weak
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6716019
Age: postnatal day 16
Image: 9d Meioc-/- 16-dpp
Specimen Label: 9d Meioc-/- 16-dpp
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-21
Strength: Strong
Sex: Male
Emaps: EMAPS:3148428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6724542
Age: postnatal adult
Image: 1E
Note: Strongly expressed in spermatocytes. Expression localized primarily to cytoplasm.
Specimen Label: 1E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-21
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6724542
Age: postnatal adult
Image: 9A
Note: Expression in spermatocytes distributed throughout cytoplasm; also concentrated in perinuclear puncta.
Specimen Label: 9A
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-21
Strength: Present
Sex: Male
Emaps: EMAPS:3147628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6724542
Age: postnatal adult
Image: 1D
Note: Expression in a subset of germ cells in a majority of seminiferous tubules.
Specimen Label: 1D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-21
Strength: Absent
Sex: Male
Emaps: EMAPS:3147628
Stage: TS28
Assay Id: MGI:6724542
Age: postnatal day 10
Image: 1-S1A
Specimen Label: 1-S1A
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-21
Strength: Present
Sex: Male
Emaps: EMAPS:3147628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6724542
Age: postnatal day 12
Image: 1-S1B
Note: Expression increased between postnatal day 10 to day 12.
Specimen Label: 1-S1B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-21
Strength: Present
Sex: Male
Emaps: EMAPS:3147628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6724542
Age: postnatal day 14
Image: 1-S1C
Specimen Label: 1-S1C
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-21
Strength: Present
Sex: Male
Emaps: EMAPS:3147628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6724542
Age: postnatal day 14
Image: 2-S1F
Specimen Label: 2-S1F
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-21
Strength: Absent
Sex: Male
Emaps: EMAPS:3147628
Stage: TS28
Assay Id: MGI:6724542
Age: postnatal day 14
Image: 2-S1G
Specimen Label: 2-S1G
Detected: false
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2023-01-26
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7428718
Age: postnatal day 15
Image: 6B Wild-type
Note: Expression in zygotene and zygotene-like germ cells.
Specimen Label: 6B Wild-type
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6724494
Assay Type: Immunohistochemistry
Annotation Date: 2023-01-26
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7428718
Age: postnatal day 15
Image: 6B Meioc-/-
Note: Expression in zygotene and zygotene-like germ cells at levels comparable to wild-type.
Specimen Label: 6B Meioc-/-
Detected: true
Specimen Num: 2
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Publication
35874829 | J:327184
 
First Author: Xiao Z
Year: 2022
Journal: Front Cell Dev Biol
Title: The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.
Volume: 10
Pages: 882994
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Publication
39367406 | J:355331
First Author: Mao Y
Year: 2024
Journal: J Neuroinflammation
Title: Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance.
Volume: 21
Issue: 1
Pages: 249
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Publication
37269288 | J:337931
First Author: Li L
Year: 2023
Journal: Cell Rep
Title: Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells.
Volume: 42
Issue: 6
Pages: 112596
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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UniProt Feature
UniProt Feature
Begin: 1
Description: 3'-5' RNA helicase YTHDC2
Type: chain
End: 1445
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Protein
A0A0J9YV44
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: true
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Protein
B2RR83
Organism: Mus musculus/domesticus
Length: 1445  
Fragment?: false
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GXD Expression
GXD Expression
Probe: MGI:6694235
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6716028
Age: postnatal day 16
Image: 9c
Note: Meioc expression co-localized with Ythdc2 in the cytoplasm of spermatocytes.
Specimen Label: 9c
Detected: true
Specimen Num: 1
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Protein
A2AG06
Organism: Mus musculus/domesticus
Length: 965  
Fragment?: false
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Protein
A0A0R3P9D4
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: true
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Protein Domain
IPR027963 | MEIOC
Type: Family
Description: In mice, MEIOC is required for meiosis completion in both male and female germ cells []. It interacts with YTHDC2 and maintains an extended meiotic prophase I in mice []. In humans, it is encoded for on the chromosomal position C17orf104.
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Publication
24269672 | -
First Author: Tanabe A
Year: 2014
Journal: Gene
Title: Transcriptional machinery of TNF-α-inducible YTH domain containing 2 (YTHDC2) gene.
Volume: 535
Issue: 1
Pages: 24-32
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Protein Domain
IPR031083 | YTHDC2-like
Type: Family
Description: This entry represents the 3'-5' RNA helicase YTHDC2 (YTH domain containing 2) from mammals and related proteins. Proteins in this family belong to the DExD/H-box family of ATP-dependent RNA helicases, whose members play multifunctional roles in processes of RNA the metabolism of RNA including transcription, alternative RNA splicing, and RNA degradation []. They bind several mitotic RNAs necessary for terminal differentiation. The presence of the YTH domain allows these proteins to recognise and bind N6-methyadenosine modified fraction of RNAs [, ]. These proteins have a conserved, functional role as critical regulators of the transition from mitosis to meiosis in the germline and ensures the successful progress of the meiotic division. They are indispensable functional binding partners of MEIOC, a meiosis-specific protein thought to regulate male and female meiosis by controlling the stability of various mRNAs []. Human YTHDC2 plays an important role in tumour cells growth [].
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HT Experiment
GSE93566 | Regulation of the transition from mitosis to meiosis by the conserved RNA-helicase YTHDC2/BGCN [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
38884383 | J:352963
 
First Author: Pfaltzgraff NG
Year: 2024
Journal: Development
Title: Destabilization of mRNAs enhances competence to initiate meiosis in mouse spermatogenic cells.
Volume: 151
Issue: 14
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Publication
17242355 | -
First Author: Villén J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Large-scale phosphorylation analysis of mouse liver.
Volume: 104
Issue: 5
Pages: 1488-93
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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