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Search results 1001 to 1100 out of 1329 for Amh

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Type Details Score
MP Term
Protein
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
Interaction Experiment
Description: SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro.
GXD Expression
Probe: MGI:6514836
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-05
Strength: Present
Sex: Male
Emaps: EMAPS:2909822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6514887
Age: embryonic day 14.5
Image: 8A left
Note: Pax8-positive cells were found co-expressing Amh at the mesonephric border of the testis at E14.5.
Specimen Label: 8A left
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:5317435
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-05
Strength: Present
Sex: Male
Emaps: EMAPS:2909822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6514865
Age: embryonic day 14.5
Image: 8A right
Note: Sox9-positive cells were found co-expressing Amh at the mesonephric border of the testis at E14.5.
Specimen Label: 8A right
Detected: true
Specimen Num: 13
Publication
First Author: Imbeaud S
Year: 1994
Journal: Hum Mol Genet
Title: Molecular genetics of the persistent müllerian duct syndrome: a study of 19 families.
Volume: 3
Issue: 1
Pages: 125-31
Protein Domain
Type: Domain
Description: Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation []. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism []. This family represents the N-terminal part of the protein, which is not thought to be essential for activity []. AMH contains a TGF-beta domain (), at the C terminus.
GXD Expression
Probe: MGI:6514836
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-05
Strength: Present
Sex: Male
Emaps: EMAPS:1868524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6514887
Age: embryonic day 16.5
Image: 8C left
Note: Pax8-positive cells were found co-expressing Amh at the border between testis cords and the rete testis at E16.5.
Specimen Label: 8C left
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:5317435
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-05
Strength: Present
Sex: Male
Emaps: EMAPS:1868524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6514865
Age: embryonic day 16.5
Image: 8C right
Note: Sox9-positive cells were found co-expressing Amh at the border between testis cords and the rete testis at E16.5.
Specimen Label: 8C right
Detected: true
Specimen Num: 15
Publication  
First Author: Sargur Madabushi S
Year: 2022
Journal: Front Oncol
Title: Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease.
Volume: 12
Pages: 969429
Publication  
First Author: Piechnik M
Year: 2022
Journal: Int J Mol Sci
Title: Sex Difference Leads to Differential Gene Expression Patterns and Therapeutic Efficacy in Mucopolysaccharidosis IVA Murine Model Receiving AAV8 Gene Therapy.
Volume: 23
Issue: 20
Allele
Name: anti-Mullerian hormone; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: transgene insertion 27, Ilpo Huhtaniemi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
GXD Expression  
Probe: MGI:5009424
Assay Type: Immunohistochemistry
Annotation Date: 2019-11-06
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6369818
Age: postnatal day 20
Note: Expression of the immature Sertoli cell marker Amh has largely been turned off in the control testis. Whereas germ cells labeled with Gcna were present in all seminiferous tubules of the control testis.
Specimen Label: 6K,M,O Control
Detected: true
Specimen Num: 7
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Allele
Name: transgene insertion, Ilpo Huhtaniemi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion, Yumiko Saga
Allele Type: Transgenic
Attribute String: Recombinase
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Bayraktar OA
Year: 2020
Journal: Nat Neurosci
Title: Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.
Volume: 23
Issue: 4
Pages: 500-509
Allele
Name: transgene insertion 8815, Robert E Braun
Allele Type: Transgenic
Attribute String: Recombinase
Genotype
Symbol: Tg(AMH-Fshr)27Hht/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(AMH-Fshr*D580Y)#Hht/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Tan KA
Year: 2005
Journal: Endocrinology
Title: The role of androgens in sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor.
Volume: 146
Issue: 6
Pages: 2674-83
Publication
First Author: Lécureuil C
Year: 2002
Journal: Genesis
Title: Sertoli and granulosa cell-specific Cre recombinase activity in transgenic mice.
Volume: 33
Issue: 3
Pages: 114-8
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: transgenic, congenic
Allele
Name: transgene insertion, Joanna E Burdette
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
Allele
Name: transgene insertion, Satoshi Inoue
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: transgene insertion, Satoshi Inoue
Allele Type: Transgenic
Attribute String: Epitope tag
Publication
First Author: di Clemente N
Year: 2003
Journal: Mol Cell Endocrinol
Title: Components of the anti-Müllerian hormone signaling pathway in gonads.
Volume: 211
Issue: 1-2
Pages: 9-14
Protein Domain
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Protein kinases are a group of enzymes that possess a catalytic subunit, which transfers the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues (such as serine, threonine, or tyrosine) in a substrate protein's side chain, resulting in a conformational change affecting protein function. Protein kinase function has been evolutionarily conserved from Escherichia coli to Homo sapiens (Human), where they play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation [].The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Anti-Mullerian hormone (AMH), also called Mullerian inhibiting substance, is a member of the transforming growth factor beta (TGF-beta) family that represses the development and function of reproductive organs []. Anti-Mullerian hormone is thought to exert its effects through two membrane-bound serine/threonine kinase receptors, type 2 and type 1. Upon ligand binding, these drive receptor-specific cytoplasmic substrates, the Smad molecules, into the nucleus where they act as transcription factors. A type 2 receptor specific for AMH was cloned through its homology with receptors of TGF-beta family members. Components of the AMH signalling pathway have been identified in gonads and gonadal cell lines. The AMH type II receptor is highly specific. In contrast, the identity of the AMH type I receptor is not clear.
Publication
First Author: Lim P
Year: 2009
Journal: Endocrinology
Title: Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis.
Volume: 150
Issue: 10
Pages: 4755-65
Allele
Name: pleckstrin homology domain containing, family A member 5; transgene insertion 1, Florian Guillou
Allele Type: Transgenic
Attribute String: No functional change, Recombinase
Publication
First Author: Walker WH
Year: 2015
Journal: PLoS One
Title: Restoration of spermatogenesis and male fertility using an androgen receptor transgene.
Volume: 10
Issue: 3
Pages: e0120783
Publication
First Author: Wu Y
Year: 2022
Journal: Cell Death Dis
Title: UHRF1 establishes crosstalk between somatic and germ cells in male reproduction.
Volume: 13
Issue: 4
Pages: 377
Publication
First Author: Chen F
Year: 2022
Journal: Biol Reprod
Title: ARHGEF15 in Sertoli cells contributes to germ cell development and testicular immune privilege†.
Volume: 107
Issue: 6
Pages: 1565-1579
Publication
First Author: Liu Y
Year: 2020
Journal: FEBS J
Title: JMY expression by Sertoli cells contributes to mediating spermatogenesis in mice.
Volume: 287
Issue: 24
Pages: 5478-5497
Allele
Name: transgene insertion, Ilpo Huhtaniemi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 14, Ilpo Huhtaniemi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 2, Teresa K Woodruff
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
Strain
Attribute String: transgenic, mutant strain, coisogenic
Genotype
Symbol: Tg(Amh-SMAD2*)#Jebu/?
Background: FVB/N-Tg(Amh-SMAD2*)#Jebu
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Jmy/Jmy Tg(Amh-cre)8815Reb/?
Background: involves: 129S * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Uhrf1/Uhrf1 Tg(Amh-cre)8815Reb/?
Background: involves: C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mirc1/Mirc1 Tg(Amh-cre)8815Reb/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Arhgef15/Arhgef15 Tg(Amh-cre)8815Reb/?
Background: involves: 129S1/SvImJ * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Imhoff FM
Year: 2013
Journal: FEBS Lett
Title: The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors.
Volume: 587
Issue: 12
Pages: 1749-53
Publication
First Author: Payen E
Year: 1995
Journal: Anim Genet
Title: Sheep gene mapping: assignment of ALDOB, CYP19, WT and SOX2 by somatic cell hybrid analysis.
Volume: 26
Issue: 5
Pages: 331-3
Publication
First Author: Quartuccio SM
Year: 2013
Journal: PLoS One
Title: Conditional inactivation of p53 in mouse ovarian surface epithelium does not alter MIS driven Smad2-dominant negative epithelium-lined inclusion cysts or teratomas.
Volume: 8
Issue: 5
Pages: e65067
Strain
Attribute String: mutant stock, transgenic
Publication
First Author: Xiao Y
Year: 2012
Journal: PLoS One
Title: Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways.
Volume: 7
Issue: 7
Pages: e41097
Publication
First Author: Meng J
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Androgens regulate the permeability of the blood-testis barrier.
Volume: 102
Issue: 46
Pages: 16696-700
Publication
First Author: Zhang H
Year: 2020
Journal: Biol Reprod
Title: Loss of Fbxw7 in Sertoli cells impairs testis development and causes infertility in mice†.
Volume: 102
Issue: 4
Pages: 963-974
Publication  
First Author: Yan RG
Year: 2020
Journal: Animals (Basel)
Title: E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice.
Volume: 10
Issue: 9
Publication
First Author: Xie M
Year: 2022
Journal: Biol Reprod
Title: Loss of Raptor induces Sertoli cells into an undifferentiated state in mice.
Volume: 107
Issue: 4
Pages: 1125-1138
Publication
First Author: Kuroki S
Year: 2015
Journal: Genesis
Title: Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination.
Volume: 53
Issue: 6
Pages: 387-93
Publication
First Author: Wen Y
Year: 2021
Journal: Theranostics
Title: hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9.
Volume: 11
Issue: 20
Pages: 10030-10046
Publication
First Author: Luo X
Year: 2024
Journal: BMC Biol
Title: Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.
Volume: 22
Issue: 1
Pages: 176
Publication
First Author: Bristol-Gould SK
Year: 2005
Journal: Endocrinology
Title: The development of a mouse model of ovarian endosalpingiosis.
Volume: 146
Issue: 12
Pages: 5228-36
Genotype
Symbol: Ar/? Tg(Amh-cre)8815Reb/?
Background: involves: 129S4/SvJaeSor * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Plekha5/Plekha5<+>
Background: involves: C57BL/6 * SJL
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Tg(AMH-Fshr*D580H)14Hht/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(AMH-Fshr*D580H)#Hht/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Elmo1/Elmo1 Tg(Amh-cre)8815Reb/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Pofut1/Pofut1 Tg(Amh-cre)#Ysa/?
Background: involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Plekha5/Plekha5<+>
Background: involves: C57BL/6 * C57BL/6J * SJL
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Plekha5/Plekha5
Background: involves: C57BL/6 * C57BL/6J * SJL
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(Amh-SMAD2*)2Tkw/?
Background: involves: CD-1
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Amh-SMAD2*)#Jebu/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ar/Ar<+> Tg(Amh-cre)8815Reb/?
Background: 129S(FVB)-Ar
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ranbp9/Ranbp9 Tg(Amh-cre)8815Reb/?
Background: involves: 129 * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rptor/Rptor Tg(Amh-cre)8815Reb/?
Background: involves: 129S/SvEv * 129S1/SvImJ * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rheb/Rheb Tg(Amh-cre)8815Reb/?
Background: involves: 129S1/SvImJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ggcx/Ggcx Tg(AMH-cre)#Sinos/?
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Meig1/Meig1 Tg(Amh-cre)8815Reb/?
Background: involves: 129S1/SvImJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Fbxw7/Fbxw7 Tg(Amh-cre)8815Reb/?
Background: involves: 129 * C57BL/6 * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mlx/Mlx Tg(Amh-cre)8815Reb/?
Background: involves: 129S4/SvJaeSor * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Arid4b/Arid4b Tg(Amh-cre)8815Reb/?
Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Arid4b/Arid4b<+> Tg(Amh-cre)8815Reb/?
Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Plekha5/Plekha5<+>
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Srsf2/Srsf2 Tg(Amh-cre)8815Reb/?
Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Patek CE
Year: 2005
Journal: Transgenic Res
Title: Gonadal effects of a mouse Denys-Drash syndrome mutation.
Volume: 14
Issue: 5
Pages: 691-702
Publication
First Author: Lourenço D
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Loss-of-function mutation in GATA4 causes anomalies of human testicular development.
Volume: 108
Issue: 4
Pages: 1597-602
Publication
First Author: Grootegoed JA
Year: 1994
Journal: Mol Cell Endocrinol
Title: Welcome to the family: the anti-müllerian hormone receptor.
Volume: 100
Issue: 1-2
Pages: 29-34
Publication
First Author: Harley VR
Year: 1994
Journal: Mol Reprod Dev
Title: The biochemical role of SRY in sex determination.
Volume: 39
Issue: 2
Pages: 184-93
Publication
First Author: Anisimov SV
Year: 2002
Journal: Genomics
Title: A quantitative and validated SAGE transcriptome reference for adult mouse heart.
Volume: 80
Issue: 2
Pages: 213-22
Publication
First Author: Li H
Year: 2009
Journal: PLoS One
Title: Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis.
Volume: 4
Issue: 10
Pages: e7501
Publication
First Author: Denolet E
Year: 2006
Journal: Mol Endocrinol
Title: The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice.
Volume: 20
Issue: 2
Pages: 321-34
Publication
First Author: Meng J
Year: 2011
Journal: Biol Reprod
Title: Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.
Volume: 85
Issue: 2
Pages: 254-60
Publication  
First Author: O'Shaughnessy PJ
Year: 2009
Journal: Reprod Biol Endocrinol
Title: Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice.
Volume: 7
Pages: 88
Publication
First Author: Wang G
Year: 2009
Journal: J Androl
Title: Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice.
Volume: 30
Issue: 3
Pages: 338-48
Publication
First Author: Zhou W
Year: 2010
Journal: Biol Reprod
Title: Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice.
Volume: 83
Issue: 5
Pages: 759-66
Publication
First Author: Nalam RL
Year: 2010
Journal: PLoS One
Title: Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction.
Volume: 5
Issue: 7
Pages: e11797
Publication
First Author: Nalam RL
Year: 2009
Journal: Mol Endocrinol
Title: Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells.
Volume: 23
Issue: 11
Pages: 1900-13
Publication
First Author: Maezawa S
Year: 2023
Journal: Cell Death Dis
Title: PRC1 suppresses a female gene regulatory network to ensure testicular differentiation.
Volume: 14
Issue: 8
Pages: 501