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Search results 1001 to 1100 out of 1214 for Bcl6

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Type Details Score
Allele
Bcor<tm2a(EUCOMM)Wtsi> | MGI:4455952
Name: BCL6 interacting corepressor; targeted mutation 2a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Bcorl1<tm2a(KOMP)Wtsi> | MGI:5299591
Name: BCL6 co-repressor-like 1; targeted mutation 2a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Bcor<tm1.1Vjba> | MGI:5925306
Name: BCL6 interacting corepressor; targeted mutation 1.1, Vivian J Bardwell
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Bcor<tm1.1Aiwa> | MGI:6154387
Name: BCL6 interacting corepressor; targeted mutation 1.1, Atsushi Iwama
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Bcor<tm1Pspt> | MGI:7861690
Name: BCL6 interacting corepressor; targeted mutation 1, Paolo Sportoletti
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Bcorl1<em1(IMPC)Tcp> | MGI:7256769
Name: BCL6 co-repressor-like 1; endonuclease-mediated mutation 1, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Bcor<em1Gpt> | MGI:7295876
Name: BCL6 interacting corepressor; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Bcorl1<em6Gpt> | MGI:7295877
Name: BCL6 co-repressor-like 1; endonuclease-mediated mutation 6, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Bcorl1<em1Smoc> | MGI:7288463
Name: BCL6 co-repressor-like 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Bcor<tm2Vjba> | MGI:7398100
Name: BCL6 interacting corepressor; targeted mutation 2, Vivian J Bardwell
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout
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Allele
Bcor<tm2.1Vjba> | MGI:7398101
Name: BCL6 interacting corepressor; targeted mutation 2.1, Vivian J Bardwell
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Bcor/?
Background: chimera involves: 129P2/OlaHsd
Zygosity: ot
Has Mutant Allele: true
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Regulatory Region
MGI:7444369 | Rr394
Type: enhancer
Organism: mouse, laboratory
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Publication
28262675 | J:244308
 
First Author: Lefebure M
Year: 2017
Journal: Nat Commun
Title: Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene.
Volume: 8
Pages: 14581
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Allele
Bcl6<em1Smoc> | MGI:7288457
Name: B cell leukemia/lymphoma 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
25557390 | -
First Author: Baron BW
Year: 2015
Journal: Biochim Biophys Acta
Title: The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases.
Volume: 1852
Issue: 5
Pages: 742-8
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Interaction Experiment
Sanchez C (2007)
Description: Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.
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Publication
36138028 | J:333961
First Author: Feng D
Year: 2022
Journal: Nat Commun
Title: Chromatin organizer SATB1 controls the cell identity of CD4(+) CD8(+) double-positive thymocytes by regulating the activity of super-enhancers.
Volume: 13
Issue: 1
Pages: 5554
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Publication
36443290 | J:350070
First Author: Takano J
Year: 2022
Journal: Nat Commun
Title: PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment.
Volume: 13
Issue: 1
Pages: 7159
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Allele
Bcor<Gt(IST13937F1)Tigm> | MGI:5194460
 
Name: BCL6 interacting corepressor; gene trap IST13937F1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Bcor<Gt(IST14238F4)Tigm> | MGI:5219149
 
Name: BCL6 interacting corepressor; gene trap IST14238F4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Bcor<Gt(IST14679B10)Tigm> | MGI:5251308
 
Name: BCL6 interacting corepressor; gene trap IST14679B10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Bcor<Gt(IST14685C3)Tigm> | MGI:5251782
 
Name: BCL6 interacting corepressor; gene trap IST14685C3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Bcor<Gt(IST14861C9)Tigm> | MGI:5269469
 
Name: BCL6 interacting corepressor; gene trap IST14861C9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Bcorl1<Gt(IST15052G2)Tigm> | MGI:5279927
 
Name: BCL6 co-repressor-like 1; gene trap IST15052G2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:6470548 | B6N.129S1(Cg)-Bcor<tm1.1Vjba>/J
Attribute String: mutant strain, congenic, targeted mutation
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Strain
MGI:7861692 | STOCK Bcor<tm1Pspt>/Cnrm
Attribute String: targeted mutation, mutant stock
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Allele
Bcorl1<em1Nju> | MGI:6764605
Name: BCL6 co-repressor-like 1; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7514794 | C57BL/6NCrl-Bcorl1<em1(IMPC)Tcp>/TcpMmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7720871 | C57BL/6NCrl-Bcorl1<em1(IMPC)Tcp>/Cmmr
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7316930 | C57BL/6N-Bcorl1<em1(IMPC)Tcp>/Cmmr
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6767140 | C57BL/6JGpt-Bcorl1<em6Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6770586 | C57BL/6JSmoc-Bcorl1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Bcor/?
Background: chimera involves: 129S1/Sv * 129X1/SvJ
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcor/?
Background: chimera involves: 129P2/OlaHsd
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcor/?
Background: chimera involves: 129S2/SvPas
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcor/?
Background: chimera involves: 129S2/SvPas
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcor/?
Background: involves: 129S1/Sv
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcorl1/?
Background: C57BL/6NCrl-Bcorl1/Cmmr
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcorl1/Bcorl1
Background: C57BL/6NCrl-Bcorl1/Cmmr
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcorl1/?
Background: C57BL/6N-Bcorl1/Cmmr
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcorl1/Bcorl1
Background: C57BL/6N-Bcorl1/Cmmr
Zygosity: hm
Has Mutant Allele: true
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Publication
31471323 | J:294563
First Author: Isshiki Y
Year: 2019
Journal: Blood Adv
Title: KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.
Volume: 3
Issue: 17
Pages: 2537-2549
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Allele
Ighm<tm1(Bcl6)Rdf> | MGI:3581517
Name: immunoglobulin heavy constant mu; targeted mutation 1, Riccardo Dalla-Favera
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6428223 | C57BL/6JSmoc-Bcl6<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
12776190 | J:87004
First Author: Srinivasan RS
Year: 2003
Journal: Oncogene
Title: The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor.
Volume: 22
Issue: 22
Pages: 3395-406
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Strain
MGI:6765291 | C57BL/6J-Bcorl1<em1Nju>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Bcorl1/?
Background: C57BL/6J-Bcorl1
Zygosity: ot
Has Mutant Allele: true
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Publication
17828269 | -
First Author: Phan RT
Year: 2007
Journal: Nat Immunol
Title: Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.
Volume: 8
Issue: 10
Pages: 1132-9
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Publication
23166356 | -
First Author: Basso K
Year: 2012
Journal: J Exp Med
Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.
Volume: 209
Issue: 13
Pages: 2455-65
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Allele
Tg(Lck-Bcl6)83Tto | MGI:3056268
Name: transgene insertion 83, Takahashi Tokuhisa
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
16943429 | -
First Author: Gearhart MD
Year: 2006
Journal: Mol Cell Biol
Title: Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets.
Volume: 26
Issue: 18
Pages: 6880-9
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Publication
37219943 | J:337823
 
First Author: Apollonio B
Year: 2023
Journal: J Clin Invest
Title: Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma.
Volume: 133
Issue: 13
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Allele
Rr394<em1Bhao> | MGI:7444371
Name: regulatory region 394; endonuclease-mediated mutation 1, Bingtao Hao
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region, Null/knockout
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Genotype
Genotype
Symbol: Ighm/?
Background: involves: 129/Sv * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Publication
15314041 | J:93656
First Author: Takamori M
Year: 2004
Journal: Int Immunol
Title: BAZF is required for activation of naive CD4 T cells by TCR triggering.
Volume: 16
Issue: 10
Pages: 1439-49
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Genotype
Genotype
Symbol: Bcor/? Commd10/Commd10<+>
Background: involves: 129S1/Sv * C57BL/6 * CBA/Ca
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcor/? H2az2/H2az2<+>
Background: involves: 129S1/Sv * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcor/? Pax3/Pax3<+>
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcor/Bcor<+> Tmem163/Tmem163<+>
Background: involves: 129S1/Sv * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcor/? Tmem163/Tmem163<+>
Background: involves: 129S1/Sv * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcor/? Isl1/Isl1<+>
Background: involves: 129S1/Sv
Zygosity: cn
Has Mutant Allele: true
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Publication
23911289 | -
First Author: Hatzi K
Year: 2013
Journal: Cell Rep
Title: A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.
Volume: 4
Issue: 3
Pages: 578-88
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Publication
32692983 | J:296645
First Author: Hamline MY
Year: 2020
Journal: Dev Biol
Title: OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the Polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR.
Volume: 468
Issue: 1-2
Pages: 110-132
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DO Term
DOID:0081064 | BN2 diffuse large B-cell lymphoma
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Allele
Tg(tetO-BCL6)1Bbn | MGI:3512421
Name: transgene insertion 1, Beverly Baron
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Allele
Tg(tetO-BCL6)2Bbn | MGI:3512423
Name: transgene insertion 2, Beverly Baron
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Genotype
Genotype
Symbol: Rr394/Rr394
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Publication
31915197 | J:285817
First Author: Mondello P
Year: 2020
Journal: Cancer Discov
Title: Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma.
Volume: 10
Issue: 3
Pages: 440-459
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Genotype
Genotype
Symbol: Bcor/Bcor<+> Isl1/Isl1<+>
Background: involves: 129S1/Sv
Zygosity: cn
Has Mutant Allele: true
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Publication
27694924 | J:241036
First Author: Hasegawa N
Year: 2017
Journal: Leukemia
Title: Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.
Volume: 31
Issue: 4
Pages: 861-871
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Publication
22253232 | J:181490
First Author: Jeon BN
Year: 2012
Journal: Cancer Res
Title: KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A.
Volume: 72
Issue: 5
Pages: 1137-48
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Publication
18066064 | J:131307
First Author: Pasqualucci L
Year: 2008
Journal: Nat Genet
Title: AID is required for germinal center-derived lymphomagenesis.
Volume: 40
Issue: 1
Pages: 108-12
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Genotype
Genotype
Symbol: Bcl6/Bcl6 Ighm/?
Background: involves: 129/Sv * 129S1/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
30538335 | J:282416
First Author: Hatzi K
Year: 2019
Journal: Nat Immunol
Title: Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.
Volume: 20
Issue: 1
Pages: 86-96
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Publication
27705745 | J:238637
   
First Author: Rose NR
Year: 2016
Journal: Elife
Title: RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.
Volume: 5
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HT Experiment
E-GEOD-22371 | Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex
Series Id: GSE22371
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
25490438 | J:217524
First Author: Chiang C
Year: 2014
Journal: Cancer Cell
Title: Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression.
Volume: 26
Issue: 6
Pages: 773-774
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Publication
27505665 | J:234910
First Author: Zeisig BB
Year: 2016
Journal: Cancer Cell
Title: Combinatorial Tethering: A Novel Mode to Recruit Non-canonical PRC1 for Normal and Malignant GC B Cell Development.
Volume: 30
Issue: 2
Pages: 185-187
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Publication
33432228 | J:302194
First Author: Rivas MA
Year: 2021
Journal: Nat Immunol
Title: Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Volume: 22
Issue: 2
Pages: 240-253
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Strain
MGI:5755469 | B6.Cg-Atmin<tm1.1Jhh> Ighm<tm1(Bcl6)Rdf> Tg(Fcer2a-cre)5Mbu
Attribute String: transgenic, targeted mutation, mutant strain, congenic
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Publication
26702068 | J:232584
First Author: Bedekovics T
Year: 2016
Journal: Blood
Title: UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
Volume: 127
Issue: 12
Pages: 1564-74
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Genotype
Genotype
Symbol: Atmin/Atmin Ighm/Ighm<+> Tg(Fcer2a-cre)5Mbu/?
Background: B6.Cg-Atmin Ighm Tg(Fcer2a-cre)5Mbu
Zygosity: cn
Has Mutant Allele: true
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Publication
17873332 | -
First Author: Rengaraj D
Year: 2007
Journal: Endocrine
Title: Expression and regulation of type II integral membrane protein family members in mouse male reproductive tissues.
Volume: 31
Issue: 2
Pages: 193-201
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Publication
19747390 | -
 
First Author: Hedlund J
Year: 2009
Journal: BMC Res Notes
Title: BRICHOS - a superfamily of multidomain proteins with diverse functions.
Volume: 2
Pages: 180
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Publication
24099305 | -
First Author: Knight SD
Year: 2013
Journal: Biochemistry
Title: The BRICHOS domain, amyloid fibril formation, and their relationship.
Volume: 52
Issue: 43
Pages: 7523-31
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Publication
24831988 | J:217351
First Author: Tai TS
Year: 2014
Journal: PLoS One
Title: Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells.
Volume: 9
Issue: 5
Pages: e96535
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Publication
16027166 | -
First Author: Fotinopoulou A
Year: 2005
Journal: J Biol Chem
Title: BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
Volume: 280
Issue: 35
Pages: 30768-72
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Publication
20036644 | -
First Author: Peng S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1-23) and amyloid beta-peptide (Abeta1-40): Implications for Bri2 effects on processing of amyloid precursor protein and Abeta aggregation.
Volume: 393
Issue: 3
Pages: 356-61
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Publication
19366692 | -
First Author: Matsuda S
Year: 2009
Journal: J Biol Chem
Title: BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.
Volume: 284
Issue: 23
Pages: 15815-25
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Protein Domain
IPR040145 | ITM2
Type: Family
Description: The family of type 2 integral membrane protein (ITM2) consists of three members, ITM2A, ITM2B and ITM2C []. Members of this family contain a BRICHOS domain, which possesses chaperone activity [,].ITM2A is a target gene of GATA-3, a T cell-specific transcription factor [].ITM2B is proteolytically cleaved at three locations; cleavage by furin in the C-terminal region generates a 23-residue peptide (ABri23), processing by ADAM10 results in release of the BRICHOS domain from the membrane-bound N-terminal part and intramembrane cleavage by SPPL2a/2b liberates the intracellular domain []. ITM2B (BRI2) is a target of BCL6 transcriptional repression and a short form of the ITM2B protein, similarly to other targets of BCL6, induces apoptosis in hematopoietic cell lines []. ITM2B interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production [, ]. ITM2C (BRI3) also inhibits amyloid precursor protein processing, but through a different mechanism to ITM2B [].
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Publication
- | J:322048
     
First Author: The Centre for Phenogenomics
Year: 2022
Journal: MGI Direct Data Submission
Title: Direct Data Submission for The Centre for Phenogenomics Alleles.
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Publication
12522145 | J:177167
First Author: Tomsig JL
Year: 2003
Journal: J Biol Chem
Title: Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.
Volume: 278
Issue: 12
Pages: 10048-54
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Publication
26385350 | J:231111
First Author: Gu X
Year: 2016
Journal: Blood
Title: AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.
Volume: 127
Issue: 1
Pages: 102-12
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Publication
22143888 | J:179049
First Author: Wesemann DR
Year: 2011
Journal: J Exp Med
Title: Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination.
Volume: 208
Issue: 13
Pages: 2733-46
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Publication
34050029 | J:306418
 
First Author: Fangazio M
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma.
Volume: 118
Issue: 22
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Publication
11358382 | J:69193
First Author: Hori M
Year: 2001
Journal: Blood Cells Mol Dis
Title: Non-Hodgkin lymphomas of mice.
Volume: 27
Issue: 1
Pages: 217-22
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Protein
Q91VK4
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
Q61500
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
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Protein
O89051
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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