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Search results 1001 to 1069 out of 1069 for Brd4

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Type Details Score
Genotype
Genotype
Symbol: Bicra/Bicra<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Publication
14755058 | J:88183
First Author: Hong HK
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice.
Volume: 101
Issue: 6
Pages: 1748-53
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Publication
12016511 | J:76561
First Author: Chae TH
Year: 2002
Journal: Mamm Genome
Title: Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7.
Volume: 13
Issue: 5
Pages: 239-44
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Protein Domain
IPR024310 | NUT
Type: Family
Description: The gene encoding Nuclear Testis (NUT) protein is found fused to BRD3 or BRD4 genes in some aggressive types of carcinoma due to chromosomal translocations [, ]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [, ]. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein function. NUT has a Nuclear Export Sequence (NES) as well as a Nuclear Localization Signal (NLS), both located towards the C-terminal end of the protein [, ]. A fused NUT-GFP protein has shown either cytoplasmic or nuclear localisation, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B, an inhibitor of CRM1-dependent nuclear export, has been shown to result in re-distribution of NUT-GFP to the nucleus [, ].
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Protein Domain
IPR024309 | NUT_N
Type: Domain
Description: This domain is found in the N-terminal region of Nuclear Testis (NUT) proteins. The NUT gene is found fused to BRD3 or BRD4 genes in some aggressive types of carcinoma, due to chromosomal translocations [, ]. The BRD family proteins contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [, ]. BRD proteins are crucial for the regulation of cell cycle progression. The function of NUT proteins is not clear. NUT proteins contain the Nuclear Export Sequence (NES) and the Nuclear Localisation Signal (NLS), both located towards the C-terminal end of the protein [, ]. NUT-GFP protein showed either cytoplasmic or nuclear localisation, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B an inhibitor of CRM1-dependent nuclear export resulted in re-distribution of NUT-GFP to the nucleus [, ]. Inspection of NUT revealed a C-terminal sequence similar to known nuclear export NUT protein carries some natively unstructured sequence.
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Protein
Q8BHP2
Organism: Mus musculus/domesticus
Length: 1126  
Fragment?: false
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Protein
Q3V0C3
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
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Publication
9323133 | -
First Author: Fornerod M
Year: 1997
Journal: Cell
Title: CRM1 is an export receptor for leucine-rich nuclear export signals.
Volume: 90
Issue: 6
Pages: 1051-60
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Publication
12543779 | -
First Author: French CA
Year: 2003
Journal: Cancer Res
Title: BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.
Volume: 63
Issue: 2
Pages: 304-7
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Publication
17934517 | -
First Author: French CA
Year: 2008
Journal: Oncogene
Title: BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.
Volume: 27
Issue: 15
Pages: 2237-42
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Publication
9311922 | -
First Author: Ossareh-Nazari B
Year: 1997
Journal: Science
Title: Evidence for a role of CRM1 in signal-mediated nuclear protein export.
Volume: 278
Issue: 5335
Pages: 141-4
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Publication
29374058 | J:283189
First Author: Alpsoy A
Year: 2018
Journal: J Biol Chem
Title: Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.
Volume: 293
Issue: 11
Pages: 3892-3903
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Publication
27292648 | J:238297
First Author: Hertweck A
Year: 2016
Journal: Cell Rep
Title: T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex.
Volume: 15
Issue: 12
Pages: 2756-70
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Publication
34138732 | J:315950
 
First Author: Kim SK
Year: 2021
Journal: Sci Adv
Title: Functional coordination of BET family proteins underlies altered transcription associated with memory impairment in fragile X syndrome.
Volume: 7
Issue: 21
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Publication
38968937 | J:352035
     
First Author: Yu J
Year: 2024
Journal: Cell
Title: Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance.
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Publication
26814967 | J:261247
First Author: Lin CY
Year: 2016
Journal: Nature
Title: Active medulloblastoma enhancers reveal subgroup-specific cellular origins.
Volume: 530
Issue: 7588
Pages: 57-62
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Publication
24444712 | J:211600
First Author: Cho H
Year: 2014
Journal: Cancer Discov
Title: RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis.
Volume: 4
Issue: 3
Pages: 318-33
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Publication
29424686 | J:316369
   
First Author: Sacta MA
Year: 2018
Journal: Elife
Title: Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages.
Volume: 7
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Publication
26058079 | J:222915
First Author: Stratikopoulos EE
Year: 2015
Journal: Cancer Cell
Title: Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy.
Volume: 27
Issue: 6
Pages: 837-51
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Publication
29339447 | J:257434
First Author: Xiao X
Year: 2018
Journal: J Exp Med
Title: Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation.
Volume: 215
Issue: 2
Pages: 559-574
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Publication
23430699 | J:198307
First Author: Puissant A
Year: 2013
Journal: Cancer Discov
Title: Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
Volume: 3
Issue: 3
Pages: 308-23
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Publication
24394663 | J:208690
First Author: Roderick JE
Year: 2014
Journal: Blood
Title: c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
Volume: 123
Issue: 7
Pages: 1040-50
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Publication
32989249 | J:307869
First Author: Lynch CJ
Year: 2020
Journal: Nat Cell Biol
Title: Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.
Volume: 22
Issue: 10
Pages: 1223-1238
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Publication
32382029 | J:288979
First Author: Gaub A
Year: 2020
Journal: Nat Commun
Title: Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation.
Volume: 11
Issue: 1
Pages: 2243
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Publication
31182641 | J:293999
 
First Author: Van de Velde S
Year: 2019
Journal: Mol Cell Biol
Title: CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers.
Volume: 39
Issue: 17
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Publication
35839775 | J:331767
First Author: Chen IP
Year: 2022
Journal: Cell Rep
Title: Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.
Volume: 40
Issue: 3
Pages: 111088
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Publication
36918560 | J:339798
First Author: Du J
Year: 2023
Journal: Nat Commun
Title: BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism.
Volume: 14
Issue: 1
Pages: 1413
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Publication
28249162 | J:255858
First Author: Hogg SJ
Year: 2017
Journal: Cell Rep
Title: BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.
Volume: 18
Issue: 9
Pages: 2162-2174
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Publication
30270106 | J:269010
First Author: Cai L
Year: 2018
Journal: Mol Cell
Title: ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer.
Volume: 72
Issue: 2
Pages: 341-354.e6
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Publication
32482868 | J:290657
First Author: Devaiah BN
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: MYC protein stability is negatively regulated by BRD4.
Volume: 117
Issue: 24
Pages: 13457-13467
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Publication
33431824 | J:300982
First Author: Latif AL
Year: 2021
Journal: Nat Commun
Title: BRD4-mediated repression of p53 is a target for combination therapy in AML.
Volume: 12
Issue: 1
Pages: 241
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Publication
31747612 | J:306460
First Author: Uppal S
Year: 2019
Journal: Cell Rep
Title: The Bromodomain Protein 4 Contributes to the Regulation of Alternative Splicing.
Volume: 29
Issue: 8
Pages: 2450-2460.e5
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Publication
36922511 | J:334067
First Author: Murakami S
Year: 2023
Journal: Nat Commun
Title: Spontaneously evolved progenitor niches escape Yap oncogene addiction in advanced pancreatic ductal adenocarcinomas.
Volume: 14
Issue: 1
Pages: 1443
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Publication
31594641 | J:291392
First Author: Song H
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Targeting cyclin-dependent kinase 9 sensitizes medulloblastoma cells to chemotherapy.
Volume: 520
Issue: 2
Pages: 250-256
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Publication
30226831 | J:270524
First Author: Zhang P
Year: 2018
Journal: J Clin Invest
Title: Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.
Volume: 128
Issue: 12
Pages: 5383-5398
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Publication
25877301 | J:223341
First Author: Zhou X
Year: 2015
Journal: Hum Mol Genet
Title: Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
Volume: 24
Issue: 14
Pages: 3982-93
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Publication
23420887 | J:194462
First Author: Belkina AC
Year: 2013
Journal: J Immunol
Title: BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.
Volume: 190
Issue: 7
Pages: 3670-8
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Publication
23921552 | J:200067
First Author: Sarai N
Year: 2013
Journal: EMBO J
Title: WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.
Volume: 32
Issue: 17
Pages: 2392-406
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Publication
29449372 | J:263691
First Author: Akuffo AA
Year: 2018
Journal: J Biol Chem
Title: Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.
Volume: 293
Issue: 16
Pages: 6187-6200
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Publication
32603312 | J:301924
 
First Author: Antolic A
Year: 2020
Journal: JCI Insight
Title: BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy.
Volume: 5
Issue: 15
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Publication
32730594 | J:303716
First Author: Yoshino S
Year: 2021
Journal: Blood
Title: Trib1 promotes acute myeloid leukemia progression by modulating the transcriptional programs of Hoxa9.
Volume: 137
Issue: 1
Pages: 75-88
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Publication
23752175 | J:204257
First Author: Schmidt J
Year: 2013
Journal: Leukemia
Title: Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276.
Volume: 27
Issue: 12
Pages: 2357-65
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Publication
27443262 | J:239430
First Author: Donato E
Year: 2017
Journal: Leukemia
Title: Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors.
Volume: 31
Issue: 2
Pages: 479-490
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Publication
26855180 | J:255671
First Author: Duan Q
Year: 2016
Journal: Biochim Biophys Acta
Title: Super enhancers at the miR-146a and miR-155 genes contribute to self-regulation of inflammation.
Volume: 1859
Issue: 4
Pages: 564-71
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Publication
26989780 | J:260575
First Author: Ghari F
Year: 2016
Journal: Sci Adv
Title: Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.
Volume: 2
Issue: 2
Pages: e1501257
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Publication
29444854 | J:265775
First Author: Brown JD
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: BET bromodomain proteins regulate enhancer function during adipogenesis.
Volume: 115
Issue: 9
Pages: 2144-2149
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Publication
28955901 | J:268423
 
First Author: Inamochi Y
Year: 2016
Journal: Biochem Biophys Rep
Title: Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression.
Volume: 7
Pages: 150-156
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Publication
31023785 | J:277111
First Author: Korfhage J
Year: 2019
Journal: Mol Cancer Res
Title: Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside.
Volume: 17
Issue: 7
Pages: 1417-1428
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Publication
30876800 | J:283885
First Author: Kohnken R
Year: 2019
Journal: J Invest Dermatol
Title: Preclinical Targeting of MicroRNA-214 in Cutaneous T-Cell Lymphoma.
Volume: 139
Issue: 9
Pages: 1966-1974.e3
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Publication
31792058 | J:285038
First Author: Werner MT
Year: 2020
Journal: J Biol Chem
Title: Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.
Volume: 295
Issue: 7
Pages: 1898-1914
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Publication
32997115 | J:297426
First Author: Ishikura S
Year: 2020
Journal: Nucleic Acids Res
Title: ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B-H4K8ac-BRD4 axis.
Volume: 48
Issue: 19
Pages: 10848-10866
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Publication
29180399 | J:319301
First Author: Kohnken R
Year: 2018
Journal: Blood
Title: Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma.
Volume: 131
Issue: 7
Pages: 771-781
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Publication
34944697 | J:356138
 
First Author: Schreiber J
Year: 2021
Journal: Biomedicines
Title: BET Proteins Regulate Expression of Osr1 in Early Kidney Development.
Volume: 9
Issue: 12
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Protein
Q9ESU6
Organism: Mus musculus/domesticus
Length: 1400  
Fragment?: false
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Protein
Q91Y44
Organism: Mus musculus/domesticus
Length: 956  
Fragment?: false
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Protein
Q3UH70
Organism: Mus musculus/domesticus
Length: 1401  
Fragment?: false
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Publication
29180474 | J:256312
First Author: Mustafi S
Year: 2018
Journal: Cancer Res
Title: Vitamin C Sensitizes Melanoma to BET Inhibitors.
Volume: 78
Issue: 2
Pages: 572-583
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Publication
12465718 | J:86755
First Author: Okazaki N
Year: 2002
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 9
Issue: 5
Pages: 179-88
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
12477932 | J:82808
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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