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Search results 1001 to 1100 out of 2972 for Ca2

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_17
Specimen Label: euxassay_007703_17
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_09
Specimen Label: euxassay_007703_09
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_10
Specimen Label: euxassay_007703_10
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_11
Specimen Label: euxassay_007703_11
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_12
Specimen Label: euxassay_007703_12
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_13
Specimen Label: euxassay_007703_13
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_14
Specimen Label: euxassay_007703_14
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_15
Specimen Label: euxassay_007703_15
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_16
Specimen Label: euxassay_007703_16
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_17
Specimen Label: euxassay_007703_17
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_18
Specimen Label: euxassay_007703_18
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_06
Specimen Label: euxassay_007703_06
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_16
Specimen Label: euxassay_007703_16
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_01
Specimen Label: euxassay_007703_01
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_02
Specimen Label: euxassay_007703_02
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_03
Specimen Label: euxassay_007703_03
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_04
Specimen Label: euxassay_007703_04
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_05
Specimen Label: euxassay_007703_05
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_06
Specimen Label: euxassay_007703_06
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_07
Specimen Label: euxassay_007703_07
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_08
Specimen Label: euxassay_007703_08
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_09
Specimen Label: euxassay_007703_09
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_10
Specimen Label: euxassay_007703_10
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_11
Specimen Label: euxassay_007703_11
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_12
Specimen Label: euxassay_007703_12
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_13
Specimen Label: euxassay_007703_13
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_14
Specimen Label: euxassay_007703_14
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_15
Specimen Label: euxassay_007703_15
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_16
Specimen Label: euxassay_007703_16
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_17
Specimen Label: euxassay_007703_17
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_18
Specimen Label: euxassay_007703_18
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_19
Specimen Label: euxassay_007703_19
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_20
Specimen Label: euxassay_007703_20
Detected: true
Specimen Num: 20
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_21
Specimen Label: euxassay_007703_21
Detected: true
Specimen Num: 21
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_22
Specimen Label: euxassay_007703_22
Detected: true
Specimen Num: 22
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_23
Specimen Label: euxassay_007703_23
Detected: true
Specimen Num: 23
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GXD Expression
GXD Expression
 
Probe: MGI:4423770
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825053
Age: embryonic day 14.5
Image: euxassay_007703_24
Specimen Label: euxassay_007703_24
Detected: true
Specimen Num: 24
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Protein Coding Gene
MGI:98359 | Sox11
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22711986 | J:186714
First Author: Wang CF
Year: 2012
Journal: Mol Cell Biol
Title: Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.
Volume: 32
Issue: 16
Pages: 3321-32
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Publication
15336956 | -
First Author: Branca D
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Calpain-related diseases.
Volume: 322
Issue: 4
Pages: 1098-104
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Publication
22496808 | -
First Author: Bate N
Year: 2012
Journal: PLoS One
Title: Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.
Volume: 7
Issue: 4
Pages: e34461
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Publication
23940116 | -
First Author: Saraiva N
Year: 2013
Journal: J Cell Biol
Title: hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2.
Volume: 202
Issue: 4
Pages: 699-713
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Publication
20094891 | -
First Author: Magnaghi-Jaulin L
Year: 2010
Journal: Chromosoma
Title: Calpain 2 is required for sister chromatid cohesion.
Volume: 119
Issue: 3
Pages: 267-74
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Publication
26907807 | -
 
First Author: Liu Y
Year: 2016
Journal: Neuropharmacology
Title: A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation.
Volume: 105
Pages: 471-477
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Publication
23977256 | J:206427
First Author: Subramanian V
Year: 2013
Journal: PLoS One
Title: Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice.
Volume: 8
Issue: 8
Pages: e72214
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Publication
22435971 | -
First Author: Storr SJ
Year: 2012
Journal: J Cell Mol Med
Title: Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.
Volume: 16
Issue: 10
Pages: 2422-8
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Publication
16054132 | -
First Author: Shih M
Year: 2006
Journal: Exp Eye Res
Title: Biochemical properties of lens-specific calpain Lp85.
Volume: 82
Issue: 1
Pages: 146-52
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Publication
22427650 | -
First Author: Ho WC
Year: 2012
Journal: J Biol Chem
Title: Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Volume: 287
Issue: 19
Pages: 15458-65
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Protein Domain
IPR042736 | EFh_PEF_CAPN2
Type: Domain
Description: This entry represents the Ca2 -binding penta-EF-hand (PEF) domain found in CAPN2 (also known as Calpain 2). CAPN2 is a ubiquitously expressed Ca2 -dependent intracellular cysteine protease that contains a short N-terminal anchor helix, followed by a calpain cysteine protease (CysPc) domain, a C2-domain-like (C2L) domain, and a C-terminal Ca2 -binding penta-EF-hand (PEF) domain []. The catalytic subunit CAPN2 in complex with a regulatory subunit encoded by CAPNS1 forms an m-calpain heterodimer[]. CAPN2 acts as the key protease responsible for N-methyl-d-aspartic acid (NMDA)-induced cytoplasmic polyadenylation element-binding protein 3 (CPEB3) degradation in neurons []. It cleaves several components of the focal adhesion complex, such as FAK and talin, triggering disassembly of the complex at the rear of the cell []. The stimulation of CAPN2 activity is required for Golgi antiapoptotic proteins (GAAPs) to promote cleavage of FA kinase (FAK), cell spreading, and enhanced migration. calpain 2 is also involved in the onset of glial differentiation []. It regulates proliferation, survival, migration, and tumorigenesis of breast cancer cells through a PP2A-Akt-FoxO-p27(Kip1) signalling cascade []. Its expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer []. Moreover, CAPN2 may play a role in fundamental mitotic functions, such as the maintenance of sister chromatid cohesion []. The activation of CAPN2 plays an essential role in hippocampal synaptic plasticity and in learning and memory []. In the eye, CAPN2, together with a lens-specific variant of CAPN3, is responsible for proteolytic cleavages of alpha and beta-crystallin. Overactivated alpha and beta-crystallin can lead to cataract formation []. Sometimes, CAPN2 compensates for loss of CAPN1, and both calpain isoforms are involved in AngII-induced aortic aneurysm formation []. The main phosphorylation sites in m-calpain are Ser50 and Ser369/Thr370.
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Protein
Q8CGQ8
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
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Protein
Q99PD7
Organism: Mus musculus/domesticus
Length: 645  
Fragment?: false
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Protein
Q91WD8
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Protein
Q8BUN9
Organism: Mus musculus/domesticus
Length: 666  
Fragment?: false
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Protein
Q8C261
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
B2RQI4
Organism: Mus musculus/domesticus
Length: 586  
Fragment?: false
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Protein
A2ATP8
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
F7B0S9
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: true
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Protein
Q8BZJ3
Organism: Mus musculus/domesticus
Length: 449  
Fragment?: false
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Protein
Q8BYP4
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Protein
A0A0R4J0Z4
Organism: Mus musculus/domesticus
Length: 605  
Fragment?: false
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Protein
E9PUL6
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Protein
Q3UWW4
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
Q8VD29
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Publication
11399074 | -
First Author: Yaremchuk A
Year: 2001
Journal: J Mol Biol
Title: A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase.
Volume: 309
Issue: 4
Pages: 989-1002
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Publication
27220631 | -
First Author: Wang H
Year: 2016
Journal: J Mol Biol
Title: Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.
Volume: 428
Issue: 13
Pages: 2769-79
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Publication
27911714 | -
First Author: Nygren PJ
Year: 2016
Journal: Biochem Soc Trans
Title: Regulation of the phosphatase PP2B by protein-protein interactions.
Volume: 44
Issue: 5
Pages: 1313-1319
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Publication
15456812 | -
First Author: Colbran RJ
Year: 2004
Journal: J Neurosci
Title: Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity.
Volume: 24
Issue: 39
Pages: 8404-9
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Protein Domain
IPR043360 | PP2B
Type: Family
Description: PP2B (calcineurin) is a unique serine/threonine protein phosphatase in its regulation by a second messenger (calcium acting via calmodulin) [, ]. PP2B is involved in many biological processes including immune responses, the second messenger cAMP pathway, sodium/potassium ion transport in the nephron, cell cycle progression in lower eukaryotes, cardiac hypertrophy and memory formation. PP2B is highly conserved from yeast to humans, but is absent from plants. PP2B is a heterodimer consisting of a catalytic subunit (CnA) and a regulatory subunit (CnB); CnB contains four Ca2 binding motifs referred to as EF hands [].
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Protein Domain
IPR019181 | LSM12_ABD
Type: Domain
Description: This domain of approximately 100 residues is conserved from plants to humans. It is an anticodon-binding domain of a prolyl-tRNA synthetase []. It is found in Lms12 and homologues. Lsm12 is a putative RNA-binding and regulation protein that might be involved in mRNA degradation or tRNA splicing []. Recently, it was demonstrated that it binds nicotinic acid adenine dinucleotide phosphate (NAADP) that confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca2 release []. Therefore, further studies of the potential crosstalk between NAADP signaling and RNA regulation are required.
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Protein Domain
IPR030776 | RGS14
Type: Family
Description: RGS14 is a regulator of G protein signaling (RGS) protein. It regulates G protein nucleotide exchange and hydrolysis by acting as a GTPase-activating protein (GAP) through its RGS domain, and as a guanine nucleotide dissociation inhibitor (GDI) through its GoLoco motif [, ]. Both domains of RGS14 target members of the Gialpha subclass []. It is a microtubule-associated protein that may modulate microtubule dynamics and spindle formation []and play an essential role during mammalian cell division []. RGS14 regulates the activation of alphaMbeta2 integrin during phagocytosis []. It is a key regulator of signalling pathways linking synaptic plasticity in CA2 pyramidal neurons to hippocampal-based learning and memory [].
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Protein Domain
IPR027708 | Tnnt3
Type: Family
Description: The troponin (Tn) complex regulates calcium-induced muscle contraction. Tn contains three subunits, Ca2 binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT), which is required for Ca(2)-mediated activation of actomyosin ATPase activity [, ]. Three different troponin T genes that encode tissue-specific isoforms of subunit T have been found in mammals and birds, encoding cardiac (TNNT2), slow (TNNT1), and fast (TNNT3) skeletal muscle TnT isoforms [, , , ].This entry represents the fast (TNNT3) skeletal muscle TnT isoform. Defects in TNNT3 are a cause of distal arthrogryposis type 2B (DA2B); also known as arthrogryposis multiplex congenita, distal, type 2B (AMCD2B) [].
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Protein Domain
IPR040723 | cPLA2_C2
Type: Domain
Description: Cytosolic phospholipases A2 (cPLA2s) consist of a family of calcium-sensitive enzymes that function to generate lipid second messengers through hydrolysis of membrane-associated glycerophospholipids. In humans, the cPLA2 family contains six isoforms. Structural information of full length cPLA2alpha apo form, shows that it is composed of two domains; an N-terminal Ca2 + binding C2 domain and a C-terminal alpha/beta hydrolase core. This entry describes the N-terminal Ca2+ binding C2 domain which is composed of an eight-stranded antiparallel β-sandwich consisting of two four-stranded β-sheets. C2 domains are present in many lipid-binding proteins including Copines, CAPRI and Rabphilin-3A all of which are involved in membrane trafficking [].
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Protein Coding Gene
MGI:1922919 | Pik3r4
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Del(5Gtf2i-Fkbp6)1Vcam | MGI:5555958
Name: deletion, Chr5, Victoria Campuzano 1; deletion, Chr 5, Victoria Campuzano 1
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
10700183 | J:60753
First Author: Kaji K
Year: 2000
Journal: Nat Genet
Title: The gamete fusion process is defective in eggs of Cd9-deficient mice.
Volume: 24
Issue: 3
Pages: 279-82
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Publication
11856873 | J:75517
First Author: Barlow GM
Year: 2001
Journal: Cytogenet Cell Genet
Title: Down syndrome cell adhesion molecule is conserved in mouse and highly expressed in the adult mouse brain.
Volume: 94
Issue: 3-4
Pages: 155-62
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Publication
23026563 | J:196221
 
First Author: Chand D
Year: 2013
Journal: Mol Cell Neurosci
Title: C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells.
Volume: 52
Pages: 38-50
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Publication
21226776 | J:174651
First Author: Nullmeier S
Year: 2011
Journal: Eur J Neurosci
Title: Region-specific alteration of GABAergic markers in the brain of heterozygous reeler mice.
Volume: 33
Issue: 4
Pages: 689-98
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Publication
10818526 | J:62422
 
First Author: Han SH
Year: 2000
Journal: Ann N Y Acad Sci
Title: Marked hippocampal neuronal damage without motor deficits after mild concussive-like brain injury in apolipoprotein E-deficient mice.
Volume: 903
Pages: 357-65
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Publication
31787886 | J:310526
 
First Author: Williams Avram SK
Year: 2019
Journal: Front Behav Neurosci
Title: NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression.
Volume: 13
Pages: 218
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Publication
29355673 | J:268200
 
First Author: Chiang MC
Year: 2018
Journal: Behav Brain Res
Title: A role for CA3 in social recognition memory.
Volume: 354
Pages: 22-30
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Publication
31558805 | J:284208
First Author: Gottschling C
Year: 2019
Journal: Sci Rep
Title: Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.
Volume: 9
Issue: 1
Pages: 13939
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Publication
9573368 | J:47598
First Author: Nagatomo I
Year: 1998
Journal: Brain Res
Title: Influence of dietary zinc on convulsive seizures and hippocampal NADPH diaphorase-positive neurons in seizure susceptible EL mouse.
Volume: 789
Issue: 2
Pages: 213-20
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Publication
16352645 | J:105731
First Author: Bearzatto B
Year: 2006
Journal: FASEB J
Title: Targeted calretinin expression in granule cells of calretinin-null mice restores normal cerebellar functions.
Volume: 20
Issue: 2
Pages: 380-2
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Publication
10856223 | J:63046
First Author: Uetani N
Year: 2000
Journal: EMBO J
Title: Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice.
Volume: 19
Issue: 12
Pages: 2775-85
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Publication
21991391 | J:178118
First Author: Li Q
Year: 2011
Journal: PLoS One
Title: Timing specific requirement of microRNA function is essential for embryonic and postnatal hippocampal development.
Volume: 6
Issue: 10
Pages: e26000
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Publication
34616037 | J:326180
First Author: Wu X
Year: 2021
Journal: Nature
Title: 5-HT modulation of a medial septal circuit tunes social memory stability.
Volume: 599
Issue: 7883
Pages: 96-101
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Publication
23279039 | J:209048
First Author: Koike M
Year: 2013
Journal: Eur J Neurosci
Title: Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system.
Volume: 37
Issue: 5
Pages: 816-30
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Publication
31000699 | J:289193
First Author: Bygrave AM
Year: 2019
Journal: Transl Psychiatry
Title: Hippocampal-prefrontal coherence mediates working memory and selective attention at distinct frequency bands and provides a causal link between schizophrenia and its risk gene GRIA1.
Volume: 9
Issue: 1
Pages: 142
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Publication
25684537 | J:259602
 
First Author: Llewellyn KJ
Year: 2015
Journal: Neurobiol Dis
Title: Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome.
Volume: 76
Pages: 77-86
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Publication
35288531 | J:322955
First Author: Kilonzo K
Year: 2022
Journal: Transl Psychiatry
Title: Distinct contributions of GluA1-containing AMPA receptors of different hippocampal subfields to salience processing, memory and impulse control.
Volume: 12
Issue: 1
Pages: 102
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Publication
16782076 | J:111191
First Author: Tehranian R
Year: 2006
Journal: Brain Res
Title: Transgenic mice that overexpress the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury.
Volume: 1101
Issue: 1
Pages: 126-35
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Publication
19261862 | J:146759
First Author: DeVito LM
Year: 2009
Journal: J Neurosci
Title: Vasopressin 1b receptor knock-out impairs memory for temporal order.
Volume: 29
Issue: 9
Pages: 2676-83
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Publication
23817783 | J:310180
First Author: Evans PR
Year: 2014
Journal: J Comp Neurol
Title: Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain.
Volume: 522
Issue: 1
Pages: 186-203
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Publication
36971428 | J:350529
First Author: Samadi M
Year: 2023
Journal: Hippocampus
Title: Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.
Volume: 33
Issue: 6
Pages: 730-744
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Publication
16014715 | J:99812
First Author: D'Hooge R
Year: 2005
Journal: J Neurosci
Title: Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis.
Volume: 25
Issue: 28
Pages: 6539-49
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Publication
33075309 | J:300855
 
First Author: Ikawa F
Year: 2021
Journal: Brain Res
Title: Detailed neuronal distribution of GPR3 and its co-expression with EF-hand calcium-binding proteins in the mouse central nervous system.
Volume: 1750
Pages: 147166
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Publication
20796170 | J:165716
First Author: Wang H
Year: 2010
Journal: J Neurochem
Title: The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice.
Volume: 115
Issue: 2
Pages: 385-98
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Publication
25133820 | J:223142
First Author: Purohit P
Year: 2014
Journal: PLoS One
Title: The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.
Volume: 9
Issue: 8
Pages: e103976
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Publication
30152044 | J:266981
First Author: Augé E
Year: 2018
Journal: Glia
Title: Astrocytes and neurons produce distinct types of polyglucosan bodies in Lafora disease.
Volume: 66
Issue: 10
Pages: 2094-2107
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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