| Type |
Details |
Score |
| Allele |
| Name: |
CD40 ligand; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, targeted mutation, congenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
CD40 antigen; endonuclease-mediated mutation 3, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
inbred strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Allele |
| Name: |
CD40 ligand; targeted mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
CD40 antigen; endonuclease-mediated mutation 4, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
CD40 ligand; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40/Cd40 |
| Background: |
B6.129P2-Cd40/J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40/Cd40 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/Cd40lg |
| Background: |
involves: 129S2/SvPas * C57BL/6J * BALB/c |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40/Cd40 |
| Background: |
B6.129S1-Cd40 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/? |
| Background: |
involves: 129S2/SvPas * C57BL/6 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/Cd40lg |
| Background: |
involves: 129S2/SvPas * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/? |
| Background: |
B6.129S2-Cd40lg/J |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/Cd40lg |
| Background: |
C57BL/6J-Cd40lg |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40/Cd40 |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/? |
| Background: |
involves: C57BL/6J |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/Cd40lg |
| Background: |
involves: C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/? |
| Background: |
involves: 129S2/SvPas * C57BL/6 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/? |
| Background: |
B6.129S2-Cd40lg/J |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40/Cd40 |
| Background: |
C57BL/6J-Cd40 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40/Cd40 |
| Background: |
C57BL/6J-Cd40 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40/Cd40 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
567
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
264
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
224
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
161
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iannacone M |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. |
| Volume: |
105 |
| Issue: |
2 |
| Pages: |
629-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Omer-Javed A |
| Year: |
2022 |
| Journal: |
Cell |
| Title: |
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells. |
| Volume: |
185 |
| Issue: |
13 |
| Pages: |
2248-2264.e21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shaw PJ |
| Year: |
2014 |
| Journal: |
J Clin Invest |
| Title: |
CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2. |
| Volume: |
124 |
| Issue: |
10 |
| Pages: |
4549-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gilbert MR |
| Year: |
2012 |
| Journal: |
J Immunol |
| Title: |
Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages. |
| Volume: |
189 |
| Issue: |
2 |
| Pages: |
711-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Davidson MG |
| Year: |
2013 |
| Journal: |
J Immunol |
| Title: |
Th17 cells induce Th1-polarizing monocyte-derived dendritic cells. |
| Volume: |
191 |
| Issue: |
3 |
| Pages: |
1175-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim G |
| Year: |
2007 |
| Journal: |
J Immunol |
| Title: |
Paradoxical effect of reduced costimulation in T cell-mediated colitis. |
| Volume: |
178 |
| Issue: |
9 |
| Pages: |
5563-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gaspal F |
| Year: |
2008 |
| Journal: |
J Immunol |
| Title: |
Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to Salmonella. |
| Volume: |
180 |
| Issue: |
5 |
| Pages: |
2824-9 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Haase C |
| Year: |
2004 |
| Journal: |
Diabetes |
| Title: |
Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD154 on the pancreatic beta-cells. |
| Volume: |
53 |
| Issue: |
10 |
| Pages: |
2588-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lincecum JM |
| Year: |
2010 |
| Journal: |
Nat Genet |
| Title: |
From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis. |
| Volume: |
42 |
| Issue: |
5 |
| Pages: |
392-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Linden AM |
| Year: |
2003 |
| Journal: |
Neuroscience |
| Title: |
Increased c-Fos expression in the centromedial nucleus of the thalamus in metabotropic glutamate 8 receptor knockout mice following the elevated plus maze test. |
| Volume: |
121 |
| Issue: |
1 |
| Pages: |
167-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goodwin RG |
| Year: |
1993 |
| Journal: |
Cell |
| Title: |
Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. |
| Volume: |
73 |
| Issue: |
3 |
| Pages: |
447-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hwaiz R |
| Year: |
2014 |
| Journal: |
Lab Invest |
| Title: |
Rac1 regulates platelet shedding of CD40L in abdominal sepsis. |
| Volume: |
94 |
| Issue: |
9 |
| Pages: |
1054-63 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion #, Gail Bishop |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharma MD |
| Year: |
2013 |
| Journal: |
Immunity |
| Title: |
An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos. |
| Volume: |
38 |
| Issue: |
5 |
| Pages: |
998-1012 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kelly LM |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. |
| Volume: |
187 |
| Issue: |
6 |
| Pages: |
3026-32 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Davidson MG |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells. |
| Volume: |
8 |
| Issue: |
10 |
| Pages: |
e76258 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Snyder CM |
| Year: |
2009 |
| Journal: |
J Immunol |
| Title: |
CD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection. |
| Volume: |
183 |
| Issue: |
6 |
| Pages: |
3932-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Soni C |
| Year: |
2020 |
| Journal: |
Immunity |
| Title: |
Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA. |
| Volume: |
52 |
| Issue: |
6 |
| Pages: |
1022-1038.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McCoy KD |
| Year: |
2006 |
| Journal: |
Immunity |
| Title: |
Natural IgE production in the absence of MHC Class II cognate help. |
| Volume: |
24 |
| Issue: |
3 |
| Pages: |
329-39 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guidotti LG |
| Year: |
2015 |
| Journal: |
Cell |
| Title: |
Immunosurveillance of the liver by intravascular effector CD8(+) T cells. |
| Volume: |
161 |
| Issue: |
3 |
| Pages: |
486-500 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
983
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
959
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
234
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
203
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
260
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
222
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dudakov JA |
| Year: |
2012 |
| Journal: |
Science |
| Title: |
Interleukin-22 drives endogenous thymic regeneration in mice. |
| Volume: |
336 |
| Issue: |
6077 |
| Pages: |
91-5 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/Cd40lg |
| Background: |
NOD.129S2-Cd40lg |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40lg/Cd40lg |
| Background: |
involves: 129S2/SvPas * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40/Cd40 |
| Background: |
involves: 129S4/SvJae * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd40/Cd40 |
| Background: |
C57BL/6N-Cd40/Ucd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim HS |
| Year: |
2019 |
| Journal: |
Sci Adv |
| Title: |
The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity. |
| Volume: |
5 |
| Issue: |
7 |
| Pages: |
eaav8152 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shedlock DJ |
| Year: |
2003 |
| Journal: |
J Immunol |
| Title: |
Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection. |
| Volume: |
170 |
| Issue: |
4 |
| Pages: |
2053-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Medler TR |
| Year: |
2023 |
| Journal: |
Sci Rep |
| Title: |
Tumor resident memory CD8 T cells and concomitant tumor immunity develop independently of CD4 help. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
6277 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vu MD |
| Year: |
2004 |
| Journal: |
J Immunol |
| Title: |
Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection. |
| Volume: |
173 |
| Issue: |
1 |
| Pages: |
214-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
De Jong YP |
| Year: |
2000 |
| Journal: |
Gastroenterology |
| Title: |
Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration. |
| Volume: |
119 |
| Issue: |
3 |
| Pages: |
715-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Centanni JM |
| Year: |
1998 |
| Journal: |
Mamm Genome |
| Title: |
Interleukin-1 receptor-associated kinase gene Il1rak maps to the mouse X chromosome. |
| Volume: |
9 |
| Issue: |
4 |
| Pages: |
340-1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ho PC |
| Year: |
2014 |
| Journal: |
Cancer Res |
| Title: |
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ. |
| Volume: |
74 |
| Issue: |
12 |
| Pages: |
3205-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Levack RC |
| Year: |
2020 |
| Journal: |
J Immunol |
| Title: |
CD11c+ T-bet+ B Cells Require IL-21 and IFN-γ from Type 1 T Follicular Helper Cells and Intrinsic Bcl-6 Expression but Develop Normally in the Absence of T-bet. |
| Volume: |
205 |
| Issue: |
4 |
| Pages: |
1050-1058 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eliopoulos AG |
| Year: |
2003 |
| Journal: |
EMBO J |
| Title: |
Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. |
| Volume: |
22 |
| Issue: |
15 |
| Pages: |
3855-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tone M |
| Year: |
2001 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Regulation of CD40 function by its isoforms generated through alternative splicing. |
| Volume: |
98 |
| Issue: |
4 |
| Pages: |
1751-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Satpathy S |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
Inhibition of terminal differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK. |
| Volume: |
185 |
| Issue: |
11 |
| Pages: |
6499-507 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharma MD |
| Year: |
2010 |
| Journal: |
Immunity |
| Title: |
Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice. |
| Volume: |
33 |
| Issue: |
6 |
| Pages: |
942-54 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pihlgren M |
| Year: |
2013 |
| Journal: |
Blood |
| Title: |
TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice. |
| Volume: |
121 |
| Issue: |
1 |
| Pages: |
85-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tan C |
| Year: |
2020 |
| Journal: |
Nat Immunol |
| Title: |
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting. |
| Volume: |
21 |
| Issue: |
10 |
| Pages: |
1267-1279 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fransen L |
| Year: |
1985 |
| Journal: |
Nucleic Acids Res |
| Title: |
Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression. |
| Volume: |
13 |
| Issue: |
12 |
| Pages: |
4417-29 |
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•
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| Publication |
| First Author: |
Cseh K |
| Year: |
1989 |
| Journal: |
J Biol Chem |
| Title: |
Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein. |
| Volume: |
264 |
| Issue: |
27 |
| Pages: |
16256-60 |
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•
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•
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| Publication |
| First Author: |
Sherry B |
| Year: |
1990 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Characterization of high molecular weight glycosylated forms of murine tumor necrosis factor. |
| Volume: |
173 |
| Issue: |
3 |
| Pages: |
1072-8 |
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•
•
•
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| Publication |
| First Author: |
Kriegler M |
| Year: |
1988 |
| Journal: |
Cell |
| Title: |
A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. |
| Volume: |
53 |
| Issue: |
1 |
| Pages: |
45-53 |
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•
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•
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| Publication |
| First Author: |
Bazan JF |
| Year: |
1993 |
| Journal: |
Curr Biol |
| Title: |
Emerging families of cytokines and receptors. |
| Volume: |
3 |
| Issue: |
9 |
| Pages: |
603-6 |
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|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
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•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, targeted mutation, spontaneous mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, transgenic, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, targeted mutation, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
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•
•
•
•
|