| Type |
Details |
Score |
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
461
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
461
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
461
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ageta-Ishihara N |
| Year: |
2015 |
| Journal: |
Nat Commun |
| Title: |
A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. |
| Volume: |
6 |
|
| Pages: |
10090 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ching KH |
| Year: |
2007 |
| Journal: |
Exp Cell Res |
| Title: |
Biochemical characterization of distinct regions of SPEC molecules and their role in phagocytosis. |
| Volume: |
313 |
| Issue: |
1 |
| Pages: |
10-21 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents a group of Cdc42-binding proteins known as SPECs (for small protein effector of Cdc42), including SPEC1 and SPEC2 from humans. SPECs modulate the activity of the Rho GTPase Cdc42, which plays important roles in actin polymerization and kinase signaling []. SPEC1 and SPEC2 play a role in F-actin accumulation in activated T lymphocytes and may play a role in early contractile events in phagocytosis []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1040
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1008
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Joberty G |
| Year: |
2001 |
| Journal: |
Nat Cell Biol |
| Title: |
Borg proteins control septin organization and are negatively regulated by Cdc42. |
| Volume: |
3 |
| Issue: |
10 |
| Pages: |
861-6 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
44
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
27
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
52
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
290
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
211
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1425
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li S |
| Year: |
2000 |
| Journal: |
Mol Cell Biol |
| Title: |
Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1. |
| Volume: |
20 |
| Issue: |
2 |
| Pages: |
697-701 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lamarche-Vane N |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. |
| Volume: |
273 |
| Issue: |
44 |
| Pages: |
29172-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brudvig JJ |
| Year: |
2018 |
| Journal: |
Sci Rep |
| Title: |
MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
13278 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Burbelo PD |
| Year: |
1995 |
| Journal: |
J Biol Chem |
| Title: |
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. |
| Volume: |
270 |
| Issue: |
49 |
| Pages: |
29071-4 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
48
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jahid S |
| Year: |
2022 |
| Journal: |
Cell Rep |
| Title: |
Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. |
| Volume: |
39 |
| Issue: |
1 |
| Pages: |
110641 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Otani T |
| Year: |
2006 |
| Journal: |
J Cell Biol |
| Title: |
Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells. |
| Volume: |
175 |
| Issue: |
1 |
| Pages: |
135-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ching KH |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse. |
| Volume: |
280 |
| Issue: |
25 |
| Pages: |
23660-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Z |
| Year: |
2014 |
| Journal: |
Mol Biol Cell |
| Title: |
Borg5 is required for angiogenesis by regulating persistent directional migration of the cardiac microvascular endothelial cells. |
| Volume: |
25 |
| Issue: |
6 |
| Pages: |
841-51 |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wagner S |
| Year: |
2021 |
| Journal: |
J Biol Chem |
| Title: |
The α3 subunit of GABAA receptors promotes formation of inhibitory synapses in the absence of collybistin. |
| Volume: |
296 |
|
| Pages: |
100709 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Krugmann S |
| Year: |
2001 |
| Journal: |
Curr Biol |
| Title: |
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. |
| Volume: |
11 |
| Issue: |
21 |
| Pages: |
1645-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Franke K |
| Year: |
2012 |
| Journal: |
EMBO J |
| Title: |
miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling. |
| Volume: |
31 |
| Issue: |
13 |
| Pages: |
2908-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Primeau M |
| Year: |
2011 |
| Journal: |
FEBS Lett |
| Title: |
Cdc42 GTPase-activating protein (CdGAP) interacts with the SH3D domain of Intersectin through a novel basic-rich motif. |
| Volume: |
585 |
| Issue: |
6 |
| Pages: |
847-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Urrutia PJ |
| Year: |
2021 |
| Journal: |
J Neurosci |
| Title: |
Tuba Activates Cdc42 during Neuronal Polarization Downstream of the Small GTPase Rab8a. |
| Volume: |
41 |
| Issue: |
8 |
| Pages: |
1636-1649 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jain M |
| Year: |
2012 |
| Journal: |
Exp Cell Res |
| Title: |
Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis. |
| Volume: |
318 |
| Issue: |
6 |
| Pages: |
753-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koduru S |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. |
| Volume: |
107 |
| Issue: |
37 |
| Pages: |
16252-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou J |
| Year: |
2009 |
| Journal: |
Free Radic Biol Med |
| Title: |
Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1. |
| Volume: |
47 |
| Issue: |
6 |
| Pages: |
741-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiang L |
| Year: |
2023 |
| Journal: |
Nat Commun |
| Title: |
Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
2654 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mitin N |
| Year: |
2007 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. |
| Volume: |
14 |
| Issue: |
9 |
| Pages: |
814-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Szczur K |
| Year: |
2006 |
| Journal: |
Blood |
| Title: |
Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. |
| Volume: |
108 |
| Issue: |
13 |
| Pages: |
4205-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tuncay H |
| Year: |
2015 |
| Journal: |
Nat Commun |
| Title: |
JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. |
| Volume: |
6 |
|
| Pages: |
8128 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
2055
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Pathway |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Elbediwy A |
| Year: |
2012 |
| Journal: |
J Cell Biol |
| Title: |
Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. |
| Volume: |
198 |
| Issue: |
4 |
| Pages: |
677-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rousseau V |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases. |
| Volume: |
278 |
| Issue: |
6 |
| Pages: |
3912-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Garrard SM |
| Year: |
2003 |
| Journal: |
EMBO J |
| Title: |
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6. |
| Volume: |
22 |
| Issue: |
5 |
| Pages: |
1125-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang L |
| Year: |
2007 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. |
| Volume: |
104 |
| Issue: |
4 |
| Pages: |
1248-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kusuhara S |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. |
| Volume: |
7 |
| Issue: |
9 |
| Pages: |
e45858 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cai Y |
| Year: |
2017 |
| Journal: |
Front Mol Neurosci |
| Title: |
Rpph1 Upregulates CDC42 Expression and Promotes Hippocampal Neuron Dendritic Spine Formation by Competing with miR-330-5p. |
| Volume: |
10 |
|
| Pages: |
27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aihara R |
| Year: |
2020 |
| Journal: |
Int Immunol |
| Title: |
DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cau J |
| Year: |
2000 |
| Journal: |
J Biol Chem |
| Title: |
Regulation of Xenopus p21-activated kinase (X-PAK2) by Cdc42 and maturation-promoting factor controls Xenopus oocyte maturation. |
| Volume: |
275 |
| Issue: |
4 |
| Pages: |
2367-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lim KB |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics. |
| Volume: |
283 |
| Issue: |
29 |
| Pages: |
20454-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zihni C |
| Year: |
2014 |
| Journal: |
J Cell Biol |
| Title: |
Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. |
| Volume: |
204 |
| Issue: |
1 |
| Pages: |
111-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang J |
| Year: |
2017 |
| Journal: |
FASEB J |
| Title: |
Intersectin 2 controls actin cap formation and meiotic division in mouse oocytes through the Cdc42 pathway. |
| Volume: |
31 |
| Issue: |
10 |
| Pages: |
4277-4285 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Endo M |
| Year: |
2020 |
| Journal: |
J Biol Chem |
| Title: |
The two splice variant forms of Cdc42 exert distinct and essential functions in neurogenesis. |
| Volume: |
295 |
| Issue: |
14 |
| Pages: |
4498-4512 |
|
•
•
•
•
•
|