|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1001 to 1056 out of 1056 for Cdk2

<< First    < Previous  |  Next >    Last >>
0.028s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
Q9D6H3
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
•
•
•
•
•
Protein
Q6P6A2
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
•
•
•
•
•
Protein
Q8CAS3
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
•
•
•
•
•
Protein
Q3UUW5
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: false
•
•
•
•
•
Protein
Q3UXL9
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
•
•
•
•
•
Publication
8712071 | -
 
First Author: Hall M
Year: 1996
Journal: Adv Cancer Res
Title: Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer.
Volume: 68
Pages: 67-108
•
•
•
•
•
Publication
1827756 | -
First Author: Xiong Y
Year: 1991
Journal: Cell
Title: Human D-type cyclin.
Volume: 65
Issue: 4
Pages: 691-9
•
•
•
•
•
Publication
10577389 | -
 
First Author: Kato J
Year: 1999
Journal: Front Biosci
Title: Induction of S phase by G1 regulatory factors.
Volume: 4
Pages: D787-92
•
•
•
•
•
Publication
7791752 | -
First Author: Resnitzky D
Year: 1995
Journal: Mol Cell Biol
Title: Different roles for cyclins D1 and E in regulation of the G1-to-S transition.
Volume: 15
Issue: 7
Pages: 3463-9
•
•
•
•
•
Protein Domain
IPR015451 | Cyclin_D
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].Among G1 regulators, D-type cyclins serve as targets of growth factors to integrate extracellular signals into the core cell cycle regulators. D-type cyclins were identified in three independent approaches; (I) a target gene of chromosomal translocations in a variety of cancers [], (II) a mammalian cyclin gene that can complement yeast G1 cyclin deficiency [], and (III) a delayed early growth factor inducible gene []. D-type cyclins are composed of three different but closely related subfamilies (D1, D2, and D3), all differentially expressed in a wide variety of organs and in a tissue-specific manner. Expression of D-type cyclins is induced in response to a variety of mitogenic signals and they function as a regulatory subunit of cyclin-dependent kinases (Cdk).D-type cyclins can interact with 4 different Cdks (Cdk2, 4, 5, and 6), among which Cdk4 and Cdk6 are apparently the major functional catalytic partners in proliferating cells. When cells are exposed to growth factor stimulation, the expression of cyclin D is maintained regardless of the point in the cell cycle. However, accumulation of active cyclin D/Cdk4 (or Cdk6) complex is rate-limiting and is required for cells to progress through G1 and to commit to entering S phase. The over expression of D-type cyclins shortens the length of G1 without affecting remainder of the cell cycle. This event is clearly different from phenotype of the cells over expressing another G1 cyclin, cyclin E, in which G1 is shortened but elongation of the S phase compensates this shortening and as a result, doubling time of the cell remains unchanged. Thus, the cyclin D/Cdk4 complex largely exerts effects on commitment of cells for the S phase entry during the G1 phase, while functions of cyclin E/Cdk2 kinase are more directly involved in the initiation of chromosomal DNA synthesis [, ].This entry is comprised of D-type cyclins that are evolutionarily conserved across a variety of species.
•
•
•
•
•
Protein
Q64451
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
•
•
•
•
•
Protein
Q8C526
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
•
•
•
•
•
Protein
A6YM30
Organism: Mus musculus/domesticus
Length: 36  
Fragment?: true
•
•
•
•
•
Protein
A5JTV6
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: true
•
•
•
•
•
Protein
Q925E2
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
•
•
•
•
•
Protein
A0A286YDC0
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
•
•
•
•
•
Protein
B1AX91
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
•
•
•
•
•
Protein
H3BK76
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
•
•
•
•
•
Protein
Q9ER40
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J1K8
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
•
•
•
•
•
Protein
P02340
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
•
•
•
•
•
Protein
Q03147
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
•
•
•
•
•
Protein
Q569E5
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
•
•
•
•
•
Protein
Q3THG5
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
•
•
•
•
•
Protein
W5VJU6
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
•
•
•
•
•
Protein
Q3UGQ1
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: true
•
•
•
•
•
Protein
O70366
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
•
•
•
•
•
Protein
Q8CAC4
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
•
•
•
•
•
Protein
A0A5Q0MU23
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
•
•
•
•
•
Protein
G3UYS2
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
•
•
•
•
•
Protein
Q91XH8
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
•
•
•
•
•
Protein
A0A158SIS7
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
•
•
•
•
•
Protein
Q549C9
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
•
•
•
•
•
Protein
I7HIK9
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
•
•
•
•
•
Protein
Q80ZA1
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
•
•
•
•
•
Protein
O88898
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
•
•
•
•
•
Protein
Q9JJP2
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: false
•
•
•
•
•
Protein
Q3UVI3
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
•
•
•
•
•
Protein
Q5CZX0
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
•
•
•
•
•
Protein
Z4YK94
Organism: Mus musculus/domesticus
Length: 638  
Fragment?: false
•
•
•
•
•
Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
•
•
•
•
•
Publication
9630226 | -
First Author: Chen X
Year: 1998
Journal: Cell
Title: Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.
Volume: 93
Issue: 5
Pages: 827-39
•
•
•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
•
•
•
•
•
Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
•
•
•
•
•
Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
•
•
•
•
•
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
12665246 | -
First Author: Matthews JM
Year: 2002
Journal: IUBMB Life
Title: Zinc fingers--folds for many occasions.
Volume: 54
Issue: 6
Pages: 351-5
•
•
•
•
•
Publication
17210253 | -
First Author: Gamsjaeger R
Year: 2007
Journal: Trends Biochem Sci
Title: Sticky fingers: zinc-fingers as protein-recognition motifs.
Volume: 32
Issue: 2
Pages: 63-70
•
•
•
•
•
Publication
15963892 | -
First Author: Hall TM
Year: 2005
Journal: Curr Opin Struct Biol
Title: Multiple modes of RNA recognition by zinc finger proteins.
Volume: 15
Issue: 3
Pages: 367-73
•
•
•
•
•
Publication
15718139 | -
First Author: Brown RS
Year: 2005
Journal: Curr Opin Struct Biol
Title: Zinc finger proteins: getting a grip on RNA.
Volume: 15
Issue: 1
Pages: 94-8
•
•
•
•
•
Publication
10529348 | -
First Author: Klug A
Year: 1999
Journal: J Mol Biol
Title: Zinc finger peptides for the regulation of gene expression.
Volume: 293
Issue: 2
Pages: 215-8
•
•
•
•
•
Publication
11179890 | -
First Author: Laity JH
Year: 2001
Journal: Curr Opin Struct Biol
Title: Zinc finger proteins: new insights into structural and functional diversity.
Volume: 11
Issue: 1
Pages: 39-46
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom