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Search results 1001 to 1100 out of 1779 for Cxcr4

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Type Details Score
HT Experiment
GSE102309 | Transcriptome of neutrophils deficient in cxcr4 and arntl
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
37039233 | J:335293
 
First Author: Halasy V
Year: 2023
Journal: Development
Title: CXCR4 and CXCL12 signaling regulates the development of extrinsic innervation to the colorectum.
Volume: 150
Issue: 8
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Publication
26195666 | J:227292
First Author: Bamidele AO
Year: 2015
Journal: J Cell Biol
Title: IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes.
Volume: 210
Issue: 2
Pages: 257-72
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Publication
30912855 | J:352981
First Author: Engevik KA
Year: 2019
Journal: J Physiol
Title: Trefoil factor 2 activation of CXCR4 requires calcium mobilization to drive epithelial repair in gastric organoids.
Volume: 597
Issue: 10
Pages: 2673-2690
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Publication
22049516 | J:181661
First Author: Juarez JG
Year: 2012
Journal: Blood
Title: Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice.
Volume: 119
Issue: 3
Pages: 707-16
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Publication
32460032 | J:301287
First Author: Ramakrishnan R
Year: 2020
Journal: Cell Rep
Title: CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia.
Volume: 31
Issue: 8
Pages: 107684
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Publication
21211783 | J:168460
First Author: Smith-Berdan S
Year: 2011
Journal: Cell Stem Cell
Title: Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches.
Volume: 8
Issue: 1
Pages: 72-83
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Publication
16543065 | J:108468
First Author: Robertson P
Year: 2006
Journal: Exp Hematol
Title: CXCR4 and CCR5 mediate homing of primitive bone marrow-derived hematopoietic cells to the postnatal thymus.
Volume: 34
Issue: 3
Pages: 308-19
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Publication
35914619 | J:330793
 
First Author: Zhang WS
Year: 2022
Journal: Metabolism
Title: S100a16 deficiency prevents hepatic stellate cells activation and liver fibrosis via inhibiting CXCR4 expression.
Volume: 135
Pages: 155271
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Publication
23794067 | J:202275
First Author: Kallikourdis M
Year: 2013
Journal: Blood
Title: The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse.
Volume: 122
Issue: 5
Pages: 666-73
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Publication
20616219 | J:165871
First Author: McDermott DH
Year: 2010
Journal: Blood
Title: Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis.
Volume: 116
Issue: 15
Pages: 2793-802
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Publication
21056990 | J:167174
First Author: Kim M
Year: 2010
Journal: Cancer Res
Title: CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche.
Volume: 70
Issue: 24
Pages: 10411-21
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Publication
21990345 | J:177414
First Author: Drury LJ
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.
Volume: 108
Issue: 43
Pages: 17655-60
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Publication
36368465 | J:334224
 
First Author: Esposito A
Year: 2023
Journal: Bone
Title: CXCR4 mediates the effects of IGF-1R signaling in rodent bone homeostasis and fracture repair.
Volume: 166
Pages: 116600
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Publication
19524567 | J:154497
First Author: Zhang Z
Year: 2009
Journal: Exp Eye Res
Title: CXCR4 but not CXCR7 is mainly implicated in ocular leukocyte trafficking during ovalbumin-induced acute uveitis.
Volume: 89
Issue: 4
Pages: 522-31
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Publication
29554149 | J:260111
First Author: Costa MJ
Year: 2018
Journal: PLoS One
Title: A mouse model for evaluation of efficacy and concomitant toxicity of anti-human CXCR4 therapeutics.
Volume: 13
Issue: 3
Pages: e0194688
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Publication
18187037 | J:131323
First Author: Hayashi H
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration.
Volume: 367
Issue: 3
Pages: 584-9
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Publication
36211464 | J:329954
 
First Author: Shams AS
Year: 2022
Journal: Front Cell Dev Biol
Title: The chemokine receptor CXCR4 regulates satellite cell activation, early expansion, and self-renewal, in response to skeletal muscle injury.
Volume: 10
Pages: 949532
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Publication
19050309 | J:149332
First Author: Nervi B
Year: 2009
Journal: Blood
Title: Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.
Volume: 113
Issue: 24
Pages: 6206-14
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Publication
29398278 | -
 
First Author: Murphy PM
Year: 2018
Journal: Cytokine
Title: Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3.
Volume: 109
Pages: 2-10
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Publication
19157683 | J:146524
First Author: Bonig H
Year: 2009
Journal: Exp Hematol
Title: Insights into the biology of mobilized hematopoietic stem/progenitor cells through innovative treatment schedules of the CXCR4 antagonist AMD3100.
Volume: 37
Issue: 3
Pages: 402-15.e1
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Publication
36096455 | J:329455
     
First Author: Thavayogarajah T
Year: 2022
Journal: Exp Hematol
Title: CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia.
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Publication
36871629 | J:360886
First Author: Rossi AP
Year: 2023
Journal: Am J Transplant
Title: Effects of invivo CXCR4 blockade and proteasome inhibition on bone marrow plasma cells in HLA-sensitized kidney transplant candidates.
Volume: 23
Issue: 6
Pages: 759-775
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Publication
31513647 | J:279454
First Author: Yellowley CE
Year: 2019
Journal: PLoS One
Title: Circulating progenitor cells and the expression of Cxcl12, Cxcr4 and angiopoietin-like 4 during wound healing in the murine ear.
Volume: 14
Issue: 9
Pages: e0222462
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Publication
35652755 | J:340636
First Author: Rathjen T
Year: 2022
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial Cell Insulin Signaling Regulates CXCR4 (C-X-C Motif Chemokine Receptor 4) and Limits Leukocyte Adhesion to Endothelium.
Volume: 42
Issue: 7
Pages: e217-e227
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Protein Coding Gene
MGI:107577 | Wbp1l
Type: protein_coding_gene
Organism: mouse, laboratory
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Interaction Experiment
Li L (2017)
Description: Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases.
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Allele
Cxcr4<em2(CXCR4)Smoc> | MGI:7289231
Name: C-X-C motif chemokine receptor 4; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
26286848 | J:230680
First Author: Massena S
Year: 2015
Journal: Blood
Title: Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans.
Volume: 126
Issue: 17
Pages: 2016-26
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Publication
37523265 | J:339323
First Author: Pereira da Costa M
Year: 2023
Journal: Cell Rep
Title: Interplay between CXCR4 and CCR2 regulates bone marrow exit of dendritic cell progenitors.
Volume: 42
Issue: 8
Pages: 112881
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Publication
30816332 | J:274255
First Author: Müller TA
Year: 2019
Journal: Leukemia
Title: PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion.
Volume: 33
Issue: 5
Pages: 1296-1301
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Publication
20534467 | J:161275
First Author: Jujo K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction.
Volume: 107
Issue: 24
Pages: 11008-13
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Publication
20493167 | J:162427
First Author: Bettink SI
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy.
Volume: 397
Issue: 2
Pages: 208-13
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GO Term
GO:0038147 | C-X-C motif chemokine 12 receptor activity
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HT Experiment
GSE86619 | Transcriptome of diurnal wild-type neutrophils and neutrophils deficient in cxcr2, cxcr4 and arntl
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
18799424 | -
First Author: Veldkamp CT
Year: 2008
Journal: Sci Signal
Title: Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12.
Volume: 1
Issue: 37
Pages: ra4
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Publication
33705493 | J:313250
First Author: Smith LK
Year: 2021
Journal: PLoS One
Title: Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.
Volume: 16
Issue: 3
Pages: e0248309
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Publication
20830712 | J:173812
First Author: Hassan S
Year: 2011
Journal: Int J Cancer
Title: CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.
Volume: 129
Issue: 1
Pages: 225-32
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Publication
19657116 | J:153283
First Author: Kawaguchi A
Year: 2009
Journal: Blood
Title: Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice.
Volume: 114
Issue: 14
Pages: 2961-8
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Publication
28804991 | J:272137
First Author: Kurosawa M
Year: 2017
Journal: Arthritis Rheumatol
Title: NF-κB2 Controls the Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in a Mouse Model of Sjögren's Syndrome.
Volume: 69
Issue: 11
Pages: 2193-2202
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Publication
15730853 | J:97112
First Author: Pelus LM
Year: 2005
Journal: Exp Hematol
Title: The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor.
Volume: 33
Issue: 3
Pages: 295-307
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Publication
29326436 | J:261034
First Author: Patrussi L
Year: 2018
Journal: Oncogene
Title: p66Shc deficiency enhances CXCR4 and CCR7 recycling in CLL B cells by facilitating their dephosphorylation-dependent release from β-arrestin at early endosomes.
Volume: 37
Issue: 11
Pages: 1534-1550
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Publication
9261420 | -
First Author: Kitchen SG
Year: 1997
Journal: J Virol
Title: CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus.
Volume: 71
Issue: 9
Pages: 6928-34
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Publication
10525044 | -
First Author: Jordan NJ
Year: 1999
Journal: J Clin Invest
Title: Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells.
Volume: 104
Issue: 8
Pages: 1061-9
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HT Experiment
GSE19284 | Microarray Analysis of Retinal Endothelial Tip Cells Identifies CXCR4 as a Mediator of Tip Cell Morphology and Branching
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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Allele
Cxcr4<tm1.1Bala> | MGI:5301553
 
Name: C-X-C motif chemokine receptor 4; targeted mutation 1.1, Karl Balabanian
Allele Type: Targeted
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GXD Expression
GXD Expression
 
Probe: MGI:5635581
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5635660
Age: embryonic day 12.5
Note: There was co-localization of expression with Cxcr4 in the vascular endothelial cell lineage.
Specimen Label: Online VIA
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5635581
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1669620
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5635660
Age: embryonic day 12.5
Note: There was co-localization of expression with Cxcr4 in the cardiac cell lineage.
Specimen Label: Online VIB
Detected: true
Specimen Num: 2
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Strain
MGI:6428511 | C57BL/6JSmoc-Cxcr4<em2(CXCR4)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Cxcr4<em3Smoc> | MGI:7289232
Name: C-X-C motif chemokine receptor 4; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein Coding Gene
MGI:1306805 | Tff2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9461627 | -
First Author: Gupta SK
Year: 1998
Journal: J Biol Chem
Title: Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines.
Volume: 273
Issue: 7
Pages: 4282-7
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Protein Coding Gene
MGI:2685813 | Entrep1
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:6714315
Assay Type: RNA in situ
Annotation Date: 2021-06-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6715221
Age: embryonic day 15.5
Note: The majority of interneurons in the subventricular zone/intermediate zone expressed both Ackr3 and Cxcr4 (57.7%), and 21% expressed only Ackr3.
Specimen Label: 3C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6714315
Assay Type: RNA in situ
Annotation Date: 2021-06-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6715221
Age: embryonic day 15.5
Note: The vast majority of interneurons in the cortical plate expressed both Ackr3 and Cxcr4 (47.5%) or Ackr3 alone (45.1%).
Specimen Label: not shown
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6714315
Assay Type: RNA in situ
Annotation Date: 2021-06-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6715221
Age: embryonic day 15.5
Note: The majority of interneurons in the subventricular zone/intermediate zone expressed both Ackr3 and Cxcr4 (57.7%), and 21% expressed only Ackr3.
Specimen Label: 3C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6163808
Assay Type: Immunohistochemistry
Annotation Date: 2021-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2535617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6491874
Age: embryonic day 10.25
Note: Co-expression with Cxcr4 xpression in muscle progenitors migrating along hypoglossal cord and in muscle progenitors in tongue anlage.
Specimen Label: 2G
Detected: true
Specimen Num: 2
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Allele
Cxcr4<em1Smoc> | MGI:7289230
Name: C-X-C motif chemokine receptor 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6354724 | C57BL/6JSmoc-Cxcr4<em3Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Cxcr4/Cxcr4<+>
Background: B6.129S2-Cxcr4
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0060591 | WHIM syndrome 1
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GXD Expression
GXD Expression
 
Probe: MGI:6163808
Assay Type: Immunohistochemistry
Annotation Date: 2021-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3110917
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6491874
Age: embryonic day 10.25
Note: Expression in progenitors prior to delamination from ventrolateral dermomyotome. Co-expression with Cxcr4 only after migrating progenitors cells have moved away from the dermomyotome.
Specimen Label: 3A
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6163808
Assay Type: Immunohistochemistry
Annotation Date: 2021-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6491874
Age: embryonic day 10.25
Note: Co-expression with Cxcr4 in muscle masses. All Cxcr4-expressing cells in premuscle masses also expressing Lbx1, but not every Lbx1-expressing cell expresses Cxcr4.
Specimen Label: 3A
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6163808
Assay Type: Immunohistochemistry
Annotation Date: 2021-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640818
Pattern: Regionally restricted
Stage: TS18
Assay Id: MGI:6491874
Age: embryonic day 10.75
Note: Co-expression with Cxcr4 in muscle masses. All Cxcr4-expressing cells in premuscle masses also expressing Lbx1, but not every Lbx1-expressing cell expresses Cxcr4.
Specimen Label: 3B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6163808
Assay Type: Immunohistochemistry
Annotation Date: 2021-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640819
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6491874
Age: embryonic day 11.25
Note: Co-expression with Cxcr4 in muscle masses. All Cxcr4-expressing cells in premuscle masses also expressing Lbx1, but not every Lbx1-expressing cell expresses Cxcr4.
Specimen Label: 3C
Detected: true
Specimen Num: 5
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Publication
11110672 | -
First Author: Clemetson KJ
Year: 2000
Journal: Blood
Title: Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets.
Volume: 96
Issue: 13
Pages: 4046-54
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Publication
10816381 | -
First Author: Xiao X
Year: 2000
Journal: Exp Mol Pathol
Title: Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells.
Volume: 68
Issue: 3
Pages: 133-8
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Publication
25080523 | J:214839
First Author: Zuk A
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: CXCRâ‚„antagonism as a therapeutic approach to prevent acute kidney injury.
Volume: 307
Issue: 7
Pages: F783-97
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Strain
MGI:6475088 | C57BL/6JSmoc-Cxcr4<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Cxcr4<tm1.1(cre/ERT2)Stum> | MGI:6719054
Name: C-X-C motif chemokine receptor 4; targeted mutation 1.1, Ralf Stumm
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Recombinase, Reporter
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Publication
16107333 | -
First Author: Balabanian K
Year: 2005
Journal: J Biol Chem
Title: The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes.
Volume: 280
Issue: 42
Pages: 35760-6
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Publication
12421931 | -
First Author: Vlahakis SR
Year: 2002
Journal: J Immunol
Title: G protein-coupled chemokine receptors induce both survival and apoptotic signaling pathways.
Volume: 169
Issue: 10
Pages: 5546-54
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Publication
8752281 | -
First Author: Oberlin E
Year: 1996
Journal: Nature
Title: The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1.
Volume: 382
Issue: 6594
Pages: 833-5
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Publication
22949334 | -
First Author: Shachar I
Year: 2013
Journal: J Leukoc Biol
Title: The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications.
Volume: 93
Issue: 1
Pages: 51-61
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Publication
28397860 | -
 
First Author: Ferre-Fernández JJ
Year: 2017
Journal: Sci Rep
Title: Whole-Exome Sequencing of Congenital Glaucoma Patients Reveals Hypermorphic Variants in GPATCH3, a New Gene Involved in Ocular and Craniofacial Development.
Volume: 7
Pages: 46175
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Publication
28414768 | -
First Author: Nie Y
Year: 2017
Journal: PLoS Pathog
Title: GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.
Volume: 13
Issue: 4
Pages: e1006328
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Protein Domain
IPR040341 | GPATCH3
Type: Family
Description: G patch domain-containing protein 3 (GPATCH3) is a transcriptional regulator during embryonic development, activating the CXCR4 promoter. The CXCR4 gene is involved in embryo neural crest cell migration. Because the GPATCH3 protein is detected in human tissues relevant to glaucoma, GPATCH3 may be involved in the pathogenesis of congenital glaucoma []. GPATCH3 is also a negative regulator of retinoic acid-inducible gene I-like receptor-mediated antiviral signaling pathways, a means to control the response triggered by the presence of viral RNA by interacting with VISA (an adaptor of virus-triggered, RLR-mediated induction of innate antiviral responses), and disrupting the assembly of the virus-induced VISA signalosome [].Proteins in this family contain a G-patch domain.
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Protein Domain
IPR039813 | CXCL12
Type: Family
Description: CXCL12 (stromal cell-derived factor-1, SDF1) is a chemokine that regulates development in hematopoietic, cardiovascular and nervous systems, and also regulates diverse cell functions, including differentiation, immune synapse formation, proliferation and survival in the immune system []. CXCL12 has two known receptors, CXCR4 and ACKR3/RDC [, ]. Binding of CXCL12 to CXCR4 induces trimeric G protein signaling leading to activation of the Src, phosphoinositide-3 kinase (PI3K)/AKT, ERK, and JNK pathways, contributing to pro-inflammatory function such as protease production and cellular migration [, ].CXCL12 is constitutively expressed in many tissues. It may also be upregulated in the context of infection and inflammation, acting both as a homeostatic and inflammatory chemokine [].
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Publication
15123627 | J:91612
First Author: Fischer AM
Year: 2004
Journal: J Biol Chem
Title: Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK.
Volume: 279
Issue: 28
Pages: 29816-20
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HT Experiment
GSE171457 | Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
39555063 | J:359109
 
First Author: Krayem I
Year: 2024
Journal: Front Immunol
Title: WBP1L regulates hematopoietic stem cell function and T cell development.
Volume: 15
Pages: 1421512
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Publication
29144457 | -
First Author: Brickner JR
Year: 2017
Journal: Nature
Title: A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Volume: 551
Issue: 7680
Pages: 389-393
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Publication
28978524 | -
First Author: Lear T
Year: 2017
Journal: Am J Physiol Cell Physiol
Title: RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling.
Volume: 313
Issue: 5
Pages: C584-C592
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Protein Domain
IPR039971 | CWC24-like
Type: Family
Description: This entry contains proteins with a CCCH-type zinc finger, which bind zinc via cysteine and histidine residues in the motif C-x8-C-x5-C-x3-H, and a C3HC4 type RING finger. Proteins with this structure include:Pre-mRNA-splicing factor CWC24, a component of the CWC complex, which is involved in pre-mRNA splicing [].RING finger protein 113A, an E3 ubiquitin-protein ligase that catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains []and CXCR4, leading to its degradation and thereby termination of CXCR4 signaling [].RING finger protein 113B, which is uncharacterized.
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Publication
10985313 | -
First Author: Anton PA
Year: 2000
Journal: AIDS
Title: Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue.
Volume: 14
Issue: 12
Pages: 1761-5
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Publication
11154210 | -
First Author: Inngjerdingen M
Year: 2001
Journal: Blood
Title: Expression and regulation of chemokine receptors in human natural killer cells.
Volume: 97
Issue: 2
Pages: 367-75
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Publication
11435493 | -
First Author: Iikura M
Year: 2001
Journal: J Leukoc Biol
Title: Chemokine receptors in human basophils: inducible expression of functional CXCR4.
Volume: 70
Issue: 1
Pages: 113-20
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Publication
11876757 | -
First Author: Zamarchi R
Year: 2002
Journal: Clin Exp Immunol
Title: Expression and functional activity of CXCR-4 and CCR-5 chemokine receptors in human thymocytes.
Volume: 127
Issue: 2
Pages: 321-30
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Publication
12370187 | -
First Author: Sun Y
Year: 2002
Journal: J Biol Chem
Title: Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation.
Volume: 277
Issue: 51
Pages: 49212-9
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Protein Domain
IPR001277 | CXCR4/ACKR2
Type: Family
Description: CXC chemokine receptor 4 (CXCR4), also known as fusin, which is a specific receptor for a CXCL12 (or SDF1). CXCR4 has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types [, , , , ]. In addition, CXCR4 can also be found on vascular endothelial cells and neuronal/nerve cells []. Upon binding to CXCR4, CXCL12 causes mobilisation of intracellular calcium and chemotaxis [, , ]. CXCL12 is known to be important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell quiescence. CXCR4 has a rather broad activity, and has been linked to cardiac, cerebellar gastric vasculature development [, ]and to hematopoiesis []. Atypical chemokine receptor 2 (ACKR2/D6) []is a chemokine-scavenging receptor or chemokine decoy receptor. It is capable of internalising and effectively scavenging its ligands through beta-arrestin-dependent activation of the cofilin pathway [, ]. ACKR2 is highly promiscuous and can bin the majority of (if not all) inflammatory CC-chemokines []. It plays an essential role in the resolution of the inflammatory response [, , ]. Although it lacks the canonical DRYLAIV motif necessary for classical signalling, ACKR2/D6 may be involved in 'atypical' signaling pathways downstream of ligand binding []. It has been shown to be involved in regulating vessel density [].
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Publication
23125030 | -
First Author: Graham GJ
Year: 2013
Journal: J Pathol
Title: Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6.
Volume: 229
Issue: 2
Pages: 168-75
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Publication
23633677 | -
First Author: Borroni EM
Year: 2013
Journal: Sci Signal
Title: β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.
Volume: 6
Issue: 273
Pages: ra30.1-11, S1-3
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Publication
19130487 | -
First Author: Graham GJ
Year: 2009
Journal: Eur J Immunol
Title: D6 and the atypical chemokine receptor family: novel regulators of immune and inflammatory processes.
Volume: 39
Issue: 2
Pages: 342-51
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Publication
12594248 | -
First Author: Fra AM
Year: 2003
Journal: J Immunol
Title: Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6.
Volume: 170
Issue: 5
Pages: 2279-82
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Publication
15004236 | -
First Author: Weber M
Year: 2004
Journal: Mol Biol Cell
Title: The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines.
Volume: 15
Issue: 5
Pages: 2492-508
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Publication
26097478 | -
 
First Author: Graham GJ
Year: 2015
Journal: Front Immunol
Title: D6/ACKR2.
Volume: 6
Pages: 280
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Publication
23479571 | -
First Author: McKimmie CS
Year: 2013
Journal: Blood
Title: An analysis of the function and expression of D6 on lymphatic endothelial cells.
Volume: 121
Issue: 18
Pages: 3768-77
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Publication
15750596 | J:97607
First Author: Jamieson T
Year: 2005
Journal: Nat Immunol
Title: The chemokine receptor D6 limits the inflammatory response in vivo.
Volume: 6
Issue: 4
Pages: 403-11
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Publication
25271254 | J:216439
First Author: Lee KM
Year: 2014
Journal: EMBO J
Title: The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.
Volume: 33
Issue: 21
Pages: 2564-80
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HT Experiment
GSE72831 | Dynamic changes in E protein activity orchestrate germinal center and plasma cell development [RNA-Seq]
Series Id: E-GEOD-72831
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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