| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aziz M |
| Year: |
2012 |
| Journal: |
J Immunol |
| Title: |
Milk fat globule-epidermal growth factor-factor 8 attenuates neutrophil infiltration in acute lung injury via modulation of CXCR2. |
| Volume: |
189 |
| Issue: |
1 |
| Pages: |
393-402 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Neher JJ |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Phagocytosis executes delayed neuronal death after focal brain ischemia. |
| Volume: |
110 |
| Issue: |
43 |
| Pages: |
E4098-107 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wagner J |
| Year: |
2022 |
| Journal: |
Nature |
| Title: |
Medin co-aggregates with vascular amyloid-β in Alzheimer's disease. |
| Volume: |
612 |
| Issue: |
7938 |
| Pages: |
123-131 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kranich J |
| Year: |
2010 |
| Journal: |
J Exp Med |
| Title: |
Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner. |
| Volume: |
207 |
| Issue: |
10 |
| Pages: |
2271-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brelstaff J |
| Year: |
2018 |
| Journal: |
Cell Rep |
| Title: |
Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. |
| Volume: |
24 |
| Issue: |
8 |
| Pages: |
1939-1948.e4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
David M |
| Year: |
1996 |
| Journal: |
J Biol Chem |
| Title: |
STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor kinase but not for tyrosine phosphorylation sites or JAK1. |
| Volume: |
271 |
| Issue: |
16 |
| Pages: |
9185-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rani CS |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. |
| Volume: |
272 |
| Issue: |
16 |
| Pages: |
10777-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Borlak J |
| Year: |
2018 |
| Journal: |
Biochim Biophys Acta Mol Basis Dis |
| Title: |
Serum proteome mapping of EGF transgenic mice reveal mechanistic biomarkers of lung cancer precursor lesions with clinical significance for human adenocarcinomas. |
| Volume: |
1864 |
| Issue: |
10 |
| Pages: |
3122-3144 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1191
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
464
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1193
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
56
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bu HF |
| Year: |
2007 |
| Journal: |
J Clin Invest |
| Title: |
Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium. |
| Volume: |
117 |
| Issue: |
12 |
| Pages: |
3673-83 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
18 |
| Description: |
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 |
| Type: |
chain |
| End: |
3567 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bos FL |
| Year: |
2011 |
| Journal: |
Circ Res |
| Title: |
CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo. |
| Volume: |
109 |
| Issue: |
5 |
| Pages: |
486-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Light A |
| Year: |
2015 |
| Journal: |
Biol Reprod |
| Title: |
LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands. |
| Volume: |
93 |
| Issue: |
3 |
| Pages: |
65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Datta R |
| Year: |
2021 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin. |
| Volume: |
118 |
| Issue: |
18 |
|
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jaskoll T |
| Year: |
1996 |
| Journal: |
Teratology |
| Title: |
Developmental expression and CORT-regulation of TGF-beta and EGF receptor mRNA during mouse palatal morphogenesis: correlation between CORT-induced cleft palate and TGF-beta 2 mRNA expression. |
| Volume: |
54 |
| Issue: |
1 |
| Pages: |
34-44 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1168
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
539
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
530
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
461
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
481
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
790
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
530
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
539
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tissir F |
| Year: |
2002 |
| Journal: |
Mech Dev |
| Title: |
Developmental expression profiles of Celsr (Flamingo) genes in the mouse. |
| Volume: |
112 |
| Issue: |
1-2 |
| Pages: |
157-60 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feng J |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity. |
| Volume: |
32 |
| Issue: |
40 |
| Pages: |
13729-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fenton TR |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. |
| Volume: |
109 |
| Issue: |
35 |
| Pages: |
14164-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ohm AM |
| Year: |
2019 |
| Journal: |
J Biol Chem |
| Title: |
EGF receptor and PKCδ kinase activate DNA damage-induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases. |
| Volume: |
294 |
| Issue: |
12 |
| Pages: |
4488-4497 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moreno-CÃ ceres J |
| Year: |
2014 |
| Journal: |
Cell Death Dis |
| Title: |
Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17. |
| Volume: |
5 |
|
| Pages: |
e1326 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eiraku M |
| Year: |
2005 |
| Journal: |
Nat Neurosci |
| Title: |
DNER acts as a neuron-specific Notch ligand during Bergmann glial development. |
| Volume: |
8 |
| Issue: |
7 |
| Pages: |
873-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Morris GE |
| Year: |
2022 |
| Journal: |
Br J Pharmacol |
| Title: |
The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1. |
| Volume: |
179 |
| Issue: |
21 |
| Pages: |
4958-4973 |
|
•
•
•
•
•
|
| Allele |
| Name: |
delta/notch-like EGF repeat containing; wild type |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Neutzner M |
| Year: |
2007 |
| Journal: |
Cancer Res |
| Title: |
MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis. |
| Volume: |
67 |
| Issue: |
14 |
| Pages: |
6777-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanwar A |
| Year: |
2023 |
| Journal: |
Front Immunol |
| Title: |
Synergistic regulation of Notch signaling by different O-glycans promotes hematopoiesis. |
| Volume: |
14 |
|
| Pages: |
1097332 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shi D |
| Year: |
2014 |
| Journal: |
Development |
| Title: |
Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct. |
| Volume: |
141 |
| Issue: |
23 |
| Pages: |
4558-68 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Involvement of Rabring7 in EGF receptor degradation as an E3 ligase. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Winkler MJ |
| Year: |
2020 |
| Journal: |
Basic Res Cardiol |
| Title: |
Functional investigation of the coronary artery disease gene SVEP1. |
| Volume: |
115 |
| Issue: |
6 |
| Pages: |
67 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
430
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
368
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Engel J |
| Year: |
1989 |
| Journal: |
FEBS Lett |
| Title: |
EGF-like domains in extracellular matrix proteins: localized signals for growth and differentiation? |
| Volume: |
251 |
| Issue: |
1-2 |
| Pages: |
1-7 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This EGF-like domain is found at the C terminus of the malaria parasite MSP1 protein. MSP1 is the merozoite surface protein 1. This domain is part of the C-terminal fragment that is proteolytically processed from the the rest of the protein and is left attached to the surface of the invading parasite []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tong J |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Odin (ANKS1A) modulates EGF receptor recycling and stability. |
| Volume: |
8 |
| Issue: |
6 |
| Pages: |
e64817 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Müller R |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila. |
| Volume: |
8 |
| Issue: |
5 |
| Pages: |
e62835 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hartman BH |
| Year: |
2010 |
| Journal: |
J Assoc Res Otolaryngol |
| Title: |
Delta/notch-like EGF-related receptor (DNER) is expressed in hair cells and neurons in the developing and adult mouse inner ear. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
187-201 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou L |
| Year: |
2009 |
| Journal: |
Cereb Cortex |
| Title: |
Role of the atypical cadherin Celsr3 during development of the internal capsule. |
| Volume: |
19 Suppl 1 |
|
| Pages: |
i114-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Han Q |
| Year: |
2013 |
| Journal: |
Neuroscience |
| Title: |
Spinal cord maturation and locomotion in mice with an isolated cortex. |
| Volume: |
253 |
|
| Pages: |
235-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Song H |
| Year: |
2000 |
| Journal: |
Mol Endocrinol |
| Title: |
Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice. |
| Volume: |
14 |
| Issue: |
8 |
| Pages: |
1147-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nauman M |
| Year: |
2023 |
| Journal: |
Sci Rep |
| Title: |
EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
17473 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Politi K |
| Year: |
2006 |
| Journal: |
Genes Dev |
| Title: |
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. |
| Volume: |
20 |
| Issue: |
11 |
| Pages: |
1496-510 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zecchin D |
| Year: |
2020 |
| Journal: |
EMBO Mol Med |
| Title: |
Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer. |
| Volume: |
12 |
| Issue: |
8 |
| Pages: |
e11987 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sugawara K |
| Year: |
2010 |
| Journal: |
J Dermatol Sci |
| Title: |
Cutaneous consequences of inhibiting EGF receptor signaling in vivo: normal hair follicle development, but retarded hair cycle induction and inhibition of adipocyte growth in Egfr(Wa5) mice. |
| Volume: |
57 |
| Issue: |
3 |
| Pages: |
155-61 |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|