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Search results 1001 to 1100 out of 1438 for Ephb2

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Ephb2/Ephb2<+>
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Efnb2/Efnb2<+> Ephb2/Ephb2
Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ephb2/Ephb2 Ephb3/Ephb3
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ephb2/Ephb2<+> Ephb3/Ephb3
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ephb2/Ephb2 Ephb3/Ephb3
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ephb1/Ephb1 Ephb2/Ephb2<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ephb1/Ephb1 Ephb2/Ephb2
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ephb2/Ephb2 Ephb3/Ephb3
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
12408869 | J:79724
First Author: Batlle E
Year: 2002
Journal: Cell
Title: Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.
Volume: 111
Issue: 2
Pages: 251-63
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Publication
10542222 | J:58260
First Author: Dodelet VC
Year: 1999
Journal: J Biol Chem
Title: A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A.
Volume: 274
Issue: 45
Pages: 31941-6
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Publication
10197531 | J:54097
First Author: Brückner K
Year: 1999
Journal: Neuron
Title: EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains.
Volume: 22
Issue: 3
Pages: 511-24
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Publication
17906625 | J:130035
First Author: Cortina C
Year: 2007
Journal: Nat Genet
Title: EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells.
Volume: 39
Issue: 11
Pages: 1376-83
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Publication
26633881 | J:250766
   
First Author: Poliak S
Year: 2015
Journal: Elife
Title: Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.
Volume: 4
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Publication
21112567 | J:168486
First Author: Nomura T
Year: 2010
Journal: Cell Stem Cell
Title: EphB signaling controls lineage plasticity of adult neural stem cell niche cells.
Volume: 7
Issue: 6
Pages: 730-43
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Publication
24453220 | J:206566
First Author: Robichaux MA
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding.
Volume: 111
Issue: 6
Pages: 2188-93
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Publication
22219273 | J:179366
First Author: Beaudoin GM 3rd
Year: 2012
Journal: J Neurosci
Title: Afadin, a Ras/Rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus.
Volume: 32
Issue: 1
Pages: 99-110
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Publication
26687224 | J:263453
First Author: Perez de Arce K
Year: 2015
Journal: Neuron
Title: Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains.
Volume: 88
Issue: 6
Pages: 1165-1172
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Genotype
Genotype
Symbol: Efnb2/Efnb2<+> Ephb2/Ephb2 Ephb3/Ephb3<+>
Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)
Zygosity: cx
Has Mutant Allele: true
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Protein Domain
IPR034238 | EphB2_rcpt_lig-bd
Type: Domain
Description: This entry represents the ligand-binding domain found in ephrin type-B receptor 2 (EphB2). EphB2 plays a role in cell positioning in the gastrointestinal tract by being expressed in proliferating progenitor cells []. It also has been implicated in colorectal cancer [, ]. A loss of EphB2, as well as EphA4, also precedes memory decline in a murine model of Alzheimers disease [].Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EhpB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands [].Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) [].
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Publication
22732593 | J:189784
First Author: Stolp J
Year: 2012
Journal: J Immunol
Title: Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice.
Volume: 189
Issue: 3
Pages: 1406-17
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Publication
21276420 | J:170939
First Author: Furukawa K
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Smad3 contributes to positioning of proliferating cells in colonic crypts by inducing EphB receptor protein expression.
Volume: 405
Issue: 4
Pages: 521-6
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Publication
28768156 | J:249752
 
First Author: Benon A
Year: 2017
Journal: Neuroscience
Title: The Syk kinases orchestrate cerebellar granule cell tangential migration.
Volume: 360
Pages: 230-239
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Publication
20678574 | J:171314
First Author: Antion MD
Year: 2010
Journal: Mol Cell Neurosci
Title: Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses.
Volume: 45
Issue: 4
Pages: 378-88
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Publication
30326247 | J:325848
 
First Author: Arthur A
Year: 2019
Journal: Exp Hematol
Title: Loss of EfnB1 in the osteogenic lineage compromises their capacity to support hematopoietic stem/progenitor cell maintenance.
Volume: 69
Pages: 43-53
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Publication
30143786 | J:288765
First Author: Arthur A
Year: 2018
Journal: Sci Rep
Title: The osteoprogenitor-specific loss of ephrinB1 results in an osteoporotic phenotype affecting the balance between bone formation and resorption.
Volume: 8
Issue: 1
Pages: 12756
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Publication
36130827 | J:333991
First Author: Zhang H
Year: 2022
Journal: J Immunol
Title: RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells.
Volume: 209
Issue: 9
Pages: 1796-1805
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Publication
9707552 | J:49560
First Author: Hock B
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.
Volume: 95
Issue: 17
Pages: 9779-84
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Publication
21652773 | J:173462
First Author: Wang D
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer.
Volume: 108
Issue: 25
Pages: 10272-7
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Publication
21852108 | J:184954
First Author: Herath NI
Year: 2012
Journal: Eur J Cancer
Title: Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis.
Volume: 48
Issue: 5
Pages: 753-62
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Publication
23486974 | J:196599
First Author: Murata Y
Year: 2013
Journal: J Neurosci
Title: Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.
Volume: 33
Issue: 11
Pages: 5040-52
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Publication
32078587 | J:301919
 
First Author: Miyagawa K
Year: 2020
Journal: JCI Insight
Title: Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo.
Volume: 5
Issue: 6
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Publication
34723325 | J:316324
 
First Author: Prospéri MT
Year: 2021
Journal: J Cell Sci
Title: Plekhh1, a partner of myosin 1 and an effector of EphB2, controls the cortical actin network during cell repulsion.
Volume: 134
Issue: 23
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Publication
15272013 | J:93464
First Author: Dail M
Year: 2004
Journal: J Biol Chem
Title: SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases.
Volume: 279
Issue: 40
Pages: 41892-902
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Publication
20639864 | J:163931
First Author: Johnson RA
Year: 2010
Journal: Nature
Title: Cross-species genomics matches driver mutations and cell compartments to model ependymoma.
Volume: 466
Issue: 7306
Pages: 632-6
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Publication
24023801 | J:205930
First Author: Dai J
Year: 2013
Journal: PLoS One
Title: Neuron glia-related cell adhesion molecule (NrCAM) promotes topographic retinocollicular mapping.
Volume: 8
Issue: 9
Pages: e73000
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Publication
10855796 | J:62323
First Author: Jeong J
Year: 2000
Journal: DNA Cell Biol
Title: Genomic structure and promoter analysis of the mouse EphA8 receptor tyrosine kinase gene.
Volume: 19
Issue: 5
Pages: 291-300
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Protein
A0A076N402
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: true
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Protein
Q52KP9
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: true
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Protein
A0A076N9K6
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: true
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Protein
A0A076N8A1
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: true
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Protein
A0A076NBC4
Organism: Mus musculus/domesticus
Length: 699  
Fragment?: true
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Protein
A0A076N1C3
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: true
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Protein
A0A076N9K1
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: true
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Protein
D3YV54
Organism: Mus musculus/domesticus
Length: 34  
Fragment?: true
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Protein
A0A5F8MPI0
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
D3Z418
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
A0A1Y7VJA6
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Publication
14704859 | -
First Author: Rothhammer T
Year: 2004
Journal: Cell Mol Life Sci
Title: The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma.
Volume: 61
Issue: 1
Pages: 118-28
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Publication
9031109 | -
First Author: Wlodarska I
Year: 1996
Journal: Leuk Lymphoma
Title: ETV6 gene rearrangements in hematopoietic malignant disorders.
Volume: 23
Issue: 3-4
Pages: 287-95
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Publication
12577325 | J:135865
First Author: Coonan JR
Year: 2003
Journal: J Comp Neurol
Title: Role of EphA4 in defining the position of a motoneuron pool within the spinal cord.
Volume: 458
Issue: 1
Pages: 98-111
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Publication
12389031 | -
First Author: Irie F
Year: 2002
Journal: Nat Neurosci
Title: EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP.
Volume: 5
Issue: 11
Pages: 1117-8
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Publication
14659698 | J:87527
First Author: Melino G
Year: 2003
Journal: Trends Biochem Sci
Title: Functional regulation of p73 and p63: development and cancer.
Volume: 28
Issue: 12
Pages: 663-70
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Publication
14499651 | -
First Author: Bloyer S
Year: 2003
Journal: Dev Biol
Title: Identification and characterization of polyhomeotic PREs and TREs.
Volume: 261
Issue: 2
Pages: 426-42
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Protein Domain
IPR013761 | SAM/pointed_sf
Type: Homologous_superfamily
Description: Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway []. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA []. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases []; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies []; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord []; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp []; p73, a p53 homologue involved in neuronal development []; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes [].
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Protein
Q8R3Y5
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
Q5SXE1
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
A0A087WPA4
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: true
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Protein
D2JZZ5
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
G5E8E3
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
A0A0R4J2B5
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
A0A087WRI8
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
Q5SXE2
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Protein
Q6PAJ3
Organism: Mus musculus/domesticus
Length: 880  
Fragment?: false
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Protein
Q3UFT3
Organism: Mus musculus/domesticus
Length: 876  
Fragment?: false
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Protein
E9QAJ7
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
Q6TDG7
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q8CC79
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: true
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Protein
A0A3B2WCY8
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: true
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Protein
D3Z292
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Publication
12858164 | -
First Author: Aviv T
Year: 2003
Journal: Nat Struct Biol
Title: The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators.
Volume: 10
Issue: 8
Pages: 614-21
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Protein
Q61127
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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Protein
Q8K070
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
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Protein
F6XZJ7
Organism: Mus musculus/domesticus
Length: 620  
Fragment?: false
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Protein
D3YXK1
Organism: Mus musculus/domesticus
Length: 519  
Fragment?: false
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Protein
Q60710
Organism: Mus musculus/domesticus
Length: 658  
Fragment?: false
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Protein
Q8VCQ6
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
Q8C8Y5
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
Q69Z37
Organism: Mus musculus/domesticus
Length: 1561  
Fragment?: false
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Protein
Q8C4H2
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
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Protein
Q9DA37
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
Q7TST3
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Protein
Q1RNF8
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein
Q0VE29
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
D3YUG0
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
Q3V1H9
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
Q6NZC7
Organism: Mus musculus/domesticus
Length: 998  
Fragment?: false
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Protein
Q9ERA0
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Protein
Q3UNW5
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
Q80VG1
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
Q811S7
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: false
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Protein
Q3UH82
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q3U247
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Protein
Q8C5C0
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
E9Q3G4
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
Q3TYF1
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
Q14AQ4
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
B9EKF8
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Protein
C4IXV3
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
Q3UR41
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
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Protein
S4R2K2
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom