Type |
Details |
Score |
Genotype |
Symbol: |
Pten/Pten<+> Tmprss2/Tmprss2 |
Background: |
involves: 129S4/SvJae * C57BL/6 * DBA/2 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tmprss2/Tmprss2 |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Etv1/Etv1 |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Etv1-cre)GM225Gsat/? |
Background: |
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Etv1-cre,-GFP)#Stoy/? |
Background: |
involves: 129S4/SvJaeSor |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Oh S |
Year: |
2012 |
Journal: |
Biochim Biophys Acta |
Title: |
ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors. |
Volume: |
1826 |
Issue: |
1 |
Pages: |
1-12 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This transcriptional activator is known as ETS translocation variant 1 (ETV1) or Ets-related protein 81 (ER81). It is a member of the larger E-twenty six (Ets) family whose members bind DNA directly via a conserved Ets domain []. ETV1 contributes to the formation of dopaminergic neurons []and also contributes to formation of proper connections between group 1a sensory afferents and motor neurons []. It is an oncoprotein implicated in Ewing tumours and different types of cancer [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Groh A |
Year: |
2010 |
Journal: |
Cereb Cortex |
Title: |
Cell-type specific properties of pyramidal neurons in neocortex underlying a layout that is modifiable depending on the cortical area. |
Volume: |
20 |
Issue: |
4 |
Pages: |
826-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun Y |
Year: |
2008 |
Journal: |
Nat Neurosci |
Title: |
A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. |
Volume: |
11 |
Issue: |
11 |
Pages: |
1283-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2013 |
Journal: |
Nat Med |
Title: |
ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. |
Volume: |
19 |
Issue: |
8 |
Pages: |
1023-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yin Q |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice. |
Volume: |
11 |
Issue: |
1 |
Pages: |
2538 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sürmeli G |
Year: |
2015 |
Journal: |
Neuron |
Title: |
Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep Layers of the Medial Entorhinal Cortex. |
Volume: |
88 |
Issue: |
5 |
Pages: |
1040-1053 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
77
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
290
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
293
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
61
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
183
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
84
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
113
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Finnegan A |
Year: |
2019 |
Journal: |
Front Genet |
Title: |
Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover of Keratinocyte Differentiation Regulators. |
Volume: |
10 |
|
Pages: |
775 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qi T |
Year: |
2020 |
Journal: |
Am J Cancer Res |
Title: |
Function and regulation of the PEA3 subfamily of ETS transcription factors in cancer. |
Volume: |
10 |
Issue: |
10 |
Pages: |
3083-3105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo B |
Year: |
2009 |
Journal: |
Mol Cell Biol |
Title: |
Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3. |
Volume: |
29 |
Issue: |
11 |
Pages: |
3204-18 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents ETS family of transcription factors, including ETS translocation variant 1-5 (ETV1-5) and related proteins from animals. Most members of this protein family contain an ETS (erythroblast transformation specific) domain and belong to the winged helix DNA-binding domain superfamily.ETV1-5 are overexpressed in multiple cancers [, , ]. ETV1 is critical for fast conduction physiology in the heart []. ETV3 is a transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation []. ETV4 is a transcriptional activator that may play a role in keratinocyte differentiation [, ]. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
230
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
249
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pten/Pten<+> Tmprss2/Tmprss2 Tg(Pbsn-cre)4Prb/? |
Background: |
involves: 129S4/SvJae * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Vitari AC |
Year: |
2011 |
Journal: |
Nature |
Title: |
COP1 is a tumour suppressor that causes degradation of ETS transcription factors. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
403-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shin S |
Year: |
2009 |
Journal: |
Cancer Res |
Title: |
Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81. |
Volume: |
69 |
Issue: |
20 |
Pages: |
8102-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ran L |
Year: |
2018 |
Journal: |
Cancer Discov |
Title: |
FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor. |
Volume: |
8 |
Issue: |
2 |
Pages: |
234-251 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klappacher GW |
Year: |
2002 |
Journal: |
Cell |
Title: |
An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. |
Volume: |
109 |
Issue: |
2 |
Pages: |
169-80 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
219
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Hollenhorst PC |
Year: |
2011 |
Journal: |
Annu Rev Biochem |
Title: |
Genomic and biochemical insights into the specificity of ETS transcription factors. |
Volume: |
80 |
|
Pages: |
437-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guan D |
Year: |
2015 |
Journal: |
J Neurophysiol |
Title: |
Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine. |
Volume: |
113 |
Issue: |
7 |
Pages: |
2014-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pathak D |
Year: |
2016 |
Journal: |
J Neurophysiol |
Title: |
Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex. |
Volume: |
115 |
Issue: |
5 |
Pages: |
2317-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guan D |
Year: |
2018 |
Journal: |
J Neurophysiol |
Title: |
Functional roles of Kv1-mediated currents in genetically identified subtypes of pyramidal neurons in layer 5 of mouse somatosensory cortex. |
Volume: |
120 |
Issue: |
2 |
Pages: |
394-408 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tomlins SA |
Year: |
2007 |
Journal: |
Nature |
Title: |
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. |
Volume: |
448 |
Issue: |
7153 |
Pages: |
595-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
80
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
282
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
477
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
374
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
437
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
477
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
454
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
459
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
513
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
429
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
335
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
551
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
409
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
237
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
430
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
510
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
485
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
272
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
267
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
242
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
528
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
51
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
428
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
142
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
480
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
522
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
79
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
43
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
409
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
167
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
65
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
306
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
486
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
127
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
125
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
146
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
429
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
43
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
142
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
241
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
319
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
267
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
358
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
209
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
203
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
69
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
249
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
409
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
352
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
268
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
44
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
551
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
149
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
513
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
267
 |
Fragment?: |
false |
|
•
•
•
•
•
|