Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
746
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
746
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
779
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
707
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
742
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
127
 |
Fragment?: |
true |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE60660 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Versemann L |
Year: |
2022 |
Journal: |
Cancers (Basel) |
Title: |
TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer. |
Volume: |
14 |
Issue: |
14 |
|
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE74538 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE30076 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
704
 |
Fragment?: |
false |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE70440 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Bitler BG |
Year: |
2015 |
Journal: |
Nat Med |
Title: |
Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. |
Volume: |
21 |
Issue: |
3 |
Pages: |
231-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu G |
Year: |
2023 |
Journal: |
Sci Transl Med |
Title: |
TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence. |
Volume: |
15 |
Issue: |
714 |
Pages: |
eadi7244 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Gonzalez ME |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
EZH2 expands breast stem cells through activation of NOTCH1 signaling. |
Volume: |
111 |
Issue: |
8 |
Pages: |
3098-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuan H |
Year: |
2020 |
Journal: |
Cancer Cell |
Title: |
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. |
Volume: |
38 |
Issue: |
3 |
Pages: |
350-365.e7 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE65082 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Zingg D |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy. |
Volume: |
20 |
Issue: |
4 |
Pages: |
854-867 |
|
•
•
•
•
•
|
Publication |
First Author: |
Serresi M |
Year: |
2018 |
Journal: |
J Exp Med |
Title: |
Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities. |
Volume: |
215 |
Issue: |
12 |
Pages: |
3115-3135 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wan L |
Year: |
2018 |
Journal: |
Mol Cell |
Title: |
Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. |
Volume: |
69 |
Issue: |
2 |
Pages: |
279-291.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu S |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells. |
Volume: |
9 |
Issue: |
1 |
Pages: |
4116 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu ZL |
Year: |
2010 |
Journal: |
Cell Death Differ |
Title: |
Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression. |
Volume: |
17 |
Issue: |
5 |
Pages: |
801-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Neo WH |
Year: |
2018 |
Journal: |
Blood |
Title: |
Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells. |
Volume: |
131 |
Issue: |
20 |
Pages: |
2223-2234 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen F |
Year: |
2022 |
Journal: |
Cancer Lett |
Title: |
EZH2 inhibition confers PIK3CA-driven lung tumors enhanced sensitivity to PI3K inhibition. |
Volume: |
524 |
|
Pages: |
151-160 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-58998 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Herrera-Merchan A |
Year: |
2012 |
Journal: |
Nat Commun |
Title: |
Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. |
Volume: |
3 |
|
Pages: |
623 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang A |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Cutting edge: Smad2 and Smad4 regulate TGF-β-mediated Il9 gene expression via EZH2 displacement. |
Volume: |
191 |
Issue: |
10 |
Pages: |
4908-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Vries NA |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gleneadie HJ |
Year: |
2023 |
Journal: |
Commun Biol |
Title: |
Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition. |
Volume: |
6 |
Issue: |
1 |
Pages: |
318 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu B |
Year: |
2015 |
Journal: |
Blood |
Title: |
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. |
Volume: |
125 |
Issue: |
2 |
Pages: |
346-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang M |
Year: |
2023 |
Journal: |
Cancers (Basel) |
Title: |
Regulation of EZH2 Expression by INPP4B in Normal Prostate and Primary Prostate Cancer. |
Volume: |
15 |
Issue: |
22 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lv Q |
Year: |
2021 |
Journal: |
Acta Pharm Sin B |
Title: |
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation. |
Volume: |
11 |
Issue: |
9 |
Pages: |
2880-2899 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang H |
Year: |
2016 |
Journal: |
Cancer Discov |
Title: |
Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer. |
Volume: |
6 |
Issue: |
9 |
Pages: |
1006-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu H |
Year: |
2017 |
Journal: |
Mol Cancer Res |
Title: |
MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation. |
Volume: |
15 |
Issue: |
9 |
Pages: |
1275-1286 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rondinelli B |
Year: |
2017 |
Journal: |
Nat Cell Biol |
Title: |
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation. |
Volume: |
19 |
Issue: |
11 |
Pages: |
1371-1378 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dudakovic A |
Year: |
2020 |
Journal: |
J Biol Chem |
Title: |
Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2. |
Volume: |
295 |
Issue: |
23 |
Pages: |
7877-7893 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE52016 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Bracken AP |
Year: |
2007 |
Journal: |
Genes Dev |
Title: |
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. |
Volume: |
21 |
Issue: |
5 |
Pages: |
525-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wong CF |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis. |
Volume: |
283 |
Issue: |
15 |
Pages: |
9836-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berg JL |
Year: |
2021 |
Journal: |
Leukemia |
Title: |
EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity. |
Volume: |
35 |
Issue: |
5 |
Pages: |
1521-1526 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu H |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. |
Volume: |
8 |
Issue: |
12 |
Pages: |
e83737 |
|
•
•
•
•
•
|
Publication |
First Author: |
McCleland ML |
Year: |
2015 |
Journal: |
J Pathol |
Title: |
Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis. |
Volume: |
237 |
Issue: |
4 |
Pages: |
508-19 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
The polycomb group protein EZH2 is required for mammalian circadian clock function. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38 activation. |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE53627 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-79035 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao R |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
Role of hPHF1 in H3K27 methylation and Hox gene silencing. |
Volume: |
28 |
Issue: |
5 |
Pages: |
1862-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim SY |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Developmental regulation of Eed complex composition governs a switch in global histone modification in brain. |
Volume: |
282 |
Issue: |
13 |
Pages: |
9962-72 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. |
|
•
•
•
•
•
|
Allele |
Name: |
enhancer of zeste 2 polycomb repressive complex 2 subunit; endonuclease-mediated mutation 1, Jeffrey Baron |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
Allele |
Name: |
enhancer of zeste 2 polycomb repressive complex 2 subunit; endonuclease-mediated mutation 1, Jill A Fahrner |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Mak W |
Year: |
2002 |
Journal: |
Curr Biol |
Title: |
Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells. |
Volume: |
12 |
Issue: |
12 |
Pages: |
1016-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Silva J |
Year: |
2003 |
Journal: |
Dev Cell |
Title: |
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. |
Volume: |
4 |
Issue: |
4 |
Pages: |
481-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Plath K |
Year: |
2003 |
Journal: |
Science |
Title: |
Role of histone H3 lysine 27 methylation in X inactivation. |
Volume: |
300 |
Issue: |
5616 |
Pages: |
131-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mak W |
Year: |
2004 |
Journal: |
Science |
Title: |
Reactivation of the paternal X chromosome in early mouse embryos. |
Volume: |
303 |
Issue: |
5658 |
Pages: |
666-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Viré E |
Year: |
2006 |
Journal: |
Nature |
Title: |
The Polycomb group protein EZH2 directly controls DNA methylation. |
Volume: |
439 |
Issue: |
7078 |
Pages: |
871-4 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Specialized Distribution of the Histone Methyltransferase Ezh2 in the Nuclear Apical Region of Round Spermatids and Its Interaction with the Histone Variant H1t2. |
|
•
•
•
•
•
|
Allele |
Name: |
enhancer of zeste 2 polycomb repressive complex 2 subunit; targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, R Keith Humphries |
Allele Type: |
Transgenic |
Attribute String: |
Epitope tag, Inserted expressed sequence |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Umlauf D |
Year: |
2004 |
Journal: |
Nat Genet |
Title: |
Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. |
Volume: |
36 |
Issue: |
12 |
Pages: |
1296-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuzmichev A |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. |
Volume: |
102 |
Issue: |
6 |
Pages: |
1859-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kalantry S |
Year: |
2006 |
Journal: |
Nat Cell Biol |
Title: |
The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. |
Volume: |
8 |
Issue: |
2 |
Pages: |
195-202 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 61, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Cha TL |
Year: |
2005 |
Journal: |
Science |
Title: |
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. |
Volume: |
310 |
Issue: |
5746 |
Pages: |
306-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tonini T |
Year: |
2004 |
Journal: |
Oncogene |
Title: |
Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A. |
Volume: |
23 |
Issue: |
28 |
Pages: |
4930-7 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ezh2/Ezh2 |
Background: |
C57BL/6J-Ezh2 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ezh2/Ezh2<+> |
Background: |
C57BL/6J-Ezh2 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ezh2/Ezh2<+> |
Background: |
C57BL/6J-Ezh2 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain is found to the N terminus of the SET domain in the EZH2 protein []. It is a zinc binding domain. |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Attwooll C |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. |
Volume: |
280 |
Issue: |
2 |
Pages: |
1199-208 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE52220 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SET domain found in EZH1.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SET domain found in EZH2.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].This family consists of EZH1 []. |
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Protein Domain |
Type: |
Family |
Description: |
The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation []. |
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HT Experiment |
Series Id: |
GSE29992 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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Publication |
First Author: |
Lambrot R |
Year: |
2012 |
Journal: |
J Androl |
Title: |
Specialized distribution of the histone methyltransferase Ezh2 in the nuclear apical region of round spermatids and its interaction with the histone variant H1t2. |
Volume: |
33 |
Issue: |
5 |
Pages: |
1058-66 |
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HT Experiment |
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Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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HT Experiment |
Series Id: |
E-GEOD-32929 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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Protein Domain |
Type: |
Family |
Description: |
This entry represents a group of histone-lysine N-methyltransferases that belong to the Polycomb group (Pc-G), including:Drosophila melanogaster Enhancer of zeste E(z).Mammalian EZH-1 and EZH-2.Arabidopsis thaliana CURLY LEAF (CLF), a transcriptional repressor of floral homeotic gene AGAMOUS.Arabidopsis thaliana CLF-like.Arabidopsis thaliana MEDEA (MEA), a suppressor of endosperm development.Arabidopsis thaliana EZA1.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
391
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
231
 |
Fragment?: |
true |
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DO Term |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
205
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
151
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
211
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
222
 |
Fragment?: |
true |
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Publication |
First Author: |
Astori A |
Year: |
2013 |
Journal: |
Oncotarget |
Title: |
CXXC5 (retinoid-inducible nuclear factor, RINF) is a potential therapeutic target in high-risk human acute myeloid leukemia. |
Volume: |
4 |
Issue: |
9 |
Pages: |
1438-48 |
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Publication |
First Author: |
Fang L |
Year: |
2018 |
Journal: |
Oncol Lett |
Title: |
Overexpression of CXXC5 is a strong poor prognostic factor in ER+ breast cancer. |
Volume: |
16 |
Issue: |
1 |
Pages: |
395-401 |
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Publication |
First Author: |
Lu H |
Year: |
2013 |
Journal: |
Cell Death Dis |
Title: |
Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4. |
Volume: |
4 |
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Pages: |
e776 |
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