|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1001 to 1100 out of 1262 for Ezh2

0.074s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 779  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: true
HT Experiment
Series Id: GSE60660
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication  
First Author: Versemann L
Year: 2022
Journal: Cancers (Basel)
Title: TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer.
Volume: 14
Issue: 14
HT Experiment
Series Id: GSE74538
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: GSE30076
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Protein
Organism: Mus musculus/domesticus
Length: 704  
Fragment?: false
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: GSE70440
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Bitler BG
Year: 2015
Journal: Nat Med
Title: Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers.
Volume: 21
Issue: 3
Pages: 231-8
Publication
First Author: Wu G
Year: 2023
Journal: Sci Transl Med
Title: TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence.
Volume: 15
Issue: 714
Pages: eadi7244
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Gonzalez ME
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: EZH2 expands breast stem cells through activation of NOTCH1 signaling.
Volume: 111
Issue: 8
Pages: 3098-103
Publication
First Author: Yuan H
Year: 2020
Journal: Cancer Cell
Title: SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways.
Volume: 38
Issue: 3
Pages: 350-365.e7
HT Experiment
Series Id: GSE65082
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Zingg D
Year: 2017
Journal: Cell Rep
Title: The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy.
Volume: 20
Issue: 4
Pages: 854-867
Publication
First Author: Serresi M
Year: 2018
Journal: J Exp Med
Title: Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.
Volume: 215
Issue: 12
Pages: 3115-3135
Publication
First Author: Wan L
Year: 2018
Journal: Mol Cell
Title: Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.
Volume: 69
Issue: 2
Pages: 279-291.e5
Publication
First Author: Wu S
Year: 2018
Journal: Nat Commun
Title: SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells.
Volume: 9
Issue: 1
Pages: 4116
Publication
First Author: Wu ZL
Year: 2010
Journal: Cell Death Differ
Title: Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression.
Volume: 17
Issue: 5
Pages: 801-10
Publication
First Author: Neo WH
Year: 2018
Journal: Blood
Title: Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.
Volume: 131
Issue: 20
Pages: 2223-2234
Publication  
First Author: Chen F
Year: 2022
Journal: Cancer Lett
Title: EZH2 inhibition confers PIK3CA-driven lung tumors enhanced sensitivity to PI3K inhibition.
Volume: 524
Pages: 151-160
HT Experiment
Series Id: E-GEOD-58998
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication  
First Author: Herrera-Merchan A
Year: 2012
Journal: Nat Commun
Title: Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease.
Volume: 3
Pages: 623
Publication
First Author: Wang A
Year: 2013
Journal: J Immunol
Title: Cutting edge: Smad2 and Smad4 regulate TGF-β-mediated Il9 gene expression via EZH2 displacement.
Volume: 191
Issue: 10
Pages: 4908-12
Publication      
First Author: de Vries NA
Year: 2015
Journal: Cell Rep
Title: Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression.
Publication
First Author: Gleneadie HJ
Year: 2023
Journal: Commun Biol
Title: Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition.
Volume: 6
Issue: 1
Pages: 318
Publication
First Author: Xu B
Year: 2015
Journal: Blood
Title: Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.
Volume: 125
Issue: 2
Pages: 346-57
Publication  
First Author: Zhang M
Year: 2023
Journal: Cancers (Basel)
Title: Regulation of EZH2 Expression by INPP4B in Normal Prostate and Primary Prostate Cancer.
Volume: 15
Issue: 22
Publication
First Author: Lv Q
Year: 2021
Journal: Acta Pharm Sin B
Title: Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation.
Volume: 11
Issue: 9
Pages: 2880-2899
Publication
First Author: Zhang H
Year: 2016
Journal: Cancer Discov
Title: Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.
Volume: 6
Issue: 9
Pages: 1006-21
Publication
First Author: Liu H
Year: 2017
Journal: Mol Cancer Res
Title: MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation.
Volume: 15
Issue: 9
Pages: 1275-1286
Publication
First Author: Rondinelli B
Year: 2017
Journal: Nat Cell Biol
Title: EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Volume: 19
Issue: 11
Pages: 1371-1378
Publication
First Author: Dudakovic A
Year: 2020
Journal: J Biol Chem
Title: Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2.
Volume: 295
Issue: 23
Pages: 7877-7893
HT Experiment
Series Id: GSE52016
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Bracken AP
Year: 2007
Journal: Genes Dev
Title: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.
Volume: 21
Issue: 5
Pages: 525-30
Publication
First Author: Wong CF
Year: 2008
Journal: J Biol Chem
Title: MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis.
Volume: 283
Issue: 15
Pages: 9836-43
Publication
First Author: Berg JL
Year: 2021
Journal: Leukemia
Title: EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.
Volume: 35
Issue: 5
Pages: 1521-1526
Publication
First Author: Wu H
Year: 2013
Journal: PLoS One
Title: Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
Volume: 8
Issue: 12
Pages: e83737
Publication
First Author: McCleland ML
Year: 2015
Journal: J Pathol
Title: Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis.
Volume: 237
Issue: 4
Pages: 508-19
Interaction Experiment
Description: The polycomb group protein EZH2 is required for mammalian circadian clock function.
Interaction Experiment
Description: Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A.
Interaction Experiment
Description: Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38 activation.
HT Experiment
Series Id: GSE53627
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: E-GEOD-79035
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Cao R
Year: 2008
Journal: Mol Cell Biol
Title: Role of hPHF1 in H3K27 methylation and Hox gene silencing.
Volume: 28
Issue: 5
Pages: 1862-72
Publication
First Author: Kim SY
Year: 2007
Journal: J Biol Chem
Title: Developmental regulation of Eed complex composition governs a switch in global histone modification in brain.
Volume: 282
Issue: 13
Pages: 9962-72
Interaction Experiment
Description: A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.
Allele
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit; endonuclease-mediated mutation 1, Jeffrey Baron
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
Allele
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit; endonuclease-mediated mutation 1, Jill A Fahrner
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Null/knockout
Publication
First Author: Mak W
Year: 2002
Journal: Curr Biol
Title: Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells.
Volume: 12
Issue: 12
Pages: 1016-20
Publication
First Author: Silva J
Year: 2003
Journal: Dev Cell
Title: Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.
Volume: 4
Issue: 4
Pages: 481-95
Publication
First Author: Plath K
Year: 2003
Journal: Science
Title: Role of histone H3 lysine 27 methylation in X inactivation.
Volume: 300
Issue: 5616
Pages: 131-5
Publication
First Author: Mak W
Year: 2004
Journal: Science
Title: Reactivation of the paternal X chromosome in early mouse embryos.
Volume: 303
Issue: 5658
Pages: 666-9
Publication
First Author: Viré E
Year: 2006
Journal: Nature
Title: The Polycomb group protein EZH2 directly controls DNA methylation.
Volume: 439
Issue: 7078
Pages: 871-4
Interaction Experiment
Description: Specialized Distribution of the Histone Methyltransferase Ezh2 in the Nuclear Apical Region of Round Spermatids and Its Interaction with the Histone Variant H1t2.
Allele
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: transgene insertion 1, R Keith Humphries
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Umlauf D
Year: 2004
Journal: Nat Genet
Title: Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.
Volume: 36
Issue: 12
Pages: 1296-300
Publication
First Author: Kuzmichev A
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.
Volume: 102
Issue: 6
Pages: 1859-64
Publication
First Author: Kalantry S
Year: 2006
Journal: Nat Cell Biol
Title: The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.
Volume: 8
Issue: 2
Pages: 195-202
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Allele
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 61, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Publication
First Author: Cha TL
Year: 2005
Journal: Science
Title: Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Volume: 310
Issue: 5746
Pages: 306-10
Publication
First Author: Tonini T
Year: 2004
Journal: Oncogene
Title: Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A.
Volume: 23
Issue: 28
Pages: 4930-7
DO Term
Genotype
Symbol: Ezh2/Ezh2
Background: C57BL/6J-Ezh2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ezh2/Ezh2<+>
Background: C57BL/6J-Ezh2
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Ezh2/Ezh2<+>
Background: C57BL/6J-Ezh2
Zygosity: ht
Has Mutant Allele: true
Protein Domain
Type: Domain
Description: This domain is found to the N terminus of the SET domain in the EZH2 protein []. It is a zinc binding domain.
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: Attwooll C
Year: 2005
Journal: J Biol Chem
Title: A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.
Volume: 280
Issue: 2
Pages: 1199-208
HT Experiment
Series Id: GSE52220
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Protein Domain
Type: Domain
Description: This entry represents the SET domain found in EZH1.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
Protein Domain
Type: Domain
Description: This entry represents the SET domain found in EZH2.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
Protein Domain
Type: Family
Description: The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].This family consists of EZH1 [].
Protein Domain
Type: Family
Description: The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
HT Experiment
Series Id: GSE29992
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Lambrot R
Year: 2012
Journal: J Androl
Title: Specialized distribution of the histone methyltransferase Ezh2 in the nuclear apical region of round spermatids and its interaction with the histone variant H1t2.
Volume: 33
Issue: 5
Pages: 1058-66
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: E-GEOD-32929
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Protein Domain
Type: Family
Description: This entry represents a group of histone-lysine N-methyltransferases that belong to the Polycomb group (Pc-G), including:Drosophila melanogaster Enhancer of zeste E(z).Mammalian EZH-1 and EZH-2.Arabidopsis thaliana CURLY LEAF (CLF), a transcriptional repressor of floral homeotic gene AGAMOUS.Arabidopsis thaliana CLF-like.Arabidopsis thaliana MEDEA (MEA), a suppressor of endosperm development.Arabidopsis thaliana EZA1.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
Protein
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
DO Term
Protein
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: true
Publication
First Author: Astori A
Year: 2013
Journal: Oncotarget
Title: CXXC5 (retinoid-inducible nuclear factor, RINF) is a potential therapeutic target in high-risk human acute myeloid leukemia.
Volume: 4
Issue: 9
Pages: 1438-48
Publication
First Author: Fang L
Year: 2018
Journal: Oncol Lett
Title: Overexpression of CXXC5 is a strong poor prognostic factor in ER+ breast cancer.
Volume: 16
Issue: 1
Pages: 395-401
Publication  
First Author: Lu H
Year: 2013
Journal: Cell Death Dis
Title: Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4.
Volume: 4
Pages: e776