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Search results 1001 to 1100 out of 1188 for Gem

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Rem2<tm1c(EUCOMM)Hmgu> | MGI:6192081
Name: rad and gem related GTP binding protein 2; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:6866110 | C57BL/6N-Gemin6<em1(IMPC)Bay>/Mmmh
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6480317 | C57BL/6N-Gemin6<em1(IMPC)Bay>/BayMmucd
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6407927 | C57BL/6N-Gemin4<em1(IMPC)Ics>/Ics
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6767894 | C57BL/6JGpt-Gemin2<em9Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6767895 | C57BL/6JGpt-Gemin6<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6769247 | C57BL/6JGpt-Rem2<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6769248 | C57BL/6JGpt-Rem2<em2Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Gemin2/Gemin2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rem1/Rem1
Background: involves: 129S6/SvEvTac * Black Swiss
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gemin4/Gemin4
Background: involves: 129S5/SvEvBrd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rem2/Rem2
Background: 129S2.B6N-Rem2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rem2/Rem2
Background: C57BL/6-Rem2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rem2/Rem2
Background: involves: 129S4/SvJaeSor * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gemin6/Gemin6
Background: C57BL/6N-Gemin6/Mmmh
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gemin6/Gemin6
Background: C57BL/6N-Gemin6/BayMmucd
Zygosity: hm
Has Mutant Allele: true
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Publication
16434402 | J:110584
First Author: Carissimi C
Year: 2006
Journal: J Biol Chem
Title: Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly.
Volume: 281
Issue: 12
Pages: 8126-34
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Publication
39337533 | J:355056
 
First Author: Salman B
Year: 2024
Journal: Int J Mol Sci
Title: Understanding the Role of the SMN Complex Component GEMIN5 and Its Functional Relationship with Demethylase KDM6B in the Flunarizine-Mediated Neuroprotection of Motor Neuron Disease Spinal Muscular Atrophy.
Volume: 25
Issue: 18
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Publication
- | J:77700
   
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, clone IMAGE: 3483507, mRNA, partial cds
Pages: BC005604
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Publication
26078055 | J:309918
First Author: Beqollari D
Year: 2015
Journal: J Gen Physiol
Title: Rem uncouples excitation-contraction coupling in adult skeletal muscle fibers.
Volume: 146
Issue: 1
Pages: 97-108
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Genotype
Genotype
Symbol: Gemin5/Gemin5<+>
Background: C57BL/6N-Gemin5/H
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gemin4/Gemin4<+>
Background: C57BL/6N-Gemin4/Ics
Zygosity: ht
Has Mutant Allele: true
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Allele
Tg(Myh6/tetO-Rem1*)1Jmol | MGI:5897306
Name: transgene insertion 1, Jeffery Molkentin
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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HT Experiment
GSE255534 | Single-cell RNA sequencing analysis of E14.5 mouse skin data
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:7853351 | C57BL/6N-A<tm1Brd> Rem1<tm1a(KOMP)Wtsi>/WtsiH
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:5557169 | B6NTac;B6N-A<tm1Brd> Rem1<tm1a(KOMP)Wtsi>/Wtsi
Attribute String: mutant strain, targeted mutation
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Strain
MGI:6344845 | C57BL/6N-A<tm1Brd> Rem1<tm1a(KOMP)Wtsi>/Mmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Rem2/Rem2 Pvalb/Pvalb<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Publication
10441394 | J:56855
First Author: Finlin BS
Year: 1999
Journal: Arch Biochem Biophys
Title: Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins.
Volume: 368
Issue: 2
Pages: 401-12
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Strain
MGI:5897334 | FVB-Tg(Myh6/tetO-Rem1*)1Jmol/J
Attribute String: transgenic, mutant strain, coisogenic
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HT Experiment
GSE254380 | High-throughput exploration of single-cell transcriptional alterations associated with remote fear memory formation
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
16166090 | J:103823
First Author: Thevenet L
Year: 2005
Journal: J Biol Chem
Title: NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY.
Volume: 280
Issue: 46
Pages: 38625-30
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Publication
11470819 | J:70593
First Author: Tucker KE
Year: 2001
Journal: J Cell Biol
Title: Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product.
Volume: 154
Issue: 2
Pages: 293-307
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Publication
23897586 | J:238830
First Author: Fallini C
Year: 2014
Journal: Dev Neurobiol
Title: Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons.
Volume: 74
Issue: 3
Pages: 319-332
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Publication
18272193 | -
First Author: Heralde FM 3rd
Year: 2008
Journal: Toxicon
Title: A rapidly diverging superfamily of peptide toxins in venomous Gemmula species.
Volume: 51
Issue: 5
Pages: 890-7
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Protein Domain
IPR026210 | Toxin_Pg
Type: Family
Description: Proteins in this family are disulphide-rich peptides expressed in Gemmula venom ducts in the gem turrids (venomous snails in the family Turridae) [].There are more than 10,000 species of predatory marine snail that use venom as their primary weapon for prey capture. Based on shell morphology, they are traditionally divided into 3 groups: cone snails, augers and turrids. Most molluscan taxonomies assign cone snails to a single large genus, Conus, while augers are assigned to several different genera; by contrast, the turrids represent a group that is much more diverse, and is now thought to comprise the vast majority of conoidean biodiversity [].The venom peptides from several species in the genus Gemmula, the gem turrids, have been characterised. Their translated open reading frames show characteristics typical of the venom peptides from Conus: an N-terminal signal sequence; a C-terminal cysteine-rich mature peptide; and an intervening pro-region. Two of these sequences, Gsp9.1 and Gsp9.2, have highly similar signal and propeptide regions, while their predicted mature peptides are more divergent (although the cysteine residues are completely conserved) []. This pattern of highly conserved and more variable regions is characteristic of gene superfamilies encoding the toxin peptides found in Conus venoms.
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Genotype
Genotype
Symbol: Gemin2/Gemin2<+> Smn1/Smn1<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * MF1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rem2/Rem2 Emx1/Emx1<+>
Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rem2/Rem2 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6N * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rem2/Rem2 Vip/Vip<+>
Background: involves: 129S4/SvJaeSor * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE215381 | c-Myc supports polyploidy and prevents senescence in the murine placenta [scRNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
E-MTAB-12180 | Single-nucleus RNA-seq of adult female and male mouse livers for sex-biased gene expression analyses
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
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Publication
38000026 | J:343100
First Author: Takada Y
Year: 2023
Journal: Sci Adv
Title: Mature mRNA processing that deletes 3' end sequences directs translational activation and embryonic development.
Volume: 9
Issue: 47
Pages: eadg6532
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HT Experiment
GSE201605 | Col2a1-Cre;Idh1LSL/+ embryonic growth plate chondrocytes - single cell RNA-sequencing
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE175498 | Single Cell RNA-Seq of the embryonic day 14.5 genital tubercle
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
15769905 | J:99312
First Author: Jerez-Timaure NC
Year: 2005
Journal: Physiol Genomics
Title: Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2.
Volume: 21
Issue: 3
Pages: 411-22
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Publication
29100089 | J:262321
First Author: Küry S
Year: 2017
Journal: Am J Hum Genet
Title: De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.
Volume: 101
Issue: 5
Pages: 768-788
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Publication
31366290 | J:294964
First Author: Vincentz JW
Year: 2019
Journal: Circ Res
Title: Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function.
Volume: 125
Issue: 6
Pages: 575-589
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Publication
16236758 | J:106808
First Author: Gabanella F
Year: 2005
Journal: Hum Mol Genet
Title: The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation.
Volume: 14
Issue: 23
Pages: 3629-42
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Publication
18255031 | J:135318
First Author: Britanova O
Year: 2008
Journal: Neuron
Title: Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.
Volume: 57
Issue: 3
Pages: 378-92
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Publication
22365546 | J:182704
First Author: Weng Q
Year: 2012
Journal: Neuron
Title: Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system.
Volume: 73
Issue: 4
Pages: 713-28
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Publication
26449520 | J:242956
First Author: Delprato A
Year: 2015
Journal: Genes Brain Behav
Title: Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice.
Volume: 14
Issue: 8
Pages: 591-606
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Publication
19998061 | J:160194
First Author: Shaw L
Year: 2010
Journal: In Vitro Cell Dev Biol Anim
Title: Gene expression profiling of the developing mouse kidney and embryo.
Volume: 46
Issue: 2
Pages: 155-65
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HT Experiment
GSE151961 | Single nucleus multi-omics regulatory atlas of the murine pituitary [snRNA-seq ]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE151958 | Single nucleus multi-omics regulatory atlas of the murine pituitary [scRNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE236559 | NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE228385 | Single-cell RNA sequencing of IkbkbV203I Tregs from spleen and bone marrow
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE246894 | Engrailed transcription factors direct embryonic medial excitatory cerebellar nuclei neuron identity and survival
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
22034435 | J:177853
First Author: Shakya R
Year: 2011
Journal: Science
Title: BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.
Volume: 334
Issue: 6055
Pages: 525-8
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Publication
19079609 | J:144358
First Author: Jeong JH
Year: 2008
Journal: PLoS One
Title: BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.
Volume: 3
Issue: 12
Pages: e3949
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Publication
26387954 | J:314628
First Author: Mitrofanova A
Year: 2015
Journal: Cell Rep
Title: Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models.
Volume: 12
Issue: 12
Pages: 2060-71
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Publication
34732703 | J:314703
First Author: Liu Y
Year: 2021
Journal: Nat Commun
Title: Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation.
Volume: 12
Issue: 1
Pages: 6323
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Publication
35235808 | J:325480
First Author: Shields MA
Year: 2022
Journal: Cell Rep
Title: Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin.
Volume: 38
Issue: 9
Pages: 110441
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Publication
14973386 | J:70981
First Author: Cardiff RD
Year: 2000
Journal: J Mammary Gland Biol Neoplasia
Title: Genetically engineered mouse models of mammary intraepithelial neoplasia.
Volume: 5
Issue: 4
Pages: 421-37
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Publication
22422829 | J:185376
First Author: Ahmad I
Year: 2012
Journal: Dis Model Mech
Title: Exploring molecular genetics of bladder cancer: lessons learned from mouse models.
Volume: 5
Issue: 3
Pages: 323-32
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Publication
26220477 | J:230087
First Author: Ju HL
Year: 2016
Journal: Int J Cancer
Title: Transgenic mouse models generated by hydrodynamic transfection for genetic studies of liver cancer and preclinical testing of anti-cancer therapy.
Volume: 138
Issue: 7
Pages: 1601-8
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HT Experiment
GSE252833 | A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE276037 | Differential contribution of Cajal-Retzius cells and Reelin to cortical morphogenesis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
11046024 | J:313950
First Author: Lee KH
Year: 2000
Journal: J Immunol
Title: Stimulatory function of gp49A, a murine Ig-like receptor, in rat basophilic leukemia cells.
Volume: 165
Issue: 9
Pages: 4970-7
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Publication
24748377 | J:215184
First Author: Szabova L
Year: 2014
Journal: PLoS One
Title: Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.
Volume: 9
Issue: 4
Pages: e95649
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Publication
12386807 | J:79667
First Author: Weiss WA
Year: 2002
Journal: Oncogene
Title: Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum.
Volume: 21
Issue: 49
Pages: 7453-63
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Publication
20826448 | J:165138
First Author: Brown JA
Year: 2010
Journal: Hum Mol Genet
Title: Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice.
Volume: 19
Issue: 22
Pages: 4515-28
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Publication
20551058 | J:162482
First Author: Warrington NM
Year: 2010
Journal: Cancer Res
Title: Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1.
Volume: 70
Issue: 14
Pages: 5717-27
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Publication
21846369 | J:216041
First Author: Zhu M
Year: 2011
Journal: Genome Biol
Title: Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage.
Volume: 12
Issue: 8
Pages: R77
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Publication
15885713 | J:100619
First Author: Klein RD
Year: 2005
Journal: Mutat Res
Title: The use of genetically engineered mouse models of prostate cancer for nutrition and cancer chemoprevention research.
Volume: 576
Issue: 1-2
Pages: 111-9
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Publication
21903772 | J:232844
First Author: Wu R
Year: 2011
Journal: Clin Cancer Res
Title: Preclinical testing of PI3K/AKT/mTOR signaling inhibitors in a mouse model of ovarian endometrioid adenocarcinoma.
Volume: 17
Issue: 23
Pages: 7359-72
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Publication
26001956 | J:225607
First Author: Shai A
Year: 2015
Journal: Cancer Res
Title: TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis.
Volume: 75
Issue: 15
Pages: 3167-80
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Publication
29185453 | J:255776
First Author: Xie Y
Year: 2017
Journal: Sci Rep
Title: Dysregulation of YAP by ARF Stimulated with Tea-derived Carbon Nanodots.
Volume: 7
Issue: 1
Pages: 16577
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Publication
10713680 | J:61035
First Author: Cardiff RD
Year: 2000
Journal: Oncogene
Title: The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting.
Volume: 19
Issue: 8
Pages: 968-88
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Publication
30811514 | J:273711
First Author: Guo X
Year: 2019
Journal: PLoS One
Title: Effect of cyclical intermittent hypoxia on Ad5CMVCre induced solitary lung cancer progression and spontaneous metastases in the KrasG12D+; p53fl/fl; myristolated p110fl/fl ROSA-gfp mouse.
Volume: 14
Issue: 2
Pages: e0212930
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Publication
26910118 | J:349034
First Author: De Velasco MA
Year: 2016
Journal: Oncotarget
Title: Efficacy of targeted AKT inhibition in genetically engineered mouse models of PTEN-deficient prostate cancer.
Volume: 7
Issue: 13
Pages: 15959-76
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Publication
26567140 | J:227253
First Author: Green S
Year: 2015
Journal: Cancer Res
Title: PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis.
Volume: 75
Issue: 24
Pages: 5378-91
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Publication
28411207 | J:243125
First Author: Zou M
Year: 2017
Journal: Cancer Discov
Title: Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer.
Volume: 7
Issue: 7
Pages: 736-749
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Publication
18316617 | J:132860
First Author: Hegedus B
Year: 2008
Journal: Cancer Res
Title: Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma.
Volume: 68
Issue: 5
Pages: 1520-8
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Publication
22511580 | J:189336
First Author: Trejo CL
Year: 2012
Journal: Cancer Res
Title: MEK1/2 inhibition elicits regression of autochthonous lung tumors induced by KRASG12D or BRAFV600E.
Volume: 72
Issue: 12
Pages: 3048-59
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Publication
9808437 | J:50712
First Author: Inokuchi S
Year: 1998
Journal: Virchows Arch
Title: Angiotensin II maintains the structure and function of glomerular mesangium via type 1a receptor. What we have learned from null mutant mice minus the angiotensin II type 1a receptor gene.
Volume: 433
Issue: 4
Pages: 349-57
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Publication
36976637 | J:336405
 
First Author: Wu C
Year: 2023
Journal: JCI Insight
Title: Reactive myelopoiesis and FX-expressing macrophages triggered by chemotherapy promote cancer lung metastasis.
Volume: 8
Issue: 9
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Publication
24312475 | J:221017
First Author: Song Y
Year: 2013
Journal: PLoS One
Title: Carcinoma initiation via RB tumor suppressor inactivation: a versatile approach to epithelial subtype-dependent cancer initiation in diverse tissues.
Volume: 8
Issue: 12
Pages: e80459
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Publication
23099891 | J:211760
First Author: Prada CE
Year: 2013
Journal: Acta Neuropathol
Title: Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.
Volume: 125
Issue: 1
Pages: 159-68
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Publication
21319287 | J:215873
First Author: Wu J
Year: 2012
Journal: Pediatr Blood Cancer
Title: Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging.
Volume: 58
Issue: 2
Pages: 173-80
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Publication
10800075 | J:62446
First Author: Nix M
Year: 2000
Journal: Cell Death Differ
Title: Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation.
Volume: 7
Issue: 5
Pages: 413-24
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Publication
35911788 | J:349038
First Author: Wang L
Year: 2022
Journal: Cancer Res Commun
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