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Search results 1001 to 1100 out of 1143 for Gla

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Type Details Score
Publication
37511396 | J:339178
 
First Author: Cai X
Year: 2023
Journal: Int J Mol Sci
Title: GSK3β Inhibition Ameliorates Atherosclerotic Calcification.
Volume: 24
Issue: 14
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Publication
37171959 | J:337581
First Author: Lacombe J
Year: 2023
Journal: Cell Rep
Title: Vitamin K-dependent carboxylation regulates Ca(2+) flux and adaptation to metabolic stress in β cells.
Volume: 42
Issue: 5
Pages: 112500
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Publication
30591517 | J:273211
First Author: Rodriguez-Laguna L
Year: 2019
Journal: J Exp Med
Title: Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly.
Volume: 216
Issue: 2
Pages: 407-418
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Publication
10691853 | J:60942
First Author: Faioni EM
Year: 2000
Journal: Br J Haematol
Title: Type II protein C deficiency: identification and molecular modelling of two natural mutants with low anticoagulant and normal amidolytic activity.
Volume: 108
Issue: 2
Pages: 265-71
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Publication
9585060 | J:47493
First Author: Muñoz SE
Year: 1998
Journal: Cancer Lett
Title: Differential modulation by dietary n-6 or n-9 unsaturated fatty acids on the development of two murine mammary gland tumors having different metastatic capabilities.
Volume: 126
Issue: 2
Pages: 149-55
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Publication
18267072 | J:135522
First Author: Waddington SN
Year: 2008
Journal: Cell
Title: Adenovirus serotype 5 hexon mediates liver gene transfer.
Volume: 132
Issue: 3
Pages: 397-409
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Publication
32634398 | J:297060
First Author: DeSisto J
Year: 2020
Journal: Dev Cell
Title: Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function.
Volume: 54
Issue: 1
Pages: 43-59.e4
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Publication
25265470 | J:218039
   
First Author: Lew ED
Year: 2014
Journal: Elife
Title: Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.
Volume: 3
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Publication
25194421 | J:259387
First Author: Zagórska A
Year: 2014
Journal: Nat Immunol
Title: Diversification of TAM receptor tyrosine kinase function.
Volume: 15
Issue: 10
Pages: 920-8
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Publication
29719259 | J:271099
First Author: Goyette MA
Year: 2018
Journal: Cell Rep
Title: The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.
Volume: 23
Issue: 5
Pages: 1476-1490
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Publication
30184491 | J:270641
First Author: Stratton JA
Year: 2018
Journal: Cell Rep
Title: Macrophages Regulate Schwann Cell Maturation after Nerve Injury.
Volume: 24
Issue: 10
Pages: 2561-2572.e6
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Publication
38011284 | J:343286
First Author: Queen R
Year: 2023
Journal: PLoS Genet
Title: Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves.
Volume: 19
Issue: 11
Pages: e1010777
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Publication
26697723 | J:233841
First Author: Inoue M
Year: 2016
Journal: Endocrinology
Title: Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.
Volume: 157
Issue: 3
Pages: 1222-33
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Protein
P19221
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Protein
H7BX99
Organism: Mus musculus/domesticus
Length: 617  
Fragment?: false
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Protein
Q3TJ94
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Publication
23928358 | J:207800
First Author: Hammed A
Year: 2013
Journal: J Biol Chem
Title: VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
Volume: 288
Issue: 40
Pages: 28733-42
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Publication
19819238 | J:156613
First Author: Le Jeune M
Year: 2010
Journal: Exp Cell Res
Title: Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein.
Volume: 316
Issue: 2
Pages: 203-15
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Publication
15229648 | J:93053
First Author: Eferl R
Year: 2004
Journal: EMBO J
Title: The Fos-related antigen Fra-1 is an activator of bone matrix formation.
Volume: 23
Issue: 14
Pages: 2789-99
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Publication
21193740 | J:183498
First Author: Boström KI
Year: 2011
Journal: Circ Res
Title: Activation of vascular bone morphogenetic protein signaling in diabetes mellitus.
Volume: 108
Issue: 4
Pages: 446-57
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Publication
9685524 | J:49368
First Author: Ohtsuki T
Year: 1998
Journal: Calcif Tissue Int
Title: Gene expression of noncollagenous bone matrix proteins in the limb joints and intervertebral disks of the twy mouse.
Volume: 63
Issue: 2
Pages: 167-72
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Publication
20595654 | J:175029
First Author: Osako MK
Year: 2010
Journal: Circ Res
Title: Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification.
Volume: 107
Issue: 4
Pages: 466-75
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Publication
20576934 | J:175034
First Author: Yao Y
Year: 2010
Journal: Circ Res
Title: Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification.
Volume: 107
Issue: 4
Pages: 485-94
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Publication
11385052 | J:69821
First Author: Fan YY
Year: 2001
Journal: J Nutr
Title: Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice.
Volume: 131
Issue: 6
Pages: 1675-81
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Publication
23954506 | J:203841
First Author: Sasaki M
Year: 2013
Journal: Bone
Title: Altered distribution of bone matrix proteins and defective bone mineralization in klotho-deficient mice.
Volume: 57
Issue: 1
Pages: 206-19
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Publication
25367751 | J:222315
First Author: Desbien AL
Year: 2015
Journal: Eur J Immunol
Title: Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ.
Volume: 45
Issue: 2
Pages: 407-17
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Publication
19583826 | J:166332
First Author: Gui T
Year: 2009
Journal: J Thromb Haemost
Title: Abnormal hemostasis in a knock-in mouse carrying a variant of factor IX with impaired binding to collagen type IV.
Volume: 7
Issue: 11
Pages: 1843-51
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Publication
27794001 | J:303440
First Author: Desbien AL
Year: 2016
Journal: J Immunol
Title: IL-18 and Subcapsular Lymph Node Macrophages are Essential for Enhanced B Cell Responses with TLR4 Agonist Adjuvants.
Volume: 197
Issue: 11
Pages: 4351-4359
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Publication
16598380 | J:128117
First Author: Nishiwaki T
Year: 2006
Journal: J Bone Miner Res
Title: Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1.
Volume: 21
Issue: 4
Pages: 596-604
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Publication
24566623 | J:209889
First Author: Izawa A
Year: 2014
Journal: Infect Immun
Title: Inflammatory bone loss in experimental periodontitis induced by Aggregatibacter actinomycetemcomitans in interleukin-1 receptor antagonist knockout mice.
Volume: 82
Issue: 5
Pages: 1904-13
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Publication
31456099 | J:352848
First Author: Hedegger K
Year: 2020
Journal: J Gastroenterol
Title: The protective effect of betacellulin against acute pancreatitis is ERBB4 dependent.
Volume: 55
Issue: 3
Pages: 317-329
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Publication
28319142 | J:247220
First Author: Liu J
Year: 2017
Journal: PLoS One
Title: MicroRNA-32 promotes calcification in vascular smooth muscle cells: Implications as a novel marker for coronary artery calcification.
Volume: 12
Issue: 3
Pages: e0174138
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Publication
19799641 | J:166313
First Author: Hasen NS
Year: 2009
Journal: Genes Brain Behav
Title: Trpc2 gene impacts on maternal aggression, accessory olfactory bulb anatomy and brain activity.
Volume: 8
Issue: 7
Pages: 639-49
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Publication
23415960 | J:195990
First Author: Li Q
Year: 2013
Journal: Am J Pathol
Title: Warfarin accelerates ectopic mineralization in Abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum.
Volume: 182
Issue: 4
Pages: 1139-50
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Publication
38743908 | J:349161
     
First Author: Nozawa A
Year: 2024
Journal: Hum Mol Genet
Title: Lymphatic endothelial cell-specific NRAS p.Q61R mutant embryos show abnormal lymphatic vessel morphogenesis.
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Publication
25388285 | J:219651
First Author: Kadayakkara DK
Year: 2015
Journal: Cancer Res
Title: Paradoxical decrease in the capture and lymph node delivery of cancer vaccine antigen induced by a TLR4 agonist as visualized by dual-mode imaging.
Volume: 75
Issue: 1
Pages: 51-61
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Publication
18202319 | J:147655
First Author: Johnson KA
Year: 2008
Journal: Circ Res
Title: Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells.
Volume: 102
Issue: 5
Pages: 529-37
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Publication
24479134 | J:206726
First Author: Brampton C
Year: 2014
Journal: Am J Pathol
Title: The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury.
Volume: 184
Issue: 1
Pages: 159-70
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Publication
28732776 | J:257144
 
First Author: Withers CN
Year: 2017
Journal: Bone
Title: Rad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice.
Volume: 103
Pages: 270-280
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Publication
19961844 | J:156721
First Author: Alfieri CM
Year: 2010
Journal: Dev Biol
Title: Wnt signaling in heart valve development and osteogenic gene induction.
Volume: 338
Issue: 2
Pages: 127-35
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Publication
8801587 | J:36964
First Author: Wainwright PE
Year: 1996
Journal: Pharmacol Biochem Behav
Title: Effects of dietary gamma-linolenic acid and prenatal ethanol on mouse brain and behavior.
Volume: 53
Issue: 4
Pages: 843-52
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Publication
17785623 | J:139841
First Author: Chang K
Year: 2007
Journal: Circulation
Title: Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: role of bone morphogenic protein antagonists in inflammation and atherosclerosis.
Volume: 116
Issue: 11
Pages: 1258-66
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Publication
22002164 | J:179829
First Author: Pantel A
Year: 2012
Journal: Eur J Immunol
Title: A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo.
Volume: 42
Issue: 1
Pages: 101-9
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Publication
25614285 | J:241197
First Author: Beazley KE
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Wnt16 attenuates TGFβ-induced chondrogenic transformation in vascular smooth muscle.
Volume: 35
Issue: 3
Pages: 573-9
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Publication
29769270 | J:263325
First Author: Seydoux E
Year: 2018
Journal: J Immunol
Title: Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses.
Volume: 201
Issue: 1
Pages: 98-112
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Publication
37057181 | J:345399
 
First Author: Xu Z
Year: 2023
Journal: Front Physiol
Title: Triple-gene deletion for osteocalcin significantly impairs the alignment of hydroxyapatite crystals and collagen in mice.
Volume: 14
Pages: 1136561
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Publication
37225978 | J:340032
First Author: Paredes A
Year: 2023
Journal: Nature
Title: γ-Linolenic acid in maternal milk drives cardiac metabolic maturation.
Volume: 618
Issue: 7964
Pages: 365-373
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Publication
29871951 | J:263961
First Author: Tabib Y
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Cell-intrinsic regulation of murine epidermal Langerhans cells by protein S.
Volume: 115
Issue: 25
Pages: E5736-E5745
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Publication
18188450 | J:131177
First Author: Angelillo-Scherrer A
Year: 2008
Journal: J Clin Invest
Title: Role of Gas6 in erythropoiesis and anemia in mice.
Volume: 118
Issue: 2
Pages: 583-96
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Publication
28495875 | J:314933
First Author: Bosurgi L
Year: 2017
Journal: Science
Title: Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.
Volume: 356
Issue: 6342
Pages: 1072-1076
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Publication
1557383 | J:23
First Author: Banfield DK
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species.
Volume: 89
Issue: 7
Pages: 2779-83
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Publication
2583108 | -
First Author: Bode W
Year: 1989
Journal: EMBO J
Title: The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.
Volume: 8
Issue: 11
Pages: 3467-75
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Publication
10051558 | -
First Author: Guinto ER
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Unexpected crucial role of residue 225 in serine proteases.
Volume: 96
Issue: 5
Pages: 1852-7
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Publication
9535876 | -
First Author: Liaw PC
Year: 1998
Journal: J Biol Chem
Title: Localization of the thrombin-binding domain on prothrombin fragment 2.
Volume: 273
Issue: 15
Pages: 8932-9
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Publication
14579355 | -
First Author: Norledge BV
Year: 2003
Journal: Proteins
Title: The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis.
Volume: 53
Issue: 3
Pages: 640-8
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Publication
19141157 | -
First Author: Lapecorella M
Year: 2008
Journal: Haemophilia
Title: Factor VII deficiency: defining the clinical picture and optimizing therapeutic options.
Volume: 14
Issue: 6
Pages: 1170-5
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Publication
22652793 | -
 
First Author: Vadivel K
Year: 2012
Journal: Front Biosci (Landmark Ed)
Title: Structural biology of factor VIIa/tissue factor initiated coagulation.
Volume: 17
Pages: 2476-94
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Protein Domain
IPR033190 | F7
Type: Family
Description: Factor VII (F7) initiates the extrinsic pathway of blood coagulation. It contains an N-terminal Gla domain followed by two epidermal growth factor-like domains (EGF1 and EGF2) and a C-terminal trypsin-like serine protease domain. It can be transformed into active forms (FVIIa) by proteolytic cleavage of the activation peptide located in the connecting region between the EGF2 and the protease domain; this results in the formation of a two-chain FVIIa molecule and a heavy chain held together by a single disulfide bond []. Its first EGF domain (EGF1) binds a calcium ion at its N terminus [].At an injury site, initiation of coagulation begins by exposure of blood to tissue factor (TF) in the extravascular space and formation of the Ca2+-dependent complex between TF and plasma FVIIa. The Ca2+/FVIIa/TF complex formed on the cell surfaces then activates both FX and FIX leading to thrombin generation and fibrin formation []. Mutations in the F7 gene cause Factor VII deficiency (FA7D), the most frequent among rare congenital bleeding disorders [].
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Protein Domain
IPR003966 | Prothrombin/thrombin
Type: Family
Description: Thrombin belongs to the MEROPS peptidase family S1, subfamily S1A.Prothrombin consists of an N-terminal gamma-carboxyglutamate (GLA) domain, two kringle domains, and the S1A peptidase catalytic domain. The cleavage of prothrombin to thrombin is catalysed by the prothrombinase enzyme complex that consists of serine protease factor Xa, cofactor Va, phospholipids and calcium. Prothromin is cleaved by this enzyme into three fragments: fragment 1 (F1) consits of the GLA domain and the first Kringle domain; fragment 2 (F2) consists of the second Kringle domain; and thrombin (peptidase catalytic domain). F1 facilitates calcium-dependent binding of the proenzyme to phospholipid surfaces. F2 interacts with factor Va, and once it is released from prothrombin, it can bind thrombin to influence its function [].Thrombin is a member of the trypsin family of S1 peptidases. It catalyses the preferential cleavage of arginine-lysine bonds, converting fibrinogen to fibrin, and releasing fibrinopeptides A and B. Thrombin can itself cleave the N-terminal fragment (fragment 1) of prothrombin, prior to its activation by factor Xa. Its effects are mediated by the thrombin receptor. Structures of the thrombin A-chain []and B-chain []have been determined. The most conserved portions of the B chain are the active-site residues and adjacent amino acids, the B loop, and the primary substrate-binding region []. The extent of sequence similarity between species and the conservation of many of the functional/structural motifs suggests that, in addition to their role in blood coagulation, vertebrate thrombins may play an important role in the general mechanisms of wound repair [].
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Publication
34248495 | J:308708
 
First Author: Martinez ME
Year: 2021
Journal: Front Neurosci
Title: The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain.
Volume: 15
Pages: 703730
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Publication
12205107 | J:78525
First Author: Lemon WJ
Year: 2002
Journal: J Med Genet
Title: Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays.
Volume: 39
Issue: 9
Pages: 644-55
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Publication
3427055 | J:240593
First Author: Engel J
Year: 1987
Journal: Biochemistry
Title: Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues.
Volume: 26
Issue: 22
Pages: 6958-65
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Publication
21144823 | J:167443
First Author: Kawashima S
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice.
Volume: 404
Issue: 1
Pages: 534-40
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Publication
19749165 | J:154311
First Author: Nakano-Kurimoto R
Year: 2009
Journal: Am J Physiol Heart Circ Physiol
Title: Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition.
Volume: 297
Issue: 5
Pages: H1673-84
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Publication
16278811 | J:102870
First Author: Razzaque MS
Year: 2005
Journal: J Pathol
Title: Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation.
Volume: 207
Issue: 4
Pages: 453-61
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Publication
24947449 | J:215491
 
First Author: Kühnisch J
Year: 2014
Journal: Bone
Title: Neurofibromin inactivation impairs osteocyte development in Nf1Prx1 and Nf1Col1 mouse models.
Volume: 66
Pages: 155-62
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Publication
29031400 | J:278390
 
First Author: Suitor K
Year: 2017
Journal: Prostaglandins Leukot Essent Fatty Acids
Title: Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets.
Volume: 126
Pages: 84-91
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Publication
11591726 | J:73263
First Author: Pudota BN
Year: 2001
Journal: J Biol Chem
Title: Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity.
Volume: 276
Issue: 50
Pages: 46878-86
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Publication
11015469 | J:97277
First Author: Petrik MB
Year: 2000
Journal: J Nutr
Title: Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice.
Volume: 130
Issue: 10
Pages: 2434-43
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Publication
23259948 | J:197656
First Author: Burstyn-Cohen T
Year: 2012
Journal: Neuron
Title: Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis.
Volume: 76
Issue: 6
Pages: 1123-32
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Gene
7421 | VDR
Type: gene
Organism: human
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Gene
1636 | ACE
Type: gene
Organism: human
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Publication
7822037 | -
First Author: Ulstrup JC
Year: 1995
Journal: Infect Immun
Title: Relationship of secretion pattern and MPB70 homology with osteoblast-specific factor 2 to osteitis following Mycobacterium bovis BCG vaccination.
Volume: 63
Issue: 2
Pages: 672-5
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Publication
7925267 | -
First Author: Huber O
Year: 1994
Journal: EMBO J
Title: Algal-CAMs: isoforms of a cell adhesion molecule in embryos of the alga Volvox with homology to Drosophila fasciclin I.
Volume: 13
Issue: 18
Pages: 4212-22
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Publication
10906123 | -
First Author: Kim JE
Year: 2000
Journal: J Biol Chem
Title: Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-beta-induced gene, betaig-h3.
Volume: 275
Issue: 40
Pages: 30907-15
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Publication
12575939 | -
First Author: Clout NJ
Year: 2003
Journal: Structure
Title: Novel fold revealed by the structure of a FAS1 domain pair from the insect cell adhesion molecule fasciclin I.
Volume: 11
Issue: 2
Pages: 197-203
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Publication
16944204 | -
First Author: Faik A
Year: 2006
Journal: Mol Genet Genomics
Title: Putative fasciclin-like arabinogalactan-proteins (FLA) in wheat (Triticum aestivum) and rice (Oryza sativa): identification and bioinformatic analyses.
Volume: 276
Issue: 5
Pages: 478-94
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Publication
15345724 | -
First Author: Kzhyshkowska J
Year: 2004
Journal: J Leukoc Biol
Title: Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors.
Volume: 76
Issue: 6
Pages: 1151-61
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Publication
7871388 | -
First Author: Matsumoto S
Year: 1995
Journal: Scand J Immunol
Title: Cloning and sequencing of a unique antigen MPT70 from Mycobacterium tuberculosis H37Rv and expression in BCG using E. coli-mycobacteria shuttle vector.
Volume: 41
Issue: 3
Pages: 281-7
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Protein
F7CT68
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Protein Domain
IPR036378 | FAS1_dom_sf
Type: Homologous_superfamily
Description: The FAS1 (fasciclin-like) domain is an extracellular module of about 140 amino acid residues. It has been suggested that the FAS1 domain represents an ancient cell adhesion domain common to plants and animals []; related FAS1 domains are also found in bacteria [].The crystal structure of FAS1 domains 3 and 4 of fasciclin I from Drosophila melanogaster (Fruit fly) has been determined, revealing a novel domain fold consisting of a seven-stranded beta wedge and at least five alpha helices; two well-ordered N-acetylglucosamine groups attached to a conserved asparagine are located in the interface region between the two FAS1 domains []. Fasciclin I is an insect neural cell adhesion molecule involved in axonal guidance that is attached to the membrane by a GPI-anchored protein.FAS1 domains are present in many secreted and membrane-anchored proteins. These proteins are usually GPI anchored and consist of: (i) a single FAS1 domain, (ii) a tandem array of FAS1 domains, or (iii) FAS1 domain(s) interspersed with other domains. Proteins known to contain a FAS1 domain include:Fasciclin I (4 FAS1 domains).Human TGF-beta induced Ig-H3 (BIgH3) protein (4 FAS1 domains), where the FAS1 domains mediate cell adhesion through an interaction with alpha3/beta1 integrin; mutation in the FAS1 domains result in corneal dystrophy [].Volvox major cell adhesion protein (2 FAS1 domains) [].Arabidopsis fasciclin-like arabinogalactan proteins (2 FAS1 domains) [].Mammalian stabilin protein, a family of fasciclin-like hyaluronan receptor homologues (7 FAS1 domains)[].Human extracellular matrix protein periostin (4 FAS1 domains).Bacterial immunogenic protein MPT70 (1 FAS1 domain) [].The FAS1 domains of both human periostin () and BIgH3 () proteins were found to contain vitamin K-dependent gamma-carboxyglutamate residues []. Gamma-carboxyglutamate residues are more commonly associated with GLA domains (), where they occur through post-translational modification catalysed by the vitamin K-dependent enzyme gamma-glutamylcarboxylase.
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Protein Domain
IPR000782 | FAS1_domain
Type: Domain
Description: The FAS1 (fasciclin-like) domain is an extracellular module of about 140 amino acid residues. It hasbeen suggested that the FAS1 domain represents an ancient cell adhesion domain common to plants and animals []; related FAS1 domains are also found in bacteria [].The crystal structure of FAS1 domains 3 and 4 of fasciclin I from Drosophila melanogaster (Fruit fly) has been determined, revealing a novel domain fold consisting of a seven-stranded beta wedge and at least five alpha helices; two well-ordered N-acetylglucosamine groups attached to a conserved asparagine are located in the interface region between the two FAS1 domains []. Fasciclin I is an insect neural cell adhesion molecule involved in axonal guidance that is attached to the membrane by a GPI-anchored protein.FAS1 domains are present in many secreted and membrane-anchored proteins. These proteins are usually GPI anchored and consist of: (i) a single FAS1 domain, (ii) a tandem array of FAS1 domains, or (iii) FAS1 domain(s) interspersed with other domains. Proteins known to contain a FAS1 domain include:Fasciclin I (4 FAS1 domains).Human TGF-beta induced Ig-H3 (BIgH3) protein (4 FAS1 domains), where the FAS1 domains mediate cell adhesion through an interaction with alpha3/beta1 integrin; mutation in the FAS1 domains result in corneal dystrophy [].Volvox major cell adhesion protein (2 FAS1 domains) [].Arabidopsis fasciclin-like arabinogalactan proteins (2 FAS1 domains) [].Mammalian stabilin protein, a family of fasciclin-like hyaluronan receptor homologues (7 FAS1 domains)[].Human extracellular matrix protein periostin (4 FAS1 domains).Bacterial immunogenic protein MPT70 (1 FAS1 domain) [].The FAS1 domains of both human periostin () and BIgH3 () proteins were found to contain vitamin K-dependent gamma-carboxyglutamate residues []. Gamma-carboxyglutamate residues are more commonly associated with GLA domains (), where they occur through post-translational modification catalysed by the vitamin K-dependent enzyme gamma-glutamylcarboxylase.
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Publication
19729839 | J:198769
First Author: Burstyn-Cohen T
Year: 2009
Journal: J Clin Invest
Title: Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis.
Volume: 119
Issue: 10
Pages: 2942-53
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Publication
27049947 | J:269075
First Author: Fourgeaud L
Year: 2016
Journal: Nature
Title: TAM receptors regulate multiple features of microglial physiology.
Volume: 532
Issue: 7598
Pages: 240-244
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Protein
P82198
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: false
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Protein
Q62009
Organism: Mus musculus/domesticus
Length: 838  
Fragment?: false
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Protein
A1L354
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: false
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Protein
Q6PDN4
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
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Protein
A1L353
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: false
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Protein
Q3TDZ5
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: true
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Protein
Q3UEV6
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
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Protein
Q6GUA3
Organism: Mus musculus/domesticus
Length: 810  
Fragment?: false
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Protein
A0A097BW18
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
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Protein
E5RKG4
Organism: Mus musculus/domesticus
Length: 1652  
Fragment?: false
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Protein
Q3UXJ2
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Protein
Q3U4U1
Organism: Mus musculus/domesticus
Length: 783  
Fragment?: false
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Protein
E5RKG2
Organism: Mus musculus/domesticus
Length: 1018  
Fragment?: false
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Protein
A0A097BW21
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q3UBG4
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: false
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Protein
Q3TAY9
Organism: Mus musculus/domesticus
Length: 644  
Fragment?: true
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