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Search results 1001 to 1100 out of 1283 for Hgf

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Type Details Score
Allele
Tg(Wap-Hgf)402Mig | MGI:3036575
Name: transgene insertion 402, Marta I Gallego
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Hgf<em2(HGF)Smoc> | MGI:7290207
Name: hepatocyte growth factor; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Hgf<em3Smoc> | MGI:7290208
Name: hepatocyte growth factor; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Hgf<em4(HGF)Smoc> | MGI:7640179
Name: hepatocyte growth factor; endonuclease-mediated mutation 4, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inserted expressed sequence, Null/knockout
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Publication
14627990 | J:86776
First Author: Gallego MI
Year: 2003
Journal: Oncogene
Title: Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways.
Volume: 22
Issue: 52
Pages: 8498-508
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GO Term
GO:0005171 | hepatocyte growth factor receptor binding
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GO Term
GO:0048012 | hepatocyte growth factor receptor signaling pathway
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GO Term
GO:0005008 | hepatocyte growth factor receptor activity
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GO Term
GO:0032605 | hepatocyte growth factor production
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Protein Coding Gene
MGI:96969 | Met
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Hgf<tm1.1Tbf> | MGI:6294039
Name: hepatocyte growth factor; targeted mutation 1.1, Thomas B Friedman
Allele Type: Targeted
Attribute String: Not Specified
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Allele
Hgf<tm1Tbf> | MGI:6294041
Name: hepatocyte growth factor; targeted mutation 1, Thomas B Friedman
Allele Type: Targeted
Attribute String: Not Specified
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GO Term
GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway
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GO Term
GO:0032646 | regulation of hepatocyte growth factor production
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Publication
10657988 | J:65035
First Author: Lindner G
Year: 2000
Journal: FASEB J
Title: Involvement of hepatocyte growth factor/scatter factor and met receptor signaling in hair follicle morphogenesis and cycling.
Volume: 14
Issue: 2
Pages: 319-32
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Strain
MGI:5576785 | FVB/N-Tg(Wap-Hgf)402Mig
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5496418 | FVB-Tg(Wap-Hgf)402Mig/Cnbc
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:6475500 | C57BL/6JSmoc-Hgf<em1(HGF)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Tg(Hgf)1Paus/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Wap-Hgf)402Mig/?
Background: FVB/N-Tg(Wap-Hgf)402Mig
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Wap-Hgf)402Mig/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hgf/Hgf
Background: B6.Cg-Hgf/Tbf
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110497 | autosomal recessive nonsyndromic deafness 39
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Genotype
Genotype
Symbol: Hgf/Hgf
Background: B6.Cg-Hgf/Tbf
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE137721 | RNA-seq analyses of cochleae from a mouse model of DFNB39
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
22085542 | -
First Author: Attar MA
Year: 2012
Journal: Exp Cell Res
Title: CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration.
Volume: 318
Issue: 3
Pages: 228-37
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Publication
12569082 | -
First Author: Zhang X
Year: 2003
Journal: Am J Physiol Renal Physiol
Title: Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1.
Volume: 284
Issue: 6
Pages: F1216-25
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Allele
Hgf<tm1Kita> | MGI:1929776
Name: hepatocyte growth factor; targeted mutation 1, Naomi Kitamura
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Hgf<em1Smoc> | MGI:7290206
Name: hepatocyte growth factor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Hgf/Hgf
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
15839837 | -
First Author: Herter S
Year: 2005
Journal: Biochem J
Title: Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.
Volume: 390
Issue: Pt 1
Pages: 125-36
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Publication
21875933 | -
First Author: Ganesan R
Year: 2011
Journal: Mol Cancer Res
Title: Proteolytic activation of pro-macrophage-stimulating protein by hepsin.
Volume: 9
Issue: 9
Pages: 1175-86
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Protein Domain
IPR038957 | Hepsin
Type: Family
Description: Hepsin is a serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL [, ].
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Publication
19595710 | J:153567
First Author: Kadoyama K
Year: 2009
Journal: Neurosci Res
Title: Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS.
Volume: 65
Issue: 2
Pages: 194-200
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Strain
MGI:6428841 | NOD.Cg-Hgf<em4(HGF)Smoc> Prkdc<scid>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tg(Eno2-Hgf)1Tnak | MGI:2446529
Name: transgene insertion 1, Toshikazu Nakamura
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(tetO-Hgf,-EGFP)24Tcre | MGI:5648118
Name: transgene insertion 24, Tiziana Crepaldi
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Reporter
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Allele
Tg(tetO/CMV-Hgf)#Agoc | MGI:5705532
Name: transgene insertion, Adolf Garcia-Ocana
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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GO Term
GO:0032686 | negative regulation of hepatocyte growth factor production
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GO Term
GO:0032726 | positive regulation of hepatocyte growth factor production
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Publication
21347410 | J:171090
First Author: Leo C
Year: 2011
Journal: PLoS One
Title: Activated Met signalling in the developing mouse heart leads to cardiac disease.
Volume: 6
Issue: 2
Pages: e14675
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Publication
26987019 | J:237183
   
First Author: Morena D
Year: 2016
Journal: Elife
Title: Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes.
Volume: 5
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Protein Domain
IPR024174 | HGF/MST1
Type: Family
Description: This entry includes hepatocyte growth factor (HGF; also called scatter factor) and HGF-like proteins (also known as macrophage stimulatory protein, MST1). Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration []. HGF is essential for placental, liver, and muscle development, whereas MST1 is not required for embryogenesis, fertility, or wound healing. Genes for HGF and its receptor, the Met tyrosine kinase, are close together on chromosome 7, so that polysomy of chromosome 7 may contribute to malignancy through overproduction of both molecules. MST1 and its receptor, the Ron tyrosine kinase, are close together on chromosome 3. HGF and MST1 are closely related to plasminogen, having similar domain architecture: signal sequence followed by a PAN (formerly apple) domain, four (rather than five) kringle domains, and a trypsin domain, which appears to lack any peptidase activity.
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Protein Domain
IPR027284 | Hepatocyte_GF
Type: Family
Description: Hepatocyte growth factor (HGF) is an activating ligand of the tyrosine kinase receptor Met. It activates Met by binding and promoting its dimerisation. This activation has been linked to promoting the invasive growth of many tumour types []. HGF acts as growth factor for a broad spectrum of tissues and cell types and has no detectable protease activity [].Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39). A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information [].
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Publication
17935811 | J:128738
First Author: Kadoyama K
Year: 2007
Journal: Neurosci Res
Title: Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS.
Volume: 59
Issue: 4
Pages: 446-56
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Strain
MGI:6476662 | NOD.Cg-Prkdc<scid> Il2rg<em1Smoc> Hgf<em3Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, spontaneous mutation, mutant strain
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Strain
MGI:5811452 | FVB-Tg(tetO-Hgf,-EGFP)24Tcre/Cnrm
Attribute String: coisogenic, mutant strain, transgenic
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Publication
24290754 | J:206839
First Author: Holland JD
Year: 2013
Journal: Cell Rep
Title: Combined Wnt/β-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome.
Volume: 5
Issue: 5
Pages: 1214-27
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Genotype
Genotype
Symbol: Cd44/Cd44 Hgf/Hgf<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Strain
MGI:5576958 | FVB.Cg-Ctnnb1<tm1Mmt> Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig
Attribute String: targeted mutation, transgenic, mutant strain
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Publication
28202523 | J:242084
First Author: Valenti G
Year: 2017
Journal: Cancer Res
Title: Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors.
Volume: 77
Issue: 8
Pages: 2134-2147
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Strain
MGI:5882802 | STOCK Tg(Myh6-tTA)6Smbf Tg(tetO-Hgf,-EGFP)24Tcre/Cnrm
Attribute String: transgenic, mutant stock
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Genotype
Genotype
Symbol: Ctnnb1/Ctnnb1<+> Tg(Wap-cre)11738Mam/? Tg(Wap-Hgf)402Mig/?
Background: FVB.Cg-Ctnnb1 Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Ggt1-tTA)#Agoc/? Tg(tetO/CMV-Hgf)#Agoc/?
Background: involves: CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CKMM-tTA)A3Rhvh/? Tg(tetO-Hgf,-EGFP)24Tcre/?
Background: involves: FVB
Zygosity: cx
Has Mutant Allele: true
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GO Term
GO:1902203 | negative regulation of hepatocyte growth factor receptor signaling pathway
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GO Term
GO:1902204 | positive regulation of hepatocyte growth factor receptor signaling pathway
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Publication
15053987 | J:89176
First Author: McIntyre BA
Year: 2004
Journal: Gene Expr Patterns
Title: Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse.
Volume: 4
Issue: 3
Pages: 351-8
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Publication
1998667 | -
First Author: McMullen BA
Year: 1991
Journal: Biochemistry
Title: Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains.
Volume: 30
Issue: 8
Pages: 2056-60
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Publication
11376658 | -
First Author: Brown PJ
Year: 2001
Journal: FEBS Lett
Title: Domains of invasion organelle proteins from apicomplexan parasites are homologous with the Apple domains of blood coagulation factor XI and plasma pre-kallikrein and are members of the PAN module superfamily.
Volume: 497
Issue: 1
Pages: 31-8
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Publication
9493272 | -
First Author: Zhou H
Year: 1998
Journal: Structure
Title: The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site.
Volume: 6
Issue: 1
Pages: 109-16
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Publication
16278292 | -
First Author: MacMillan D
Year: 2005
Journal: J Cell Sci
Title: In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin.
Volume: 118
Issue: Pt 23
Pages: 5443-51
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Protein Domain
IPR003609 | Pan_app
Type: Domain
Description: Plasma kallikrein () and coagulation factor XI () are two related plasma serine proteases activated by factor XIIA and which share the same domain topology: an N-terminal region that contains four tandem repeats of about 90 amino acids and a C-terminal catalytic domain. The 90 amino-acid repeated domain contains 6 conserved cysteines. It has been shown [, ]that three disulfide bonds link the first and sixth, second and fifth, and third and fourth cysteines. The domain can be drawn in the shape of an apple and has been accordingly called the 'apple domain'.The apple domains of plasma prekallikrein are known to mediate its binding to high molecular weight kininogen [], the apple domains of factor XI bind to factor XIIa, platelets, kininogen, factor IX and heparin [].The apple domains display some sequence similarity with the N domain of plasminogen/hepatocyte growth factor (HGF) and to some nematode and protozoan proteins []. They all belong to the same domain superfamily that have been called the PAN module []. The N domain of hepatocyte growth factor binds to the c-Met receptor and to the heparin molecule. The structure of the PAN module of HGF has been solved. It contains a characteristic hairpin-loop structure stabilised by two disulfide bridges, Cys-1 and 6 are not conserved in HGF PAN modules [].Apart from the cysteines, there are a number of other conserved positions in the apple domain. This entry represents the PAN domain of the plasma kalllikrein/coagulation factor XI subgroup proteins.
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Protein Domain
IPR019516 | Glomulin/ALF4
Type: Family
Description: In the human adult, FKBP-12, also known as FAP68 or FK506-binding protein, (protein product of the gene glomulin) is expressed at highlevels in skeletal muscle, heart, brain and kidney, and at low levels in smaller arteries and veins. The high expression of glomulin in murine vasculature suggests an important role in blood vessel development and/or maintenance, which is supported by the vascular phenotype seen in GVM patients with mutations in this gene []. It is a cytoplasmic protein, specifically bound by the non-phosphorylated form of the hepatocyte growth factor, HGF, receptor and is released upon HGF stimulation and receptor phosphorylation, suggesting a potential role for FKBP12 in linking HGF signaling to the regulation of protein synthesis []. FKBP12 is found to regulate Ca2+release from the sarcoplasmic reticulum (SR) by its action on the IP3 receptors (IP3Rs), which crucially regulate diverse cell signalling processes from reproduction to apoptosis, possibly via the kinase rapamycin (mTOR), that potentiates Ca2+ release from the IP3R in smooth muscle []. This entry also include the aberrant root formation protein 4 (At5g11030) from Arabidopsis. It is required for the initiation of lateral roots independent from auxin signaling [].
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Strain
MGI:5576895 | FVB.Cg-Cxcr4<tm2Yzo> Ctnnb1<tm1Mmt> Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig
Attribute String: mutant strain, congenic, targeted mutation, transgenic
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Publication
33574090 | J:305545
First Author: Quinn HM
Year: 2021
Journal: Cancer Res
Title: YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer.
Volume: 81
Issue: 8
Pages: 2116-2127
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Genotype
Genotype
Symbol: Tg(Eno2-Hgf)1Tnak/? Tg(SOD1*G93A)
1Gur/?
Background: involves: C57BL/6 * C57BL/6J * SJL/J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ctnnb1/Ctnnb1<+> Cxcr4/Cxcr4 Tg(Wap-cre)11738Mam/? Tg(Wap-Hgf)402Mig/?
Background: FVB.Cg-Cxcr4 Ctnnb1 Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a Tg(CKMM-tTA)A3Rhvh/? Tg(tetO-Hgf,-EGFP)24Tcre/?
Background: involves: 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a<+> Tg(CKMM-tTA)A3Rhvh/? Tg(tetO-Hgf,-EGFP)24Tcre/?
Background: involves: 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a Pax7/Pax7 Tg(CKMM-tTA)A3Rhvh/? Tg(tetO-Hgf,-EGFP)24Tcre/?
Background: involves: 129S2/SvPas * 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a Pax7/Pax7<+> Tg(CKMM-tTA)A3Rhvh/? Tg(tetO-Hgf,-EGFP)24Tcre/?
Background: involves: 129S2/SvPas * 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
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Protein
Q8BZM1
Organism: Mus musculus/domesticus
Length: 596  
Fragment?: false
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Protein
Q3TMW7
Organism: Mus musculus/domesticus
Length: 596  
Fragment?: false
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Protein
Q3T9A5
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
D6RGR3
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
D3Z0L3
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: true
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Publication
10561497 | -
First Author: Tordai H
Year: 1999
Journal: FEBS Lett
Title: The PAN module: the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a novel domain found in numerous nematode proteins.
Volume: 461
Issue: 1-2
Pages: 63-7
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Publication
11571281 | -
First Author: Grisendi S
Year: 2001
Journal: J Biol Chem
Title: Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor.
Volume: 276
Issue: 49
Pages: 46632-8
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Publication
14731255 | -
First Author: DiDonato RJ
Year: 2004
Journal: Plant J
Title: Arabidopsis ALF4 encodes a nuclear-localized protein required for lateral root formation.
Volume: 37
Issue: 3
Pages: 340-53
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Publication
1846706 | -
First Author: Bottaro DP
Year: 1991
Journal: Science
Title: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.
Volume: 251
Issue: 4995
Pages: 802-4
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Publication
7939629 | -
First Author: Wang MH
Year: 1994
Journal: Science
Title: Identification of the ron gene product as the receptor for the human macrophage stimulating protein.
Volume: 266
Issue: 5182
Pages: 117-9
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Protein Domain
IPR016244 | Tyr_kinase_HGF/MSP_rcpt
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This entry represents the receptor tyrosine kinases for HGF (hepatocyte growth factor) and MSP (macrophage-stimulating protein) []. The HGF receptor functions in cell proliferation, scattering, morphogenesis and survival [, ].
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Publication
1998666 | -
First Author: McMullen BA
Year: 1991
Journal: Biochemistry
Title: Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule.
Volume: 30
Issue: 8
Pages: 2050-6
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Publication
8662705 | -
First Author: Herwald H
Year: 1996
Journal: J Biol Chem
Title: Mapping of the discontinuous kininogen binding site of prekallikrein. A distal binding segment is located in the heavy chain domain A4.
Volume: 271
Issue: 22
Pages: 13061-7
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Publication
9632702 | -
First Author: Ho DH
Year: 1998
Journal: J Biol Chem
Title: A binding site for heparin in the apple 3 domain of factor XI.
Volume: 273
Issue: 26
Pages: 16382-90
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Protein
A0A0U1RNM3
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: false
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Publication
12948444 | J:85300
First Author: Helmbacher F
Year: 2003
Journal: Neuron
Title: Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools.
Volume: 39
Issue: 5
Pages: 767-77
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Publication
16117796 | J:100658
First Author: Kurita K
Year: 2005
Journal: J Invest Dermatol
Title: Suppression of progressive loss of coat color in microphthalmia-vitiligo mutant mice.
Volume: 125
Issue: 3
Pages: 538-44
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